Elizabeth A Milward

Summary

Affiliation: University of Newcastle
Country: Australia

Publications

  1. doi request reprint Emerging real-time technologies in molecular medicine and the evolution of integrated 'pharmacomics' approaches to personalized medicine and drug discovery
    Elizabeth A Milward
    School of Biomedical Sciences and Pharmacy and Centre for Bioinformatics, Biomarker Discovery and Information Based Medicine, The University of Newcastle, Callaghan, NSW 2308, Australia
    Pharmacol Ther 136:295-304. 2012
  2. ncbi request reprint The matrix metalloproteinases and CNS plasticity: an overview
    E A Milward
    School of Biomedical Sciences, University of Newcastle and Hunter Medical Research Institute, Callaghan NSW 2308, Australia
    J Neuroimmunol 187:9-19. 2007
  3. doi request reprint A cross-sectional community study of serum iron measures and cognitive status in older adults
    Elizabeth A Milward
    The School of Biomedical Sciences, University of Newcastle, Callaghan, Australia
    J Alzheimers Dis 20:617-23. 2010
  4. doi request reprint Changes in brain transcripts related to Alzheimer's disease in a model of HFE hemochromatosis are not consistent with increased Alzheimer's disease risk
    Daniel M Johnstone
    School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia
    J Alzheimers Dis 30:791-803. 2012
  5. pmc Evaluation of Different Normalization and Analysis Procedures for Illumina Gene Expression Microarray Data Involving Small Changes
    Daniel M Johnstone
    Centre for Bioinformatics, Biomarker Discovery and Information Based Medicine, The University of Newcastle, Callaghan, NSW 2308, Australia
    Microarrays (Basel) 2:131-52. 2013
  6. doi request reprint Brain transcriptome perturbations in the Hfe(-/-) mouse model of genetic iron loading
    Daniel Johnstone
    School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, Australia
    Brain Res 1448:144-52. 2012
  7. doi request reprint Haemochromatosis HFE gene polymorphisms as potential modifiers of hereditary nonpolyposis colorectal cancer risk and onset age
    Zumin Shi
    Research Centre for Gender, Health and Ageing, University of Newcastle, Callaghan, Australia
    Int J Cancer 125:78-83. 2009
  8. doi request reprint Long-term mortality risks associated with mild anaemia in older persons: the Busselton Health Study
    Kerry A Chalmers
    School of Psychology, The University of Newcastle and Hunter Medical Research Institute, Callaghan, New South Wales, Australia
    Age Ageing 41:759-64. 2012
  9. doi request reprint Molecular genetic approaches to understanding the roles and regulation of iron in brain health and disease
    Daniel Johnstone
    School of Biomedical Sciences and Pharmacy and Hunter Medical Research Institute, The University of Newcastle, Callaghan, New South Wales, Australia
    J Neurochem 113:1387-402. 2010
  10. doi request reprint Beyond statistics: a new combinatorial approach to identifying biomarker panels for the early detection and diagnosis of Alzheimer's disease
    Elizabeth A Milward
    School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia Centre for Bioinformatics, Biomarker Discovery and Information Based Medicine, The University of Newcastle, Callaghan, NSW, Australia
    J Alzheimers Dis 39:211-7. 2014

Collaborators

Detail Information

Publications15

  1. doi request reprint Emerging real-time technologies in molecular medicine and the evolution of integrated 'pharmacomics' approaches to personalized medicine and drug discovery
    Elizabeth A Milward
    School of Biomedical Sciences and Pharmacy and Centre for Bioinformatics, Biomarker Discovery and Information Based Medicine, The University of Newcastle, Callaghan, NSW 2308, Australia
    Pharmacol Ther 136:295-304. 2012
    ..This review considers how the latest generation of advances in ultra-rapid macromolecular sequencing will accelerate the evolution of personalized medicine and more systematic, rational drug discovery...
  2. ncbi request reprint The matrix metalloproteinases and CNS plasticity: an overview
    E A Milward
    School of Biomedical Sciences, University of Newcastle and Hunter Medical Research Institute, Callaghan NSW 2308, Australia
    J Neuroimmunol 187:9-19. 2007
    ....
  3. doi request reprint A cross-sectional community study of serum iron measures and cognitive status in older adults
    Elizabeth A Milward
    The School of Biomedical Sciences, University of Newcastle, Callaghan, Australia
    J Alzheimers Dis 20:617-23. 2010
    ..We conclude abnormal body iron stores (low or high) are unlikely to have clinically significant effects on cognition or dementia risk in community-dwelling older people...
  4. doi request reprint Changes in brain transcripts related to Alzheimer's disease in a model of HFE hemochromatosis are not consistent with increased Alzheimer's disease risk
    Daniel M Johnstone
    School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia
    J Alzheimers Dis 30:791-803. 2012
    ..As Hfe-/- mice did not have higher brain iron levels than wildtype controls, these studies highlight the need for further research in models of more severe hemochromatosis with brain iron loading...
  5. pmc Evaluation of Different Normalization and Analysis Procedures for Illumina Gene Expression Microarray Data Involving Small Changes
    Daniel M Johnstone
    Centre for Bioinformatics, Biomarker Discovery and Information Based Medicine, The University of Newcastle, Callaghan, NSW 2308, Australia
    Microarrays (Basel) 2:131-52. 2013
    ..This report provides some basic guidelines for optimizing outcomes when working with Illumina datasets involving small expression changes. ..
  6. doi request reprint Brain transcriptome perturbations in the Hfe(-/-) mouse model of genetic iron loading
    Daniel Johnstone
    School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, Australia
    Brain Res 1448:144-52. 2012
    ....
  7. doi request reprint Haemochromatosis HFE gene polymorphisms as potential modifiers of hereditary nonpolyposis colorectal cancer risk and onset age
    Zumin Shi
    Research Centre for Gender, Health and Ageing, University of Newcastle, Callaghan, Australia
    Int J Cancer 125:78-83. 2009
    ..Understanding the mechanisms by which HFE interrelates with colorectal malignancies could lead to reduction of disease risk in HNPCC...
  8. doi request reprint Long-term mortality risks associated with mild anaemia in older persons: the Busselton Health Study
    Kerry A Chalmers
    School of Psychology, The University of Newcastle and Hunter Medical Research Institute, Callaghan, New South Wales, Australia
    Age Ageing 41:759-64. 2012
    ..The objective of this study was to examine the long-term relationships of haemoglobin concentration with all-cause and cause-specific mortality in a community-based sample of Australian adults surveyed in 1978...
  9. doi request reprint Molecular genetic approaches to understanding the roles and regulation of iron in brain health and disease
    Daniel Johnstone
    School of Biomedical Sciences and Pharmacy and Hunter Medical Research Institute, The University of Newcastle, Callaghan, New South Wales, Australia
    J Neurochem 113:1387-402. 2010
    ....
  10. doi request reprint Beyond statistics: a new combinatorial approach to identifying biomarker panels for the early detection and diagnosis of Alzheimer's disease
    Elizabeth A Milward
    School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia Centre for Bioinformatics, Biomarker Discovery and Information Based Medicine, The University of Newcastle, Callaghan, NSW, Australia
    J Alzheimers Dis 39:211-7. 2014
    ..We argue that the AD research community should take fuller advantage of these approaches to accelerate discovery. ..
  11. pmc Multivariate protein signatures of pre-clinical Alzheimer's disease in the Alzheimer's disease neuroimaging initiative (ADNI) plasma proteome dataset
    Daniel Johnstone
    Priority Research Centre for Bioinformatics, Biomarker Discovery and Information Based Medicine, The University of Newcastle, Callaghan, New South Wales, Australia
    PLoS ONE 7:e34341. 2012
    ..We conducted independent analyses of this dataset to identify plasma protein signatures predicting pre-clinical AD...
  12. doi request reprint Noncitrus fruits as novel dietary environmental modifiers of iron stores in people with or without HFE gene mutations
    Elizabeth A Milward
    School of Biomedical Sciences and Hunter Medical Research Institute, University of Newcastle, Callaghan, NSW, Australia
    Mayo Clin Proc 83:543-9. 2008
    ..To investigate whether citrus fruit, noncitrus fruit, and other dietary factors act as environmental modifiers of iron status in the absence or presence of hemochromatotic HFE gene mutations...
  13. pmc Advantages of Array-Based Technologies for Pre-Emptive Pharmacogenomics Testing
    Al Shahandeh
    School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan 2308, Australia
    Microarrays (Basel) 5:. 2016
    ..This commentary considers some of the applications where microarrays continue to offer advantages over next-generation sequencing technologies. ..
  14. doi request reprint Genome-wide microarray analysis of brain gene expression in mice on a short-term high iron diet
    Daniel Johnstone
    School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia
    Neurochem Int 56:856-63. 2010
    ..The latter involve intralysosomal lipofuscin build-up that may reflect lysosomal iron accumulation. The findings suggest that high iron intake may cause subtle brain effects of clinical relevance in some circumstances...
  15. pmc Pathological relationships involving iron and myelin may constitute a shared mechanism linking various rare and common brain diseases
    Moones Heidari
    School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia
    Rare Dis 4:e1198458. 2016
    ..The findings may help understand interrelationships of iron and myelin in more common conditions such as hemochromatosis, multiple sclerosis and various psychiatric disorders. ..