Affiliation: University of Sydney
- Brain gene expression, metabolism, and bioenergetics: interrelationships in murine models of cerebral and noncerebral malariaCaroline Rae
Discipline of Biochemistry, School of Molecular and Microbial Biosciences, The University of Sydney, Sydney NSW 2006, Australia
FASEB J 18:499-510. 2004..This was accompanied by mild up-regulation of expression of metabolic enzymes. These changes are consistent with benign hypermetabolism whose cause remains a subject of speculation...
- Group I and II metabotropic glutamate receptors alter brain cortical metabolic and glutamate/glutamine cycle activity: a 13C NMR spectroscopy and metabolomic studyCaroline Rae
School of Molecular and Microbial Biosciences, The University of Sydney, New South Wales, Australia
J Neurochem 92:405-16. 2005..All ligand effects were separated from control and from each other using two principal components. The ramifications of these findings are discussed...
- Enlarged temporal lobes in Turner syndrome: an X-chromosome effect?Caroline Rae
Discipline of Biochemistry, School of Molecular and Microbial Biosciences, The University of Sydney, Sydney, NSW 2006, Australia
Cereb Cortex 14:156-64. 2004..These temporal lobe abnormalities are discussed with reference to genes which are absent in Turner syndrome and to hormonal differences between Turner syndrome subjects and 46,XX controls...
- Oral creatine monohydrate supplementation improves brain performance: a double-blind, placebo-controlled, cross-over trialCaroline Rae
Discipline of Biochemistry, School of Molecular and Microbial Biosciences G08, The University of Sydney, Sydney, NSW 2006, Australia
Proc Biol Sci 270:2147-50. 2003..These findings underline a dynamic and significant role of brain energy capacity in influencing brain performance...
- Inhibition of glutamine transport depletes glutamate and GABA neurotransmitter pools: further evidence for metabolic compartmentationCaroline Rae
Discipline of Biochemistry, School of Molecular and Microbial Biosciences, The University of Sydney, New South Wales, Australia
J Neurochem 85:503-14. 2003..The resultant implications for metabolic compartmentation and regulation of metabolism by transport processes are discussed...
- A metabolomic approach to ionotropic glutamate receptor subtype function: a nuclear magnetic resonance in vitro investigationCaroline Rae
School of Molecular and Microbial Biosciences, The University of Sydney, Sydney, New South Wales, Australia
J Cereb Blood Flow Metab 26:1005-17. 2006..D-Ser was highly stimulatory of net flux into the Krebs cycle. These data show that the metabolic response to iGluR perturbation in vitro is a sensitive discriminator of function...
- Understanding your inhibitions: effects of GABA and GABAA receptor modulation on brain cortical metabolismFatima A Nasrallah
Prince of Wales Medical Research Institute, and Brain Sciences UNSW, Randwick, New South Wales, Australia
J Neurochem 108:57-71. 2009..These results highlight the utility of a different but robust approach to study of the GABAergic system using metabolic systems analysis...
- Now I know my ABC. A systems neurochemistry and functional metabolomic approach to understanding the GABAergic systemCaroline Rae
Prince of Wales Medical Research Institute, Randwick, New South Wales, Australia
J Neurochem 109:109-16. 2009....
- Effects of L-glutamate transport inhibition by a conformationally restricted glutamate analogue (2S,1'S,2'R)-2-(carboxycyclopropyl)glycine (L-CCG III) on metabolism in brain tissue in vitro analysed by NMR spectroscopyCharbel El Hajj Moussa
Department of Anatomy and Histology, The University of Sydney, Australia
Neurochem Res 27:27-35. 2002..At 50 microM, intracellular L-CCG III could reach > 10 mM and metabolism might be affected directly...
- Brain metabolic markers reflect susceptibility status in cytokine gene knockout mice with murine cerebral malariaSapan B Parekh
Discipline of Pathology, Institute for Biomedical Research, The University of Sydney, Sydney, NSW 2006, Australia
Int J Parasitol 36:1409-18. 2006..Thus these metabolic changes are firmly linked both to the immune system response to malaria and to the occurrence of pathogenic changes in experimental CM...
- The effects of large neutral amino acid supplements in PKU: an MRS and neuropsychological studySuzanne Schindeler
Western Sydney Genetics Program, The Children s Hospital at Westmead, Sydney, Australia
Mol Genet Metab 91:48-54. 2007....
- For want of a nail. ramifications of a single gene deletion, dystrophin, in the brain of the mouseTrent Wallis
Discipline of Biochemistry, School of Molecular and Microbial Biosciences, The University of Sydney, NSW, 2006, Australia
Front Biosci 9:74-84. 2004..We relate these findings to known functional deficits and discuss the possible mechanisms behind the altered gene expression...
- Inhibitors of glutamate transport modulate distinct patterns in brain metabolismCharbel E H Moussa
Anatomy and Histology, Institute for Biomedical Research, School of Medical Science, Sydney, Australia
J Neurosci Res 85:342-50. 2007..This indicates that different inhibition mechanisms or different colocalisation of the separate transporter subtypes with glutamate receptors can produce significantly different metabolic and functional outcomes for the brain...
- Hippocampal area metabolites relate to severity and cognitive function in obstructive sleep apneaDelwyn J Bartlett
Woolcock Institute of Medical Research, University of Sydney, Sydney, NSW, Australia
Sleep Med 5:593-6. 2004..As the hippocampus is particularly susceptible to hypoxia, we hypothesized that it may show biochemical abnormalities, and they may relate to apnea severity...
- Rottlerin inhibits (Na+, K+)-ATPase activity in brain tissue and alters D-aspartate dependent redistribution of glutamate transporter GLAST in cultured astrocytesKhoa T D Nguyen
School of Medical Sciences and Bosch Institute for Biomedical Research, The University of Sydney, Sydney, NSW 2006, Australia
Neurochem Res 34:1767-74. 2009....
- Understanding your inhibitions: modulation of brain cortical metabolism by GABA(B) receptorsFatima A Nasrallah
Prince of Wales Medical Research Institute, Randwick, New South Wales, Australia
J Cereb Blood Flow Metab 27:1510-20. 2007..This is consistent with GABAergic activity being context dependent, and this conclusion should be taken into account when evaluating functional imaging data involving modulation of neuronal inhibition...
- Effects of glutamate transport substrates and glutamate receptor ligands on the activity of Na-/K(+)-ATPase in brain tissue in vitroEllas K Nanitsos
School of Medical Sciences and Institute for Biomedical Research, The University of Sydney, New South Wales, Australia
Clin Exp Pharmacol Physiol 31:762-9. 2004....
- HIV, vascular and aging injuries in the brain of clinically stable HIV-infected adults: a (1)H MRS studyLucette A Cysique
University of New South Wales, St Vincent s Clinical School, Sydney, Australia
PLoS ONE 8:e61738. 2013..Moreover, their significance and relation to more classical HAND biomarkers remain unclear...
- Cerebellar morphology in developmental dyslexiaCaroline Rae
Department of Biochemistry, The University of Sydney, NSW, Australia
Neuropsychologia 40:1285-92. 2002....
- Brain bioenergetics and cognitive abilityCaroline Rae
Russell Cairns Unit, Radcliffe Infirmary, The University of Oxford, Oxford, UK
Dev Neurosci 25:324-31. 2003..We assessed how these observations may be interpreted in the context of a metabolic vs. histological debate...
- Corpus callosum morphology and its relationship to cognitive function in neurofibromatosis type 1Natalie Pride
Department of Psychology, Macquarie University, Sydney, Australia
J Child Neurol 25:834-41. 2010....
- Immunopathogenesis of cerebral malariaNicholas H Hunt
Molecular Immunopathology Unit, Institute for Biomedical Research, University of Sydney, Sydney, NSW, Australia
Int J Parasitol 36:569-82. 2006....
- Abnormalities in brain biochemistry associated with lack of dystrophin: studies of the mdx mouseCaroline Rae
Department of Biochemistry, The University of Sydney, Sydney, NSW 2006, Australia
Neuromuscul Disord 12:121-9. 2002..Using brain cortical slices we found no difference in the response of dystrophic tissue to hypoosmotic shock, but increased, substrate-dependent oxygen consumption rates at low oxygen partial pressures...
- Skeletal muscle abnormalities and exercise capacity in adults with a Fontan circulationRachael Cordina
Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia
Heart 99:1530-4. 2013..We sought to investigate whether adults with the Fontan circulation exhibit reduced skeletal muscle mass and/or metabolic abnormalities...
- Metabolomics of Neurotransmitters and Related Metabolites in Post-Mortem Tissue from the Dorsal and Ventral Striatum of Alcoholic Human BrainMohammed Abul Kashem
Lab of Neurochemistry, Discipline of Anatomy and Histology, Bosch Institute for Biomedical Research and School of Medical Sciences, Sydney Medical School, Anderson Stuart Bldg F13, The University of Sydney, Sydney, NSW, 2006, Australia
Neurochem Res 41:385-97. 2016..We conclude that neurotransmitter systems in both the DS (CN and P) and the VS (NAc) were significantly influenced by long-term heavy alcohol intake associated with alcoholism . ..
- Metabolites from cerebrospinal fluid in aneurysmal subarachnoid haemorrhage correlate with vasospasm and clinical outcome: a pattern-recognition 1H NMR studyVictoria G Dunne
Department of Neurosurgery, Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Sydney, Australia
NMR Biomed 18:24-33. 2005..Thus, the approach allowed the prediction of outcome as well as confirming the presence of aSAH...
- Alanine metabolism, transport, and cycling in the brainStefan Broer
School of Biochemistry and Molecular Biology, Australian National University, Acton, Canberra ACT, Australia
J Neurochem 102:1758-70. 2007..Our results show that system L isoform LAT2 is critical for alanine uptake into astrocytes. However, alanine does not provide any significant carbon for energy or neurotransmitter metabolism under the conditions studied...
- Modulation of brain metabolism by very low concentrations of the commonly used drug delivery vehicle dimethyl sulfoxide (DMSO)Fatima A Nasrallah
Prince of Wales Medical Research Institute, Randwick, Australia
J Neurosci Res 86:208-14. 2008..Therefore, care should be taken when evaluating the actions of drugs administered in combination with DMSO...
- An investigation of neuronal integrity in severe paediatric traumatic brain injuryLouise Parry
Rehabilitation Department, The Children s Hosptial at Westmead, Australia
Child Neuropsychol 10:248-61. 2004..Findings indicate a role of proton MRS as a measure of neuronal integrity following severe paediatric TBI and suggest a potential association of MRS with specific neuropsychological impairments...
- Memory training alters hippocampal neurochemistry in healthy elderlyMichael J Valenzuela
Neuropsychiatric Institute, The Prince of Wales Hospital, Euroa Centre, Randwick, NSW 2031, Australia
Neuroreport 14:1333-7. 2003..Biochemical changes related to cellular energy and cell-membrane turnover were found to increase after structured memory exercises and were limited to the medial temporal lobe...