Vitali Sintchenko

Summary

Affiliation: University of New South Wales
Country: Australia

Publications

  1. ncbi request reprint Which clinical decisions benefit from automation? A task complexity approach
    Vitali Sintchenko
    Centre for Health Informatics, University of New South Wales, Sydney 2052, Australia
    Int J Med Inform 70:309-16. 2003
  2. pmc Comparative impact of guidelines, clinical data, and decision support on prescribing decisions: an interactive web experiment with simulated cases
    Vitali Sintchenko
    Centre for Health Informatics, University of New South Wales, Sydney 2052, Australia
    J Am Med Inform Assoc 11:71-7. 2004
  3. ncbi request reprint Are clinicians' information needs and decision support affected by different models of care? Experimental study
    Vitali Sintchenko
    Centre for Health Informatics, University of New South Wales, Australia
    Stud Health Technol Inform 129:895-9. 2007
  4. pmc Handheld computer-based decision support reduces patient length of stay and antibiotic prescribing in critical care
    Vitali Sintchenko
    Centre for Health Informatics, University of New South Wales, UNSW, Sydney 2052
    J Am Med Inform Assoc 12:398-402. 2005
  5. ncbi request reprint Are we measuring the right end-points? Variables that affect the impact of computerised decision support on patient outcomes: a systematic review
    Vitali Sintchenko
    Centre for Health Informatics, University of New South Wales, Sydney, Australia
    Med Inform Internet Med 32:225-40. 2007
  6. doi request reprint Genome-wide analysis of single nucleotide polymorphisms in Bordetella pertussis using comparative genomic sequencing
    Ram P Maharjan
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia
    Res Microbiol 159:602-8. 2008
  7. pmc Computational bacterial genome-wide analysis of phylogenetic profiles reveals potential virulence genes of Streptococcus agalactiae
    Frank Po Yen Lin
    Centre for Health Informatics, University of New South Wales, Sydney, Australia
    PLoS ONE 6:e17964. 2011
  8. pmc Improving resolution of public health surveillance for human Salmonella enterica serovar Typhimurium infection: 3 years of prospective multiple-locus variable-number tandem-repeat analysis (MLVA)
    Vitali Sintchenko
    Centre for Infectious Diseases and Microbiology Public Health, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Sydney, NSW 2145, Australia
    BMC Infect Dis 12:78. 2012
  9. doi request reprint Insight into evolution of Bordetella pertussis from comparative genomic analysis: evidence of vaccine-driven selection
    Sophie Octavia
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia
    Mol Biol Evol 28:707-15. 2011
  10. pmc Towards bioinformatics assisted infectious disease control
    Vitali Sintchenko
    Centre for Health Informatics, University of New South Wales, Sydney, New South Wales, Australia
    BMC Bioinformatics 10:S10. 2009

Collaborators

Detail Information

Publications55

  1. ncbi request reprint Which clinical decisions benefit from automation? A task complexity approach
    Vitali Sintchenko
    Centre for Health Informatics, University of New South Wales, Sydney 2052, Australia
    Int J Med Inform 70:309-16. 2003
    ..To describe a model for analysing complex medical decision making tasks and for evaluating their suitability for automation...
  2. pmc Comparative impact of guidelines, clinical data, and decision support on prescribing decisions: an interactive web experiment with simulated cases
    Vitali Sintchenko
    Centre for Health Informatics, University of New South Wales, Sydney 2052, Australia
    J Am Med Inform Assoc 11:71-7. 2004
    ..The aim of this study was to compare the clinical impact of computerized decision support with and without electronic access to clinical guidelines and laboratory data on antibiotic prescribing decisions...
  3. ncbi request reprint Are clinicians' information needs and decision support affected by different models of care? Experimental study
    Vitali Sintchenko
    Centre for Health Informatics, University of New South Wales, Australia
    Stud Health Technol Inform 129:895-9. 2007
    ..Systems that target preventive model decisions may have higher adoption and impact...
  4. pmc Handheld computer-based decision support reduces patient length of stay and antibiotic prescribing in critical care
    Vitali Sintchenko
    Centre for Health Informatics, University of New South Wales, UNSW, Sydney 2052
    J Am Med Inform Assoc 12:398-402. 2005
    ..This study assessed the effect of a handheld computer-based decision support system (DSS) on antibiotic use and patient outcomes in a critical care unit...
  5. ncbi request reprint Are we measuring the right end-points? Variables that affect the impact of computerised decision support on patient outcomes: a systematic review
    Vitali Sintchenko
    Centre for Health Informatics, University of New South Wales, Sydney, Australia
    Med Inform Internet Med 32:225-40. 2007
    ..Complex interventions as clinical EDSS may require new metrics of assessment to describe the impact on patient outcomes...
  6. doi request reprint Genome-wide analysis of single nucleotide polymorphisms in Bordetella pertussis using comparative genomic sequencing
    Ram P Maharjan
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia
    Res Microbiol 159:602-8. 2008
    ..The data also allowed us to compare genomic diversity with other "clonal" human pathogens such as Mycobacterium tuberculosis and Yersinia pestis, showing that B. pertussis may be one of the least variable pathogenic bacterial species...
  7. pmc Computational bacterial genome-wide analysis of phylogenetic profiles reveals potential virulence genes of Streptococcus agalactiae
    Frank Po Yen Lin
    Centre for Health Informatics, University of New South Wales, Sydney, Australia
    PLoS ONE 6:e17964. 2011
    ..This computational pipeline can also be extended to in silico analysis of virulence determinants of other bacterial pathogens...
  8. pmc Improving resolution of public health surveillance for human Salmonella enterica serovar Typhimurium infection: 3 years of prospective multiple-locus variable-number tandem-repeat analysis (MLVA)
    Vitali Sintchenko
    Centre for Infectious Diseases and Microbiology Public Health, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Sydney, NSW 2145, Australia
    BMC Infect Dis 12:78. 2012
    ..This paper describes the dynamics of human STM infection in a prospective study of STM MLVA typing for public health surveillance...
  9. doi request reprint Insight into evolution of Bordetella pertussis from comparative genomic analysis: evidence of vaccine-driven selection
    Sophie Octavia
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia
    Mol Biol Evol 28:707-15. 2011
    ..Our findings suggest that B. pertussis, despite its high population homogeneity, is evolving in response to vaccination pressure with recent expansion of clones carrying variants of genes encoding ACV antigens...
  10. pmc Towards bioinformatics assisted infectious disease control
    Vitali Sintchenko
    Centre for Health Informatics, University of New South Wales, Sydney, New South Wales, Australia
    BMC Bioinformatics 10:S10. 2009
    ..It leverages on breakthroughs in rapid, high-throughput molecular profiling of microorganisms and text mining...
  11. pmc Bordetella pertussis clones identified by multilocus variable-number tandem-repeat analysis
    Jacob Kurniawan
    University of New South Wales, Sydney, New South Wales, Australia
    Emerg Infect Dis 16:297-300. 2010
    ..Typing of genes encoding acellular vaccine antigens showed changes that may be vaccine driven in 2 MTs prevalent in Australia...
  12. doi request reprint Better colonisation of newly emerged Bordetella pertussis in the co-infection mouse model study
    Azadeh Safarchi
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia
    Vaccine 34:3967-71. 2016
    ..Nevertheless, we found that ACV enhanced clearance of both SNP cluster I and II strains from the mouse respiratory tract. ..
  13. pmc Identifying Likely Transmission Pathways within a 10-Year Community Outbreak of Tuberculosis by High-Depth Whole Genome Sequencing
    Alexander C Outhred
    NSW Mycobacterium Reference Laboratory, Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research Pathology West, Sydney, Australia
    PLoS ONE 11:e0150550. 2016
    ..Whole-genome sequencing provides optimal strain resolution, facilitating detailed mapping of potential transmission pathways...
  14. doi request reprint Genomic dissection of Australian Bordetella pertussis isolates from the 2008-2012 epidemic
    Azadeh Safarchi
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia
    J Infect 72:468-77. 2016
    ..The emergence and expansion of prn non-expressing isolates (Prn negative), were also observed. We aimed to investigate the microevolution and genomic diversity of epidemic B. pertussis isolates...
  15. pmc Impact of a web-based personally controlled health management system on influenza vaccination and health services utilization rates: a randomized controlled trial
    Annie Y S Lau
    Centre for Health Informatics, Australian Institute of Health Innovation, University of New South Wales, Sydney, Australia
    J Am Med Inform Assoc 19:719-27. 2012
    ..To assess the impact of a web-based personally controlled health management system (PCHMS) on the uptake of seasonal influenza vaccine and primary care service utilization among university students and staff...
  16. pmc Genetic relationships of phage types and single nucleotide polymorphism typing of Salmonella enterica Serovar Typhimurium
    Stanley Pang
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia
    J Clin Microbiol 50:727-34. 2012
    ..However, 12 SNP profiles contained more than one phage type, and more SNPs would be needed for further differentiation. SNP typing should be considered as a replacement for phage typing for the identification of S. Typhimurium strains...
  17. pmc Whole Genome Sequencing Demonstrates Limited Transmission within Identified Mycobacterium tuberculosis Clusters in New South Wales, Australia
    Ulziijargal Gurjav
    Marie Bashir Institute for Infectious Diseases and Biosecurity, The University of Sydney, Sydney, Australia
    PLoS ONE 11:e0163612. 2016
    ..tuberculosis transmission within NSW, even within identified MIRU-24 clusters. Routine whole genome sequencing could provide valuable public health guidance in low burden settings...
  18. doi request reprint Newly emerging clones of Bordetella pertussis carrying prn2 and ptxP3 alleles implicated in Australian pertussis epidemic in 2008-2010
    Sophie Octavia
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Australia
    J Infect Dis 205:1220-4. 2012
    ..The data suggest increasing selection among the B. pertussis population in Australia in favor of strains carrying prn2 and ptxP3 under the pressure of acellular vaccine-induced immunity...
  19. doi request reprint Three-year longitudinal study of genotypes of Mycobacterium tuberculosis in a low prevalence population
    Blanca Gallego
    Centre for Health Informatics, University of New South Wales, Sydney, Australia
    Pathology 42:267-72. 2010
    ..To investigate the molecular epidemiology of tuberculosis, temporal and spatial distribution of Mycobacterium tuberculosis isolates and associations between genotypes and clinical characteristics, in a low prevalence population...
  20. ncbi request reprint Commonly used molecular epidemiology markers of Streptococcus agalactiae do not appear to predict virulence
    Frank Lin
    Centre for Health Informatics, University of New South Wales, Sydney, New South Wales, Australia
    Pathology 41:576-81. 2009
    ..The aim of this study was to test the hypothesis that GBS virulence can be predicted by using the molecular epidemiology markers...
  21. pmc Whole genome sequencing of Salmonella Typhimurium illuminates distinct outbreaks caused by an endemic multi-locus variable number tandem repeat analysis type in Australia, 2014
    Anastasia Phillips
    Centre for Infectious Diseases and Microbiology Public Health, Westmead Hospital, Sydney, NSW, Australia
    BMC Microbiol 16:211. 2016
    ..g. multilocus variable number tandem repeat analysis, MLVA) may provide insufficient discrimination. Whole genome sequencing (WGS) offers potentially greater discriminatory power to support infectious disease surveillance...
  22. pmc Protocol for a randomised controlled trial examining the impact of a web-based personally controlled health management system on the uptake of influenza vaccination rates
    Annie Y S Lau
    Centre for Health Informatics, Australian Institute of Health Innovation, University of New South Wales, Sydney, Australia
    BMC Health Serv Res 12:86. 2012
    ..g., influenza) but there are few comparative studies about patterns of use and impact of these systems...
  23. doi request reprint Selection and emergence of pertussis toxin promoter ptxP3 allele in the evolution of Bordetella pertussis
    Connie Lam
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia
    Infect Genet Evol 12:492-5. 2012
    ..pertussis and its emergence is concurrent with the change to the non-vaccine prn2 allele. Our results suggest that the globally distributed cluster I of B. pertussis has the ability to evade vaccine induced selection pressure...
  24. doi request reprint Genotype heterogeneity of Mycobacterium tuberculosis within geospatial hotspots suggests foci of imported infection in Sydney, Australia
    Ulziijargal Gurjav
    Sydney Medical School and the Marie Bashir Institute for Infectious Diseases and Biosecurity, The University of Sydney, Sydney, Australia Centre for Infectious Diseases and Microbiology Public Health, Westmead Hospital, Sydney, Australia
    Infect Genet Evol 40:346-51. 2016
    ..These findings provide important epidemiological insight and demonstrate the value of combining tuberculosis genotyping and spatiotemporal data to guide better-targeted public health interventions. ..
  25. pmc Genomic Variability of Serial Human Isolates of Salmonella enterica Serovar Typhimurium Associated with Prolonged Carriage
    Sophie Octavia
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia
    J Clin Microbiol 53:3507-14. 2015
    ..These findings have important implications for the detection of possible transmission events suspected by public health genomic surveillance of S. Typhimurium infections. ..
  26. pmc It Is Not All about Single Nucleotide Polymorphisms: Comparison of Mobile Genetic Elements and Deletions in Listeria monocytogenes Genomes Links Cases of Hospital-Acquired Listeriosis to the Environmental Source
    Qinning Wang
    Centre for Infectious Diseases and Microbiology Public Health, Westmead Hospital, Sydney, NSW, Australia
    J Clin Microbiol 53:3492-500. 2015
    ..The identification of SNPs and clonally distinctive MGEs strengthened evidence to distinguish outbreak-related isolates of L. monocytogenes from cocirculating endemic strains. ..
  27. pmc Investigating genome reduction of Bordetella pertussis using a multiplex PCR-based reverse line blot assay (mPCR/RLB)
    Connie Lam
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia
    BMC Res Notes 7:727. 2014
    ..By comparing the presence or absence of RDs, we aimed to determine the genomic variability of a diverse collection of B. pertussis strains and how they have changed over time...
  28. pmc Prospective genotyping of hospital-acquired methicillin-resistant Staphylococcus aureus isolates by use of a novel, highly discriminatory binary typing system
    Matthew V N O'Sullivan
    Centre for Infectious Diseases and Microbiology, Sydney Medical School and Sydney Emerging Infections and Biosecurity Institute, University of Sydney, Westmead Hospital, Sydney, New South Wales, Australia
    J Clin Microbiol 50:3513-9. 2012
    ..The system is rapid, inexpensive, discriminatory, and suitable for routine, high-throughput use in the hospital microbiology laboratory...
  29. pmc Defining reference sequences for Nocardia species by similarity and clustering analyses of 16S rRNA gene sequence data
    Manal Helal
    Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia
    PLoS ONE 6:e19517. 2011
    ....
  30. doi request reprint Transmission of multi-drug resistant tuberculosis in Mongolia is driven by Beijing strains of Mycobacterium tuberculosis resistant to all first-line drugs
    Ulziijargal Gurjav
    Sydney Medical School, Marie Bashir Institute for Infectious Diseases and Biosecurity, The University of Sydney, Sydney, Australia Centre for Infectious Diseases and Microbiology Public Health, Westmead Hospital, Sydney, Australia Electronic address
    Tuberculosis (Edinb) 101:49-53. 2016
    ..Mongolia has high and rising rates of multi-drug resistant tuberculosis (MDR-TB). Spatio-temporal and programmatic evidence suggests a major contribution from MDR-TB transmission, but genotypic evidence has not been assessed...
  31. doi request reprint Nontoxic Metal-Cyclam Complexes, a New Class of Compounds with Potency against Drug-Resistant Mycobacterium tuberculosis
    Mingfeng Yu
    School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia
    J Med Chem 59:5917-21. 2016
    ..tuberculosis strains, indicating a distinct mode of action. These compounds warrant further appraisal as novel agents to control TB in humans. ..
  32. pmc Defining the Core Genome of Salmonella enterica Serovar Typhimurium for Genomic Surveillance and Epidemiological Typing
    Songzhe Fu
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia
    J Clin Microbiol 53:2530-8. 2015
    ..Defining the S. Typhimurium core genome allows standardization of genes/regions to be used for high-resolution epidemiological typing and genomic surveillance of S. Typhimurium. ..
  33. pmc Genomic Epidemiology of Clostridium botulinum Isolates from Temporally Related Cases of Infant Botulism in New South Wales, Australia
    Nadine McCallum
    Centre for Infectious Diseases and Microbiology Public Health, Westmead Hospital, Westmead, NSW, Australia The Marie Bashir Institute for Infectious Diseases and Biosecurity, Sydney Medical School, The University of Sydney, Sydney, NSW, Australia
    J Clin Microbiol 53:2846-53. 2015
    ..Analyses showed that the high resolution of WGS provided important phylogenetic information that would not be captured by standard seven-loci MLST. ..
  34. pmc Delineating community outbreaks of Salmonella enterica serovar Typhimurium by use of whole-genome sequencing: insights into genomic variability within an outbreak
    Sophie Octavia
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia
    J Clin Microbiol 53:1063-71. 2015
    ..It can also inform a more targeted public health response by providing important supplementary evidence that cases of disease are or are not associated with food-borne outbreaks of S. Typhimurium. ..
  35. pmc Linear normalised hash function for clustering gene sequences and identifying reference sequences from multiple sequence alignments
    Manal Helal
    Sydney Emerging Infections and Biosecurity Institute, Sydney Medical School Westmead, University of Sydney, Sydney, New South Wales, Australia
    Microb Inform Exp 2:2. 2012
    ..The aim of this study was to develop a method that would identify the cluster centroids and the optimal number of clusters for a given sensitivity level and could work equally well for the different sequence datasets...
  36. pmc A PubMed-wide associational study of infectious diseases
    Vitali Sintchenko
    Centre for Health Informatics, University of New South Wales, Sydney, New South Wales, Australia
    PLoS ONE 5:e9535. 2010
    ..This study is the first attempt to integrate online repositories of text-based publications and microbial genome databases in order to explore the dynamics of relationships between pathogens and infectious diseases...
  37. doi request reprint Biosurveillance of emerging biothreats using scalable genotype clustering
    Blanca Gallego
    Centre for Health Informatics, University of New South Wales, Coogee Campus, Sydney, NSW 2052, Australia
    J Biomed Inform 42:66-73. 2009
    ..Innovative bacterial genotyping technologies can enhance early warning systems for public health by aiding the detection of moderate and small epidemics...
  38. doi request reprint SnpFilt: A pipeline for reference-free assembly-based identification of SNPs in bacterial genomes
    Carmen H S Chan
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, 2052, Australia
    Comput Biol Chem 65:178-184. 2016
    ..SnpFilt is available from https://github.com/LanLab/SnpFilt...
  39. doi request reprint Pertactin negative Bordetella pertussis demonstrates higher fitness under vaccine selection pressure in a mixed infection model
    Azadeh Safarchi
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia
    Vaccine 33:6277-81. 2015
    ..Our findings of greater ability of Prn negative strains to colonise ACV-immunised mice are consistent with reports of selective advantage for these strains in ACV-immunised humans. ..
  40. doi request reprint Antibiotic susceptibility of diverse Mycobacterium abscessus complex strains in New South Wales, Australia
    Kyra Y L Chua
    1Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research Pathology West, Westmead Hospital, Westmead 2Marie Bashir Institute for Infectious Diseases and Biosecurity, The University of Sydney, Sydney, NSW, Australia
    Pathology 47:678-82. 2015
    ..Further studies correlating in vitro susceptibility profiles with clinical outcomes of M. abscessus infections treated with combination antimicrobial therapy are warranted. ..
  41. pmc Added value of whole-genome sequencing for management of highly drug-resistant TB
    Alexander C Outhred
    Sydney Medical School and the Marie Bashir Institute for Infectious Diseases and Biosecurity, The University of Sydney, Sydney, Australia NSW Mycobacterium Reference Laboratory, Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research Pathology West, Sydney, Australia Children s Hospital at Westmead, Sydney, Australia
    J Antimicrob Chemother 70:1198-202. 2015
    ..Following a fatal case of XDR TB, we investigated the potential benefit of using whole-genome sequencing to generate an in silico drug susceptibility profile...
  42. doi request reprint Potent antimycobacterial activity of the pyridoxal isonicotinoyl hydrazone analog 2-pyridylcarboxaldehyde isonicotinoyl hydrazone: a lipophilic transport vehicle for isonicotinic acid hydrazide
    Samantha Ellis
    Microbial Immunity and Pathogenesis Group, Department of Infectious Diseases and Immunology S E, L L, J A T, and Molecular Pharmacology and Pathology Program, Department of Pathology and Bosch Institute D S K, M L H H, D R R, University of Sydney, Sydney, New South Wales, Australia and Centre for Infectious Diseases and Microbiology, Institute of Clinical Pathology and Medical Research Pathology West, Westmead Hospital, Sydney, New South Wales, Australia P J, V S
    Mol Pharmacol 85:269-78. 2014
    ..These results demonstrate that iron-chelating agents such as PCIH may be of benefit in the treatment and control of mycobacterial infection. ..
  43. doi request reprint Rapid and accurate typing of Bordetella pertussis targeting genes encoding acellular vaccine antigens using real time PCR and High Resolution Melt analysis
    Wai Fong Chan
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia
    J Microbiol Methods 77:326-9. 2009
    ..These rapid methods are suitable for large-scale studies of vaccine-driven evolution of Bordetella pertussis...
  44. doi request reprint Identification of non-tuberculous mycobacteria: utility of the GenoType Mycobacterium CM/AS assay compared with HPLC and 16S rRNA gene sequencing
    Andie S Lee
    Centre for Infectious Diseases and Microbiology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Sydney, Australia
    J Med Microbiol 58:900-4. 2009
    ..The GenoType Mycobacterium assay enables rapid identification of a broad range of potentially clinically significant Mycobacterium species, but some species require further testing to differentiate or confirm ambiguous results...
  45. doi request reprint Laboratory-guided detection of disease outbreaks: three generations of surveillance systems
    Vitali Sintchenko
    Centre for Infectious Diseases and Microbiology, Western Clinical School, The University of Sydney, Westmead Hospital, Sydney, Australia
    Arch Pathol Lab Med 133:916-25. 2009
    ..Traditional biothreat surveillance systems are vulnerable to incomplete and delayed reporting of public health threats...
  46. pmc In silico prioritisation of candidate genes for prokaryotic gene function discovery: an application of phylogenetic profiles
    Frank P Y Lin
    Centre for Health Informatics, University of New South Wales, Sydney, Australia
    BMC Bioinformatics 10:86. 2009
    ..Here we present two prokaryotic CGP methods, based on phylogenetic profiles, to assist with this task...
  47. doi request reprint Genome sequencing reveals novel deletions associated with secondary resistance to pyrazinamide in MDR Mycobacterium tuberculosis
    Elena Martinez
    Centenary Institute, Sydney, Australia Marie Bashir Institute for Infectious Diseases and Biosecurity, The University of Sydney, Sydney, Australia NSW Mycobacterium Reference Laboratory, Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research Pathology West, Sydney, Australia Centre for Infectious Diseases and Microbiology Public Health, Westmead Hospital, Western Sydney Local Health District, Sydney, Australia
    J Antimicrob Chemother 70:2511-4. 2015
    ..We assessed the utility of WGS versus standard PCR amplification assays for the characterization of pyrazinamide resistance in MDR-TB isolates identified in New South Wales, Australia, over an 8 year period...
  48. pmc Temporal dynamics of Mycobacterium tuberculosis genotypes in New South Wales, Australia
    Ulziijargal Gurjav
    Sydney Medical School and the Marie Bashir Institute for Infectious Diseases and Biosecurity, The University of Sydney, Sydney, Australia
    BMC Infect Dis 14:455. 2014
    ..Here we describe recent changes in the distribution of M. tuberculosis genotypes in New South Wales (NSW), Australia and compared strain types with drug resistance, site of disease and demographic data...
  49. pmc Effectiveness of hospital-wide methicillin-resistant Staphylococcus aureus (MRSA) infection control policies differs by ward specialty
    Rosemarie Sadsad
    Centre for Infectious Diseases and Microbiology Public Health, Westmead Hospital, Sydney, New South Wales, Australia Centre for Health Informatics, Australian Institute of Health Innovation, University of New South Wales, Sydney, New South Wales, Australia Sydney Medical School Westmead, The University of Sydney, Sydney, New South Wales, Australia
    PLoS ONE 8:e83099. 2013
    ..This can aid the timely and cost effective design of synergistic and context specific infection control policies. ..
  50. ncbi request reprint Point-of-care testing for community-acquired pneumonia: do we have all the answers?
    Dominic E Dwyer
    Centre for Infectious Diseases and Microbiology Laboratory Services, Westmead Hospital, Sydney, New South Wales, Australia
    Med J Aust 187:40-2. 2007
    ..POCTs are a valuable tool for surveillance, for rapid investigation of outbreaks, and for use in laboratories with limited diagnostic facilities...
  51. pmc Influenza outbreak during Sydney World Youth Day 2008: the utility of laboratory testing and case definitions on mass gathering outbreak containment
    Sebastiaan J van Hal
    Centre for Infectious Diseases and Microbiology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, Sydney, New South Wales, Australia
    PLoS ONE 4:e6620. 2009
    ..However, the utility of these clinical case definitions and laboratory testing in mass gathering outbreaks remains unknown...
  52. ncbi request reprint Utility of genotyping of Mycobacterium tuberculosis in the contact investigation: a decision analysis
    Vitali Sintchenko
    Centre for Infectious Diseases and Microbiology Public Health, Sydney West Area Health Services, Sydney, NSW, Australia
    Tuberculosis (Edinb) 87:176-84. 2007
    ..The main factors affecting utilities were the likelihood of new epidemiological links being identified after the second interview and the local rate of clustering of M. tuberculosis isolates...
  53. ncbi request reprint Which clinical decisions benefit from automation? A task complexity approach
    Vitali Sintchenko
    Centre for Health Informatics at the University of New South Wales, Sydney 2056, Australia
    Stud Health Technol Inform 90:639-43. 2002
    ..The model described allows for task automation without lowering of decision quality...
  54. ncbi request reprint Is Bordetella pertussis susceptibility to erythromycin changing? MIC trends among Australian isolates 1971-2006
    Vitali Sintchenko
    J Antimicrob Chemother 60:1178-9. 2007
  55. ncbi request reprint Developing decision support systems in clinical bioinformatics
    Vitali Sintchenko
    Centre for Infectious Diseases and Microbiology Public Health, Western Clinical School, The University of Sydney, New South Wales, Australia
    Methods Mol Med 141:331-51. 2008
    ..It provides a roadmap for identifying decision tasks for automation and selecting optimal tools for building task-specific systems. Key success factors for EDSS implementation and evaluation are also outlined...