Doug W Smith

Summary

Affiliation: University of Newcastle
Country: Australia

Publications

  1. ncbi request reprint Increased mitochondrial DNA deletions in substantia nigra dopamine neurons of the aged rat
    Gemma M Parkinson
    School of Biomedical Sciences and Pharmacy, Medical Sciences Building, Room 306C, University of Newcastle, Callaghan, NSW 2308, Australia
    Curr Aging Sci 7:155-60. 2014
  2. ncbi request reprint Characterisation of mitochondrial DNA deletions by long-PCR in central nervous system regions of young, middle- and old-aged rats
    Ashley Cahif
    School of Biomedical Sciences and Pharmacy, Medical Sciences Building, Room 306C, University of Newcastle, Callaghan, NSW 2308, Australia
    Curr Aging Sci 6:232-8. 2013
  3. ncbi request reprint Role of neuronal nitric oxide in the dopamine deficit of HPRT-deficient mice
    Doug W Smith
    Center for Molecular Genetics, Department of Pediatrics, University of California, San Diego, CA, USA
    Metab Brain Dis 22:39-43. 2007
  4. pmc Purity and enrichment of laser-microdissected midbrain dopamine neurons
    Amanda L Brown
    Neurobiology of Ageing Laboratory, School of Biomedical Sciences and Pharmacy, Centre for Translational Neuroscience and Mental Health Research, University of Newcastle, Newcastle, NSW 2308, Australia
    Biomed Res Int 2013:747938. 2013
  5. pmc mTORC1 inhibition in the nucleus accumbens 'protects' against the expression of drug seeking and 'relapse' and is associated with reductions in GluA1 AMPAR and CAMKIIα levels
    Morgan H James
    Neurobiology of Addiction Laboratory, School of Biomedical Sciences and Pharmacy and the Centre for Translational Neuroscience and Mental Health Research, University of Newcastle and the Hunter Medical Research Institute, Newcastle, NSW, Australia
    Neuropsychopharmacology 39:1694-702. 2014
  6. doi request reprint Altered expression of histone and synaptic plasticity associated genes in the hippocampus of streptozotocin-induced diabetic mice
    Jency Thomas
    University of Newcastle, Callaghan, NSW, Australia
    Metab Brain Dis 28:613-8. 2013
  7. pmc Improved RNA preservation for immunolabeling and laser microdissection
    Amanda L Brown
    Faculty of Health, School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle NSW 2308, Australia
    RNA 15:2364-74. 2009
  8. doi request reprint Age-related gene expression changes in substantia nigra dopamine neurons of the rat
    Gemma M Parkinson
    Preclinical Neurobiology Research Program, School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia Centre for Translational Neuroscience and Mental Health Research, University of Newcastle, Callaghan, NSW 2308, Australia Hunter Medical Research Institute, 1 Kookaburra Circuit, New Lambton Heights, NSW 2305, Australia Electronic address
    Mech Ageing Dev 149:41-9. 2015
  9. doi request reprint Orexin-1 receptor signalling within the ventral tegmental area, but not the paraventricular thalamus, is critical to regulating cue-induced reinstatement of cocaine-seeking
    Morgan H James
    Neurobiology of Addiction Laboratory, School of Biomedical Sciences and Pharmacy and the Centre for Brain and Mental Health Research, University of Newcastle and the Hunter Medical Research Institute, Newcastle, NSW, Australia
    Int J Neuropsychopharmacol 14:684-90. 2011
  10. pmc Fluoxetine prevents development of an early stress-related molecular signature in the rat infralimbic medial prefrontal cortex. Implications for depression?
    Rafael A Barreto
    School of Biomedical Sciences and Pharmacy Faculty of Health, University of Newcastle, Callaghan, NSW, 2308, Australia
    BMC Neurosci 13:125. 2012

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Increased mitochondrial DNA deletions in substantia nigra dopamine neurons of the aged rat
    Gemma M Parkinson
    School of Biomedical Sciences and Pharmacy, Medical Sciences Building, Room 306C, University of Newcastle, Callaghan, NSW 2308, Australia
    Curr Aging Sci 7:155-60. 2014
    ....
  2. ncbi request reprint Characterisation of mitochondrial DNA deletions by long-PCR in central nervous system regions of young, middle- and old-aged rats
    Ashley Cahif
    School of Biomedical Sciences and Pharmacy, Medical Sciences Building, Room 306C, University of Newcastle, Callaghan, NSW 2308, Australia
    Curr Aging Sci 6:232-8. 2013
    ..These findings are remarkably consistent with previous human brain data and further underscore the value of the rat model for investigation of ageing-related changes in the mitochondrial genome. ..
  3. ncbi request reprint Role of neuronal nitric oxide in the dopamine deficit of HPRT-deficient mice
    Doug W Smith
    Center for Molecular Genetics, Department of Pediatrics, University of California, San Diego, CA, USA
    Metab Brain Dis 22:39-43. 2007
    ..These results indicate that NOS1 produced nitric oxide does not contribute to the dopamine deficit seen in HPRT deficiency...
  4. pmc Purity and enrichment of laser-microdissected midbrain dopamine neurons
    Amanda L Brown
    Neurobiology of Ageing Laboratory, School of Biomedical Sciences and Pharmacy, Centre for Translational Neuroscience and Mental Health Research, University of Newcastle, Newcastle, NSW 2308, Australia
    Biomed Res Int 2013:747938. 2013
    ..This study demonstrates that it is possible to laser-microdissect dopamine neurons to a high degree of cell purity. Therefore gene expression profiles can be precisely attributed to the targeted microdissected cells. ..
  5. pmc mTORC1 inhibition in the nucleus accumbens 'protects' against the expression of drug seeking and 'relapse' and is associated with reductions in GluA1 AMPAR and CAMKIIα levels
    Morgan H James
    Neurobiology of Addiction Laboratory, School of Biomedical Sciences and Pharmacy and the Centre for Translational Neuroscience and Mental Health Research, University of Newcastle and the Hunter Medical Research Institute, Newcastle, NSW, Australia
    Neuropsychopharmacology 39:1694-702. 2014
    ..These effects appear to involve a role for mTORC1 in the regulation of GluA1 AMPARs and CAMKIIα in the NACsh. ..
  6. doi request reprint Altered expression of histone and synaptic plasticity associated genes in the hippocampus of streptozotocin-induced diabetic mice
    Jency Thomas
    University of Newcastle, Callaghan, NSW, Australia
    Metab Brain Dis 28:613-8. 2013
    ..The present study will improve our understanding of the neural mechanisms that might underpin diabetes-related cognitive dysfunction. ..
  7. pmc Improved RNA preservation for immunolabeling and laser microdissection
    Amanda L Brown
    Faculty of Health, School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle NSW 2308, Australia
    RNA 15:2364-74. 2009
    ..Our described method yields high quality RNA from immunolabeled microdissected cells, an essential requirement for meaningful genomics investigations of normal and pathological cells isolated from complex tissues...
  8. doi request reprint Age-related gene expression changes in substantia nigra dopamine neurons of the rat
    Gemma M Parkinson
    Preclinical Neurobiology Research Program, School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia Centre for Translational Neuroscience and Mental Health Research, University of Newcastle, Callaghan, NSW 2308, Australia Hunter Medical Research Institute, 1 Kookaburra Circuit, New Lambton Heights, NSW 2305, Australia Electronic address
    Mech Ageing Dev 149:41-9. 2015
    ..Together, these results suggest that altered neurotrophic signalling and tyrosine hydroxylase activity may contribute to altered DA neuron signalling and motor nervous system regulation in ageing. ..
  9. doi request reprint Orexin-1 receptor signalling within the ventral tegmental area, but not the paraventricular thalamus, is critical to regulating cue-induced reinstatement of cocaine-seeking
    Morgan H James
    Neurobiology of Addiction Laboratory, School of Biomedical Sciences and Pharmacy and the Centre for Brain and Mental Health Research, University of Newcastle and the Hunter Medical Research Institute, Newcastle, NSW, Australia
    Int J Neuropsychopharmacol 14:684-90. 2011
    ..We hypothesize that blockade of VTA OrxR1 signalling may reduce nucleus accumbens dopamine in response to drug cue presentation...
  10. pmc Fluoxetine prevents development of an early stress-related molecular signature in the rat infralimbic medial prefrontal cortex. Implications for depression?
    Rafael A Barreto
    School of Biomedical Sciences and Pharmacy Faculty of Health, University of Newcastle, Callaghan, NSW, 2308, Australia
    BMC Neurosci 13:125. 2012
    ..The ILmPFC is thought to be involved in the processing of emotionally contextual information and in orchestrating the related autonomic responses, and it is one of the brain regions implicated in both stress responses and depression...
  11. doi request reprint Down-regulated striatal gene expression for synaptic plasticity-associated proteins in addiction and relapse vulnerable animals
    Amanda L Brown
    Neurobiology of Addiction Laboratory, School of Biomedical Sciences and Pharmacy, Centre for Brain and Mental Health Research, University of Newcastle and the Hunter Medical Research Institute, Newcastle, NSW, Australia
    Int J Neuropsychopharmacol 14:1099-110. 2011
    ....
  12. ncbi request reprint Discrepant effects of culture conditions on survival and function of dopaminergic neurons
    Doug W Smith
    Center for Molecular Genetics, Department of Pediatrics, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0634, USA
    Neuroreport 15:1025-8. 2004
    ..These results demonstrate that dopaminergic neurons can be grown in serum-free conditions but that the choice of culture conditions has a marked influence on cell survival and function...
  13. doi request reprint Region-specific changes in mitochondrial D-loop in aged rat CNS
    Simone C McInerny
    Discipline of Anatomy, School of Biomedical Sciences, Faculty of Health and The Center for Brain and Mental Health Research, University of Newcastle, Callaghan, NSW 2308, Australia
    Mech Ageing Dev 130:343-9. 2009
    ..Mitochondrial genome copy number varied between regions, in addition to an overall 18% decrease with age across the whole brain. These results suggest the age-related decline in OXPHOS may be related to a reduction in D-loop function...
  14. pmc An emerging role for the Mammalian target of rapamycin in "pathological" protein translation: relevance to cocaine addiction
    Christopher V Dayas
    School of Biomedical Sciences and Pharmacy, Centre for Translational Neuroscience and Mental Health Research, Hunter Medical Research Institute, University of Newcastle Callaghan, NSW, Australia
    Front Pharmacol 3:13. 2012
    ....
  15. ncbi request reprint Oxidative stress and dopamine deficiency in a genetic mouse model of Lesch-Nyhan disease
    Jasper E Visser
    Department of Neurology, Meyer 6 181, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Brain Res Dev Brain Res 133:127-39. 2002
    ..Overall, these data provide evidence for increased oxidative stress, but the failure to protect the knockout mice by over-expressing SOD1 argues that oxidative stress is not the sole process responsible for the loss of striatal dopamine...