Colin L Masters

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. pmc Utility of an improved model of amyloid-beta (Aβ₁₋₄₂) toxicity in Caenorhabditis elegans for drug screening for Alzheimer's disease
    Gawain McColl
    The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Victoria 3010, Australia
    Mol Neurodegener 7:57. 2012
  2. pmc Intracellular amyloid formation in muscle cells of Abeta-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification
    Alicia N Minniti
    Centro de Regulación Celular y Patología Joaquín V, Luco CRCP, MIFAB, Centro de Envejecimiento y Regeneración CARE, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, 8331010 Santiago, Chile
    Mol Neurodegener 4:2. 2009
  3. pmc Protocol for a randomized controlled trial evaluating the effect of physical activity on delaying the progression of white matter changes on MRI in older adults with memory complaints and mild cognitive impairment: the AIBL Active trial
    Elizabeth V Cyarto
    National Ageing Research Institute, Melbourne, Australia
    BMC Psychiatry 12:167. 2012
  4. pmc Biochemistry of amyloid β-protein and amyloid deposits in Alzheimer disease
    Colin L Masters
    The Mental Health Research Institute, The University of Melbourne, Parkville 3010, Australia
    Cold Spring Harb Perspect Med 2:a006262. 2012
  5. pmc Prion subcellular fractionation reveals infectivity spectrum, with a high titre-low PrPres level disparity
    Victoria Lewis
    Department of Pathology, The University of Melbourne, Parkville, VIC 3010, Australia
    Mol Neurodegener 7:18. 2012
  6. pmc C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress
    Jodi Meyerowitz
    Department of Pathology, The University of Melbourne, Victoria, 3010, Australia
    Mol Neurodegener 6:57. 2011
  7. ncbi Molecular mechanisms for Alzheimer's disease: implications for neuroimaging and therapeutics
    Colin L Masters
    Department of Pathology, The University of Melbourne, Vic, Australia
    J Neurochem 97:1700-25. 2006
  8. ncbi Pathways to the discovery of the Abeta amyloid of Alzheimer's disease
    Colin L Masters
    Department of Pathology, The University of Melbourne, and The Mental Health Research Institute of Victoria, Australia
    J Alzheimers Dis 9:155-61. 2006
  9. ncbi Alzheimer's centennial legacy: prospects for rational therapeutic intervention targeting the Abeta amyloid pathway
    Colin L Masters
    Department of Pathology, The University of Melbourne, 3010, Victoria, Australia
    Brain 129:2823-39. 2006
  10. doi Formation of dopamine-mediated alpha-synuclein-soluble oligomers requires methionine oxidation
    Su Ling Leong
    Department of Pathology, The University of Melbourne, Parkville, Vic, Australia
    Free Radic Biol Med 46:1328-37. 2009

Detail Information

Publications130 found, 100 shown here

  1. pmc Utility of an improved model of amyloid-beta (Aβ₁₋₄₂) toxicity in Caenorhabditis elegans for drug screening for Alzheimer's disease
    Gawain McColl
    The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Victoria 3010, Australia
    Mol Neurodegener 7:57. 2012
    ..Ease of culturing and a short life cycle make this animal model well suited to rapid screening of candidate compounds...
  2. pmc Intracellular amyloid formation in muscle cells of Abeta-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification
    Alicia N Minniti
    Centro de Regulación Celular y Patología Joaquín V, Luco CRCP, MIFAB, Centro de Envejecimiento y Regeneración CARE, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, 8331010 Santiago, Chile
    Mol Neurodegener 4:2. 2009
    ..In addition, it is also known that Abeta is involved in Inclusion Body Myositis, a common myopathy of the elderly in which the peptide accumulates intracellularly...
  3. pmc Protocol for a randomized controlled trial evaluating the effect of physical activity on delaying the progression of white matter changes on MRI in older adults with memory complaints and mild cognitive impairment: the AIBL Active trial
    Elizabeth V Cyarto
    National Ageing Research Institute, Melbourne, Australia
    BMC Psychiatry 12:167. 2012
    ..The aim of AIBL Active is to determine whether a 24-month physical activity program can delay the progression of white matter changes on magnetic resonance imaging (MRI)...
  4. pmc Biochemistry of amyloid β-protein and amyloid deposits in Alzheimer disease
    Colin L Masters
    The Mental Health Research Institute, The University of Melbourne, Parkville 3010, Australia
    Cold Spring Harb Perspect Med 2:a006262. 2012
    ....
  5. pmc Prion subcellular fractionation reveals infectivity spectrum, with a high titre-low PrPres level disparity
    Victoria Lewis
    Department of Pathology, The University of Melbourne, Parkville, VIC 3010, Australia
    Mol Neurodegener 7:18. 2012
    ....
  6. pmc C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress
    Jodi Meyerowitz
    Department of Pathology, The University of Melbourne, Victoria, 3010, Australia
    Mol Neurodegener 6:57. 2011
    ..Cell cultures were treated overnight with the mitochondrial inhibitor paraquat and examined for TDP-43 and SG processing...
  7. ncbi Molecular mechanisms for Alzheimer's disease: implications for neuroimaging and therapeutics
    Colin L Masters
    Department of Pathology, The University of Melbourne, Vic, Australia
    J Neurochem 97:1700-25. 2006
    ....
  8. ncbi Pathways to the discovery of the Abeta amyloid of Alzheimer's disease
    Colin L Masters
    Department of Pathology, The University of Melbourne, and The Mental Health Research Institute of Victoria, Australia
    J Alzheimers Dis 9:155-61. 2006
    ..The proteolytic enzymes which process APP and the Abeta fragment itself are now the prime validated drug targets for therapeutic intervention...
  9. ncbi Alzheimer's centennial legacy: prospects for rational therapeutic intervention targeting the Abeta amyloid pathway
    Colin L Masters
    Department of Pathology, The University of Melbourne, 3010, Victoria, Australia
    Brain 129:2823-39. 2006
    ..A variety of therapeutic strategies aimed at disease modification are now in clinical development...
  10. doi Formation of dopamine-mediated alpha-synuclein-soluble oligomers requires methionine oxidation
    Su Ling Leong
    Department of Pathology, The University of Melbourne, Parkville, Vic, Australia
    Free Radic Biol Med 46:1328-37. 2009
    ..Our study defines methionine oxidation as the dominant mechanism by which DA generates soluble alpha-synuclein oligomers and highlights the potential role for oxidative stress in modulating alpha-synuclein aggregation...
  11. ncbi Enhanced toxicity and cellular binding of a modified amyloid beta peptide with a methionine to valine substitution
    Giuseppe D Ciccotosto
    Department of Pathology, University of Melbourne, Victoria 3010, Australia
    J Biol Chem 279:42528-34. 2004
    ..These findings provide further evidence that the toxicity of Abeta is regulated by binding to neuronal cells...
  12. pmc Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII(atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model
    Cynthia P W Soon
    Department of Pathology, Mental Health Research Institute, School of Chemistry, The University of Melbourne, Parkville, Victoria, Australia
    J Biol Chem 286:44035-44. 2011
    ..CuII(atsm) therefore represents a potential new class of neuroprotective agents targeting multiple major disease pathways of motor neurons with therapeutic potential for ALS...
  13. doi Sustained activation of glial cell epidermal growth factor receptor by bis(thiosemicarbazonato) metal complexes is associated with inhibition of protein tyrosine phosphatase activity
    Katherine Ann Price
    Department of Pathology, The University of Melbourne, Victoria 3010, Australia
    J Med Chem 52:6606-20. 2009
    ..These studies provide an important insight into the mechanism of action of a neuroprotective M(II)(btsc) and provide a basis for future studies into this novel approach to AD therapy...
  14. pmc Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation
    Peter J Crouch
    Department of Pathology, Centre for Neuroscience, School of Chemistry, and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, Victorial, 3010, Australia
    Proc Natl Acad Sci U S A 106:381-6. 2009
    ..This study demonstrates that increasing intracellular copper bioavailability can restore cognitive function by inhibiting the accumulation of neurotoxic Abeta trimers and phosphorylated tau...
  15. doi Decline in cognitive function over 18 months in healthy older adults with high amyloid-β
    Kathryn A Ellis
    Mental Health Research Institute, The University of Melbourne, Parkville, Vic, Australia
    J Alzheimers Dis 34:861-71. 2013
    ....
  16. ncbi Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity
    Anthony R White
    Department of Pathology, University of Melbourne, Cnr Grattan Street and Royal Parade, Victoria 3010, Australia
    J Biol Chem 281:17670-80. 2006
    ..Our findings identify an alternative mechanism of action for CQ in the reduction of Abeta deposition in the brains of CQ-treated animals and potentially in Alzheimer disease patients...
  17. doi Stereospecific interactions are necessary for Alzheimer disease amyloid-β toxicity
    Giuseppe D Ciccotosto
    Department of Pathology, The University of Melbourne, VIC 3010, Australia
    Neurobiol Aging 32:235-48. 2011
    ..This suggests that Aβ mediated toxicity in Alzheimer disease is dependent upon Aβ binding to phosphatidylserine on neuronal cells...
  18. doi BDNF Val66Met, Aβ amyloid, and cognitive decline in preclinical Alzheimer's disease
    Yen Ying Lim
    Mental Health Research Institute, The University of Melbourne, Parkville, Victoria, Australia
    Neurobiol Aging 34:2457-64. 2013
    ..High Aβ levels coupled with Met carriage may be useful prognostic markers of accelerated cognitive decline and hippocampal degeneration in individuals in the preclinical stage of AD. ..
  19. ncbi Overexpression of Abeta is associated with acceleration of onset of motor impairment and superoxide dismutase 1 aggregation in an amyotrophic lateral sclerosis mouse model
    Qiao Xin Li
    Department of Pathology, The University of Melbourne, and The Mental Health Research Institute of Victoria, Parkville, VIC 3010, Australia
    Aging Cell 5:153-65. 2006
    ..SOD1(G93A) mice. This study supports abnormal SOD1 protein aggregation as the pathogenic mechanism in ALS, and implicates a potential role for Abeta in the development of ALS by exacerbating SOD1(G93A) aggregation...
  20. doi Amyloid-beta peptide (Abeta) neurotoxicity is modulated by the rate of peptide aggregation: Abeta dimers and trimers correlate with neurotoxicity
    Lin Wai Hung
    Department of Pathology, The University of Melbourne, Parkville, Victoria 3010, Australia
    J Neurosci 28:11950-8. 2008
    ....
  21. doi Dominant roles of the polybasic proline motif and copper in the PrP23-89-mediated stress protection response
    Cathryn L Haigh
    Department of Pathology, The University of Melbourne, 3010, Australia
    J Cell Sci 122:1518-28. 2009
    ..Our findings show that N2 is a biologically active fragment that is able to modulate stress-induced intracellular ROS through interaction of its structurally defined N-terminal polybasic region with cell-surface proteoglycans...
  22. doi Predicting Alzheimer disease with β-amyloid imaging: results from the Australian imaging, biomarkers, and lifestyle study of ageing
    Christopher C Rowe
    Austin Health, Department of Nuclear Medicine and Centre for Positron Emission Tomography, Heidelberg, Victoria, Australia
    Ann Neurol 74:905-13. 2013
    ..We aimed to determine the prognostic value of β-amyloid imaging, alone and in combination with memory performance, hippocampal atrophy, and apolipoprotein E ε4 status in nondemented, older individuals...
  23. doi Effect of amyloid on memory and non-memory decline from preclinical to clinical Alzheimer's disease
    Yen Ying Lim
    1 The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia
    Brain 137:221-31. 2014
    ..Further, these results suggest that grouping amyloid data into at least two categories of abnormality may be useful in determining the disease risk level in non-demented individuals. ..
  24. doi Activation of epidermal growth factor receptor by metal-ligand complexes decreases levels of extracellular amyloid beta peptide
    Katherine A Price
    Department of Pathology, The University of Melbourne, Victoria 3010, Australia
    Int J Biochem Cell Biol 40:1901-17. 2008
    ..These findings provide the first evidence that metal-ligand complexes can activate the epidermal growth factor receptor with potentially neuroprotective effects...
  25. ncbi Correlative studies support lipid peroxidation is linked to PrP(res) propagation as an early primary pathogenic event in prion disease
    Marcus W Brazier
    Department of Pathology, The University of Melbourne, VIC 3010, Australia
    Brain Res Bull 68:346-54. 2006
    ....
  26. doi Increased proportions of C1 truncated prion protein protect against cellular M1000 prion infection
    Victoria Lewis
    Department of Pathology, University of Melbourne, Parkville, Victoria, Australia
    J Neuropathol Exp Neurol 68:1125-35. 2009
    ....
  27. ncbi Alternative transcripts of presenilin-1 associated with frontotemporal dementia
    Genevieve Evin
    Department of Pathology, The University of Melbourne, and Mental Health Research Institute, Parkville, Victoria 3010, Australia
    Neuroreport 13:917-21. 2002
    ..RT-PCR analysis using nested primers showed the presence of PS1 gene products with deletions within the exon 4-8 region. Our results suggest that alternative transcription of PS1 may be associated with FTD...
  28. pmc Paradoxical condensation of copper with elevated beta-amyloid in lipid rafts under cellular copper deficiency conditions: implications for Alzheimer disease
    Ya Hui Hung
    Oxidation Biology Laboratory, The Mental Health Research Institute of Victoria, Parkville, Victoria, Australia
    J Biol Chem 284:21899-907. 2009
    ..copper complexes are more likely to form. This explains the paradoxical hypermetallation of Abeta with copper under tissue copper deficiency conditions in AD...
  29. pmc Platinum-based inhibitors of amyloid-beta as therapeutic agents for Alzheimer's disease
    Kevin J Barnham
    Department of Pathology, University of Melbourne, Parkville, Victoria, 3010, Australia
    Proc Natl Acad Sci U S A 105:6813-8. 2008
    ..The potent effect of the L-PtCl(2) complexes identifies this class of compounds as therapeutic agents for AD...
  30. ncbi Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex
    Genevieve Evin
    Department of Pathology, The University of Melbourne, Parkville 3010, and The Mental Health Research Institute, Parkville 3052, Australia
    Biochemistry 44:4332-41. 2005
    ..From these observations, we propose a model for the structure of active gamma-secretase that would consist of dimerization of 400-500 kDa subunits and be consistent with the apparent molecular mass of the complex...
  31. ncbi The amyloid precursor protein (APP) of Alzheimer disease and its paralog, APLP2, modulate the Cu/Zn-Nitric Oxide-catalyzed degradation of glypican-1 heparan sulfate in vivo
    Roberto Cappai
    Department of Pathology and Center for Neuroscience, The University of Melbourne, Victoria 3010, Australia
    J Biol Chem 280:13913-20. 2005
    ..These observation identify a functional relationship between the heparan sulfate and copper ion binding activities of APP/APLP2 in their modulation of the nitroxyl anion-catalyzed heparan sulfate degradation in glypican-1...
  32. ncbi Selective intracellular release of copper and zinc ions from bis(thiosemicarbazonato) complexes reduces levels of Alzheimer disease amyloid-beta peptide
    Paul S Donnelly
    School of Chemistry, The University of Melbourne, Parkville, Victoria 3010, Australia
    J Biol Chem 283:4568-77. 2008
    ..However, a role for alternative metal-induced Abeta metabolism has not been ruled out. These studies demonstrate that MII(btsc) complexes have potential for Alzheimer disease therapy...
  33. doi Cognition and beta-amyloid in preclinical Alzheimer's disease: data from the AIBL study
    Kerryn E Pike
    Department of Nuclear Medicine, Centre for PET, Austin Health, Heidelberg, Vic, Australia
    Neuropsychologia 49:2384-90. 2011
    ..The finding of gender differences deserves further research to answer definitively the important question of gender susceptibility to adverse cognitive effects from β-amyloid...
  34. pmc Pathogenic mutations within the hydrophobic domain of the prion protein lead to the formation of protease-sensitive prion species with increased lethality
    Bradley M Coleman
    Department of Biochemistry and Molecular Biology, The University of Melbourne, Parkville, Victoria, Australia
    J Virol 88:2690-703. 2014
    ....
  35. doi Changes in plasma amyloid beta in a longitudinal study of aging and Alzheimer's disease
    Alan Rembach
    The Mental Health Research Institute, The University of Melbourne, Victoria, Australia Electronic address
    Alzheimers Dement 10:53-61. 2014
    ..A practical biomarker is required to facilitate the preclinical diagnosis of Alzheimer's disease (AD)...
  36. pmc Metals and amyloid-beta in Alzheimer's disease
    Christa J Maynard
    Department of Pathology, The University of Melbourne, Parkville, Victoria 3010, Australia
    Int J Exp Pathol 86:147-59. 2005
    ..Clinical trials are currently studying agents that can remedy abnormal Abeta-metal interactions...
  37. doi Histidine 14 modulates membrane binding and neurotoxicity of the Alzheimer's disease amyloid-beta peptide
    Danielle G Smith
    Department of Pathology, The University of Melbourne Parkville, Victoria, Australia
    J Alzheimers Dis 19:1387-400. 2010
    ..Our data suggests that it is the imidazole sidechain of histidine 14 that modulates this interaction and strategies inhibiting this interaction may have therapeutic potential for Alzheimer's disease...
  38. doi Longitudinal analysis of serum copper and ceruloplasmin in Alzheimer's disease
    Alan Rembach
    The Mental Health Research Institute, The University of Melbourne, Vic, Australia
    J Alzheimers Dis 34:171-82. 2013
    ..The aim of this study was to determine the diagnostic value of serum copper, CP, and non-CP copper levels in a large cohort of AD subjects...
  39. ncbi In vitro gamma-secretase cleavage of the Alzheimer's amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc
    David E Hoke
    Department of Pathology, The University of Melbourne and The Mental Health Research Institute, Parkville, Victoria, Australia
    FEBS J 272:5544-57. 2005
    ..These studies further refine our knowledge of the complexes and biochemical factors needed for gamma-secretase activity and suggest a mechanism by which zinc dysregulation may contribute to Alzheimer's disease pathogenesis...
  40. doi The Alzheimer's therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity
    Peter J Crouch
    Department of Pathology, The University of Melbourne, Victoria, Australia
    J Neurochem 119:220-30. 2011
    ..Intracellular translocation of Zn and Cu via the metal chaperone activity of PBT2 may be an important mechanism by which PBT2 improves cognitive function in people with AD...
  41. pmc Anionic phospholipid interactions of the prion protein N terminus are minimally perturbing and not driven solely by the octapeptide repeat domain
    Martin P Boland
    Department of Pathology, University of Melbourne, Parkville 3010, Australia
    J Biol Chem 285:32282-92. 2010
    ..Potential functional implications related to cellular stress responses are discussed...
  42. ncbi Decreased phosphatidylethanolamine binding protein expression correlates with Abeta accumulation in the Tg2576 mouse model of Alzheimer's disease
    Amee J George
    Department of Pathology, University of Melbourne, Parkville 3010, Australia
    Neurobiol Aging 27:614-23. 2006
    ..Down-regulation of PEBP may result in lower levels of HCNP or altered coordination of signal transduction pathways that may contribute to neuronal dysfunction and pathogenesis in AD...
  43. doi Mouse-adapted sporadic human Creutzfeldt-Jakob disease prions propagate in cell culture
    Victoria A Lawson
    Department of Pathology, The University of Melbourne, Parkville, Victoria 3010, Australia
    Int J Biochem Cell Biol 40:2793-801. 2008
    ..Our observations underscore the likelihood that, in contrast to prions derived from non-human mammals, additional unidentified cofactors or subcellular environment are critical for the generation of human prions...
  44. doi Cognitive consequences of high Aβ amyloid in mild cognitive impairment and healthy older adults: implications for early detection of Alzheimer's disease
    Yen Ying Lim
    Mental Health Research Institute, The University of Melbourne, Parkville, Victoria, Australia
    Neuropsychology 27:322-32. 2013
    ..We aimed to determine the extent to which high Aβ amyloid influenced cognitive function in healthy older adults and adults with MCI...
  45. ncbi Diverse fibrillar peptides directly bind the Alzheimer's amyloid precursor protein and amyloid precursor-like protein 2 resulting in cellular accumulation
    Anthony R White
    Department of Pathology, The University of Melbourne, 3010, Victoria, Australia
    Brain Res 966:231-44. 2003
    ..These findings show that diverse fibrillogenic peptides can induce accumulation of APP and APLP2 and this mechanism could contribute to pathogenesis in neurodegenerative disorders...
  46. doi Stronger effect of amyloid load than APOE genotype on cognitive decline in healthy older adults
    Yen Ying Lim
    Mental Health Research Institute, The University of Melbourne, Parkville, Australia
    Neurology 79:1645-52. 2012
    ..Although the APOE ε4 allele is associated with more rapid decline in memory in healthy older adults, the significance of elevated cerebral β-amyloid (Aβ) load for longitudinal changes in cognition is unclear...
  47. doi Acute exposure to prion infection induces transient oxidative stress progressing to be cumulatively deleterious with chronic propagation in vitro
    Cathryn L Haigh
    Department of Pathology, The University of Melbourne, Parkville, 3010, Australia
    Free Radic Biol Med 51:594-608. 2011
    ..Such observations strengthen the direct links between heightened ROS and ongoing prion propagation with eventual cellular demise...
  48. doi Increasing the predictive accuracy of amyloid-β blood-borne biomarkers in Alzheimer's disease
    Andrew D Watt
    Department of Pathology, The University of Melbourne, Parkville, Melbourne, Victoria, Australia
    J Alzheimers Dis 24:47-59. 2011
    ..Furthermore, the findings indicate that the incorporation of non-amyloid markers into predictive models, function to increase the accuracy of the diagnostic potential of Aβ...
  49. ncbi Surveillance of Creutzfeldt-Jakob disease in Australia: 2008
    Genevieve M Klug
    Australiian National Creutzfeldt Jakob Disease Registry, Department of Pathology, The University of Melbourne, Victoria, Australia
    Commun Dis Intell Q Rep 32:232-6. 2008
    ..16 deaths per million per year. In this short report, we provide updated Australian TSE figures and describe recent changes in surveillance mechanisms and review their impact on case notifications and eventual CJD classification...
  50. ncbi Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations
    Janetta G Culvenor
    Department of Pathology, The University of Melbourne, Australia
    Eur J Biochem 271:375-85. 2004
    ..Higher molecular mass presenilin 1-reactive species were detected in brain containing presenilin 1 exon 9 deletion mutation. This abnormality was confirmed using cells transfected with the same presenilin deletion mutation...
  51. doi Chronic exposure to high levels of zinc or copper has little effect on brain metal homeostasis or Abeta accumulation in transgenic APP-C100 mice
    Christa J Maynard
    Department of Pathology, The University of Melbourne, Melbourne, Vic, 3010, Australia
    Cell Mol Neurobiol 29:757-67. 2009
    ....
  52. pmc Conservation of a glycine-rich region in the prion protein is required for uptake of prion infectivity
    Christopher F Harrison
    Department of Biochemistry and Molecular Biology, The University of Melbourne, Parkville, Victoria 3010, Australia
    J Biol Chem 285:20213-23. 2010
    ..These data suggest that this region of PrP(C) is critical in the misfolding process and could serve as a novel, species-independent target for prion disease therapeutics...
  53. doi Cu2+ binding modes of recombinant alpha-synuclein--insights from EPR spectroscopy
    Simon C Drew
    Department of Pathology, The University of Melbourne, Victoria 3010, Australia
    J Am Chem Soc 130:7766-73. 2008
    ..In total, four Cu(2+) binding modes were identified within pH 5.0-7.4, providing a more comprehensive picture of the Cu(2+) binding properties of recombinant alphaS...
  54. doi Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging
    Christopher C Rowe
    Austin Health, Department of Nuclear Medicine and Centre for PET, Heidelberg, Victoria, Australia
    Neurobiol Aging 31:1275-83. 2010
    ....
  55. ncbi Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cellular copper levels in primary mouse cortical neurons and embryonic fibroblasts
    Shayne A Bellingham
    Department of Genetics, The University of Melbourne, Victoria, Australia
    J Neurochem 91:423-8. 2004
    ....
  56. doi Serum matrix metalloproteinase-9 activity is dysregulated with disease progression in the mutant SOD1 transgenic mice
    Cynthia P W Soon
    Department of Pathology, The University of Melbourne, Parkville, VIC 3010, Australia
    Neuromuscul Disord 20:260-6. 2010
    ..These data indicate that circulating MMP-9 is altered throughout the course of disease progression in mice. Further studies in human ALS may validate the suitability of serum MMP-9 activity as a biomarker for early stage disease...
  57. ncbi Radioiodinated clioquinol as a biomarker for beta-amyloid: Zn complexes in Alzheimer's disease
    Carlos Opazo
    Oxidation Disorders Laboratory, Mental Health Research Institute of Victoria, and Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia
    Aging Cell 5:69-79. 2006
    ..These data support metallated Abeta species as the neuropharmacological target of CQ and indicate that this drug class may have potential as in vivo imaging agents for Alzheimer neuropathology...
  58. doi PrPC-related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site
    Cathryn L Haigh
    Department of Pathology, The University of Melbourne, Parkville, Melbourne, 3010, Australia
    Cell Res 19:1062-78. 2009
    ..Further, the primary sequence appears to confer a mutual dependence of N1/C1 cleavage and membrane integrity on the fidelity of PrP(C)-related signal transduction in response to exogenous stimuli...
  59. ncbi Linker histone H1 binds to disease associated amyloid-like fibrils
    James A Duce
    Centre for Neuroscience, The University of Melbourne, Victoria 3010, Australia
    J Mol Biol 361:493-505. 2006
    ..We conclude that the binding of histone H1 to a general amyloid-like motif indicates that histone H1 may play an important common role in diseases associated with amyloid-like fibrils...
  60. doi Three-month stability of the CogState brief battery in healthy older adults, mild cognitive impairment, and Alzheimer's disease: results from the Australian Imaging, Biomarkers, and Lifestyle-rate of change substudy (AIBL-ROCS)
    Yen Ying Lim
    Mental Health Research Institute, The University of Melbourne, Parkville, Victoria, Australia
    Arch Clin Neuropsychol 28:320-30. 2013
    ..This may potentially be used to inform future estimates of cognitive change in clinical trials...
  61. ncbi Cholesterol and Clioquinol modulation of A beta(1-42) interaction with phospholipid bilayers and metals
    Tong Lay Lau
    School of Chemistry, Bio21 Institute, The University of Melbourne, Victoria 3010, Australia
    Biochim Biophys Acta 1768:3135-44. 2007
    ..The results are consistent with oligomeric beta-sheet structured peptides only partially penetrating the bilayer and cholesterol reducing the membrane disruption...
  62. ncbi Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets
    Genevieve Evin
    Department of Pathology, University of Melbourne, Parkville, Australia
    J Neurosci Res 74:386-92. 2003
    ..Finally, the finding of the same secretase products in platelets and neurons make platelets a potentially useful and easily accessible clinical tool to monitor effects of novel therapies based on inhibition of beta- or gamma-secretase...
  63. pmc The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease
    Lin W Hung
    The Mental Health Research Institute, The University of Melbourne, Victoria 3010 Australia
    J Exp Med 209:837-54. 2012
    ..Our results show that Cu(II)(atsm) is effective in reversing parkinsonian defects in animal models and has the potential to be a successful treatment of PD...
  64. doi Differential diagnosis in Alzheimer's disease and dementia with Lewy bodies via VMAT2 and amyloid imaging
    Victor L Villemagne
    Mental Health Research Institute, University of Melbourne, Melbourne, Vic, Australia
    Neurodegener Dis 10:161-5. 2012
    ..The noninvasive evaluation of nigrostriatal dopaminergic integrity by PET can provide useful information for the differential diagnosis between dementia with Lewy bodies (DLB) and Alzheimer's disease (AD)...
  65. doi Investigation of matrix metalloproteinases, MMP-2 and MMP-9, in plasma reveals a decrease of MMP-2 in Alzheimer's disease
    Nastasia K H Lim
    Department of Pathology, The University of Melbourne, Parkville VIC, Australia
    J Alzheimers Dis 26:779-86. 2011
    ..16, p < 0.05), but there was no association with PiB. This is the first report of a change in MMP-2 activity in AD plasma and these findings may provide some insight into AD pathogenesis...
  66. ncbi Surveillance of Creutzfeldt-Jakob disease in Australia: 2009 update
    Genevieve M Klug
    Department of Pathology, The University of Melbourne, Victoria
    Commun Dis Intell Q Rep 33:188-91. 2009
    ..18 deaths per million per year. In this short report, we provide updated Australian human TSE figures and discuss a recently published investigation of geographical TSE clustering in regional New South Wales...
  67. doi A serial analysis of gene expression profile of the Alzheimer's disease Tg2576 mouse model
    Amee J George
    Department of Pathology, The University of Melbourne and The Mental Health Research Institute of Victoria, Parkville, VIC 3052, Australia
    Neurotox Res 17:360-79. 2010
    ..The novel approach of profiling the Tg2576 mouse brain using SAGE has identified different genes that could subsequently be examined for their potential as peripheral diagnostic and prognostic markers for Alzheimer's disease...
  68. doi Characterization of PiB binding to white matter in Alzheimer disease and other dementias
    Michelle T Fodero-Tavoletti
    Department of Pathology, University of Melbourne, and Department of Nuclear Medicine, Centre for PET, Austin Hospital, Heidelberg, Victoria, Australia
    J Nucl Med 50:198-204. 2009
    ..Although the specificity of PiB for Abeta plaques in gray matter has been well described, the nature of PiB binding to white matter remains unclear. In this study, we characterized the binding of PiB to human white matter homogenates...
  69. doi Zinc induces depletion and aggregation of endogenous TDP-43
    Aphrodite Caragounis
    Department of Pathology, The University of Melbourne, Melbourne, VIC 3010, Australia
    Free Radic Biol Med 48:1152-61. 2010
    ..These studies describe for the first time specific induction of endogenous TDP-43 aggregation in neuronal-like cells and suggest that specific Zn-associated processes could affect TDP-43 metabolism in neurodegenerative diseases...
  70. doi Amyloid imaging with (18)F-florbetaben in Alzheimer disease and other dementias
    Victor L Villemagne
    Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia
    J Nucl Med 52:1210-7. 2011
    ....
  71. ncbi Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge
    David P Smith
    Department of Pathology, Centre for Neuroscience, and School of Chemistry, University of Melbourne, Victoria 3010, Australia
    J Biol Chem 281:15145-54. 2006
    ..These findings indicate that the generation of the Abeta toxic species is modulated by the Cu2+ concentration and the ability to form an intermolecular His bridge...
  72. ncbi Amyloid-beta peptide disruption of lipid membranes and the effect of metal ions
    Tong Lay Lau
    School of Chemistry, The University of Melbourne, Melbourne, VIC 3010, Australia
    J Mol Biol 356:759-70. 2006
    ..Incorporated peptides appear to disrupt the membrane more severely than associated peptides, which may have implications for the role of Abeta in disease states...
  73. pmc Membrane-targeted strategies for modulating APP and Abeta-mediated toxicity
    Katherine A Price
    Department of Pathology, The University of Melbourne, Victoria, Australia
    J Cell Mol Med 13:249-61. 2009
    ..The putative role of copper (Cu) in AD is also discussed, and we highlight how targeting the cell membrane with Cu complexes has therapeutic potential in AD...
  74. doi Formation of a high affinity lipid-binding intermediate during the early aggregation phase of alpha-synuclein
    David P Smith
    Department of Pathology, The University of Melbourne, Victoria, 3010, Australia
    Biochemistry 47:1425-34. 2008
    ..Oligomeric alpha-syn is known to be toxic, and it is feasible that the high affinity binding species described here may correspond to a toxic species involved in PD...
  75. ncbi Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis
    Kevin J Barnham
    Department of Pathology, The University of Melbourne, Victoria 3010, Australia
    J Biol Chem 278:17401-7. 2003
    ..The surface location of this site, structural homology of CuBD to copper chaperones, and the role of APP in neuronal copper homeostasis are consistent with the CuBD acting as a neuronal metallotransporter...
  76. ncbi Proteasome-mediated degradation of the C-terminus of the Alzheimer's disease beta-amyloid protein precursor: effect of C-terminal truncation on production of beta-amyloid protein
    Janelle Nunan
    Department of Pathology, University of Melbourne, Victoria, Australia
    J Neurosci Res 74:378-85. 2003
    ..Therefore, the proteasome-dependent trafficking pathway of APP may be a valid therapeutic target for altering Abeta production in the Alzheimer's disease brain...
  77. ncbi Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease beta-amyloid
    Kevin J Barnham
    Department of Pathology, University of Melbourne, Victoria, Australia
    FASEB J 18:1427-9. 2004
    ..Confirming the theoretical results, mutation of the tyrosine residue to alanine inhibited H2O2 production, Cu-induced radicalization, dityrosine cross-linking, and neurotoxicity...
  78. ncbi Iron inhibits neurotoxicity induced by trace copper and biological reductants
    Anthony R White
    Department of Pathology and Centre for Neuroscience, The University of Melbourne, 3010, Carlton South, Victoria, Australia
    J Biol Inorg Chem 9:269-80. 2004
    ..These findings have important implications for trace biometal interactions and free radical-mediated damage during neurodegenerative illnesses such as Alzheimer's disease and old-age dementia...
  79. doi 18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease
    Michelle T Fodero-Tavoletti
    Department of Pathology, The University of Melbourne, Victoria, 3010, Australia
    Brain 134:1089-100. 2011
    ..The preclinical examination of THK523 has demonstrated its high affinity and selectivity for tau pathology both in vitro and in vivo, indicating that (18)F-THK523 fulfils ligand criteria for human imaging trials...
  80. doi Addressing population aging and Alzheimer's disease through the Australian imaging biomarkers and lifestyle study: collaboration with the Alzheimer's Disease Neuroimaging Initiative
    Kathryn A Ellis
    Department of Psychiatry, Academic Unit for Psychiatry of Old Age, University of Melbourne, Kew, Victoria, Australia
    Alzheimers Dement 6:291-6. 2010
    ..Cross-sectional analysis of baseline data is revealing links between cognition, brain amyloid burden, structural brain changes, biomarkers, and lifestyle...
  81. ncbi Nicastrin expression in mouse peripheral tissues is not co-ordinated with presenilin and is high in muscle
    Nancy T Ilaya
    Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia
    J Neurochem 91:230-7. 2004
    ..These findings suggest a function for nicastrin in muscle other than participation in the gamma-secretase complex...
  82. doi Restored degradation of the Alzheimer's amyloid-beta peptide by targeting amyloid formation
    Peter J Crouch
    Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia
    J Neurochem 108:1198-207. 2009
    ..This provides new data indicating that therapeutic compounds designed to modulate Abeta-metal interactions can inhibit Abeta accumulation by restoring the catalytic potential of Abeta-degrading proteases...
  83. pmc Differential modulation of Alzheimer's disease amyloid beta-peptide accumulation by diverse classes of metal ligands
    Aphrodite Caragounis
    Department of Pathology, The University of Melbourne, Victoria 3010, Australia
    Biochem J 407:435-50. 2007
    ..Given that a structurally diverse array of ligands was assessed, the results are consistent with the effects being due to metal transport rather than the chelating ligand interacting directly with a receptor...
  84. ncbi Selecting cells with different Alzheimer's disease gamma-secretase activity using FACS. Differential effect on presenilin exon 9 gamma- and epsilon-cleavage
    M Fleur Sernee
    Department of Pathology, The University of Melbourne, Parkville, Victoria, Australia
    Eur J Biochem 270:495-506. 2003
    ..The single aspartate mutations showed a concomitant reduction in Abeta secretion, whereas the D257A/D385A and DeltaE9 mutations had no effect on Abeta secretion...
  85. ncbi Contrasting, species-dependent modulation of copper-mediated neurotoxicity by the Alzheimer's disease amyloid precursor protein
    Anthony R White
    Department of Pathology, The University of Melbourne, Victoria 3010, Australia
    J Neurosci 22:365-76. 2002
    ..Our findings also suggest that targeting of inhibitors to histidine residues at positions 147 and 151 of APP could significantly alter the oxidative potential of APP...
  86. ncbi Metal ions, pH, and cholesterol regulate the interactions of Alzheimer's disease amyloid-beta peptide with membrane lipid
    Cyril C Curtain
    Department of Pathology, University of Melbourne, Victoria 3052, Australia
    J Biol Chem 278:2977-82. 2003
    ..Peptides that did not insert into the membrane formed beta-sheet structures on the surface of the lipid...
  87. doi Amyloid precursor protein processing and retinal pathology in mouse models of Alzheimer's disease
    R Michael Dutescu
    Department of Pathology and Centre for Neuroscience, The University of Melbourne, Parkville, Victoria 3010, Australia
    Graefes Arch Clin Exp Ophthalmol 247:1213-21. 2009
    ..We therefore investigated retinal APP processing and eye morphology in Alzheimer;s transgenic mouse models...
  88. ncbi Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron
    Christa J Maynard
    Department of Pathology, The University of Melbourne, Victoria 3010, Australia
    J Biol Chem 277:44670-6. 2002
    ..These findings, complemented by our previous findings of elevated copper levels in APP knock-out mice, support roles for APP and Abeta in physiological metal regulation...
  89. doi Inhibition of gamma-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes
    Robyn A Sharples
    Department of Biochemistry and Molecular Biology, The University of Melbourne, Parkville Victoria 3010, Australia
    FASEB J 22:1469-78. 2008
    ..These results provide further evidence for a novel pathway in which APP fragments are released from cells and have implications for the analysis of APP processing and diagnostics for Alzheimer's disease...
  90. ncbi Delineating common molecular mechanisms in Alzheimer's and prion diseases
    Kevin J Barnham
    Department of Pathology, and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC 3010, Australia
    Trends Biochem Sci 31:465-72. 2006
    ..Key sequence and chemical similarities between prion protein (PrP) and Abeta indicate that similar therapeutic strategies might be applicable for the treatment of Alzheimer's and prion diseases...
  91. ncbi Altered glycosylation of acetylcholinesterase in APP (SW) Tg2576 transgenic mice occurs prior to amyloid plaque deposition
    Lisa R Fodero
    Laboratory of Molecular Neurobiology, Department of Pathology, The University of Melbourne, Melbourne, Australia
    J Neurochem 81:441-8. 2002
    ..The study supports the possibility that glycosylation may also be a useful biomarker of AD...
  92. ncbi Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta1-42
    Peter J Crouch
    Centre for Neuroscience, The University of Melbourne, Victoria 3010, Australia
    J Neurosci 25:672-9. 2005
    ..We conclude that Cu2+-dependent Abeta-mediated inhibition of COX may be an important contributor to the neurodegeneration process in Alzheimer's disease...
  93. doi PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analyses
    Noel G Faux
    Mental Health Research Institute, The University of Melbourne, Parkville, Vic, Australia
    J Alzheimers Dis 20:509-16. 2010
    ..72, p=0.056). There were no correlations between changes in CSF amyloid-beta or tau species and cognitive changes. These findings further encourage larger-scale testing of PBT2 for AD...
  94. ncbi Clioquinol inhibits peroxide-mediated toxicity through up-regulation of phosphoinositol-3-kinase and inhibition of p53 activity
    Gulay Filiz
    Centre for Neuroscience and Department of Pathology, The University of Melbourne, Victoria 3010, Australia
    Int J Biochem Cell Biol 40:1030-42. 2008
    ..These findings have important implications for the development of protective metal ligand-based therapies for treatment of disorders involving oxidative stress...
  95. doi A manganese-superoxide dismutase/catalase mimetic extends survival in a mouse model of human prion disease
    Marcus W Brazier
    Department of Pathology, The University of Melbourne, Victoria 3010, Australia
    Free Radic Biol Med 45:184-92. 2008
    ....
  96. ncbi Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial
    Craig W Ritchie
    Departments of Pathology, The University of Melbourne, The Mental Health Research Institute of Victoria, Parkville, Victoria, Australia
    Arch Neurol 60:1685-91. 2003
    ..Alzheimer disease (AD) may be caused by the toxic accumulation of beta-amyloid (Abeta)...
  97. doi SAGE analysis of genes differentially expressed in presymptomatic TgSOD1G93A transgenic mice identified cellular processes involved in early stage of ALS pathology
    Michel Guipponi
    Division of Molecular Medicine, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, 3050, Australia
    J Mol Neurosci 41:172-82. 2010
    ....
  98. doi Imaging of amyloid beta in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: proof of mechanism
    Christopher C Rowe
    Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia
    Lancet Neurol 7:129-35. 2008
    ..18)F-BAY94-9172 is an Abeta ligand that, due to the half-life of (18)F, is suitable for clinical use. We thus studied the effectiveness of this ligand in identifying patients with AD...
  99. pmc Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease
    James A Duce
    Mental Health Research Institute, The University of Melbourne, Parkville, Victoria 3052, Australia
    Cell 142:857-67. 2010
    ..Abnormal exchange of cortical zinc may link amyloid pathology with neuronal iron accumulation in AD...
  100. ncbi Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation
    Kevin J Barnham
    Department of Pathology, The University of Melbourne and The Mental Health Research Institute of Victoria, Victoria 3010, Australia
    J Biol Chem 278:42959-65. 2003
    ..We hypothesize that Met(O)Abeta production contributes to the elevation of soluble Abeta seen in the brain in Alzheimer's disease...
  101. doi A domain level interaction network of amyloid precursor protein and Abeta of Alzheimer's disease
    Victoria M Perreau
    Neuroproteomics and Neurogenomics Platform, National Neurosciences Facility, The University of Melbourne, Parkville, Vic, Australia
    Proteomics 10:2377-95. 2010
    ..Gene ontology and network analysis were used to identify potentially novel functional relationships among interacting proteins...