Grant W Waterer
Affiliation: University of Western Australia
- Monotherapy versus combination antimicrobial therapy for pneumococcal pneumoniaGrant W Waterer
Department of Medicine, University of Western Australia, Perth, Western Australia, Australia
Curr Opin Infect Dis 18:157-63. 2005..In the past 5 years a number of studies have suggested that combination antibiotic therapy may be superior to monotherapy for pneumococcal pneumonia. This review outlines the major findings for and against combination therapy...
- Medium-term survival after hospitalization with community-acquired pneumoniaGrant W Waterer
Department of Medicine, University of Western Australia, Royal Perth Hospital, Perth, Western Australia, Australia
Am J Respir Crit Care Med 169:910-4. 2004....
- Choosing the right combination therapy in severe community-acquired pneumoniaGrant W Waterer
School of Medicine and Pharmacology, University of Western Australia, MRF Building, Royal Perth Hospital, GPO Box X2213, Perth 6847, Australia
Crit Care 10:115. 2006..Several mechanisms exist by which quinolones could be inferior to macrolides in combination therapy, so if these findings are confirmed by other groups they have significant implications for physicians treating patients with severe CAP...
- Heat shock protein 70-2+1267 AA homozygotes have an increased risk of septic shock in adults with community-acquired pneumoniaGrant W Waterer
Department of Medicine, University of Western Australia
Crit Care Med 31:1367-72. 2003....
- Delayed administration of antibiotics and atypical presentation in community-acquired pneumoniaGrant W Waterer
University of Western Australia, School of Medicine and Pharmacology, 4th Floor MRF Building, Royal Perth Hospital, GPO Box X2213, Perth, WA, Australia 6847
Chest 130:11-5. 2006..We investigated the factors that predict a prolonged TFAD and their association with mortality...
- Feasibility of real-time polymerase chain reaction in whole blood to identify Streptococcus pneumoniae in patients with community-acquired pneumoniaCordelia Kee
School of Medicine and Pharmacology, University of Western Australia, Perth 6009, Western Australia
Diagn Microbiol Infect Dis 61:72-5. 2008..Our findings suggest the lytA PCR is more sensitive, and the quantitative aspect of the assay shows promise as an aid to clinical judgment...
- The septic shock associated HSPA1B1267 polymorphism influences production of HSPA1A and HSPA1BSuzanna E L Temple
School of Medicine and Pharmacology, University of Western Australia, GPO Box X2213, 6847 Perth, Western Australia, Australia
Intensive Care Med 30:1761-7. 2004..To identify a functional polymorphic site(s) within HSPA1A and/or HSPA1B which is in linkage disequilibrium with the silent mutation HSPA1B1267A>G and explains its association with septic shock...
- Pathogenic bacteria and TNF do not induce production of macrophage migration inhibitory factor (MIF) by human monocytesSuzanna E L Temple
School of Medicine and Pharmacology, RPH Unit M570, University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia
Cytokine 46:316-8. 2009..Exposure of leukocytes to TNF did not induce MIF. Hence elevated levels of serum MIF observed in sepsis may not reflect MIF produced by blood leukocytes stimulated directly by bacteria or TNF...
- Genetic risk of acute pulmonary infections and sepsisGrant W Waterer
School of Medicine and Pharmacology, University of Western Australia, Level 4 MRF Building, Royal Perth Hospital, GPO Box X2213, Perth 6847, Australia
Expert Rev Respir Med 4:229-38. 2010..Finally, our approach to reporting genetic studies needs to change to minimize the number of publications of spurious findings...
- Endotoxin induced TNF and IL-10 mRNA production is higher in male than female donors: correlation with elevated expression of TLR4Suzanna E L Temple
School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia
Cell Immunol 251:69-71. 2008..TLR4 expression was also significantly higher in cells from men. These gender differences in the immune response may help to elucidate the sexual dimorphism observed in infectious diseases...
- Quantitative rt-PCR holds promise as a screening tool for patients with severe sepsisShelley Kirkbright
Emergency Medicine, Royal Perth Hospital, University of Western Australia and Centre for Clinical Research in Emergency Medicine, Western Australian Institute for Medical Research, Perth, Perth, Western Australia, Australia
Emerg Med Australas 23:502-6. 2011..The aim of the present study was to determine if the quantification of bacterial 16S rDNA could be clinically useful in predicting patients at increased risk of developing septic shock...
- Bacterial infection elicits heat shock protein 72 release from pleural mesothelial cellsJulius F Varano Della Vergiliana
Pleural Disease Unit, Lung Institute of Western Australia, Centre for Asthma, Allergy and Respiratory Research, School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia
PLoS ONE 8:e63873. 2013..05). The data establish that pleural mesothelial cells can release Hsp72 in response to bacterial infection and levels are raised in infectious pleural effusions. The biological role of HSP70 in pleural infection warrants exploration...
- Genetic susceptibility to pneumoniaGrant W Waterer
School of Medicine and Pharmacology, University of Western Australia, Royal Perth Hospital, GP0 Box X2213, Perth, Western Australia
Clin Chest Med 26:29-38. 2005..IL-10 and IL-1 receptor antagonist polymorphisms have an important role in the anti-inflammatory response. Specific organ dysfunction, such as ARDS or DIC, may be related to polymorphisms in specific effector genes...
- Bioterrorism for the respiratory physicianGrant W Waterer
Centre for Asthma, Allergy and Respiratory Research and Lung Institute of Western Australia, The University of Western Australia, Perth, Australia
Respirology 14:5-11. 2009..The pathogenesis, clinical manifestations and treatment of these agents will be discussed as well as historical examples of their use. Other potential bioterrorism agents with respiratory manifestations will also be discussed briefly...
- Genetic predisposition to respiratory infection and sepsisLi Ping Chung
School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia
Crit Rev Clin Lab Sci 48:250-68. 2011..In addition, a summary of the expanding research in the field of epigenetics and post-sepsis immunosuppression will be discussed...
- Management of community-acquired pneumonia in adultsGrant W Waterer
University of Western Australia, Perth, Australia
Am J Respir Crit Care Med 183:157-64. 2011....
- Alleles carried at positions -819 and -592 of the IL10 promoter affect transcription following stimulation of peripheral blood cells with Streptococcus pneumoniaeSuzanna E L Temple
School of Medicine and Pharmacology, Royal Perth Hospital, University of Western Australia, GPO Box X2213, WA 6847, Perth, Australia
Immunogenetics 55:629-32. 2003..The results suggest that the -819 and/or -592 alleles affect transcription...
- Decreasing beta-lactam resistance in Pneumococci from the Memphis region: analysis of 2,152 isolates From 1996 to 2001Grant W Waterer
Department of Medicine, University of Western Australia, Crawley, Australia
Chest 124:519-25. 2003..In recent years, we have seen a significant shift in antibiotic use away from beta-lactams toward the newer quinolones and macrolides. We hypothesized that these changes would cause a shift in pneumococcal antibiotic resistance patterns...
- Community-acquired pneumonia: genomics, epigenomics, transcriptomics, proteomics, and metabolomicsGrant W Waterer
Department of Medicine, University of Western Australia, Perth, Australia
Semin Respir Crit Care Med 33:257-65. 2012..Current and potential future uses of these platforms are discussed, and both key findings and key barriers to further progress are highlighted...
- The need for translational research in respiratory medicineY C Gary Lee
School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
Transl Respir Med 1:9. 2013..The results of these work need to be disseminated quickly and widely. The creation of an open access journal, such as Translational Respiratory Medicine, dedicated to translational respiratory research can help foster progress. ..
- A quantitative LightCycler PCR to detect Streptococcus pneumoniae in blood and CSFRobert van Haeften
Department of Microbiology and Infectious Diseases, Royal Perth Hospital, Perth, Australia
Diagn Microbiol Infect Dis 47:407-14. 2003..pneumoniae infections, while bacterial load quantitation has opened up exciting possibilities for patient management...
- Science review: Genetic variability in the systemic inflammatory responseGrant W Waterer
Department of Medicine, University of Western Australia, Australia
Crit Care 7:308-14. 2003..However, large, phenotypically detailed studies are required to address all of the other potential polymorphisms in inflammatory molecule genes and their interactions...
- Public health management of pandemic (H1N1) 2009 infection in Australia: a failure!Grant W Waterer
School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
Respirology 15:51-6. 2010..In this paper, two senior academics discuss the management of pandemic (H1N1) 2009 infection in Australia from the public health perspective...
- SMART-COP: a tool for predicting the need for intensive respiratory or vasopressor support in community-acquired pneumoniaPatrick G P Charles
Departments of 1Infectious Diseases and 2Respiratory and Sleep Medicine, Austin Health, Heidelberg, VIC 3084, Australia
Clin Infect Dis 47:375-84. 2008....
- The etiology of community-acquired pneumonia in Australia: why penicillin plus doxycycline or a macrolide is the most appropriate therapyPatrick G P Charles
Department of Infectious Diseases, Austin Health, Heidelberg, Vic, Australia
Clin Infect Dis 46:1513-21. 2008..Local treatment guidelines promote the use of combination therapy with agents such as penicillin or amoxycillin combined with either doxycycline or a macrolide...
- Intracellular adhesion molecule Gly241Arg polymorphism has no impact on ARDS or septic shock in community-acquired pneumoniaMichael W Quasney
Department of Pediatrics, Crippled Children s Foundation Research Center, University of Tennessee, Memphis, 38103, USA
Chest 121:85S-86S. 2002
- Tumor necrosis factor gene polymorphisms and the variable presentation and outcome of community-acquired pneumoniaRichard G Wunderink
Methodist Le Bonheur Healthcare Foundation, University of Tennessee, Memphis, TN, USA
Chest 121:87S. 2002
- Pharmaceutical industry research and cost savings in community-acquired pneumoniaLori A Kessler
Physicians Research Network, Methodist Le Bonheur Healthcare Foundation, Memphis, Tenn 38104, USA
Am J Manag Care 8:798-800. 2002..To provide financial justification for continuing pharmaceutical research in an environment that has met with increasing resistance from insurance carriers to paying for the care of patients enrolled in research studies...
- The diagnostic dilemma in suspected ventilator-associated pneumonia: one size will never fit allGrant W Waterer
Chest 123:335-7. 2003
- Combination antibiotic therapy with macrolides in community-acquired pneumonia: more smoke but is there any fire?Grant W Waterer
Chest 123:1328-9. 2003
- Genetics of sepsis and pneumoniaRichard G Wunderink
Research Department, Methodist LeBonheur Healthcare, Memphis, Tennessee, USA
Curr Opin Crit Care 9:384-9. 2003..Recent association studies in pneumonia and sepsis will be reviewed...
- Association between surfactant protein B + 1580 polymorphism and the risk of respiratory failure in adults with community-acquired pneumoniaMichael W Quasney
Division of Critical Care, Department of Pediatrics, University of Tennessee, Memphis, Children s Foundation Research Center of Memphis, Le Bonheur Children s Medical Center, 50 N Dunlap, Memphis, TN 38103, USA
Crit Care Med 32:1115-9. 2004..The objective was to determine whether the SP-B + 1580 CC genotype is associated with an increased risk of respiratory failure and ARDS in adults with community-acquired pneumonia...
- Community-acquired pneumonia: pathophysiology and host factors with focus on possible new approaches to management of lower respiratory tract infectionsRichard G Wunderink
Northwestern University Feinberg School of Medicine, 676 North St Clair, Suite 14 044, Chicago, IL 60611, USA
Infect Dis Clin North Am 18:743-59, vii. 2004..This article reviews genetic variation in the molecules involved in the known patho-genic mechanisms of CAP, including cough, bacterial recognition, inflammation and the compensatory anti-inflammatory response,and organ dysfunction...
- Genetics of community-acquired pneumoniaRichard G Wunderink
Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
Semin Respir Crit Care Med 26:553-62. 2005..The real value of these genetic studies in CAP and other severe infections will be when the management of an individual patient can be optimized by therapy based on the individual's genotype for molecules important in outcome...
- Pleurodesis practice for malignant pleural effusions in five English-speaking countries: survey of pulmonologistsY C Gary Lee
University of Oxford and Osler Chest Unit, Churchill Hospital, Oxford OX3 7BN, UK
Chest 124:2229-38. 2003..Pleurodesis is important in the management of malignant pleural effusions, but no consensus exists on the optimal agent or methods of pleurodesis. How pleurodesis is practiced worldwide has not been studied...
- The impact of estrogen and progesterone on asthmaCatherine L Haggerty
Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Ann Allergy Asthma Immunol 90:284-91; quiz 291-3, 347. 2003..This paper describes evidence of a positive effect of both endogenous and exogenous estrogen and progesterone on lung function across the life span in women...
- High-mobility group box 1 (HMGB1) as a potential therapeutic target in sepsis--more questions than answersGrant W Waterer
Crit Care Med 35:1205-6. 2007
- Polymorphism studies in critical illness--we have to raise the barGrant W Waterer
Crit Care Med 35:1424-5. 2007