Lyn March

Summary

Affiliation: University of Sydney
Country: Australia

Publications

  1. ncbi request reprint Epidemiology of osteoarthritis in Australia
    Lynette M March
    Florance and Cope Professorial Department of Rheumatology, Royal North Shore Hospital, St Leonards, NWS, Australia
    Med J Aust 180:S6-10. 2004
  2. doi request reprint Weight loss in obese people has structure-modifying effects on medial but not on lateral knee articular cartilage
    A Anandacoomarasamy
    Institute of Bone and Joint Research, Kolling Institute, Royal North Shore Hospital, University of Sydney, Sydney, New South Wales, Australia
    Ann Rheum Dis 71:26-32. 2012
  3. doi request reprint Costs and outcomes of total hip and knee joint replacement for rheumatoid arthritis
    L M March
    Department of Rheumatology, Institute of Bone and Joint Research, University of Sydney, Building 35, Block 4, Level 4, Royal North Shore Hospital, St Leonards, NSW, 2065, Australia
    Clin Rheumatol 27:1235-42. 2008
  4. doi request reprint The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study
    Marita Cross
    University of Sydney, Institute of Bone and Joint Research, Royal North Shore Hospital, St Leonards, New South Wales, Australia
    Ann Rheum Dis 73:1323-30. 2014
  5. doi request reprint Serum uric acid plays a protective role for bone loss in peri- and postmenopausal women: a longitudinal study
    Joanna Makovey
    Institute of Bone and Joint Research, Kolling Institute, Royal North Shore Hospital, University of Sydney, Sydney, Australia
    Bone 52:400-6. 2013
  6. doi request reprint Protease-activated receptor 2, rather than protease-activated receptor 1, contributes to the aggressive properties of synovial fibroblasts in rheumatoid arthritis
    Meilang Xue
    Kolling Institute of Medical Research and University of Sydney at Royal North Shore Hospital, St Leonards, New South Wales, Australia
    Arthritis Rheum 64:88-98. 2012
  7. doi request reprint Endogenous protein C is essential for the functional integrity of human endothelial cells
    Meilang Xue
    Sutton Research Laboratories, Institute of Bone and Joint Research, Kolling Institute of Medical Research, The University of Sydney at Royal North Shore Hospital, Level 10, The Kolling Building, St Leonards, NSW 2065, Australia
    Cell Mol Life Sci 67:1537-46. 2010
  8. ncbi request reprint Activated protein C stimulates expression of angiogenic factors in human skin cells, angiogenesis in the chick embryo and cutaneous wound healing in rodents
    Meilang Xue
    Sutton Arthritis Research Laboratories, Institute of Bone and Joint Research, University of Sydney, NSW, Australia
    Clin Hemorheol Microcirc 34:153-61. 2006
  9. ncbi request reprint Differential regulation of matrix metalloproteinase 2 and matrix metalloproteinase 9 by activated protein C: relevance to inflammation in rheumatoid arthritis
    Meilang Xue
    Institute of Bone and Joint Research, University of Sydney at Royal North Shore Hospital, St Leonards, New South Wales, Australia
    Arthritis Rheum 56:2864-74. 2007
  10. pmc Protease activated receptor-2 mediates activated protein C-induced cutaneous wound healing via inhibition of p38
    Sohel M Julovi
    Sutton Arthritis Research Laboratories, Institute of Bone and Joint Research, Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, Sydney, Australia
    Am J Pathol 179:2233-42. 2011

Detail Information

Publications44

  1. ncbi request reprint Epidemiology of osteoarthritis in Australia
    Lynette M March
    Florance and Cope Professorial Department of Rheumatology, Royal North Shore Hospital, St Leonards, NWS, Australia
    Med J Aust 180:S6-10. 2004
    ..Services to provide these cost-effective procedures need to be increased. Primary and secondary prevention programs aimed at reducing obesity, preventing injury and improving rehabilitation and physical activity are urgently required...
  2. doi request reprint Weight loss in obese people has structure-modifying effects on medial but not on lateral knee articular cartilage
    A Anandacoomarasamy
    Institute of Bone and Joint Research, Kolling Institute, Royal North Shore Hospital, University of Sydney, Sydney, New South Wales, Australia
    Ann Rheum Dis 71:26-32. 2012
    ..Obesity is an important risk factor for knee osteoarthritis (OA), Weight loss can reduce the symptoms of knee OA. No prospective studies assessing the impact of weight loss on knee cartilage structure and composition have been performed...
  3. doi request reprint Costs and outcomes of total hip and knee joint replacement for rheumatoid arthritis
    L M March
    Department of Rheumatology, Institute of Bone and Joint Research, University of Sydney, Building 35, Block 4, Level 4, Royal North Shore Hospital, St Leonards, NSW, 2065, Australia
    Clin Rheumatol 27:1235-42. 2008
    ..Patient out-of-pocket costs significantly decreased postoperatively; however, these costs remain substantial compared to osteoarthritis total joint replacement patients...
  4. doi request reprint The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study
    Marita Cross
    University of Sydney, Institute of Bone and Joint Research, Royal North Shore Hospital, St Leonards, New South Wales, Australia
    Ann Rheum Dis 73:1323-30. 2014
    ..To estimate the global burden of hip and knee osteoarthritis (OA) as part of the Global Burden of Disease 2010 study and to explore how the burden of hip and knee OA compares with other conditions...
  5. doi request reprint Serum uric acid plays a protective role for bone loss in peri- and postmenopausal women: a longitudinal study
    Joanna Makovey
    Institute of Bone and Joint Research, Kolling Institute, Royal North Shore Hospital, University of Sydney, Sydney, Australia
    Bone 52:400-6. 2013
    ..Whether this relationship is present in women and how UA relates to changes in BMD longitudinally has not been examined...
  6. doi request reprint Protease-activated receptor 2, rather than protease-activated receptor 1, contributes to the aggressive properties of synovial fibroblasts in rheumatoid arthritis
    Meilang Xue
    Kolling Institute of Medical Research and University of Sydney at Royal North Shore Hospital, St Leonards, New South Wales, Australia
    Arthritis Rheum 64:88-98. 2012
    ..To investigate whether protease-activated receptor 1 (PAR-1) and/or PAR-2 promotes the invasiveness/proliferation of synovial fibroblasts (SFs) and to determine the signaling mechanisms of these pathways...
  7. doi request reprint Endogenous protein C is essential for the functional integrity of human endothelial cells
    Meilang Xue
    Sutton Research Laboratories, Institute of Bone and Joint Research, Kolling Institute of Medical Research, The University of Sydney at Royal North Shore Hospital, Level 10, The Kolling Building, St Leonards, NSW 2065, Australia
    Cell Mol Life Sci 67:1537-46. 2010
    ..These newly described actions of endogenous PC act to stabilize endothelial cells and enhance barrier function, to potentially promote the functional integrity of blood vessels...
  8. ncbi request reprint Activated protein C stimulates expression of angiogenic factors in human skin cells, angiogenesis in the chick embryo and cutaneous wound healing in rodents
    Meilang Xue
    Sutton Arthritis Research Laboratories, Institute of Bone and Joint Research, University of Sydney, NSW, Australia
    Clin Hemorheol Microcirc 34:153-61. 2006
    ..In summary, our results demonstrate that APC promotes cutaneous wound healing at least partly by stimulation of angiogenesis...
  9. ncbi request reprint Differential regulation of matrix metalloproteinase 2 and matrix metalloproteinase 9 by activated protein C: relevance to inflammation in rheumatoid arthritis
    Meilang Xue
    Institute of Bone and Joint Research, University of Sydney at Royal North Shore Hospital, St Leonards, New South Wales, Australia
    Arthritis Rheum 56:2864-74. 2007
    ..To investigate the in vitro effect of activated protein C (APC), a natural anticoagulant and novel antiinflammatory agent, on the regulation of the gelatinases matrix metalloproteinase 2 (MMP-2) and MMP-9...
  10. pmc Protease activated receptor-2 mediates activated protein C-induced cutaneous wound healing via inhibition of p38
    Sohel M Julovi
    Sutton Arthritis Research Laboratories, Institute of Bone and Joint Research, Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, Sydney, Australia
    Am J Pathol 179:2233-42. 2011
    ..In summary, although APC acts through both PAR-1 and PAR-2 to activate Akt and to increase keratinocyte proliferation, APC-induced murine wound healing depends on PAR-2 activity and inhibition of P-p38...
  11. doi request reprint Treatment of chronic leg ulcers with topical activated protein C
    Kaley Whitmont
    Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia
    Arch Dermatol 144:1479-83. 2008
    ..We report 4 cases of nonhealing lower limb skin ulcers that were treated with activated protein C...
  12. doi request reprint Prevalence and Determinants of Fatigue Following Total Knee Replacement: A Longitudinal Cohort Study
    Alison Hodges
    University of Sydney, Lidcombe, New South Wales, Australia
    Arthritis Care Res (Hoboken) 68:1434-42. 2016
    ..To evaluate the prevalence and determinants of clinically important fatigue before and up to 12 months after total knee replacement (TKR) surgery...
  13. pmc Activated protein C inhibits proliferation and tumor necrosis factor α-stimulated activation of p38, c-Jun NH2-terminal kinase (JNK) and Akt in rheumatoid synovial fibroblasts
    Sohel M Julovi
    Sutton Arthritis Research Laboratories, Sydney Medical School, The University of Sydney at Royal North Shore Hospital, St Leonards, Australia
    Mol Med 19:324-31. 2013
    ..These results provide the first evidence that APC selectively inhibits proliferation and the inflammatory signaling pathways of RSFs. Thus, APC may reduce synovial hyperplasia and pannus invasion in rheumatoid arthritis. ..
  14. ncbi request reprint New therapeutic applications for the anticoagulant, activated protein C
    Chris Jackson
    Institute of Bone and Joint Research, Kolling Institute, Sutton Arthritis Research Laboratories, Department of Rheumatology, University of Sydney at Royal North Shore Hospital, 2065 Australia
    Expert Opin Biol Ther 8:1109-22. 2008
    ..Originally thought to be synthesised exclusively by the liver, recent reports have shown that PC is also produced by endothelial cells, smooth muscle cells, keratinocytes and some leukocytes...
  15. pmc Activated protein C mediates a healing phenotype in cultured tenocytes
    Meilang Xue
    Institute of Bone and Joint Research, Kolling Institute of Medical Research, The University of Sydney at Royal North Shore Hospital, St Leonards, NSW, Australia
    J Cell Mol Med 13:749-57. 2009
    ..Furthermore, EPCR is expressed by tenocytes and mediates the actions of APC, at least partly by signalling through selective MAP kinases. These data implicate APC as a potential healing agent for injured tendons...
  16. doi request reprint Self-Reported Knee Instability Before and After Total Knee Replacement Surgery
    Genevieve Fleeton
    University of Sydney, Sydney, New South Wales, Australia
    Arthritis Care Res (Hoboken) 68:463-71. 2016
    ....
  17. doi request reprint Treatment of chronic diabetic lower leg ulcers with activated protein C: a randomised placebo-controlled, double-blind pilot clinical trial
    Kaley Whitmont
    Department of Rheumatology, Sutton Arthritis Research Laboratory, Institute of Bone and Joint, Kolling Institute of Medical Research, University of Sydney at Royal North Shore Hospital, St Leonards, NSW, Australia
    Int Wound J 12:422-7. 2015
    ..This pilot trial suggests that APC is a safe topical agent for healing chronic lower leg ulcers in patients with diabetes and provides supporting evidence for a larger clinical trial. ..
  18. doi request reprint The global burden of rheumatoid arthritis: estimates from the global burden of disease 2010 study
    Marita Cross
    Institute of Bone and Joint Research, University of Sydney, Royal North Shore Hospital, St Leonards, New South Wales, Australia
    Ann Rheum Dis 73:1316-22. 2014
    ..To estimate the global burden of rheumatoid arthritis (RA), as part of the Global Burden of Disease 2010 study of 291 conditions and how the burden of RA compares with other conditions...
  19. doi request reprint The global burden of gout: estimates from the Global Burden of Disease 2010 study
    Emma Smith
    Department of Rheumatology, Royal North Shore Hospital, Northern Clinical School, Institute of Bone and Joint Research, University of Sydney, St Leonards, New South Wales, Australia
    Ann Rheum Dis 73:1470-6. 2014
    ..As part of the GBD 2010 Study, the Musculoskeletal Disorders and Risk Factors Expert Group estimated the global burden of gout...
  20. pmc Obesity & osteoarthritis
    Lauren K King
    Department of Rheumatology, Concord Hospital, Sydney The University of Sydney, Australia
    Indian J Med Res 138:185-93. 2013
    ..Further work is required to determine the relative contributions of mechanical and metabolic factors in the pathogenesis of OA. ..
  21. doi request reprint Cartilage defects are associated with physical disability in obese adults
    Ananthila Anandacoomarasamy
    Department of Rheumatology, Institute of Bone and Joint Research, Kolling Institute, Sydney, NSW 2065, Australia
    Rheumatology (Oxford) 48:1290-3. 2009
    ..To describe the associations between physical disability measures and knee cartilage defects in obese adults...
  22. ncbi request reprint Hypovitaminosis D and parathyroid hormone response in the elderly: effects on bone turnover and mortality
    Jian Sheng Chen
    Institute of Bone and Joint Research, Royal North Shore Hospital, St Leonards, Sydney, New South Wales, Australia
    Clin Endocrinol (Oxf) 68:290-8. 2008
    ..To investigate whether absence of secondary hyperparathyroidism in the presence of hypovitaminosis D has altered bone turnover, fracture risk and mortality...
  23. doi request reprint Endogenous MMP-9 and not MMP-2 promotes rheumatoid synovial fibroblast survival, inflammation and cartilage degradation
    Meilang Xue
    Sutton Research Laboratory, Department of Rheumatology, Kolling Institute of Medical Research, University of Sydney at Royal North Shore Hospital, St Leonards, NSW, Australia and Bio Safety Research Institute, Chonbuk National University, College of Veterinary Medicine, Jeonju, South Korea
    Rheumatology (Oxford) 53:2270-9. 2014
    ..The aim of this study was to investigate the effect of endogenous matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9) on the invasive characteristics of RA synovial fibroblasts...
  24. doi request reprint Burden of disability due to musculoskeletal (MSK) disorders
    Lyn March
    University of Sydney Institute of Bone and Joint Research, and Royal North Shore Hospital, St Leonards, NSW, Australia
    Best Pract Res Clin Rheumatol 28:353-66. 2014
    ..Trends over time and predictions of increasing MSK disability with demographic changes are addressed and the particular challenges facing the developing world are highlighted...
  25. doi request reprint The epidemiology of osteoarthritis in Asia
    Marlene Fransen
    Faculty of Health Sciences, School of Medicine, University of Sydney, Sydney, New South Wales School of Population Health, University of Queensland, Brisbane, Queensland, Australia
    Int J Rheum Dis 14:113-21. 2011
    ..The results of Asian-based studies evaluating risk factors from population-based cohorts or case-control studies, and the current evidence on OA morbidity burden in Asia is also outlined...
  26. doi request reprint Glucosamine and chondroitin for knee osteoarthritis: a double-blind randomised placebo-controlled clinical trial evaluating single and combination regimens
    Marlene Fransen
    Faculty of Health Sciences, University of Sydney, Lidcombe, New South Wales, Australia
    Ann Rheum Dis 74:851-8. 2015
    ..To determine if the dietary supplements, glucosamine and/or chondroitin, result in reduced joint space narrowing (JSN) and pain among people with symptomatic knee osteoarthritis...
  27. doi request reprint The global burden of other musculoskeletal disorders: estimates from the Global Burden of Disease 2010 study
    Emma Smith
    Northern Clinical School, Institute of Bone and Joint Research, University of Sydney, St Leonards, New South Wales, Australia Department of Rheumatology, Royal North Shore Hospital, St Leonards, New South Wales, Australia
    Ann Rheum Dis 73:1462-9. 2014
    ....
  28. doi request reprint High osteoporotic fracture risk and CVD risk co-exist in postmenopausal women
    Joanna Makovey
    Institute of Bone and Joint Research, Kolling Institute, Royal North Shore Hospital, University of Sydney, Sydney, Australia
    Bone 52:120-5. 2013
    ..Osteoporosis related risk factors such as BMD have been associated with cardiovascular endpoints in previous studies but there have been no studies of integrated risk using risk factor algorithms...
  29. ncbi request reprint Obesity and the musculoskeletal system
    Ananthila Anandacoomarasamy
    Institute of Bone and Joint Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
    Curr Opin Rheumatol 21:71-7. 2009
    ..To describe recent developments highlighting the effects and mechanisms of obesity and weight loss on the musculoskeletal system...
  30. ncbi request reprint Longterm effects of intraarticular hyaluronan on synovial fluid in osteoarthritis of the knee
    Hanish Bagga
    University of Sydney Institute of Bone and Joint Research, Royal North Shore Hospital, St Leonards, NSW, Australia
    J Rheumatol 33:946-50. 2006
    ..We examined the effect of IA Hylan GF-20 injections on synovial fluid (SF) hyaluronan (HA) concentration, viscosity, and elasticity over a 6-month period in patients with mild to moderate OA of the knees...
  31. doi request reprint Patient expectations of hip and knee joint replacement surgery and postoperative health status
    Marita Cross
    1 Institute of Bone and Joint Research, University of Sydney, Sydney, New South Wales, Australia 2 Centre of National Research on Disability, University of Queensland, Brisbane, Queensland, Australia 3 Sydney Orthopaedic Research Institute, Chatswood, Sydney, New South Wales, Australia
    Patient 2:51-60. 2009
    ..To explore the relationship between preoperative patient expectations and postoperative health status in patients undergoing joint replacement surgery, with particular emphasis on the types of expectations held by patients...
  32. pmc Maximum recovery after knee replacement--the MARKER study rationale and protocol
    Chung Wei Christine Lin
    The George Institute for International Health, The University of Sydney, Sydney, NSW 2050, Australia
    BMC Musculoskelet Disord 10:69. 2009
    ....
  33. ncbi request reprint Evidence-based medicine is affordable: the cost-effectiveness of current compared with optimal treatment in rheumatoid and osteoarthritis
    Gavin Andrews
    World Health Organization Collaborating Centre for Evidence Health Policy, School of Psychiatry, University of New South Wales at St Vincent s Hospital, Sydney, Australia
    J Rheumatol 33:671-80. 2006
    ....
  34. pmc Web-Based Study of Risk Factors for Pain Exacerbation in Osteoarthritis of the Knee (SPARK-Web): Design and Rationale
    Joanna Makovey
    Northern Clinical School, Kolling Institute, Institute of Bone and Joint Research, Department of Rheumatology, RNSH, University of Sydney, St Leonards, NSW, Australia
    JMIR Res Protoc 4:e80. 2015
    ..Many persons with symptomatic knee OA experience recurrent pain exacerbations. Knowledge and clarification of risk factors for pain exacerbation may allow those affected to minimize reoccurrence of these episodes...
  35. doi request reprint Early rehabilitation after total knee replacement surgery: a multicenter, noninferiority, randomized clinical trial comparing a home exercise program with usual outpatient care
    Annie S Y Han
    University of Sydney, Lidcombe, New South Wales, Australia
    Arthritis Care Res (Hoboken) 67:196-202. 2015
    ..To determine, at 6 weeks postsurgery, if a monitored home exercise program (HEP) is not inferior to usual care rehabilitation for patients undergoing primary unilateral total knee replacement (TKR) surgery for osteoarthritis...
  36. doi request reprint Improving adherence with the use of hip protectors among older people living in nursing care facilities: a cluster randomized trial
    Ian D Cameron
    Rehabilitation Studies Unit, Sydney Medical School, University of Sydney, Ryde NSW, Australia
    J Am Med Dir Assoc 12:50-7. 2011
    ..To test different adherent strategies aimed at improving hip protector use among nursing care facility residents...
  37. ncbi request reprint Consensus on the Need for a Hierarchical List of Patient-reported Pain Outcomes for Metaanalyses of Knee Osteoarthritis Trials: An OMERACT Objective
    Robin Christensen
    From the Musculoskeletal Statistics Unit, The Parker Institute, Department of Rheumatology, Copenhagen University Hospital Bispebjerg and Frederiksberg, Denmark Institute of Population Health, and Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada Institute of Social and Preventive Medicine and Clinical Trials Unit Bern, Department of Clinical Research, University of Bern, Bern, Switzerland Cochrane Collaboration, London Department of Biostatistics, University of Liverpool, Liverpool, UK Departments of Epidemiology and Biostatistics, and Rheumatology, VU University Medical Center, Amsterdam, The Netherlands Quintiles Inc Division of Rheumatology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, and Monash Department of Clinical Epidemiology, Cabrini Health, Melbourne Northern Clinical School, Institute of Bone and Joint Research, University of Sydney, Department of Rheumatology, Sydney, Australia Department of Epidemiology and Biostatistics and the EMGO Institute for Health and Care Research, VU University Medical Center Amsterdam, Amsterdam, The Netherlands Birmingham Veterans Affairs VA Medical Center and University of Alabama at Birmingham, Birmingham, Alabama, US National Institute of Arthritis and Musculoskeletal and Skin Diseases P50 AR060772 and U34 AR062891, Department of Infectious Diseases
    J Rheumatol . 2015
    ..A group of international experts convened to address issues regarding the need to develop hierarchical lists of outcome measurement instruments for a particular outcome for metaanalyses...
  38. pmc Current evidence for osteoarthritis treatments
    Ananthila Anandacoomarasamy
    Institute of Bone and Joint Research, Royal North Shore Hospital, University of Sydney, Australia
    Ther Adv Musculoskelet Dis 2:17-28. 2010
    ..This review provides the current evidence for symptomatic management of OA including nonpharmacological, pharmacological and surgical approaches. The current state of evidence for disease-modifying therapy in OA is also reviewed...
  39. pmc Physical functioning measures and risk of falling in older people living in residential aged care facilities
    Nicholas Wilson
    University of Sydney, Departments of Clinical Pharmacology and Aged Care, Sydney, Australia
    Ther Adv Musculoskelet Dis 3:9-15. 2011
    ..In residents of RACFs, we aimed to produce sex-specific means and empirical norms of objective physical function measures to ascertain whether these measures are predictors of falls...
  40. doi request reprint Developing a minimum standard of care for treating people with osteoarthritis of the hip and knee
    Lyn March
    Institute of Bone and Joint Research, University of Sydney, Department of Rheumatology, Royal North Shore Hospital, St Leonards, NSW 2065, Australia
    Best Pract Res Clin Rheumatol 24:121-45. 2010
    ..An integrated, chronic disease model of care is proposed to best implement OA management and a check list of clinical indicators/performance measures is provided...
  41. ncbi request reprint Association Between Measures of Fatigue and Health-Related Quality of Life in Rheumatoid Arthritis and Osteoarthritis
    Marita Cross
    1 Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, New South Wales, Australia 2 Centre for National Research on Disability, University of Queensland, Brisbane, Queensland, Australia 3 Health Sciences, University of Queensland, Brisbane, Queensland, Australia
    Patient 1:97-104. 2008
    ..To assess the relationship between fatigue and health-related quality of life (HR-QOL) among people with osteoarthritis (OA) and rheumatoid arthritis (RA)...
  42. ncbi request reprint High bone turnover is an independent predictor of mortality in the frail elderly
    Philip N Sambrook
    Institute of Bone and Joint Research, Royal North Shore Hospital, The University of Sydney, Sydney, Australia
    J Bone Miner Res 21:549-55. 2006
    ..In a prospective study of 1112 frail subjects (79% female; mean age, 86 years), high bone turnover was an independent predictor of all-cause mortality. This association seemed to be mainly manifested in deaths from cardiovascular causes...
  43. ncbi request reprint Elevation of activated protein C in synovial joints in rheumatoid arthritis and its correlation with matrix metalloproteinase 2
    Nathalie Buisson-Legendre
    Institute of Bone and Joint Research, University of Sydney, Sydney, New South Wales, Australia
    Arthritis Rheum 50:2151-6. 2004
    ..To investigate the involvement of the anticoagulant serine protease activated protein C (APC) in tissue remodeling in rheumatoid arthritis (RA)...
  44. ncbi request reprint Activated protein C prevents inflammation yet stimulates angiogenesis to promote cutaneous wound healing
    Christopher J Jackson
    The Sutton Arthritis Research Laboratories, Institute of Bone and Joint Research, University of Sydney, Sydney, New South Wales, Australia
    Wound Repair Regen 13:284-94. 2005
    ..These unique properties of APC make it an attractive therapeutic agent to promote the healing of chronic wounds...