N J Waterhouse

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. ncbi request reprint CTL: Caspases Terminate Life, but that's not the whole story
    N J Waterhouse
    Cancer Immunology Laboratory, Research Division, Peter MacCallum Cancer Institute, St Andrews Place, East Melbourne, Australia
    Tissue Antigens 59:175-83. 2002
  2. ncbi request reprint Functional dissociation of DeltaPsim and cytochrome c release defines the contribution of mitochondria upstream of caspase activation during granzyme B-induced apoptosis
    N J Waterhouse
    Cancer Cell Death, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett Street, Melbourne, Victoria 8006, Australia
    Cell Death Differ 13:607-18. 2006
  3. ncbi request reprint Calpain activation is upstream of caspases in radiation-induced apoptosis
    N J Waterhouse
    Queensland Cancer Fund Research Unit, Queensland Institute of Medical Research, Royal Brisbane Hospital, Herston, Australia
    Cell Death Differ 5:1051-61. 1998
  4. ncbi request reprint Granzyme B-mediated apoptosis proceeds predominantly through a Bcl-2-inhibitable mitochondrial pathway
    M J Pinkoski
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 276:12060-7. 2001
  5. pmc Cytochrome c maintains mitochondrial transmembrane potential and ATP generation after outer mitochondrial membrane permeabilization during the apoptotic process
    N J Waterhouse
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Cell Biol 153:319-28. 2001
  6. ncbi request reprint p53 triggers apoptosis in oncogene-expressing fibroblasts by the induction of Noxa and mitochondrial Bax translocation
    M Schuler
    Division of Cellular Immunology, La Jolla Institute for Allergy, San Diego, CA, USA
    Cell Death Differ 10:451-60. 2003
  7. ncbi request reprint A new quantitative assay for cytochrome c release in apoptotic cells
    N J Waterhouse
    Cell Death Differ 10:853-5. 2003
  8. doi request reprint Blocking granule-mediated death by primary human NK cells requires both protection of mitochondria and inhibition of caspase activity
    K A Sedelies
    Cancer Cell Death Laboratory, Cancer Immunology Program, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett Street, Melbourne, Victoria 8006, Australia
    Cell Death Differ 15:708-17. 2008

Collaborators

  • J A Trapani
  • D R Green
  • J Silke
  • Sharad Kumar
  • K A Sedelies
  • M Schuler
  • J C Goldstein
  • M J Pinkoski
  • P I Bird
  • R W Johnstone
  • J Oliaro
  • V R Sutton
  • C J P Clarke
  • A Ciccone
  • O Susanto
  • F L Scott
  • S Hoffarth
  • F Breitenb├╝cher
  • U Maurer
  • J A Heibein
  • T Kuwana
  • D D Newmeyer
  • R C Bleackley
  • B B Wolf

Detail Information

Publications8

  1. ncbi request reprint CTL: Caspases Terminate Life, but that's not the whole story
    N J Waterhouse
    Cancer Immunology Laboratory, Research Division, Peter MacCallum Cancer Institute, St Andrews Place, East Melbourne, Australia
    Tissue Antigens 59:175-83. 2002
    ..Here we will discuss the mechanisms by which these stellar killers achieve their goal...
  2. ncbi request reprint Functional dissociation of DeltaPsim and cytochrome c release defines the contribution of mitochondria upstream of caspase activation during granzyme B-induced apoptosis
    N J Waterhouse
    Cancer Cell Death, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett Street, Melbourne, Victoria 8006, Australia
    Cell Death Differ 13:607-18. 2006
    ..This functional dissociation of cytochrome c and SMAC release from loss of DeltaPsim demonstrates the essential contribution of Bid upstream of caspase activation during granzyme B-induced apoptosis...
  3. ncbi request reprint Calpain activation is upstream of caspases in radiation-induced apoptosis
    N J Waterhouse
    Queensland Cancer Fund Research Unit, Queensland Institute of Medical Research, Royal Brisbane Hospital, Herston, Australia
    Cell Death Differ 5:1051-61. 1998
    ..These results support a role for calpain in the early phases of the radiation-induced apoptosis pathway, upstream of the caspases...
  4. ncbi request reprint Granzyme B-mediated apoptosis proceeds predominantly through a Bcl-2-inhibitable mitochondrial pathway
    M J Pinkoski
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 276:12060-7. 2001
    ..Bcl-2 blocks the rapid destruction of targets by granzyme B by blocking mitochondrial involvement in the process...
  5. pmc Cytochrome c maintains mitochondrial transmembrane potential and ATP generation after outer mitochondrial membrane permeabilization during the apoptotic process
    N J Waterhouse
    Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Cell Biol 153:319-28. 2001
    ....
  6. ncbi request reprint p53 triggers apoptosis in oncogene-expressing fibroblasts by the induction of Noxa and mitochondrial Bax translocation
    M Schuler
    Division of Cellular Immunology, La Jolla Institute for Allergy, San Diego, CA, USA
    Cell Death Differ 10:451-60. 2003
    ..Hence, in oncogene-expressing MEF p53 induces apoptosis by BH3 protein-dependent caspase activation...
  7. ncbi request reprint A new quantitative assay for cytochrome c release in apoptotic cells
    N J Waterhouse
    Cell Death Differ 10:853-5. 2003
  8. doi request reprint Blocking granule-mediated death by primary human NK cells requires both protection of mitochondria and inhibition of caspase activity
    K A Sedelies
    Cancer Cell Death Laboratory, Cancer Immunology Program, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett Street, Melbourne, Victoria 8006, Australia
    Cell Death Differ 15:708-17. 2008
    ....