J D Sedgwick
Affiliation: University of Sydney
- Central nervous system microglial cell activation and proliferation follows direct interaction with tissue-infiltrating T cell blastsJ D Sedgwick
Centenary Institute of Cancer Medicine and Cell Biology, Royal Prince Alfred Hospital, Camperdown, Sydney, Australia
J Immunol 160:5320-30. 1998..These outcomes are consistent with direct tissue macrophage-T cell interactions in situ that lead to activation, proliferation, and expansion of the responding tissue-resident cell...
- Challenging cytokine redundancy: inflammatory cell movement and clinical course of experimental autoimmune encephalomyelitis are normal in lymphotoxin-deficient, but not tumor necrosis factor-deficient, miceD Sean Riminton
Centenary Institute of Cancer Medicine and Cell Biology, Sydney, New South Wales 2050, Australia
J Exp Med 187:1517-28. 1998..We conclude from these studies that TNF and LT are functionally distinct cytokines in vivo, and despite sharing common receptors, show no redundancy of function nor mutual compensation...
- Generation of splenic follicular structure and B cell movement in tumor necrosis factor-deficient miceM C Cook
Centenary Institute of Cancer Medicine and Cell Biology, Sydney, NSW, Australia 2050
J Exp Med 188:1503-10. 1998..Thus, TNF is necessary for creating the permissive environment for B cell movement and function, but is not itself responsible for these processes...
- Structural deficiencies in granuloma formation in TNF gene-targeted mice underlie the heightened susceptibility to aerosol Mycobacterium tuberculosis infection, which is not compensated for by lymphotoxinA G Bean
Centenary Institute of Cancer Medicine and Cell Biology, Newtown, Australia
J Immunol 162:3504-11. 1999..Thus, the enhanced susceptibility of TNF-/- is not compensated for by the presence of LT alpha, and the critical role of TNF is not in the activation of T cells and macrophages but in the local organization of granulomas...
- Increased thymic B cells but maintenance of thymic structure, T cell differentiation and negative selection in lymphotoxin-alpha and TNF gene-targeted miceA P Grech
Centenary Institute of Cancer Medicine and Cell Biology, Newtown, NSW, Australia
Dev Immunol 8:61-74. 2000....
- Lymphotoxin controls alphaEbeta7-integrin expression by peripheral CD8+ T cellsM J Gabor
Centenary Institute of Cancer Medicine and Cell Biology, Sydney, NSW, Australia
Immunol Cell Biol 79:323-31. 2001....
- Distinct roles for lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissueH Korner
Centenary Institute of Cancer Medicine and Cell Biology, Sydney, Australia
Eur J Immunol 27:2600-9. 1997....
- Critical points of tumor necrosis factor action in central nervous system autoimmune inflammation defined by gene targetingH Korner
Centenary Institute of Cancer Medicine and Cell Biology, Royal Prince Alfred Hospital, Sydney, New South Wales, 2050 Australia
J Exp Med 186:1585-90. 1997..These results are consistent with the TNF dependence of processes controlling initial leukocyte movement within the CNS. Nevertheless, potent alternative mechanisms exist to mediate all other phases of EAE...
- Allele-specific PCR analysis for detection of the gld Fas-ligand point mutationR M Hoek
Centenary Institute of Cancer Medicine and Cell Biology, Royal Prince Alfred Hospital, Sydney, NSW, Australia
J Immunol Methods 210:109-12. 1997..This approach permits the screening of back-crossed F1 progeny within one day, using whole blood samples as a source of genomic DNA. The technique is fast, robust, easily learnt, and unambiguous...