R R Reddel

Summary

Affiliation: University of Sydney
Country: Australia

Publications

  1. pmc Induction of alternative lengthening of telomeres-associated PML bodies by p53/p21 requires HP1 proteins
    Wei Qin Jiang
    Cancer Research Unit, Children s Medical Research Institute, Westmead 2145, New South Wales, Australia
    J Cell Biol 185:797-810. 2009
  2. pmc Control of telomere length by a trimming mechanism that involves generation of t-circles
    Hilda A Pickett
    Cancer Research Group, Children s Medical Research Institute, Westmead, NSW, Australia
    EMBO J 28:799-809. 2009
  3. pmc Telomere elongation involves intra-molecular DNA replication in cells utilizing alternative lengthening of telomeres
    Alessandra Muntoni
    Cancer Research Unit, Children s Medical Research Institute, Sydney, NSW 2145, Australia
    Hum Mol Genet 18:1017-27. 2009
  4. doi Senescence: an antiviral defense that is tumor suppressive?
    Roger R Reddel
    Cancer Research Unit, Children s Medical Research Institute, 214 Hawkesbury Road, Westmead, New South Wales 2145, Australia
    Carcinogenesis 31:19-26. 2010
  5. ncbi Alternative lengthening of telomeres, telomerase, and cancer
    Roger R Reddel
    Children s Medical Research Institute, 214 Hawkesbury Road, Westmead, NSW 2145, Sydney, Australia
    Cancer Lett 194:155-62. 2003
  6. ncbi The role of senescence and immortalization in carcinogenesis
    R R Reddel
    Children s Medical Research Institute, 214 Hawkesbury Road, Westmead, Sydney, NSW 2145, Australia
    Carcinogenesis 21:477-84. 2000
  7. ncbi Alternative lengthening of telomeres: dangerous road less travelled
    Roger R Reddel
    Cancer Research Unit, Children s Medical Research Institute, Westmead, New South Wales 2145, Sydney, Australia
    Lancet 361:1840-1. 2003
  8. ncbi A reassessment of the telomere hypothesis of senescence
    R R Reddel
    Children s Medical Research Institute, Wentworthville, NSW, Australia
    Bioessays 20:977-84. 1998
  9. ncbi Genes involved in the control of cellular proliferative potential
    R R Reddel
    Children s Medical Research Institute, Westmead, Sydney, NSW, Australia
    Ann N Y Acad Sci 854:8-19. 1998
  10. pmc Coexistence of alternative lengthening of telomeres and telomerase in hTERT-transfected GM847 cells
    K Perrem
    Cancer Research Group, Children's Medical Research Institute, Westmead, Sydney, New South Wales 2145, Australia
    Mol Cell Biol 21:3862-75. 2001

Collaborators

  • T M Bryan
  • J Yuan
  • S C Kaul
  • Peter Baumann
  • Nadia Zaffaroni
  • Susan J Clark
  • Antony W Braithwaite
  • T R Cech
  • B C Baguley
  • J Arturo Londono-Vallejo
  • M R Eccles
  • Axel A Neumann
  • Jeremy D Henson
  • Renu Wadhwa
  • Wei Qin Jiang
  • Alessandra Muntoni
  • Ze Huai Zhong
  • Anthony J Cesare
  • Ying Cao
  • Scott B Cohen
  • Hilda A Pickett
  • Yu Jen Chen
  • Clare L Fasching
  • Christian D Toouli
  • Raffaella Villa
  • Aurora Costa
  • Janice A Royds
  • A C M Chang
  • Thomas R Yeager
  • Jane R Noble
  • A A Neumann
  • Helen Varley
  • A Nguyen
  • Lorel M Colgin
  • L I Huschtscha
  • W Q Jiang
  • Maria Grazia Daidone
  • Andy C M Chang
  • D A Jellinek
  • L M Colgin
  • David A Jellinek
  • Jennie N Jeyapalan
  • Lily I Huschtscha
  • Raphael E Pollock
  • Kim Moran-Jones
  • T R Yeager
  • Michael J McKay
  • Nicola J Royle
  • Tomoko Yaguchi
  • K Perrem
  • M A Dunham
  • J R Noble
  • Akira Nguyen
  • Rebecca L Johnston
  • Mark Hills
  • Hamish G Campbell
  • Anna K Wiles
  • Amanda S Nouwens
  • Cinzia De Marco
  • Dario Baratti
  • Marcello Deraco
  • Lorenza Venturini
  • Shigeki Kusamura
  • Rosita Motta
  • Alberto Vannelli
  • George O Lovrecz
  • Nicolai Bache
  • Z H Zhong
  • J D Henson
  • Phillip J Robinson
  • Mark E Graham
  • Thomas Carroll
  • Mario Teo
  • Kamaljit Kaur
  • Laura Daprai
  • Olivia M Pereira-Smith
  • Sabrina Cantù
  • David McDowell
  • Silvana Pilotti
  • Alessandro Gronchi
  • Martin R MacFarlane
  • Custer C Deocaris
  • Vicky Hakin-Smith
  • George E Xinarianos
  • Luigi Mariani
  • Ronald Boet
  • Syuichi Takano
  • Jenny L Foxon
  • Mark J Snee
  • Diana L Learoyd

Detail Information

Publications53

  1. pmc Induction of alternative lengthening of telomeres-associated PML bodies by p53/p21 requires HP1 proteins
    Wei Qin Jiang
    Cancer Research Unit, Children s Medical Research Institute, Westmead 2145, New South Wales, Australia
    J Cell Biol 185:797-810. 2009
    ....
  2. pmc Control of telomere length by a trimming mechanism that involves generation of t-circles
    Hilda A Pickett
    Cancer Research Group, Children s Medical Research Institute, Westmead, NSW, Australia
    EMBO J 28:799-809. 2009
    ..Additionally, these results indicate that some phenotypic characteristics attributed to alternative lengthening of telomeres (ALT) result from increased mean telomere length, rather than from the ALT mechanism itself...
  3. pmc Telomere elongation involves intra-molecular DNA replication in cells utilizing alternative lengthening of telomeres
    Alessandra Muntoni
    Cancer Research Unit, Children s Medical Research Institute, Sydney, NSW 2145, Australia
    Hum Mol Genet 18:1017-27. 2009
    ..This is the first direct evidence that the ALT mechanism involves more than one method of telomere elongation...
  4. doi Senescence: an antiviral defense that is tumor suppressive?
    Roger R Reddel
    Cancer Research Unit, Children s Medical Research Institute, 214 Hawkesbury Road, Westmead, New South Wales 2145, Australia
    Carcinogenesis 31:19-26. 2010
    ..Recent progress in understanding how tumor cells evade senescence is also reviewed here...
  5. ncbi Alternative lengthening of telomeres, telomerase, and cancer
    Roger R Reddel
    Children s Medical Research Institute, 214 Hawkesbury Road, Westmead, NSW 2145, Sydney, Australia
    Cancer Lett 194:155-62. 2003
    ..It is expected that these similarities and differences will have implications for prognosis and treatment...
  6. ncbi The role of senescence and immortalization in carcinogenesis
    R R Reddel
    Children s Medical Research Institute, 214 Hawkesbury Road, Westmead, Sydney, NSW 2145, Australia
    Carcinogenesis 21:477-84. 2000
    ..It has also been found that some of the most common genetic changes known to occur in cancer have a key role in the immortalization process...
  7. ncbi Alternative lengthening of telomeres: dangerous road less travelled
    Roger R Reddel
    Cancer Research Unit, Children s Medical Research Institute, Westmead, New South Wales 2145, Sydney, Australia
    Lancet 361:1840-1. 2003
  8. ncbi A reassessment of the telomere hypothesis of senescence
    R R Reddel
    Children s Medical Research Institute, Wentworthville, NSW, Australia
    Bioessays 20:977-84. 1998
    ..Although evidence consistent with the telomere hypothesis continues to accumulate, on the basis of recent findings it is suggested that instead of a single clock mechanism there are multiple inducers of senescence...
  9. ncbi Genes involved in the control of cellular proliferative potential
    R R Reddel
    Children s Medical Research Institute, Westmead, Sydney, NSW, Australia
    Ann N Y Acad Sci 854:8-19. 1998
    ....
  10. pmc Coexistence of alternative lengthening of telomeres and telomerase in hTERT-transfected GM847 cells
    K Perrem
    Cancer Research Group, Children's Medical Research Institute, Westmead, Sydney, New South Wales 2145, Australia
    Mol Cell Biol 21:3862-75. 2001
    ..Further, the transfection data indicate that ALT and telomerase can coexist in the same cells...
  11. ncbi Loss of p16INK4 expression by methylation is associated with lifespan extension of human mammary epithelial cells
    L I Huschtscha
    Children s Medical Research Institute, Sydney, NSW, Australia
    Cancer Res 58:3508-12. 1998
    ..Although postselection HMECs are widely considered to be normal, these data indicate that they have sustained an epigenetic alteration...
  12. ncbi Alternative lengthening of telomeres in human cells
    R R Reddel
    Children's Medical Research Institute, 214 Hawkesbury Road, Westmead, Sydney, New South Wales, 2145 Australia
    Radiat Res 155:194-200. 2001
    ..The development of telomere-targeted anticancer therapies will be facilitated by an understanding of the molecular mechanisms of ALT and of the means whereby ALT is repressed in normal cells...
  13. ncbi Immortalized cells with no detectable telomerase activity. A review
    R R Reddel
    Children s Medical Research Institute, Sydney, NSW, Australia
    Biochemistry (Mosc) 62:1254-62. 1997
    ..This is consistent with a non-reciprocal recombinational mechanism similar to that found in telomerase-defective mutant yeast strains...
  14. doi Upregulation of survivin during immortalization of nontransformed human fibroblasts transduced with telomerase reverse transcriptase
    J Yuan
    Children s Cancer Institute Australia for Medical Research, New South Wales, Australia
    Oncogene 28:2678-89. 2009
    ..Selection during the immortalization process for cells expressing high levels of survivin may account for the abundance of survivin in diverse tumor types...
  15. pmc The hTERTalpha splice variant is a dominant negative inhibitor of telomerase activity
    L M Colgin
    Children s Medical Research Institute, Westmead, New South Wales, Australia
    Neoplasia 2:426-32. 2000
    ..Telomerase inhibition induced a senescence-like state in HT1080 cells and apoptosis in a jejunal fibroblast cell line. These results suggest a possible role for hTERT splice variants in the regulation of telomerase activity...
  16. doi Stanniocalcin-1 acts in a negative feedback loop in the prosurvival ERK1/2 signaling pathway during oxidative stress
    A Nguyen
    Cancer Research Unit, Children s Medical Research Institute, New South Wales, Australia
    Oncogene 28:1982-92. 2009
    ..Therefore, STC1 expression downregulates prosurvival ERK1/2 signaling and reduces survival under conditions of oxidative stress...
  17. ncbi Effects of simian virus 40 T-antigens on normal human mammary epithelial cells reveal evidence for spontaneous alterations in addition to loss of p16(INK4a) expression
    L I Huschtscha
    Children's Medical Research Institute, 214 Hawkesbury Road, Westmead, NSW 2145, Australia
    Exp Cell Res 265:125-34. 2001
    ..Postselection HMECs are a widely used in vitro model system, but these observations indicate they have undergone changes in gene expression in addition to loss of p16(INK4a) expression...
  18. ncbi Constructing immortalized human cell lines
    T R Yeager
    Children s Medical Research Institute 214 Hawkesbury Road, Westmead, Sydney, NSW 2145, Australia
    Curr Opin Biotechnol 10:465-9. 1999
    ....
  19. ncbi Identification of candidate alternative lengthening of telomeres genes by methionine restriction and RNA interference
    W Q Jiang
    Cancer Research Unit, Children s Medical Research Institute, Westmead, NSW, Australia
    Oncogene 26:4635-47. 2007
    ..Because of the close linkage between ALT-mediated telomere maintenance and ability to form APBs, the eight proteins identified by this screen as being required for APB formation are also likely to be required for the ALT mechanism...
  20. ncbi Telomere maintenance by recombination in human cells
    M A Dunham
    Cancer Research Unit, Children s Medical Research Institute, Westmead, Sydney, Australia
    Nat Genet 26:447-50. 2000
    ..Here we show that DNA sequences are copied from telomere to telomere in an immortalized human ALT cell line, indicating that ALT occurs by means of homologous recombination and copy switching...
  21. ncbi Mammalian stanniocalcins and cancer
    A C M Chang
    Cancer Research Unit, Children s Medical Research Institute, 214 Hawkesbury Road, Westmead 2145, NSW, Australia
    Endocr Relat Cancer 10:359-73. 2003
    ..This article reviews the data currently available regarding the mammalian STCs, and discusses the roles they may play in normal physiology and in breast and other cancers...
  22. ncbi Genetic differences between the pancytosolic and perinuclear forms of murine mortalin
    R Wadhwa
    Children s Medical Research Institute, Sydney, New South Wales, Australia
    Exp Cell Res 226:381-6. 1996
    ..Furthermore, there appears to be a correlation between frequency of spontaneous immortalization of cultured mouse fibroblasts and the mot loci present in the mouse strain from which they were derived...
  23. pmc Stanniocalcin 1 and 2 are secreted as phosphoproteins from human fibrosarcoma cells
    D A Jellinek
    Cancer Research Unit, Children s Medical Research Institute, Locked Bag 23, Wentworthville 2145, NSW, Australia
    Biochem J 350:453-61. 2000
    ..We conclude that these human fibrosarcoma cells express both STC1 and STC2 as secreted phosphoproteins in vivo, with STC2 being phosphorylated by an ecto-CK2-like enzyme...
  24. doi Multiple mechanisms of telomere maintenance exist and differentially affect clinical outcome in diffuse malignant peritoneal mesothelioma
    Raffaella Villa
    Department of Experimental Oncology and Surgery, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale dei Tumori, Milan, Italy
    Clin Cancer Res 14:4134-40. 2008
    ....
  25. ncbi Upregulation of mortalin/mthsp70/Grp75 contributes to human carcinogenesis
    Renu Wadhwa
    Gene Function Research Center, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki, Japan
    Int J Cancer 118:2973-80. 2006
    ..The study demonstrates that upregulation of mortalin contributes significantly to tumorigenesis, and thus is a good candidate target for cancer therapy...
  26. ncbi The first molecular details of ALT in human tumor cells
    Alessandra Muntoni
    Cancer Research Unit, Children s Medical Research Institute, 214 Hawkesbury Road, Westmead, Sydney, New South Wales 2145, Australia
    Hum Mol Genet 14:R191-6. 2005
    ..Understanding the molecular basis of ALT has important implications for the diagnosis and treatment of tumors that use this TMM...
  27. ncbi Overexpressed mortalin (mot-2)/mthsp70/GRP75 and hTERT cooperate to extend the in vitro lifespan of human fibroblasts
    Sunil C Kaul
    National Institute of Advanced Industrial Science and Technology AIST, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8566, Japan
    Exp Cell Res 286:96-101. 2003
    ..Together, mot-2 and hTERT permitted bypass of senescence, a substantial extension of lifespan, and possibly immortalization. This is the first demonstration that mot-2 and telomerase can cooperate in the immortalization process...
  28. ncbi Alternative lengthening of telomeres in mammalian cells
    Jeremy D Henson
    Children s Medical Research Institute, 214 Hawkesbury Road, Westmead, Sydney 2145, Australia
    Oncogene 21:598-610. 2002
    ..The existence of ALT adds some complexity to proposed uses of telomere-related parameters in cancer diagnosis and prognosis, and poses challenges for the design of anticancer therapeutics designed to inhibit telomere maintenance...
  29. ncbi Rhodacyanine dye MKT-077 inhibits in vitro telomerase assay but has no detectable effects on telomerase activity in vivo
    Renu Wadhwa
    Gene Discovery Research Center, National Institute of Advanced Industrial Science and Technology, Ibaraki 305 8566, Japan
    Cancer Res 62:4434-8. 2002
    ..The data suggested that inhibition of telomerase activity is unlikely to be a prime cause of MKT-077-induced toxicity in cancer cells...
  30. ncbi Telomere maintenance and cancer -- look, no telomerase
    Axel A Neumann
    Cancer Research Unit, Children s Medical Research Institute, 214 Hawkesbury Road, Westmead, Sydney, New South Wales 2145, Australia
    Nat Rev Cancer 2:879-84. 2002
  31. doi Telomere uncapping and alternative lengthening of telomeres
    Anthony J Cesare
    Cancer Research Unit, Children s Medical Research Institute, 214 Hawkesbury Road, Westmead, New South Wales 2145, Australia
    Mech Ageing Dev 129:99-108. 2008
    ....
  32. doi A sensitive direct human telomerase activity assay
    Scott B Cohen
    Cancer Research Unit, Children s Medical Research Institute, 214 Hawkesbury Road, Westmead, NSW 2145, Australia
    Nat Methods 5:355-60. 2008
    ..Telomerase extension products are released by heating in denaturing formamide buffer to disrupt the avidin-biotin interaction, and then separated and visualized by standard techniques...
  33. doi Amplification of telomerase reverse transcriptase gene in human mammary epithelial cells with limiting telomerase RNA expression levels
    Ying Cao
    Children s Medical Research Institute, Westmead, University of Sydney, New South Wales, Australia
    Cancer Res 68:3115-23. 2008
    ..These data indicate that some hTERT-transduced normal cells may express high levels of the transgene but fail to up-regulate endogenous hTR expression sufficiently to enable expression of robust levels of telomerase activity...
  34. doi Increased copy number of the TERT and TERC telomerase subunit genes in cancer cells
    Ying Cao
    Cancer Research Unit, Children s Medical Research Institute, 214 Hawkesbury Road, Westmead, NSW 2145 Australia, and University of Sydney, NSW 2006, Australia
    Cancer Sci 99:1092-9. 2008
    ....
  35. doi PAX8 regulates telomerase reverse transcriptase and telomerase RNA component in glioma
    Yu Jen Chen
    Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Cancer Res 68:5724-32. 2008
    ..Additionally, PAX8 small interfering RNA down-regulated hTERT and hTR. Collectively, these results show that PAX8 may have a role in telomerase regulation...
  36. ncbi Molecular characterization of inter-telomere and intra-telomere mutations in human ALT cells
    Helen Varley
    Department of Genetics, University of Leicester, University Road, Leicester, LE1 7RH, UK
    Nat Genet 30:301-5. 2002
    ..We also identified simple intra-allelic mutations at high frequency, which evidently contribute to telomere instability in ALT+ cells...
  37. ncbi Hsp70 family member, mot-2/mthsp70/GRP75, binds to the cytoplasmic sequestration domain of the p53 protein
    Renu Wadhwa
    Chugai Research Institute for Medical Sciences, 153 2 Nagai, Niihari Mura, Ibaraki, 300 41, Japan
    Exp Cell Res 274:246-53. 2002
    ..Therefore, perturbation of mot-p53 interactions can be employed to abrogate cytoplasmic retention of wild-type p53 in tumors...
  38. ncbi Comparison of human mammary epithelial cells immortalized by simian virus 40 T-Antigen or by the telomerase catalytic subunit
    Christian D Toouli
    Children s Medical Research Institute, 214 Hawkesbury Road, Westmead 2145, Australia
    Oncogene 21:128-39. 2002
    ..Although SV40-immortalized cells are useful for studies of carcinogenesis, hTERT-immortalized cells retain more properties of normal cells...
  39. ncbi Alternative lengthening of telomeres is characterized by high rates of telomeric exchange
    J Arturo Londono-Vallejo
    Institut National de la Sante et de la Recherche Medicale, Paris, France
    Cancer Res 64:2324-7. 2004
    ....
  40. ncbi DNA damage induces alternative lengthening of telomeres (ALT) associated promyelocytic leukemia bodies that preferentially associate with linear telomeric DNA
    Clare L Fasching
    Children s Medical Research Institute, Westmead, and University of Sydney, New South Wales, Sydney, Australia
    Cancer Res 67:7072-7. 2007
    ..We partially purified APBs and showed that the telomeric repeat DNA they contain is predominantly linear. We propose that a function of APBs is to sequester linear telomeric DNA...
  41. ncbi A SUMO ligase for ALT
    Roger R Reddel
    Nat Struct Mol Biol 14:570-1. 2007
  42. pmc hnRNP A2, a potential ssDNA/RNA molecular adapter at the telomere
    Kim Moran-Jones
    Department of Biochemistry and Molecular Biology, The University of Queensland QLD 4072, Australia
    Nucleic Acids Res 33:486-96. 2005
    ..Our results support a model in which hnRNP A2 acts as a molecular adapter between single-stranded telomeric repeats, or telomerase RNA, and another segment of ssDNA...
  43. ncbi A robust assay for alternative lengthening of telomeres in tumors shows the significance of alternative lengthening of telomeres in sarcomas and astrocytomas
    Jeremy D Henson
    Children s Medical Research Institute, New South Wales, Australia
    Clin Cancer Res 11:217-25. 2005
    ..We aimed to establish and validate an ALT assay suitable for archived paraffin-embedded tumors and to use it to examine the prevalence and clinical significance of ALT in various types of tumors that are often telomerase negative...
  44. pmc Suppression of alternative lengthening of telomeres by Sp100-mediated sequestration of the MRE11/RAD50/NBS1 complex
    Wei Qin Jiang
    Children s Medical Research Institute, 214 Hawkesbury Rd, Westmead, NSW 2145, Australia
    Mol Cell Biol 25:2708-21. 2005
    ..Spontaneously generated C-terminally truncated Sp100 that did not sequester the MRE11, RAD50, and NBS1 proteins failed to inhibit ALT. These findings identify for the first time proteins that are required for the ALT mechanism...
  45. ncbi Telomerase-independent telomere length maintenance in the absence of alternative lengthening of telomeres-associated promyelocytic leukemia bodies
    Clare L Fasching
    Children s Medical Research Institute, Westmead, Sydney, New South Wales, Australia
    Cancer Res 65:2722-9. 2005
    ..In addition, these cells are capable of copying a targeted DNA tag from one telomere into other telomeres. These data show that APBs are not always essential for ALT-mediated telomere maintenance...
  46. ncbi Activation of the ALT pathway for telomere maintenance can affect other sequences in the human genome
    Jennie N Jeyapalan
    Department of Genetics, University of Leicester, UK
    Hum Mol Genet 14:1785-94. 2005
    ..The elevation of MS32 instability upon activation of the ALT pathway and telomere length maintenance suggests there is overlap between the underlying processes that may be tractable through analysis of the D1S8 locus...
  47. ncbi Molecular markers and long-term survivors of glioblastoma multiforme
    Michael J McKay
    Cancer J 10:333. 2004
  48. ncbi Alterations in the p16(INK4a) and p53 tumor suppressor genes of hTERT-immortalized human fibroblasts
    Jane R Noble
    Children s Medical Research Institute, 214 Hawkesbury Rd, Westmead, Sydney NSW 2145, Australia
    Oncogene 23:3116-21. 2004
    ....
  49. ncbi Association of mutant TP53 with alternative lengthening of telomeres and favorable prognosis in glioma
    Yu Jen Chen
    Department of Pathology, University of Otago, Dunedin, New Zealand
    Cancer Res 66:6473-6. 2006
    ..We found an association between TP53 mutation and ALT mechanism and between wild-type TP53 and telomerase and absence of a known TMM (P < 0.0001). We suggest that TP53 deficiency plays a permissive role in the activation of ALT...
  50. ncbi Telomere maintenance mechanisms in liposarcomas: association with histologic subtypes and disease progression
    Aurora Costa
    Department of Experimental Oncology and Laboratories, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano, Italy
    Cancer Res 66:8918-24. 2006
    ..58 versus 1.15). Our results indicate that ALT can support fully malignant liposarcomas and is associated with unfavorable disease outcome...
  51. ncbi Human POT1 facilitates telomere elongation by telomerase
    Lorel M Colgin
    Children s Medical Research Institute, 214 Hawkesbury Road, Westmead, NSW 2145, Australia
    Curr Biol 13:942-6. 2003
    ..hPOT1 was unable to lengthen the telomeres of telomerase-negative cells unless telomerase activity was induced. These data suggest that a normal function of hPOT1 is to facilitate telomere elongation by telomerase...
  52. ncbi Protein composition of catalytically active human telomerase from immortal cells
    Scott B Cohen
    Cancer Research Unit, Children s Medical Research Institute, 214 Hawkesbury Road, Westmead NSW 2145, Australia
    Science 315:1850-3. 2007
    ..Mass spectrometric sequencing of the protein components and molecular size determination indicated an enzyme composition of two molecules each of telomerase reverse transcriptase, telomerase RNA, and dyskerin...
  53. ncbi Disruption of telomere maintenance by depletion of the MRE11/RAD50/NBS1 complex in cells that use alternative lengthening of telomeres
    Ze Huai Zhong
    Cancer Research Unit, Children s Medical Research Institute, Westmead 2145, Sydney 2006, New South Wales, Australia
    J Biol Chem 282:29314-22. 2007
    ..A., Choi, J. H., Cesare, A. J., Ozgur, S., and Griffith, J. D. (2007) Cancer Res. 67, 1513-1519), also a marker for ALT. We conclude that the MRN complex, and especially NBS1, is required for the ALT mechanism...