R F Minchin

Summary

Affiliation: University of Western Australia
Country: Australia

Publications

  1. ncbi request reprint Mutational analysis of the large periplasmic loop 7-8 of the putrescine transporter PotE in Escherichia coli
    Rodney F Minchin
    Centre for Medical Research, University of Western Australia and Laboratory for Cancer Medicine, Western Australian Institute for Medical Research, Royal Perth Hospital, Perth, WA 6000, Australia
    Int J Biochem Cell Biol 36:271-80. 2004
  2. ncbi request reprint The pharmacology of gene therapy
    R F Minchin
    Department of Pharmacology, University of Western Australia, Nedlands, WA 6907, Australia
    Croat Med J 40:381-91. 1999
  3. ncbi request reprint Polyinosinic acid and polycationic liposomes attenuate the hepatic clearance of circulating plasmid DNA
    R F Minchin
    Laboratory for Cancer Medicine, Western Australian Institute for Medical Research, Royal Perth Hospital and Department of Pharmacology, University of Western Australia, Perth, Western Australia
    J Pharmacol Exp Ther 296:1006-12. 2001
  4. ncbi request reprint Cross-linking studies and membrane localization and assembly of radiolabelled large mechanosensitive ion channel (MscL) of Escherichia coli
    C C Häse
    Department of Pharmacology, University of Western Australia, Nedlands, Australia
    Biochem Biophys Res Commun 232:777-82. 1997
  5. ncbi request reprint Estradiol-regulated expression of the immunophilins cyclophilin 40 and FKBP52 in MCF-7 breast cancer cells
    P Kumar
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, WA 6009, Australia
    Biochem Biophys Res Commun 284:219-25. 2001
  6. ncbi request reprint Functional polymorphism of the human arylamine N-acetyltransferase type 1 gene caused by C190T and G560A mutations
    N J Butcher
    Department of Pharmacology, University of Western Australia, Nedlands, Australia
    Pharmacogenetics 8:67-72. 1998
  7. ncbi request reprint Pharmacogenetics of the arylamine N-acetyltransferases
    N J Butcher
    Laboratory for Cancer Medicine, Western Australian Institute for Medical Research, Royal Perth Hospital
    Pharmacogenomics J 2:30-42. 2002
  8. pmc Estimation of the pore size of the large-conductance mechanosensitive ion channel of Escherichia coli
    C C Cruickshank
    Department of Pharmacology, University of Western Australia, Nedlands
    Biophys J 73:1925-31. 1997
  9. ncbi request reprint 1998 International Meeting on the Arylamine N-Acetyltransferases: synopsis of the workshop on nomenclature, biochemistry, molecular biology, interspecies comparisons, and role in human disease risk
    K F Ilett
    Department of Pharmacology, University of Western Australia, Perth, Australia
    Drug Metab Dispos 27:957-9. 1999
  10. ncbi request reprint Inactivation of human arylamine N-acetyltransferase 1 by the hydroxylamine of p-aminobenzoic acid
    N J Butcher
    Department of Pharmacology, University of Western Australia, Western Australia 6907, Nedlands, Australia
    Biochem Pharmacol 60:1829-36. 2000

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Mutational analysis of the large periplasmic loop 7-8 of the putrescine transporter PotE in Escherichia coli
    Rodney F Minchin
    Centre for Medical Research, University of Western Australia and Laboratory for Cancer Medicine, Western Australian Institute for Medical Research, Royal Perth Hospital, Perth, WA 6000, Australia
    Int J Biochem Cell Biol 36:271-80. 2004
    ..The study shows that loop 7-8 is important for PotE function, possibly by forming a re-entrant loop in the channel of the transporter...
  2. ncbi request reprint The pharmacology of gene therapy
    R F Minchin
    Department of Pharmacology, University of Western Australia, Nedlands, WA 6907, Australia
    Croat Med J 40:381-91. 1999
    ..This review discusses some of the pharmacological aspects of gene delivery and the fate of vectors in vivo, and then highlights how drugs are being used to modulate gene therapy...
  3. ncbi request reprint Polyinosinic acid and polycationic liposomes attenuate the hepatic clearance of circulating plasmid DNA
    R F Minchin
    Laboratory for Cancer Medicine, Western Australian Institute for Medical Research, Royal Perth Hospital and Department of Pharmacology, University of Western Australia, Perth, Western Australia
    J Pharmacol Exp Ther 296:1006-12. 2001
    ..This study shows that pharmacological manipulation of the uptake and degradation of DNA can alter its distribution and clearance in vivo. These results may be useful in optimizing gene delivery procedures for in vivo gene therapy...
  4. ncbi request reprint Cross-linking studies and membrane localization and assembly of radiolabelled large mechanosensitive ion channel (MscL) of Escherichia coli
    C C Häse
    Department of Pharmacology, University of Western Australia, Nedlands, Australia
    Biochem Biophys Res Commun 232:777-82. 1997
    ....
  5. ncbi request reprint Estradiol-regulated expression of the immunophilins cyclophilin 40 and FKBP52 in MCF-7 breast cancer cells
    P Kumar
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, WA 6009, Australia
    Biochem Biophys Res Commun 284:219-25. 2001
    ..These results suggest that estradiol regulates CyP40 and FKBP52 mRNA expression through both transcriptional and posttranscriptional mechanisms...
  6. ncbi request reprint Functional polymorphism of the human arylamine N-acetyltransferase type 1 gene caused by C190T and G560A mutations
    N J Butcher
    Department of Pharmacology, University of Western Australia, Nedlands, Australia
    Pharmacogenetics 8:67-72. 1998
    ..Because NAT1 can bioactivate several carcinogens, this polymorphism may have implications for cancer risk in individual subjects...
  7. ncbi request reprint Pharmacogenetics of the arylamine N-acetyltransferases
    N J Butcher
    Laboratory for Cancer Medicine, Western Australian Institute for Medical Research, Royal Perth Hospital
    Pharmacogenomics J 2:30-42. 2002
    ..This review focuses on recent advances in the molecular genetics of the human NATs...
  8. pmc Estimation of the pore size of the large-conductance mechanosensitive ion channel of Escherichia coli
    C C Cruickshank
    Department of Pharmacology, University of Western Australia, Nedlands
    Biophys J 73:1925-31. 1997
    ..This channel diameter is consistent with the proposed homohexameric model of the MscL...
  9. ncbi request reprint 1998 International Meeting on the Arylamine N-Acetyltransferases: synopsis of the workshop on nomenclature, biochemistry, molecular biology, interspecies comparisons, and role in human disease risk
    K F Ilett
    Department of Pharmacology, University of Western Australia, Perth, Australia
    Drug Metab Dispos 27:957-9. 1999
    ..The full text of all meeting abstracts can be viewed at...
  10. ncbi request reprint Inactivation of human arylamine N-acetyltransferase 1 by the hydroxylamine of p-aminobenzoic acid
    N J Butcher
    Department of Pharmacology, University of Western Australia, Western Australia 6907, Nedlands, Australia
    Biochem Pharmacol 60:1829-36. 2000
    ..This is in contrast to our findings for PABA, which appears to reduce NAT1 activity by down-regulating the enzyme, leading to a decrease in NAT1 protein content...
  11. pmc Regulation of the Hsp90-binding immunophilin, cyclophilin 40, is mediated by multiple sites for GA-binding protein (GABP)
    P Kumar
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, Australia
    Cell Stress Chaperones 6:78-91. 2001
    ..Our results identify GABP as a key regulator of CyP40 expression. GABP is a common target of mitogen and stress-activated pathways and may integrate these diverse extracellular signals to regulate CyP40 gene expression...
  12. pmc Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70
    Amerigo Carrello
    Laboratory for Molecular Endocrinology, Western Australian Institute for Medical Research, The University of Western Australia, Nedlands, Western Australia 6009, Australia
    Cell Stress Chaperones 9:167-81. 2004
    ..Similar to Hop, CyP40 was shown not to influence the adenosine triphosphatase activity of Hsc70. Our results suggest that CyP40 may have a modulating role in Hsc70 as well as Hsp90 cellular function...
  13. ncbi request reprint Proteasomal degradation of N-acetyltransferase 1 is prevented by acetylation of the active site cysteine: a mechanism for the slow acetylator phenotype and substrate-dependent down-regulation
    Neville J Butcher
    Laboratory for Cancer Medicine, Western Australian Institute for Medical Research, Royal Perth Hospital, Perth, Western Australia 6000
    J Biol Chem 279:22131-7. 2004
    ..From this study, we conclude that NAT1 exists in the cell in either a stable acetylated state or an unstable non-acetylated state and that mutations in the NAT1 gene that prevent protein acetylation produce a slow acetylator phenotype...
  14. ncbi request reprint Concentration-dependent effects of N1, N11-diethylnorspermine on melanoma cell proliferation
    Rodney F Minchin
    School of Biomedical Sciences, University of Queensland, Brisbane, Queensland, Australia
    Int J Cancer 118:509-12. 2006
    ..Taken together, these results suggest that DENSPM, at clinically relevant concentrations, can mimic endogenous polyamines and induce proliferation in resistant human melanoma cells...
  15. ncbi request reprint Induction of human arylamine N-acetyltransferase type I by androgens in human prostate cancer cells
    Neville J Butcher
    School of Biomedical Sciences, University of Queensland, St Lucia, Queensland 4072, Australia
    Cancer Res 67:85-92. 2007
    ..These results show that human NAT1 is induced by androgens, which may have implications for cancer risk in individuals...