Malcolm A Lyons

Summary

Affiliation: University of New South Wales
Country: Australia

Publications

  1. ncbi request reprint Quantitative trait loci that determine lipoprotein cholesterol levels in DBA/2J and CAST/Ei inbred mice
    Malcolm A Lyons
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Lipid Res 44:953-67. 2003
  2. ncbi request reprint New quantitative trait loci that contribute to cholesterol gallstone formation detected in an intercross of CAST/Ei and 129S1/SvImJ inbred mice
    Malcolm A Lyons
    Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Physiol Genomics 14:225-39. 2003
  3. ncbi request reprint Quantitative trait loci that determine lipoprotein cholesterol levels in an intercross of 129S1/SvImJ and CAST/Ei inbred mice
    Malcolm A Lyons
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Physiol Genomics 17:60-8. 2004
  4. ncbi request reprint QTL mapping for genetic determinants of lipoprotein cholesterol levels in combined crosses of inbred mouse strains
    Henning Wittenburg
    The Jackson Laboratory, Bar Harbor, ME, USA
    J Lipid Res 47:1780-90. 2006
  5. ncbi request reprint Susceptibility to cholesterol gallstone formation: evidence that LITH genes also encode immune-related factors
    Malcolm A Lyons
    Centre for Medical Research, University of Western Australia, and Western Australian Institute for Medical Research, Level 6, MRF Building, Rear, 50 Murray St, Perth WA 6000, Australia
    Biochim Biophys Acta 1761:1133-47. 2006
  6. ncbi request reprint Single and interacting QTLs for cholesterol gallstones revealed in an intercross between mouse strains NZB and SM
    Malcolm A Lyons
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Mamm Genome 16:152-63. 2005
  7. ncbi request reprint Association of a lithogenic Abcg5/Abcg8 allele on Chromosome 17 (Lith9) with cholesterol gallstone formation in PERA/EiJ mice
    Henning Wittenburg
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Mamm Genome 16:495-504. 2005
  8. ncbi request reprint Genetic contributors to lipoprotein cholesterol levels in an intercross of 129S1/SvImJ and RIIIS/J inbred mice
    Malcolm A Lyons
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Physiol Genomics 17:114-21. 2004
  9. ncbi request reprint Lith6: a new QTL for cholesterol gallstones from an intercross of CAST/Ei and DBA/2J inbred mouse strains
    Malcolm A Lyons
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Lipid Res 44:1763-71. 2003
  10. ncbi request reprint FXR and ABCG5/ABCG8 as determinants of cholesterol gallstone formation from quantitative trait locus mapping in mice
    Henning Wittenburg
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Gastroenterology 125:868-81. 2003

Detail Information

Publications13

  1. ncbi request reprint Quantitative trait loci that determine lipoprotein cholesterol levels in DBA/2J and CAST/Ei inbred mice
    Malcolm A Lyons
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Lipid Res 44:953-67. 2003
    ....
  2. ncbi request reprint New quantitative trait loci that contribute to cholesterol gallstone formation detected in an intercross of CAST/Ei and 129S1/SvImJ inbred mice
    Malcolm A Lyons
    Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Physiol Genomics 14:225-39. 2003
    ..Our work continues to demonstrate the genetic complexity and to elucidate the pathophysiology of cholesterol gallstone formation. It should facilitate the development of new approaches for treating this common human disorder...
  3. ncbi request reprint Quantitative trait loci that determine lipoprotein cholesterol levels in an intercross of 129S1/SvImJ and CAST/Ei inbred mice
    Malcolm A Lyons
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Physiol Genomics 17:60-8. 2004
    ..Our analysis furthers the knowledge of the genetic control of lipoprotein levels and points to the importance of Hdlq10, which was detected repeatedly in multiple studies...
  4. ncbi request reprint QTL mapping for genetic determinants of lipoprotein cholesterol levels in combined crosses of inbred mouse strains
    Henning Wittenburg
    The Jackson Laboratory, Bar Harbor, ME, USA
    J Lipid Res 47:1780-90. 2006
    ....
  5. ncbi request reprint Susceptibility to cholesterol gallstone formation: evidence that LITH genes also encode immune-related factors
    Malcolm A Lyons
    Centre for Medical Research, University of Western Australia, and Western Australian Institute for Medical Research, Level 6, MRF Building, Rear, 50 Murray St, Perth WA 6000, Australia
    Biochim Biophys Acta 1761:1133-47. 2006
    ..In turn, inflammatory mediators may exert a spectrum of effects in response to genetic variation within lipid homeostatic genes...
  6. ncbi request reprint Single and interacting QTLs for cholesterol gallstones revealed in an intercross between mouse strains NZB and SM
    Malcolm A Lyons
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Mamm Genome 16:152-63. 2005
    ..The QTLs identified herein largely contributed to gallstone formation rather than gallstone severity. Cloning the genes underlying these murine QTLs should facilitate prediction and cloning of the orthologous human genes...
  7. ncbi request reprint Association of a lithogenic Abcg5/Abcg8 allele on Chromosome 17 (Lith9) with cholesterol gallstone formation in PERA/EiJ mice
    Henning Wittenburg
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Mamm Genome 16:495-504. 2005
    ..Significantly higher mRNA expression of Abcg5 and Abcg8 in strain PERA compared with strains I/Ln and DBA/2 further substantiated that the PERA allele of Abcg5/Abcg8 was responsible for lithogenicity underlying Lith9...
  8. ncbi request reprint Genetic contributors to lipoprotein cholesterol levels in an intercross of 129S1/SvImJ and RIIIS/J inbred mice
    Malcolm A Lyons
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Physiol Genomics 17:114-21. 2004
    ..Overall, we detected eight QTLs for lipoprotein cholesterol concentrations on Chrs 1, 9, 12, and 17 (each two per chromosome), including a new QTL for non-HDL cholesterol, Nhdlq3, on Chr 17...
  9. ncbi request reprint Lith6: a new QTL for cholesterol gallstones from an intercross of CAST/Ei and DBA/2J inbred mouse strains
    Malcolm A Lyons
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Lipid Res 44:1763-71. 2003
    ....
  10. ncbi request reprint FXR and ABCG5/ABCG8 as determinants of cholesterol gallstone formation from quantitative trait locus mapping in mice
    Henning Wittenburg
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Gastroenterology 125:868-81. 2003
    ..Cholesterol gallstone formation is a complex genetic trait. To identify additional cholesterol gallstone susceptibility loci, we performed a quantitative trait locus analysis using an intercross of PERA/Ei and I/LnJ inbred strains of mice...
  11. pmc Combining data from multiple inbred line crosses improves the power and resolution of quantitative trait loci mapping
    Renhua Li
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genetics 169:1699-709. 2005
    ..Moreover, combined-cross analysis can establish the allelic states of a QTL among a set of parental lines, thus providing critical information for narrowing QTL regions by haplotype analysis...
  12. ncbi request reprint Cholesterol gallstone susceptibility loci: a mouse map, candidate gene evaluation, and guide to human LITH genes
    Malcolm A Lyons
    Centre for Medical Research, University of Western Australia, Western Australian Institute for Medical Research, Perth, Australia
    Gastroenterology 131:1943-70. 2006
  13. ncbi request reprint Arachidonate 5-lipoxygenase variants in atherosclerosis, obesity, and bone traits
    Malcolm A Lyons
    Circ Res 98:e66. 2006