Genomes and Genes
Christopher A Reid
Affiliation: University of Melbourne
- Epilepsy, energy deficiency and new therapeutic approaches including dietChristopher A Reid
Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Australia Electronic address
Pharmacol Ther 144:192-201. 2014..Finally, newer therapeutic approaches based on diet manipulation in the context of energy deficiency are discussed. ..
- Multiple molecular mechanisms for a single GABAA mutation in epilepsyChristopher A Reid
Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Australia
Neurology 80:1003-8. 2013..To understand the molecular basis and differential penetrance of febrile seizures and absence seizures in patients with the γ2(R43Q) GABA receptor mutation...
- HCN channelopathies: pathophysiology in genetic epilepsy and therapeutic implicationsChristopher A Reid
Florey Neuroscience Institute and The Centre for Neuroscience, The University of Melbourne, Parkville, Victoria, Australia
Br J Pharmacol 165:49-56. 2012..We also discuss what is known about the pharmacological manipulation of HCN channels in the context of epilepsy and how this may help future efforts in developing HCN-channel-based therapy...
- Presynaptic Ca2+ channels: a functional patchworkChristopher A Reid
Department of Physiology, University of Melbourne, Grattan St, 3010, Parkville, Victoria, Australia
Trends Neurosci 26:683-7. 2003..The patchwork distribution of Ca(2+) channel subtypes might therefore enable terminal-specific modulation of transmitter release, enhancing the power of synaptic processing...
- Spontaneous release from mossy fiber terminals inhibits Ni2+-sensitive T-type Ca2+ channels of CA3 pyramidal neurons in the rat organotypic hippocampal sliceChristopher A Reid
Department of Physiology, The University of Melbourne, Melbourne, Victoria, 3010, Australia
Hippocampus 18:623-30. 2008..This change in AP firing was completely reversed by the addition of Ni(2+). This mechanism may reduce the impact of T-type Ca(2+) channels in a region where large synaptic events are common...
- Sub region-specific modulation of synchronous neuronal burst firing after a kainic acid insult in organotypic hippocampal culturesChristopher A Reid
Department of Physiology, The University of Melbourne, Melbourne, Australia
BMC Neurosci 9:59. 2008..The effect of an excitotoxic insult (kainic acid, KA) on Mg2+-free-induced synchronized neuronal firing was tested in organotypic hippocampal culture by measuring extracellular field activity in CA1 and CA3...
- Excitotoxic-mediated transcriptional decreases in HCN2 channel function increase network excitability in CA1Brendan E L Adams
Department of Physiology, The University of Melbourne, Australia
Exp Neurol 219:249-57. 2009..Lamotrigine, known to increase Ih, reversed the impact of KA on burst duration in CA1 at both time-points linking a transcriptional reduction in HCN2 function to increased burst duration...
- Developmental impact of a familial GABAA receptor epilepsy mutationCindy Chiu
Howard Florey Institute, The University of Melbourne, Parkville, Melbourne, Australia
Ann Neurol 64:284-93. 2008..Our objective was to determine whether developmental expression of the mutation alters seizure susceptibility later in life...
- Decreases in HCN mRNA expression in the hippocampus after kindling and status epilepticus in adult ratsKim L Powell
Department of Medicine, Royal Melbourne Hospital, Melbourne, Victoria, Australia
Epilepsia 49:1686-95. 2008..Here HCN1 and HCN2 mRNA expression was quantitatively measured at different time points during epileptogenesis in two distinct animal models of TLE; the kainic acid (KA)-induced status epilepticus (SE) and amygdala kindling models...
- Seizure-like thalamocortical rhythms initiate in the deep layers of the cortex in a co-culture modelBrendan E L Adams
Department of Physiology, Centre for Neuroscience and Medicine RMH WH, The University of Melbourne, Melbourne, Victoria 3010, Australia
Exp Neurol 227:203-9. 2011..We propose that thalamocortical oscillatory network activity initiates in deep layers of the cortex with reciprocal thalamic interconnections enabling sustained hyper-synchronization...
- Axon initial segment dysfunction in epilepsyVerena C Wimmer
Florey Neuroscience Institutes, University of Melbourne, Parkville 3010, Victoria, Australia
J Physiol 588:1829-40. 2010..This article highlights the molecular coincidence of epilepsy mutations at the AIS and reviews pathogenic mechanisms converging at the AIS...
- Mossy fiber sprouting interacts with sodium channel mutations to increase dentate gyrus excitabilityEvan A Thomas
Howard Florey Institute, Parkville, Victoria, Australia
Epilepsia 51:136-45. 2010..The purpose of this study was to use computational approaches to explore the interaction between changes in sodium channel availability caused by mutations and mossy fiber sprouting...
- Oxcarbazepine, not its active metabolite, potentiates GABAA activation and aggravates absence seizuresThomas Zheng
Department of Medicine The University of Melbourne, The Royal Melbourne Hospital, Victoria, Australia
Epilepsia 50:83-7. 2009..We examined whether structural analogs of CBZ, oxcarbazepine (OXC), and its active metabolite, monohydroxy derivative (MHD), also potentiate GABA(A) receptor current and aggravate seizures...
- Perturbations in cortical development and neuronal network excitability arising from prenatal exposure to benzodiazepines in miceMatilda Haas
The Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria, Australia
Eur J Neurosci 37:1584-93. 2013..Therefore, exposure of the fetal brain to benzodiazepines has consequences for the positioning of neurons and cortical network excitability...
- A Cav3.2 T-type calcium channel point mutation has splice-variant-specific effects on function and segregates with seizure expression in a polygenic rat model of absence epilepsyKim L Powell
Department of Medicine, The Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia
J Neurosci 29:371-80. 2009..This gain-of-function mutation, the first reported in the GAERS polygenic animal model, has a novel mechanism of action, being dependent on exonic splicing for its functional consequences to be expressed...
- Temperature elevation increases GABA(A) -mediated cortical inhibition in a mouse model of genetic epilepsyElisa L Hill
Florey Neuroscience Institutes, The University of Melbourne, Parkville, Victoria, Australia
Epilepsia 52:179-84. 2011....
- Enhanced in vitro CA1 network activity in a sodium channel β1(C121W) subunit model of genetic epilepsyRobert J Hatch
The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia
Epilepsia 55:601-8. 2014..To investigate the network consequences of this neuronal dysfunction and to establish a genetic disease state model we developed an in vitro assay to investigate CA1 network properties and antiepileptic drug sensitivity...
- Rhythmic neuronal activity in S2 somatosensory and insular cortices contribute to the initiation of absence-related spike-and-wave dischargesThomas W Zheng
Departments of Medicine, Surgery and Neurology, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria 3050, Australia
Epilepsia 53:1948-58. 2012..Our goal was to characterize the interictal, preictal and ictal neuronal activity in the primary and secondary cortical regions (S1, S2) and in the adjacent insular cortex (IC) in Genetic Absence Epilepsy Rats from Strasbourg (GAERS)...
- Early development of electrical excitability in the mouse enteric nervous systemMarlene M Hao
Department of Anatomy, University of Melbourne, and Florey Neuroscience Institutes, Melbourne, Victoria 3010, Australia
J Neurosci 32:10949-60. 2012..Spontaneous depolarizations resembling excitatory postsynaptic potentials were observed at E12.5. The ENS is one of the earliest parts of the developing nervous system to exhibit mature forms of electrical activity...
- Cocaine-mediated synaptic potentiation is absent in VTA neurons from mGlu5-deficient miceMichael K Bird
Howard Florey Institute, University of Melbourne, Parkville, Victoria, Australia
Int J Neuropsychopharmacol 13:133-41. 2010..In contrast, the mGlu5 receptor may not be essential for psychostimulant behavioural sensitization; although it probably impacts other aspects drug addiction, such as motivation to self-administer...
- Increased thalamic inhibition in the absence seizure prone DBA/2J mouseHeneu O Tan
Howard Florey Institute, The University of Melbourne, Parkville, Australia
Epilepsia 49:921-5. 2008..Increased susceptibility of the DBA2/J strain to develop SWDs and increase in the 6-12 Hz EEG power may be due to a hypersynchronous ventrobasal thalamus as a consequence of increased GABAergic input...
- Low blood glucose precipitates spike-and-wave activity in genetically predisposed animalsChristopher A Reid
Florey Neuroscience Institute, The University of Melbourne, Parkville, Victoria, Australia
Epilepsia 52:115-20. 2011..Herein we investigate if lowering blood glucose increases spike-wave activity in mouse models with varying seizure susceptibility...
- Two lines of transgenic mice expressing cre-recombinase exhibit increased seizure susceptibilityTae Hwan Kim
Florey Neuroscience Institutes, The University of Melbourne, Parkville, Melbourne, Victoria 3010, Australia
Epilepsy Res 104:11-6. 2013..These data highlight that appropriate control experiments that compare wild-type mice to those that carry the cre-transgene but not the loxP-flanked target are essential when using this method...
- Reduced cortical inhibition in a mouse model of familial childhood absence epilepsyHeneu O Tan
Howard Florey Institute, University of Melbourne, Parkville 3010, Australia
Proc Natl Acad Sci U S A 104:17536-41. 2007..We hypothesize that a subtle reduction in cortical inhibition underlies childhood absence epilepsy seen in humans harboring the R43Q mutation...
- Axon initial segment dysfunction in a mouse model of genetic epilepsy with febrile seizures plusVerena C Wimmer
Florey Neuroscience Institutes, The University of Melbourne, Parkville, Victoria, Australia
J Clin Invest 120:2661-71. 2010..We therefore conclude that Na+ channel beta1 subunits modulate AIS excitability and that epilepsy can arise if this modulation is impaired...
- The P2X7 receptor drives microglial activation and proliferation: a trophic role for P2X7R poreMastura Monif
Department of Physiology, The University of Melbourne, Melbourne, Victoria 3010, Australia
J Neurosci 29:3781-91. 2009..Collectively, and contrary to previous reports describing P2X(7)R as a "death receptor," we provide evidence for a novel trophic role for P2X(7)R pore in microglia...
- Spike-and-wave discharge mediated reduction in hippocampal HCN1 channel function associates with learning deficits in a genetic mouse model of epilepsyA Marie Phillips
Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville 3010, Australia Department of Genetics, University of Melbourne, Parkville 3010, Australia Electronic address
Neurobiol Dis 64:30-5. 2014..SWD-free mice harboring the R43Q mutation had no learning deficit. We conclude that SWDs reduce hippocampal HCN1 expression and function, and that the reduction associates with a spatial learning deficit. ..
- Triheptanoin reduces seizure susceptibility in a syndrome-specific mouse model of generalized epilepsyTae Hwan Kim
The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria 3010, Australia
Epilepsy Res 103:101-5. 2013..In summary, triheptanoin may be an effective and well tolerated dietary therapy for generalized epilepsy...
- HCN channelopathy and cardiac electrophysiologic dysfunction in genetic and acquired rat epilepsy modelsKim L Powell
Department of Medicine, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia
Epilepsia 55:609-20. 2014..We hypothesized that the development of epilepsy is associated with altered cardiac electrophysiologic function and altered cardiac HCN channel expression...
- Reduced dendritic arborization and hyperexcitability of pyramidal neurons in a Scn1b-based model of Dravet syndromeChristopher A Reid
1 Florey Institute for Neuroscience and Mental Health, The University of Melbourne, Parkville, 3010, Australia
Brain 137:1701-15. 2014..These results suggest a novel mechanism of disease genesis in genetic epilepsy and demonstrate an effective mechanism-based treatment of the disease...
- Genetic and pharmacological modulation of giant depolarizing potentials in the neonatal hippocampus associates with increased seizure susceptibilityErnesto Vargas
Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria 3010, Australia
J Physiol 591:57-65. 2013..These results provide evidence that a human GABA(A) receptor epilepsy mutation exerts a developmental influence by modulating the number of GDPs. It also draws attention to the potential risk of early treatment with bumetanide...
- Acute effect of carbamazepine on corticothalamic 5-9-Hz and thalamocortical spindle (10-16-Hz) oscillations in the ratThomas W Zheng
Neuropsychologie Cognitive et Physiopathologie de la Schizophrénie, INSERM U1114, Strasbourg, France Fédération de Médecine Translationnelle de Strasbourg FMTS, NeuroPole de Strasbourg, Faculte de Medecine, Universite de Strasbourg, INSERM U1114, 11 rue Humann, Strasbourg, 67085, France Department of Medicine, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Vic, Australia
Eur J Neurosci 39:788-99. 2014..In conclusion, CBZ potentiates GABAA receptor-mediated TC spindle oscillations. Furthermore, we propose that CT 5-9-Hz waves can trigger TC spindles...
- The mechanism of carbamazepine aggravation of absence seizuresLige Liu
Department of Medicine, University of Melbourne, Royal Melbourne Hospital, Royal Parade, Parkville 3050, Victoria, Australia
J Pharmacol Exp Ther 319:790-8. 2006..These data demonstrate that CBZ acts at the VB thalamus to aggravate absence seizures in GAERS and that activation of GABA(A) receptors is critical to this effect...
- Enhanced spatial memory and hippocampal long-term potentiation in p75 neurotrophin receptor knockout miceGraham L Barrett
Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
Hippocampus 20:145-52. 2010....
- Mechanisms of human inherited epilepsiesChristopher A Reid
Howard Florey Institute, The University of Melbourne, Parkville, Melbourne, Australia
Prog Neurobiol 87:41-57. 2009..Piecing together this puzzle should allow us to understand the underlying pathology of epilepsy ultimately providing novel therapeutic strategies to complete the clinic-bench-clinic cycle...
- Null mutation of the alpha4 nicotinic receptor subunit increases the propensity of muscarinic-mediated neuronal bursting in mouse hippocampal slicesChristopher A Reid
Department of Medicine, Monash Medical Centre, Monash University, Melbourne, VIC 3800, Australia
Neuropharmacology 51:587-96. 2006....
- Reduction of p75 neurotrophin receptor ameliorates the cognitive deficits in a model of Alzheimer's diseaseMark Murphy
Department of Anatomy and Neuroscience, University of Melbourne, Melbourne, Victoria, Australia Electronic address
Neurobiol Aging 36:740-52. 2015..These mice are rescued from the deficits in learning and memory and hippocampal function which were found in the Tg2576 mice. These findings suggest that reduction of p75 can ameliorate some of the primary symptoms of AD. ..
- KCNT1 gain of function in 2 epilepsy phenotypes is reversed by quinidineCarol J Milligan
Ion Channels and Disease Group, Epilepsy Division, Florey Institute of Neuroscience and Mental Health, Parkville, Australia
Ann Neurol 75:581-90. 2014..We aim to investigate the electrophysiological and pharmacological characteristics of hKCNT1 mutations and examine developmental expression levels...
- New therapeutic opportunities in epilepsy: a genetic perspectiveChristopher A Reid
Florey Neuroscience Institutes, The University of Melbourne, Parkville, Melbourne, Australia
Pharmacol Ther 128:274-80. 2010..Here we discuss how we can use knowledge of genetic mechanisms to improve treatment strategies now and into the future...
- Oxcarbazepine and its active metabolite, (S)-licarbazepine, exacerbate seizures in a mouse model of genetic generalized epilepsyTae Hwan Kim
Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Melbourne, Australia
Epilepsia 56:e6-9. 2015..Furthermore, generalized seizure exacerbation for first-, second-, and third-generation carbamazepine-based compounds is likely to occur through a common mechanism...
- Low glycaemic index diet reduces seizure susceptibility in a syndrome-specific mouse model of generalized epilepsyTae Hwan Kim
Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Australia Department of Anatomy and Neuroscience, The University of Melbourne, Parkville, Melbourne, Australia
Epilepsy Res 108:139-43. 2014..Here we investigate if diets containing carbohydrates with varying glycaemic index (GI) can modulate seizure susceptibility in a mouse model of generalized epilepsy...
- Glutamate is associated with a higher risk of seizures in patients with gliomasTanya I Yuen
Departments of Surgery, Royal Melbourne Hospital, University of Melbourne, Victoria, Australia
Neurology 79:883-9. 2012..To investigate the relationship of glutamate and glutamate transporter expression in human gliomas and surrounding peritumoral brain to the presence of tumor-associated seizures (TAS)...
- The role of dendritic spines: comparing the complex with the simpleChristopher A Reid
Department of Medicine, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria, 3168, Australia
Eur J Pharmacol 447:173-6. 2002..We compare the similarities and differences displayed by these spines in compartmentalising Ca(2+) and discuss a potential role for the morphologically complex spines found on CA3 pyramidal neurons...
- Loss of synaptic Zn2+ transporter function increases risk of febrile seizuresMichael S Hildebrand
Epilepsy Research Centre, Department of Medicine, University of Melbourne, Austin Health, Heidelberg 3084, Victoria, Australia
Sci Rep 5:17816. 2015..Together our data suggest that reduced synaptic Zn(2+) increases the risk of FS and more broadly support the idea that impaired synaptic Zn(2+) homeostasis can contribute to neuronal hyperexcitability...
- Mapping somatosensory connectivity in adult mice using diffusion MRI tractography and super-resolution track density imagingKay Richards
Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia
Neuroimage 102:381-92. 2014....
- Neurons derived from human embryonic stem cells extend long-distance axonal projections through growth along host white matter tracts after intra-cerebral transplantationMark Denham
Centre for Neuroscience, University of Melbourne, Parkville, Vic, Australia
Front Cell Neurosci 6:11. 2012..These findings illustrate the intrinsic capacity for neurons derived from human ES cells to integrate at a structural and functional level following transplantation...
- Optical quantal analysis reveals a presynaptic component of LTP at hippocampal Schaffer-associational synapsesNigel J Emptage
Division of Neurophysiology, National Institute for Medical Research, Mill Hill, NW7 1AA, London, United Kingdom
Neuron 38:797-804. 2003..In most cases, the store-dependent evoked Ca(2+) transient in the spine was also increased after induction, a novel postsynaptic aspect of LTP...
- Optical quantal analysis indicates that long-term potentiation at single hippocampal mossy fiber synapses is expressed through increased release probability, recruitment of new release sites, and activation of silent synapsesChristopher A Reid
Division of Neurophysiology, National Institute for Medical Research, London NW7 1AA, United Kingdom
J Neurosci 24:3618-26. 2004....