M J Smyth

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. pmc Innate immune surveillance of spontaneous B cell lymphomas by natural killer cells and gammadelta T cells
    Shayna E A Street
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre Peter Mac, 8006, Victoria, Australia
    J Exp Med 199:879-84. 2004
  2. pmc Normal thymocyte negative selection in TRAIL-deficient mice
    Erika Cretney
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett St, Melbourne, Victoria 8006, Australia
    J Exp Med 198:491-6. 2003
  3. pmc Suppression of lymphoma and epithelial malignancies effected by interferon gamma
    Shayna E A Street
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Institute, East Melbourne, Victoria 8006, Australia
    J Exp Med 196:129-34. 2002
  4. ncbi request reprint Unlocking the secrets of cytotoxic granule proteins
    M J Smyth
    Cancer Immunology Division, Trescowthick Laboratories, Peter MacCallum Cancer Institute, Melbourne, Australia
    J Leukoc Biol 70:18-29. 2001
  5. ncbi request reprint A fresh look at tumor immunosurveillance and immunotherapy
    M J Smyth
    Cancer Immunology, Trescowthick Laboratories, Peter MacCallum Cancer Institute, Locked Bag 1, A Beckett St, 8006, Australia
    Nat Immunol 2:293-9. 2001
  6. ncbi request reprint The anti-tumor activity of IL-12: mechanisms of innate immunity that are model and dose dependent
    M J Smyth
    Cancer Immunology, Peter MacCallum Cancer Institute, St Andrews Place, East Melbourne, Victoria, Australia
    J Immunol 165:2665-70. 2000
  7. ncbi request reprint Lymphocyte-mediated immunosurveillance of epithelial cancers?
    M J Smyth
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Institute, Locked Bag 1, A Beckett St, 8006, Australia
    Trends Immunol 22:409-11. 2001
  8. ncbi request reprint Role of TNF in lymphocyte-mediated cytotoxicity
    M J Smyth
    Cellular Cytotoxicity Laboratory, Austin Research Institute, Austin
    Microsc Res Tech 50:196-208. 2000
  9. ncbi request reprint NKT cells - conductors of tumor immunity?
    Mark J Smyth
    Cancer Immunology, Trescowthick Laboratories, Peter MacCallum Cancer Institute, East Melbourne, Victoria, Australia
    Curr Opin Immunol 14:165-71. 2002
  10. pmc Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon gamma-dependent natural killer cell protection from tumor metastasis
    M J Smyth
    Cancer Immunology, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Institute, East Melbourne, Victoria 3002, Australia
    J Exp Med 193:661-70. 2001

Collaborators

Detail Information

Publications134 found, 100 shown here

  1. pmc Innate immune surveillance of spontaneous B cell lymphomas by natural killer cells and gammadelta T cells
    Shayna E A Street
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre Peter Mac, 8006, Victoria, Australia
    J Exp Med 199:879-84. 2004
    ..These results reflect a critical role for NK cells and gammadeltaTCR+ T cells in innate immune surveillance of B cell lymphomas, mediated by as yet undetermined pathway(s) of tumor recognition...
  2. pmc Normal thymocyte negative selection in TRAIL-deficient mice
    Erika Cretney
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett St, Melbourne, Victoria 8006, Australia
    J Exp Med 198:491-6. 2003
    ..We were unable to demonstrate a role for TRAIL signaling in any of these models, suggesting that this pathway is not a critical factor for thymocyte negative selection...
  3. pmc Suppression of lymphoma and epithelial malignancies effected by interferon gamma
    Shayna E A Street
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Institute, East Melbourne, Victoria 8006, Australia
    J Exp Med 196:129-34. 2002
    ..A significant incidence of late onset adenocarcinoma observed in both IFN-gamma- and pfp-deficient mice indicated that some epithelial tissues were also subject to immunosurveillance...
  4. ncbi request reprint Unlocking the secrets of cytotoxic granule proteins
    M J Smyth
    Cancer Immunology Division, Trescowthick Laboratories, Peter MacCallum Cancer Institute, Melbourne, Australia
    J Leukoc Biol 70:18-29. 2001
    ....
  5. ncbi request reprint A fresh look at tumor immunosurveillance and immunotherapy
    M J Smyth
    Cancer Immunology, Trescowthick Laboratories, Peter MacCallum Cancer Institute, Locked Bag 1, A Beckett St, 8006, Australia
    Nat Immunol 2:293-9. 2001
    ....
  6. ncbi request reprint The anti-tumor activity of IL-12: mechanisms of innate immunity that are model and dose dependent
    M J Smyth
    Cancer Immunology, Peter MacCallum Cancer Institute, St Andrews Place, East Melbourne, Victoria, Australia
    J Immunol 165:2665-70. 2000
    ..Overall, both NK and NKT cells can contribute to natural and IL-12-induced immunity against tumors, and the relative role of each population is tumor and therapy dependent...
  7. ncbi request reprint Lymphocyte-mediated immunosurveillance of epithelial cancers?
    M J Smyth
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Institute, Locked Bag 1, A Beckett St, 8006, Australia
    Trends Immunol 22:409-11. 2001
    ..These findings have rejuvenated interest in the immunosurveillance of tumors, and recent data have provided evidence that the immune system influences the development of some spontaneous epithelial malignancies...
  8. ncbi request reprint Role of TNF in lymphocyte-mediated cytotoxicity
    M J Smyth
    Cellular Cytotoxicity Laboratory, Austin Research Institute, Austin
    Microsc Res Tech 50:196-208. 2000
    ..This review describes the key molecular details of the action of TNF and discusses the evidence for TNF-mediated cytotoxicity being critical to lymphocyte function and immunoregulation...
  9. ncbi request reprint NKT cells - conductors of tumor immunity?
    Mark J Smyth
    Cancer Immunology, Trescowthick Laboratories, Peter MacCallum Cancer Institute, East Melbourne, Victoria, Australia
    Curr Opin Immunol 14:165-71. 2002
    ....
  10. pmc Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon gamma-dependent natural killer cell protection from tumor metastasis
    M J Smyth
    Cancer Immunology, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Institute, East Melbourne, Victoria 3002, Australia
    J Exp Med 193:661-70. 2001
    ..These results indicated that TRAIL induction on NK cells plays a critical role in IFN-gamma-mediated antimetastatic effects of IL-12 and alpha-GalCer...
  11. ncbi request reprint New aspects of natural-killer-cell surveillance and therapy of cancer
    Mark J Smyth
    Cancer Immunology Laboratory, Trescowthick Research Laboratories, Research Division, Peter MacCallum Cancer Institute, Locked Bag 1, A Beckett Street, Melbourne 8006, Australia
    Nat Rev Cancer 2:850-61. 2002
  12. ncbi request reprint Cytokines in cancer immunity and immunotherapy
    Mark J Smyth
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Center Peter Mac, Victoria, Australia
    Immunol Rev 202:275-93. 2004
    ..In this review, we define the contrasting roles that cytokines play in promoting tumor immunity, inflammation, and carcinogenesis. We also discuss the more promising aspects of clinical cytokine use in cancer patients...
  13. ncbi request reprint Nature's TRAIL--on a path to cancer immunotherapy
    Mark J Smyth
    Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Institute, East Melbourne, Victoria 3002, Australia
    Immunity 18:1-6. 2003
    ....
  14. ncbi request reprint Cutting edge: granzymes A and B are not essential for perforin-mediated tumor rejection
    Mark J Smyth
    Cancer Immunology Program, Peter MacCallum Cancer Institute, East Melbourne, Victoria, Australia
    J Immunol 171:515-8. 2003
    ....
  15. ncbi request reprint Redirected perforin-dependent lysis of colon carcinoma by ex vivo genetically engineered CTL
    P K Darcy
    Cellular Cytotoxicity Laboratory, The Austin Research Institute, Heidelberg, Victoria, Australia
    J Immunol 164:3705-12. 2000
    ..This series of experiments has revealed the utility of scFv anti-CEA chimeras in providing mouse T cells the capacity to reject colon carcinoma in an Ag- and perforin-specific manner...
  16. ncbi request reprint Multiple deficiencies underlie NK cell inactivity in lymphotoxin-alpha gene-targeted mice
    M J Smyth
    Cellular Cytotoxicity Laboratory, The Austin Research Institute, Heidelberg, Victoria, Australia
    J Immunol 163:1350-3. 1999
    ..5- to 3-fold in LT-alpha-deficient mice, as compared with wild-type mice. Combined defects in NK cell development and effector function contribute to compromised NK cell antitumor function in LT-alpha-deficient mice...
  17. ncbi request reprint IL-21 induces the functional maturation of murine NK cells
    Jason Brady
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Immunol 172:2048-58. 2004
    ..These developmental changes suggested that IL-21 functions to induce the terminal differentiation of mouse NK cells, resulting in heightened NK cell-mediated cytotoxicity and immune surveillance...
  18. pmc Differential tumor surveillance by natural killer (NK) and NKT cells
    M J Smyth
    Cellular Cytotoxicity Laboratory, Austin Research Institute, Austin and Repatriation Medical Centre, Heidelberg, 3084 Victoria, Australia
    J Exp Med 191:661-8. 2000
    ..This is the first description of an antitumor function for NKT cells in the absence of exogenously administered potent stimulators such as IL-12 or alpha-galactosylceramide...
  19. ncbi request reprint Perforin-dependent cytolytic responses in beta2-microglobulin-deficient mice
    M J Smyth
    Cellular Cytotoxicity Laboratory, The Austin Research Institute, Studley Road, Heidelberg, Victoria, 3084, Australia
    Cell Immunol 196:51-9. 1999
    ..Dependence on perforin function was demonstrated for the cytotoxicity of these effectors in vitro and for the ability of these effectors to reject a variety of tumors in vivo...
  20. ncbi request reprint Perforin and interferon-gamma activities independently control tumor initiation, growth, and metastasis
    S E Street
    Cancer Immunology, Peter MacCallum Cancer Institute, Victoria, Australia
    Blood 97:192-7. 2001
    ....
  21. ncbi request reprint P-glycoprotein protects leukemia cells against caspase-dependent, but not caspase-independent, cell death
    R W Johnstone
    The Austin Research Institute, Austin Hospital, Heidelberg, Victoria, Australia
    Blood 93:1075-85. 1999
    ..This study has confirmed a potential novel physiological function for P-glycoprotein and it now remains to dissect the molecular mechanisms involved in the inhibition of capsase-dependent cell death by P-glycoprotein...
  22. ncbi request reprint Adoptive transfer: the role of perforin in mouse cytotoxic T lymphocyte rejection of human tumor xenografts in vivo
    M J Smyth
    Cellular Cytotoxicity Laboratory, The Austin Research Institute, Heidelberg, Victoria, Australia
    Xenotransplantation 5:146-53. 1998
    ..These data indicate that perforin, and hence direct cytotoxicity, plays a key role in the ability of adoptively transferred CD8+ cytotoxic T lymphocytes to eradicate established xenografts...
  23. ncbi request reprint Perforin is a major contributor to NK cell control of tumor metastasis
    M J Smyth
    Cellular Immunity Laboratory, Austin Research Institute, Heidelberg, Victoria, Australia
    J Immunol 162:6658-62. 1999
    ..Depletion of NK subsets resulted in greater numbers of metastases than observed in perforin-deficient mice, suggesting that perforin-independent effector functions of NK cells may also contribute to protection from tumor metastasis...
  24. pmc m144, a murine cytomegalovirus (MCMV)-encoded major histocompatibility complex class I homologue, confers tumor resistance to natural killer cell-mediated rejection
    E Cretney
    Cellular Immunity Laboratory, The Austin Research Institute, Melbourne, Victoria, Australia
    J Exp Med 190:435-44. 1999
    ....
  25. ncbi request reprint P-glycoprotein does not protect cells against cytolysis induced by pore-forming proteins
    R W Johnstone
    Peter MacCallum Cancer Institute, Trescowthick Research Laboratories, St Andrews Place, East Melbourne 3002, Victoria, Australia
    J Biol Chem 276:16667-73. 2001
    ..Based on these results, we conclude that P-gp does not affect cell lysis induced by pore-forming proteins...
  26. pmc The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species
    A A Ruefli
    Cancer Immunology Division, The Peter MacCallum Cancer Institute, Trescowthick Research Laboratories, Saint Andrews Place, East Melbourne, Victoria 3002, Australia
    Proc Natl Acad Sci U S A 98:10833-8. 2001
    ..These data provide evidence of a mechanism of cell death mediated by transcriptional events that result in the cleavage of Bid, disruption of the mitochondrial membrane, and production of reactive oxygen species to induce cell death...
  27. doi request reprint Gene-modified T cells as immunotherapy for multiple myeloma and acute myeloid leukemia expressing the Lewis Y antigen
    S Peinert
    Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, Victoria, Australia
    Gene Ther 17:678-86. 2010
    ..Consequently, we plan to use T cells manufactured under Good Manufacturing Practice conditions in a phase I immunotherapy study for patients with Le(Y)-positive myeloma or AML...
  28. ncbi request reprint Cloning and expression of the recombinant mouse natural killer cell granzyme Met-ase-1
    J M Kelly
    Cellular Cytotoxicity Laboratory, Austin Research Institute, Austin Hospital, Heidelberg, 3084 Victoria, Australia
    Immunogenetics 44:340-50. 1996
    ....
  29. ncbi request reprint NK cells and NKT cells collaborate in host protection from methylcholanthrene-induced fibrosarcoma
    M J Smyth
    Cancer Immunology, Peter MacCallum Cancer Institute, St Andrews Place, East Melbourne, Victoria 8006, Australia
    Int Immunol 13:459-63. 2001
    ..In contrast, sarcoma incidence and growth rate were reduced using IL-12 therapy, this effect was mediated in the absence of T cells (including NKT cells), but not NK cells...
  30. pmc NKG2D recognition and perforin effector function mediate effective cytokine immunotherapy of cancer
    Mark J Smyth
    Cancer Immunology Program, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett St, 8006, Victoria, Australia
    J Exp Med 200:1325-35. 2004
    ....
  31. ncbi request reprint Granzymes: a variety of serine protease specificities encoded by genetically distinct subfamilies
    M J Smyth
    Cellular Cytotoxicity Laboratory, Austin Research Institute, Austin Hospital, Heidelberg, Victoria, Australia
    J Leukoc Biol 60:555-62. 1996
    ....
  32. ncbi request reprint Proapoptotic functions of cytotoxic lymphocyte granule constituents in vitro and in vivo
    J A Trapani
    The Research Division, The John Connell Laboratory, Peter MacCallum Cancer Institute, St Andrew s Place, Austin Research Institute, Heidelberg, 3084, Australia au
    Curr Opin Immunol 12:323-9. 2000
    ....
  33. ncbi request reprint NK cell TRAIL eliminates immature dendritic cells in vivo and limits dendritic cell vaccination efficacy
    Yoshihiro Hayakawa
    Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    J Immunol 172:123-9. 2004
    ..These data suggested that NK cell TRAIL might regulate responses to vaccination by controlling the survival of Ag-loaded DC...
  34. ncbi request reprint Rejection of syngeneic colon carcinoma by CTLs expressing single-chain antibody receptors codelivering CD28 costimulation
    Nicole M Haynes
    Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Institute, St Andrew s Place, East Melbourne, Victoria, Australia
    J Immunol 169:5780-6. 2002
    ....
  35. ncbi request reprint CD4+CD25+ T regulatory cells suppress NK cell-mediated immunotherapy of cancer
    Mark J Smyth
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Australia
    J Immunol 176:1582-7. 2006
    ..Our data illustrate at least one mechanism by which Treg can suppress NK cell antitumor activity and highlight the effectiveness of combining Treg inhibition with subsequent NK cell activation to promote strong innate antitumor immunity...
  36. ncbi request reprint Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice
    Erika Cretney
    Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Institute, A Beckett Street, East Melbourne, 8006 Victoria, Australia
    J Immunol 168:1356-61. 2002
    ..TRAIL gene-targeted mice were also more sensitive to the chemical carcinogen methylcholanthrene. These results substantiated TRAIL as an important natural effector molecule used in the host defense against transformed cells...
  37. ncbi request reprint T cells gene-engineered with DAP12 mediate effector function in an NKG2D-dependent and major histocompatibility complex-independent manner
    Michele W L Teng
    Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria 8006, Australia
    J Biol Chem 280:38235-41. 2005
    ..Overall, this study demonstrated the significant potential of suppressing tumors and other cellular targets expressing NKG2D-L by endowing T cells with innate NK cell-like function...
  38. pmc A critical role for natural killer T cells in immunosurveillance of methylcholanthrene-induced sarcomas
    Nadine Y Crowe
    Department of Pathology and Immunology, Monash University Medical School, Melbourne, Victoria 3181, Australia
    J Exp Med 196:119-27. 2002
    ....
  39. ncbi request reprint Cutting edge: tumor rejection mediated by NKG2D receptor-ligand interaction is dependent upon perforin
    Yoshihiro Hayakawa
    Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Institute, A Beckett Street, St Andrews Place, East Melbourne, 8006 Victoria, Australia
    J Immunol 169:5377-81. 2002
    ..Thus, these results indicated that NKG2D acted as a natural cytotoxicity receptor to stimulate perforin-mediated elimination of ligand-expressing tumor cells...
  40. ncbi request reprint Induction of tumor-specific T cell memory by NK cell-mediated tumor rejection
    Janice M Kelly
    Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Institute, St Andrews Place, East Melbourne, Victoria, Australia
    Nat Immunol 3:83-90. 2002
    ..Thus CD27-CD70 interactions provide a key link between innate NK cell responses and adaptive T cell immunity...
  41. pmc Alpha-galactosylceramide (KRN7000) suppression of chemical- and oncogene-dependent carcinogenesis
    Yoshihiro Hayakawa
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett Street, Melbourne 8006, Australia
    Proc Natl Acad Sci U S A 100:9464-9. 2003
    ..Taken together, our results demonstrate that NK1.1+alphabetaTCR+ cell-based immune therapy can inhibit primary tumorigenesis...
  42. pmc An essential role for tumor necrosis factor in natural killer cell-mediated tumor rejection in the peritoneum
    M J Smyth
    Cellular Cytotoxicity Laboratory, The Austin Research Institute, Heidelberg, Victoria 3084, Australia
    J Exp Med 188:1611-9. 1998
    ..Overall, these data show that NK cells delivering perforin are the major effectors of class I- tumor rejection in the peritoneum, and that TNF is specifically critical for their recruitment to the peritoneum...
  43. doi request reprint Absence of retroviral vector-mediated transformation of gene-modified T cells after long-term engraftment in mice
    J A Westwood
    Cancer Immunology Research Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
    Gene Ther 15:1056-66. 2008
    ..This study indicates that the use of retroviral vectors to transduce T cells does not lead to malignant transformation...
  44. ncbi request reprint CTL granules: evolution of vesicles essential for combating virus infections
    J A Trapani
    Austin Research Institute, Studley Road, Heidelberg 3084, Australia
    Immunol Today 20:351-6. 1999
    ..Here, Joseph Trapani and colleagues argue that CTL cytolytic granules are the principal apoptotic means of eliminating viruses and possess multiple independent mechanisms to counter the viral anti-apoptotic machinery...
  45. ncbi request reprint Mutational analysis of P-glycoprotein: suppression of caspase activation in the absence of ATP-dependent drug efflux
    K M Tainton
    Cancer Immunology Program, The Peter MacCallum Cancer Centre, Trescowthick Research Laboratories, East Melbourne, Victoria, Australia
    Cell Death Differ 11:1028-37. 2004
    ..The structure-function analyses described herein provide novel insight into the mechanisms of action of P-gp in mediating MDR...
  46. ncbi request reprint Delayed kinetics of tumor necrosis factor-mediated bystander lysis by peptide-specific CD8+ cytotoxic T lymphocytes
    M J Smyth
    Cellular Cytotoxicity Laboratory, The Austin Research Institute, Heidelberg, Australia
    Eur J Immunol 28:4162-9. 1998
    ..By contrast, there was no evidence that soluble FasL-mediated bystander lysis. For the first time, these data indicate that CD8+ CTL may use FasL or TNF in a kinetically and physically distinct fashion to mediate bystander killing...
  47. ncbi request reprint Hypothesis: cytotoxic lymphocyte granule serine proteases activate target cell endonucleases to trigger apoptosis
    M J Smyth
    Cellular Cytotoxicity Laboratory, Austin Research Institute, Heidelberg, Victoria, Australia
    Clin Exp Pharmacol Physiol 21:67-70. 1994
    ..In cytotoxic effectors, these nuclear substrates are normally protected from granzymes by endogenous inhibitors...
  48. doi request reprint Influenza A infection enhances cross-priming of CD8+ T cells to cell-associated antigens in a TLR7- and type I IFN-dependent fashion
    Joe Wei
    Ludwig Institute for Cancer Research, Austin Health, Heidelberg, Melbourne, Victoria, Australia
    J Immunol 185:6013-22. 2010
    ..These observations suggest that IAV infection of tumor cells may facilitate improved cross-presentation of tumor Ags and may be used to augment clinical vaccine efficacy...
  49. ncbi request reprint Glycolipid antigen drives rapid expansion and sustained cytokine production by NK T cells
    Nadine Y Crowe
    Department of Pathology and Immunology, Monash University, Central and Eastern Clinical School, Prahran, Victoria, Australia
    J Immunol 171:4020-7. 2003
    ..This study provides critical new insight into how NKT cells can have such a major impact on immune responses, lasting many days beyond the initial stimulation of these cells...
  50. pmc Sequential activation of NKT cells and NK cells provides effective innate immunotherapy of cancer
    Mark J Smyth
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
    J Exp Med 201:1973-85. 2005
    ..Overall, the data suggest that NK cell antitumor function can be enhanced greatly by strategies that are designed to expand and differentiate NK cells via DC activation of NKT cells...
  51. ncbi request reprint Functional analysis of granzyme M and its role in immunity to infection
    Lily I Pao
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    J Immunol 175:3235-43. 2005
    ..These data confirm a role for GrzM in the host response to MCMV infection, but suggest that GrzM is not critical for NK cell-mediated cytotoxicity...
  52. ncbi request reprint Met-ase: cloning and distinct chromosomal location of a serine protease preferentially expressed in human natural killer cells
    M J Smyth
    Cellular Cytotoxicity Laboratory, Austin Research Institute, Austin Hospital, Heidelberg, Victoria, Australia
    J Immunol 151:6195-205. 1993
    ..The gene for the Hu-Met-1 serine protease is located on chromosome 19, which distinguishes it from any other member of the human granzyme family...
  53. doi request reprint Ex vivo culture of chimeric antigen receptor T cells generates functional CD8+ T cells with effector and central memory-like phenotype
    P Neeson
    Hematology and Immunology Translational Research Lab, Peter MacCallum Cancer Center, Melbourne, Australia
    Gene Ther 17:1105-16. 2010
    ..This study confirms CD8(+) LeY-T cells have a CM- and EM-like phenotype and heterogeneous function consistent with potential to persist in vivo after adoptive transfer...
  54. pmc Fas ligand-mediated lysis of self bystander targets by human papillomavirus-specific CD8+ cytotoxic T lymphocytes
    M J Smyth
    Cellular Cytotoxicity Laboratory, The Austin Research Institute, Heidelberg 3084, Victoria, Australia
    J Virol 72:5948-54. 1998
    ....
  55. ncbi request reprint Single-chain antigen recognition receptors that costimulate potent rejection of established experimental tumors
    Nicole M Haynes
    Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Institute, Royal Melbourne Hospital Research Foundation, A Beckett Street, Victoria, Australia 8006
    Blood 100:3155-63. 2002
    ..Our study has illustrated the practical advantage of engineering a T-cell signaling complex that codelivers CD28 activation, dependent only upon the tumor's expression of the appropriate tumor associated antigen...
  56. ncbi request reprint Perforin-dependent nuclear entry of granzyme B precedes apoptosis, and is not a consequence of nuclear membrane dysfunction
    J A Trapani
    Cellular Cytotoxicity Laboratory, The Austin Research Institute, Studley Road, Heidelberg, 3084, Australia
    Cell Death Differ 5:488-96. 1998
    ..Rather, a perforin-dependent signal results in a redistribution of grB from the cytoplasm to the nucleus, where it may contribute to the nuclear changes associated with apoptosis...
  57. pmc The drug efflux protein, P-glycoprotein, additionally protects drug-resistant tumor cells from multiple forms of caspase-dependent apoptosis
    M J Smyth
    Cellular Cytotoxicity Laboratory, The Austin Research Institute, Studley Road, Heidelberg, 3084, Victoria, Australia
    Proc Natl Acad Sci U S A 95:7024-9. 1998
    ..These observations suggest that, in addition to effluxing drugs, P-gp may play a specific role in regulating some caspase-dependent apoptotic pathways...
  58. doi request reprint Characterizing the anti-tumor function of adoptively transferred NK cells in vivo
    Hollie J Pegram
    Cancer Immunology Program, Cancer Immunotherapy Research Laboratory, Peter MacCallum Cancer Centre, 14 St Andrews Place, East Melbourne, Vic, 3002, Australia
    Cancer Immunol Immunother 59:1235-46. 2010
    ..Overall, the results of this study have important implications for enhancing NK cell-based immunotherapies...
  59. pmc Differential antitumor immunity mediated by NKT cell subsets in vivo
    Nadine Y Crowe
    Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia
    J Exp Med 202:1279-88. 2005
    ....
  60. pmc NKG2D function protects the host from tumor initiation
    Mark J Smyth
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    J Exp Med 202:583-8. 2005
    ..These findings suggest an important early role for the NKG2D in controlling and shaping tumor formation...
  61. ncbi request reprint A role for IFN-gamma in primary and secondary immunity generated by NK cell-sensitive tumor-expressing CD80 in vivo
    Janice M Kelly
    Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Institute, East Melbourne, Victoria, Australia
    J Immunol 168:4472-9. 2002
    ..Our findings demonstrate a key role for IFN-gamma in innate and adaptive immunity triggered by CD80 expression on tumor cells...
  62. pmc Adoptive transfer of T cells modified with a humanized chimeric receptor gene inhibits growth of Lewis-Y-expressing tumors in mice
    Jennifer A Westwood
    Cancer Immunology Program and Department of Hematology and Medical Oncology, Peter MacCallum Cancer Centre, St Andrew s Place, Melbourne, Victoria 3002, Australia
    Proc Natl Acad Sci U S A 102:19051-6. 2005
    ..This study supports the use of humanized gene-modified T cells as a potential therapy for Le(Y+) malignancies...
  63. ncbi request reprint DX5/CD49b-positive T cells are not synonymous with CD1d-dependent NKT cells
    Daniel G Pellicci
    University of Melbourne, Department of Microbiology and Immunology, Parkville, Victoria, Australia
    J Immunol 175:4416-25. 2005
    ..In summary, our data demonstrate that DX5/CD49b is a poor marker for identifying CD1d-dependent NKT cells...
  64. ncbi request reprint Purification and cloning of a novel serine protease, RNK-Met-1, from the granules of a rat natural killer cell leukemia
    M J Smyth
    Cellular Cytotoxicity Laboratory, Austin Research Institute, Austin Hospital, Heidelberg, Victoria, Australia
    J Biol Chem 267:24418-25. 1992
    ..These data indicate that RNK-Met-1 is a serine protease with unique activity that is expressed in the granules of large granular lymphocytes...
  65. ncbi request reprint CD1-restricted T cells and tumor immunity
    J B Swann
    Department of Microbiology and Immunology, University of Melbourne, 3010 Parkville, Victoria, Australia
    Curr Top Microbiol Immunol 314:293-323. 2007
    ..We also highlight a growing field of research that has found that NKT cells are capable of suppressing anti-tumor immunity and discuss the progress to date for the immunotherapeutic use of NKT cells...
  66. ncbi request reprint Cloning and characterization of a novel NK cell-specific serine protease gene and its functional 5'-flanking sequences
    M J Smyth
    Cellular Cytotoxicity Laboratory, Austin Research Institute, Austin Hospital, Heidelberg, Victoria, Australia
    Immunogenetics 42:101-11. 1995
    ..These data are consistent with the NK cell-specific expression of RNK-Met-1 and suggest the potential utility of this gene promoter in the development of transgene models of NK cell biology in vivo...
  67. ncbi request reprint Antitumor activity of dual-specific T cells and influenza virus
    A Murphy
    Cancer Immunology Research Program, Peter MacCallum Cancer Centre, Melbourne, Australia
    Cancer Gene Ther 14:499-508. 2007
    ..This is the first demonstration that the potent immunogenic nature of an infectious agent can be utilized to directly impact on T-cell expansion and activity against tumor in vivo...
  68. ncbi request reprint Combined natural killer T-cell based immunotherapy eradicates established tumors in mice
    Michele W L Teng
    Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Cancer Res 67:7495-504. 2007
    ..In summary, sequential tumor cell apoptosis and amplification of dendritic cell function by NKT cell agonists represents an exciting and novel approach for cancer treatment...
  69. ncbi request reprint Innate immune recognition and suppression of tumors
    Yoshihiro Hayakawa
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Victoria 3002, Australia
    Adv Cancer Res 95:293-322. 2006
    ..Evidence clearly implicate that NKG2D recognition plays an important role in tumor immune surveillance...
  70. ncbi request reprint IL-21 enhances tumor-specific CTL induction by anti-DR5 antibody therapy
    Mark J Smyth
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Center, A Beckett Street, Victoria 8006, Australia
    J Immunol 176:6347-55. 2006
    ..These results indicate that a rational combination of Ab-based therapy that causes tumor cell apoptosis and a cytokine that promotes T cell memory is a useful new strategy for cancer immunotherapy...
  71. ncbi request reprint CD27 dissects mature NK cells into two subsets with distinct responsiveness and migratory capacity
    Yoshihiro Hayakawa
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    J Immunol 176:1517-24. 2006
    ..These findings clearly reclassify mature NK cells into two distinct subsets and begin to discern their specific role in immune responses...
  72. ncbi request reprint Cutting edge: novel priming of tumor-specific immunity by NKG2D-triggered NK cell-mediated tumor rejection and Th1-independent CD4+ T cell pathway
    Jennifer A Westwood
    Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Centre, A Beckett Street, East Melbourne, 8006 Victoria, Australia
    J Immunol 172:757-61. 2004
    ....
  73. doi request reprint Endogenous IL-21 restricts CD8+ T cell expansion and is not required for tumor immunity
    Henrik S√łndergaard
    Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    J Immunol 183:7326-36. 2009
    ....
  74. ncbi request reprint Sequential production of interferon-gamma by NK1.1(+) T cells and natural killer cells is essential for the antimetastatic effect of alpha-galactosylceramide
    Mark J Smyth
    Cancer Immunology, Trescowthick Laboratories, Peter MacCallum Cancer Institute, East Melbourne, Victoria, Australia
    Blood 99:1259-66. 2002
    ....
  75. doi request reprint Multiple antitumor mechanisms downstream of prophylactic regulatory T-cell depletion
    Michele W L Teng
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Cancer Res 70:2665-74. 2010
    ..These studies reveal that Tregs control multiple redundant elements of the immune effector response capable of inhibiting tumor initiation and underscore the importance of effectively targeting these cells in any cancer immunotherapy...
  76. ncbi request reprint Innate tumor immune surveillance
    Mark J Smyth
    Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, 3002, Victoria, Australia
    Adv Exp Med Biol 590:103-11. 2007
  77. ncbi request reprint Fas ligand-mediated bystander lysis of syngeneic cells in response to an allogeneic stimulus
    M J Smyth
    Cellular Cytotoxicity Laboratory, The Austin Research Institute, Heidelberg, Victoria, Australia
    J Immunol 158:5765-72. 1997
    ..These data suggest that CTL responses to foreign Ag may evoke a certain amount of collateral damage to local host Fas-sensitive cells...
  78. ncbi request reprint Multiple physiological functions for multidrug transporter P-glycoprotein?
    R W Johnstone
    Cellular Cytotoxicity Laboratory, The Austin Research Institute, Austin Hospital, Studley Road, Heidelberg 3084, Victoria, Australia
    Trends Biochem Sci 25:1-6. 2000
    ....
  79. ncbi request reprint The natural killer cell serine protease gene Lmet1 maps to mouse chromosome 10
    K Y Thia
    Cellular Cytotoxicity Laboratory, Austin Research Institute, Austin Hospital, Heidelberg, Australia
    Immunogenetics 41:47-9. 1995
  80. ncbi request reprint Granzymes: exogenous proteinases that induce target cell apoptosis
    M J Smyth
    Cellular Cytotoxicity Laboratory, Austin Research Institute, Heidelberg, Australia
    Immunol Today 16:202-6. 1995
    ....
  81. pmc Mechanism of action of immunomodulatory drugs (IMiDS) in multiple myeloma
    H Quach
    Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Victoria 3053, Australia
    Leukemia 24:22-32. 2010
    ....
  82. ncbi request reprint A role for P-glycoprotein in regulating cell death
    R W Johnstone
    Cellular Cytotoxicity Laboratory, The Austin Research Institute, Australia, Victoria
    Leuk Lymphoma 38:1-11. 2000
    ..There is now a lively debate regarding the possible role of P-gp in regulating cell differentiation, proliferation and survival...
  83. pmc Type I natural killer T cells suppress tumors caused by p53 loss in mice
    Jeremy B Swann
    Peter MacCallum Cancer Centre, East Melbourne, Australia
    Blood 113:6382-5. 2009
    ....
  84. ncbi request reprint From cancer immunosurveillance to cancer immunotherapy
    John Stagg
    Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Vic, Australia
    Immunol Rev 220:82-101. 2007
    ....
  85. ncbi request reprint Peripheral NK1.1 NKT cells are mature and functionally distinct from their thymic counterparts
    Finlay W McNab
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia
    J Immunol 179:6630-7. 2007
    ..1(+) NKT cells in the periphery. We conclude that the vast majority of peripheral NK1.1(-) NKT cells are part of a previously unrecognized, mature NKT cell subset...
  86. doi request reprint Cancer vaccines for established cancer: how to make them better?
    Daniel M Andrews
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Vic, Australia
    Immunol Rev 222:242-55. 2008
    ..Application of this knowledge is resulting in encouraging new data in pre-clinical settings, where multiple arms of the immune system are targeted for cancer therapy...
  87. doi request reprint Interleukin 21 enhances antibody-mediated tumor rejection
    Mark J Smyth
    Cancer Immunology Program, Peter MacCallum Cancer Center, East Melbourne, Victoria, Australia
    Cancer Res 68:3019-25. 2008
    ..These data further support the use of IL-21 in adjuvant settings where strong T cell-mediated immune responses to tumors can be generated...
  88. ncbi request reprint Type I IFN contributes to NK cell homeostasis, activation, and antitumor function
    Jeremy B Swann
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, 8006 Victoria, Australia
    J Immunol 178:7540-9. 2007
    ..This study demonstrates that endogenous type I IFN is a central mediator of NK cell antitumor responses...
  89. pmc IL-23 suppresses innate immune response independently of IL-17A during carcinogenesis and metastasis
    Michele W L Teng
    Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
    Proc Natl Acad Sci U S A 107:8328-33. 2010
    ..Overall, these data indicate the general role that IL-23 plays in suppressing natural or cytokine-induced innate immunity, promoting tumor development and metastases independently of IL-17A...
  90. ncbi request reprint NK cell-based cancer immunotherapy
    John Stagg
    Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Drug News Perspect 20:155-63. 2007
    ..In this review, we summarize the role of NK cells in the control of tumor growth and discuss potential cancer therapies incorporating NK cell-mediated antitumor activity...
  91. doi request reprint Immunogenic anti-cancer chemotherapy as an emerging concept
    Nicole M Haynes
    Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Vic, Australia
    Curr Opin Immunol 20:545-57. 2008
    ..Combined these approaches have enormous potential to improve the current outcomes from conventional cancer therapy...
  92. pmc Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim
    Thomas Kaufmann
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia
    Immunity 30:56-66. 2009
    ..These observations identify caspase-8 and the BH3-only proteins Bid and Bim as potential therapeutic targets for treatment of inflammatory liver diseases...
  93. doi request reprint Immune-mediated dormancy: an equilibrium with cancer
    Michele W L Teng
    Peter MacCallum Cancer Centre, Victoria, Australia
    J Leukoc Biol 84:988-93. 2008
    ..These findings form a framework for future studies aimed at validating immune-mediated cancer dormancy in humans with the hopes of devising new, immunotherapeutic strategies to treat established cancer...
  94. ncbi request reprint Distinct receptor repertoire formation in mouse NK cell subsets regulated by MHC class I expression
    Yoshihiro Hayakawa
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Victoria, Australia, 3002
    J Leukoc Biol 83:106-11. 2008
    ....
  95. ncbi request reprint Gene-engineered T cells as a superior adjuvant therapy for metastatic cancer
    Michael H Kershaw
    Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    J Immunol 173:2143-50. 2004
    ..T cell adjuvant treatment of day 8 metastatic disease resulted in dramatic increases in survival of mice, and this survival was significantly greater than that afforded by either doxorubicin, 5-fluorouracil, or herceptin...
  96. ncbi request reprint NKT cells are not critical for HSV-1 disease resolution
    Ann L Cornish
    Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Victoria, Australia
    Immunol Cell Biol 84:13-9. 2006
    ..Instead, the resolution or severity of the infection may depend on the HSV-1 strain under investigation...
  97. ncbi request reprint TNF contributes to the immunopathology of perforin/Fas ligand double deficiency
    Erika Cretney
    Cancer Immunology, Trescowthick Research Laboratories, Peter MacCallum Cancer Institute, East Melbourne, Victoria, Australia
    Immunol Cell Biol 80:436-40. 2002
    ..We conclude that TNF is necessary for the full manifestation of immune dysregulation caused by pfp/FasL-deficiency, in particular in the early and overwhelming tissue infiltration and destruction caused by inflammatory cells...
  98. ncbi request reprint Adoptive transfer of gene-engineered CD4+ helper T cells induces potent primary and secondary tumor rejection
    Maria Moeller
    Cancer Immunology Program, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett St, East Melbourne, 8006, Victoria, Australia
    Blood 106:2995-3003. 2005
    ..Overall, this study has highlighted the therapeutic potential of using combined transfer of antigen-specific gene-modified CD8+ and CD4+ T cells to significantly enhance T-cell adoptive transfer strategies for cancer therapy...
  99. ncbi request reprint Unexpectedly, induction of cytotoxic T lymphocytes enhances the humoral response after DNA immunization
    Christopher M Dyer
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Blood 103:3073-5. 2004
    ..Our finding of CTL-mediated antibody enhancement has important implications for tumor and viral immunobiology and vaccination...
  100. ncbi request reprint Regulation of antitumour immunity by CD1d-restricted NKT cells
    Jeremy Swann
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Victoria 3002, Australia
    Immunol Cell Biol 82:323-31. 2004
    ..This intriguing cell type is the focus of this review...
  101. pmc Perforin-mediated cytotoxicity is critical for surveillance of spontaneous lymphoma
    M J Smyth
    Austin Research Institute, Heidelberg, 3084, Victoria, Australia
    J Exp Med 192:755-60. 2000
    ..This study is the first that implicates direct cytotoxicity by lymphocytes in regulating lymphomagenesis...