Lu Liu

Summary

Affiliation: University of New South Wales
Country: Australia

Publications

  1. ncbi request reprint Bufokinin: actions and distribution in the toad cardiovascular system
    L Liu
    School of Physiology and Pharmacology, University of New South Wales, Sydney, Australia
    Clin Exp Pharmacol Physiol 27:911-6. 2000
  2. ncbi request reprint Radioligand binding and functional characterisation of tachykinin receptors in chicken small intestine
    L Liu
    School of Physiology and Pharmacology, University of New South Wales, Sydney, Australia
    Naunyn Schmiedebergs Arch Pharmacol 364:305-13. 2001
  3. ncbi request reprint Purification, characterization, and biological activity of a substance P-related peptide from the gut of the Australian lungfish, Neoceratodus forsteri
    Lu Liu
    School of Physiology and Pharmacology, University of New South Wales, Sydney, New South Wales 2052, Australia
    Gen Comp Endocrinol 125:104-12. 2002
  4. ncbi request reprint Pharmacological and biochemical investigation of receptors for the toad gut tachykinin peptide, bufokinin, in its species of origin
    L Liu
    School of Physiology and Pharmacology, University of New South Wales, Sydney, Australia
    Naunyn Schmiedebergs Arch Pharmacol 360:187-95. 1999
  5. ncbi request reprint Roles of substance P receptors in human colon circular muscle: alterations in diverticular disease
    Lu Liu
    Department of Physiology and Pharmacology, University of New South Wales, Sydney, NSW 2052, Australia
    J Pharmacol Exp Ther 302:627-35. 2002
  6. ncbi request reprint Molecular identification and characterization of three isoforms of tachykinin NK(1)-like receptors in the cane toad Bufo marinus
    Lu Liu
    School of Medical Sciences, Univ of New South Wales, Sydney 2052, Australia
    Am J Physiol Regul Integr Comp Physiol 287:R575-85. 2004
  7. doi request reprint Distinct differences in tachykinin gene expression in ulcerative colitis, Crohn's disease and diverticular disease: a role for hemokinin-1?
    L Liu
    Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, Australia
    Neurogastroenterol Motil 23:475-83, e179-80. 2011
  8. ncbi request reprint Tachykinin peptides and receptors: putting amphibians into perspective
    Lu Liu
    Department of Physiology and Pharmacology, School of Medical Sciences, University of New South Wales, Sydney 2052, Australia
    Peptides 26:1369-82. 2005
  9. doi request reprint Cyclooxygenase-dependent alterations in substance P-mediated contractility and tachykinin NK1 receptor expression in the colonic circular muscle of patients with slow transit constipation
    Lu Liu
    Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney 2052, Australia
    J Pharmacol Exp Ther 329:282-9. 2009
  10. ncbi request reprint Tachykinin NK2 receptor and functional mechanisms in human colon: changes with indomethacin and in diverticular disease and ulcerative colitis
    Elizabeth Burcher
    Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney 2052, NSW, Australia
    J Pharmacol Exp Ther 324:170-8. 2008

Collaborators

  • Kylie J Mansfield
  • Michael Murray
  • Kate H Moore
  • J Michael Conlon
  • Fiona J Warner
  • Matthew J Morgan
  • ELIZABETH BUCHER
  • B A Neilan
  • Agot Johansson
  • Prajni Sadananda
  • Victor Hruby
  • Elizabeth Burcher
  • Liying Dai
  • Denis W King
  • D Shevy Perera
  • David Z Lubowski
  • Yael Azriel
  • Teri M Furlong
  • Li Chun Xu
  • Paolo Grieco
  • Xi Wei
  • Wendy Chen Nee Chua
  • Martin Gerard McCabe
  • Yuko Tsutsui
  • Zachary Newby
  • Pär Olsson
  • Bridget R Southwell
  • Daniel M L Vianna
  • Pascal Carrive
  • Ettore Novellino
  • Dev Trivedi
  • Ji Hong Shao
  • Fei Shang
  • Ning Cong
  • Pietro Campiglia
  • Xiang Mei Ren
  • Kevin Chandler
  • Mei rong Zhang
  • Minying Cai
  • Qin Du
  • Alexander Mayorov
  • Ai Qin Xu
  • Guangxin Lin
  • Kenneth J Vaux
  • Yin Xiao
  • Liping Wu
  • Richard J Millard
  • Junqi Ling
  • Tom T Lee
  • L Magnus Bäcklund
  • Patrick L Wintrode
  • Danita M Pearson
  • Daniel V Santi
  • Richard J Morse
  • Koichi Ichimura
  • Anne Gershenson
  • Karen Plant
  • Janet S Finer-Moore
  • Prasanna Venkatraman
  • Yaoquan Liu
  • Vincent Peter Collins
  • Robert M Stroud
  • Jorgen Carlsson
  • Lars Gedda
  • Asa Liljegren
  • V Peter Collins

Detail Information

Publications29

  1. ncbi request reprint Bufokinin: actions and distribution in the toad cardiovascular system
    L Liu
    School of Physiology and Pharmacology, University of New South Wales, Sydney, Australia
    Clin Exp Pharmacol Physiol 27:911-6. 2000
    ..The lack of any reflex tachycardia in response to the falls in blood pressure was of note...
  2. ncbi request reprint Radioligand binding and functional characterisation of tachykinin receptors in chicken small intestine
    L Liu
    School of Physiology and Pharmacology, University of New South Wales, Sydney, Australia
    Naunyn Schmiedebergs Arch Pharmacol 364:305-13. 2001
    ..The study provides evidence for a tachykinin receptor with similarities to the NK1 receptor in the chicken small intestine. In addition, senktide may act on a receptor similar to the mammalian NK3 receptor...
  3. ncbi request reprint Purification, characterization, and biological activity of a substance P-related peptide from the gut of the Australian lungfish, Neoceratodus forsteri
    Lu Liu
    School of Physiology and Pharmacology, University of New South Wales, Sydney, New South Wales 2052, Australia
    Gen Comp Endocrinol 125:104-12. 2002
    ..The sequence of lungfish SP is identical to that of bufokinin, a SP-related peptide previously isolated from the intestine of the cane toad, Bufo marinus, supporting the hypothesis that lungfishes and amphibians share a common ancestor...
  4. ncbi request reprint Pharmacological and biochemical investigation of receptors for the toad gut tachykinin peptide, bufokinin, in its species of origin
    L Liu
    School of Physiology and Pharmacology, University of New South Wales, Sydney, Australia
    Naunyn Schmiedebergs Arch Pharmacol 360:187-95. 1999
    ..The study also provides evidence that bufokinin and its receptor play an important physiological role in regulating intestinal motility...
  5. ncbi request reprint Roles of substance P receptors in human colon circular muscle: alterations in diverticular disease
    Lu Liu
    Department of Physiology and Pharmacology, University of New South Wales, Sydney, NSW 2052, Australia
    J Pharmacol Exp Ther 302:627-35. 2002
    ..The attenuated contractility in specimens with diverticular disease may reflect disease-related alterations of the tachykinin receptor system...
  6. ncbi request reprint Molecular identification and characterization of three isoforms of tachykinin NK(1)-like receptors in the cane toad Bufo marinus
    Lu Liu
    School of Medical Sciences, Univ of New South Wales, Sydney 2052, Australia
    Am J Physiol Regul Integr Comp Physiol 287:R575-85. 2004
    ....
  7. doi request reprint Distinct differences in tachykinin gene expression in ulcerative colitis, Crohn's disease and diverticular disease: a role for hemokinin-1?
    L Liu
    Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, Australia
    Neurogastroenterol Motil 23:475-83, e179-80. 2011
    ..We aimed to examine the expression of genes encoding tachykinin peptides and receptors in colon from patients with ulcerative colitis (UC), Crohn's disease (CD), and acute diverticular disease (DD)...
  8. ncbi request reprint Tachykinin peptides and receptors: putting amphibians into perspective
    Lu Liu
    Department of Physiology and Pharmacology, School of Medical Sciences, University of New South Wales, Sydney 2052, Australia
    Peptides 26:1369-82. 2005
    ..We conclude that tachykinin peptides and receptors are well conserved in terms of their structures, physiological functions and coupling mechanisms during tetrapod evolution...
  9. doi request reprint Cyclooxygenase-dependent alterations in substance P-mediated contractility and tachykinin NK1 receptor expression in the colonic circular muscle of patients with slow transit constipation
    Lu Liu
    Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney 2052, Australia
    J Pharmacol Exp Ther 329:282-9. 2009
    ..Our results also indicate some malfunction of the enteric nervous system in STC...
  10. ncbi request reprint Tachykinin NK2 receptor and functional mechanisms in human colon: changes with indomethacin and in diverticular disease and ulcerative colitis
    Elizabeth Burcher
    Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney 2052, NSW, Australia
    J Pharmacol Exp Ther 324:170-8. 2008
    ..60 fmol/mg, n = 25, p = 0.01). In contrast, no gender-related differences were seen in NK(2) receptor mRNA in control colonic muscle, indicating that the gender difference is a post-translational event...
  11. ncbi request reprint Age-related changes of P2X(1) receptor mRNA in the bladder detrusor from men with and without bladder outlet obstruction
    Wendy Chen Nee Chua
    Department of Physiology and Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia
    Exp Gerontol 42:686-92. 2007
    ..0054; Spearman coefficient r=-0.520) but not obstructed detrusor (n=19; p=0.093; r=-0.396). Downregulation of P2X(1) mRNA expression might occur as a result of an increased component of neural ATP release in the aging bladder...
  12. ncbi request reprint Structure-activity studies of bufokinin, substance P and their C-terminal fragments at bufokinin receptors in the small intestine of the cane toad, Bufo marinus
    Lu Liu
    School of Physiology and Pharmacology, University of New South Wales, 2052, NSW, Sydney, Australia
    Biochem Pharmacol 63:217-24. 2002
    ....
  13. ncbi request reprint Quantitative structure-activity analyses of bufokinin and other tachykinins at bufokinin (bNK1) receptors of the small intestine of the cane toad, Bufo marinus
    Lu Liu
    Department of Physiology and Pharmacology, University of New South Wales, Sydney, NSW 2052, Australia
    Biochem Pharmacol 69:329-38. 2005
    ....
  14. ncbi request reprint Molecular characterization of M2 and M3 muscarinic receptor expression in bladder from women with refractory idiopathic detrusor overactivity
    Kylie J Mansfield
    Department of Physiology and Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, Australia
    BJU Int 99:1433-8. 2007
    ....
  15. doi request reprint Acid and stretch, but not capsaicin, are effective stimuli for ATP release in the porcine bladder mucosa: Are ASIC and TRPV1 receptors involved?
    Prajni Sadananda
    Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia
    Eur J Pharmacol 683:252-9. 2012
    ..The pig bladder is a well-known model for the human bladder, however these data suggest that it should be used with caution, particularly for TRPV1 related studies...
  16. doi request reprint Inverse expression of prostaglandin E2-related enzymes highlights differences between diverticulitis and inflammatory bowel disease
    Liying Dai
    Department of Pharmacology, School of Medical Sciences, UNSW Australia, Sydney, NSW, 2052, Australia
    Dig Dis Sci 60:1236-46. 2015
    ..Information about the involvement of 15-PGDH in colonic inflammation is sparse...
  17. doi request reprint Hemokinin-1 stimulates prostaglandin E₂ production in human colon through activation of cyclooxygenase-2 and inhibition of 15-hydroxyprostaglandin dehydrogenase
    Liying Dai
    Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, Australia
    J Pharmacol Exp Ther 340:27-36. 2012
    ....
  18. ncbi request reprint The molecular basis of urgency: regional difference of vanilloid receptor expression in the human urinary bladder
    Lu Liu
    Department of Physiology and Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, Australia
    Neurourol Urodyn 26:433-8; discussion 439; discussion 451-3. 2007
    ....
  19. pmc Muscarinic receptor subtypes in human bladder detrusor and mucosa, studied by radioligand binding and quantitative competitive RT-PCR: changes in ageing
    Kylie J Mansfield
    Department of Physiology and Pharmacology, University of New South Wales, Sydney, NSW 2052, Australia
    Br J Pharmacol 144:1089-99. 2005
    ..0001) and female (P=0.019) detrusor. These findings correspond with reports of decreased detrusor contractility with ageing...
  20. doi request reprint Complex actions of neurotensin in ascending and sigmoid colonic muscle: Involvement of enteric mediators
    Yael Azriel
    Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, Australia
    Eur J Pharmacol 644:195-202. 2010
    ..The enteric mediators influenced by neurotensin are regionally specific. In taenia coli strips from both ascending and sigmoid colon, neurotensin contractions were unchanged in the presence of inhibitors, suggesting direct actions only...
  21. doi request reprint Hypocretin/orexin contributes to the expression of some but not all forms of stress and arousal
    Teri M Furlong
    School of Medical Sciences, University of New South Wales, NSW 2052, Australia
    Eur J Neurosci 30:1603-14. 2009
    ..When it does, hypocretin will at least contribute to the cardiovascular response. The findings are of clinical relevance to some forms of psychological stress...
  22. ncbi request reprint Characterization of receptors for two Xenopus gastrointestinal tachykinin peptides in their species of origin
    Agot Johansson
    Department of Zoophysiology, University of Goteborg, Box 463, SE 405 30, Sweden
    Naunyn Schmiedebergs Arch Pharmacol 370:35-45. 2004
    ..Antagonists appear to interact differently with amphibian receptors, compared with mammalian receptors...
  23. pmc High-resolution array-based comparative genomic hybridization of medulloblastomas and supratentorial primitive neuroectodermal tumors
    Martin Gerard McCabe
    Department of Pathology, University of Cambridge, Division of Molecular Histopathology, UK
    J Neuropathol Exp Neurol 65:549-61. 2006
    ....
  24. ncbi request reprint Expression of mineralization markers in dental pulp cells
    Xi Wei
    Guanghua College of Stomatology, Sun Yat Sen University, Guangzhou, China
    J Endod 33:703-8. 2007
    ..In conclusion, we isolated DPCs with stem cell characteristics. MEPE and DSPP showed a similar regulatory pattern of DPCs mineralization. MEPE along with DSPP may be potential odontogenetic differentiation markers...
  25. pmc The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261
    Zachary Newby
    University of California at San Francisco, San Francisco, California 94143 0448, USA
    Biochemistry 45:7415-28. 2006
    ..Changes to atomic vibrations in crystals of a ternary complex of Escherichia coli Tyr261Trp are associated with a greater than 2000-fold drop in kcat/Km. These results underline the important contribution of dynamics to catalysis in TS...
  26. ncbi request reprint Evaluation of androgen receptor transcriptional activities of some pesticides in vitro
    Li Chun Xu
    The Department of Public Health, Xuzhou Medical College, 84 West Huai hai Road, Xuzhou, Jiangsu 221002, China
    Toxicology 243:59-65. 2008
    ..It is suggested that parathion possesses the highest activity, and permethrin and cypermethrin acted as poor antiandrogens. The present study provides insight into the mechanism of the pesticides...
  27. pmc Design and microwave-assisted synthesis of novel macrocyclic peptides active at melanocortin receptors: discovery of potent and selective hMC5R receptor antagonists
    Paolo Grieco
    Department of Chemistry, University of Arizona, Tucson, Arizona 85721, USA
    J Med Chem 51:2701-7. 2008
    ..Compound 9 will be used to further investigate and more clearly understand the physiological roles played by the MC5 receptor in humans and other animals...
  28. ncbi request reprint The conformational dynamics of a metastable serpin studied by hydrogen exchange and mass spectrometry
    Yuko Tsutsui
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Biochemistry 45:6561-9. 2006
    ..A surprising degree of flexibility is seen in beta-strand 6A, and it is speculated that this flexibility may deter the formation of edge-edge polymers...
  29. ncbi request reprint Internalisation and retention of EGF-dextran associated radioactivity in transfected Chinese hamster ovary cells expressing the human EGF-receptor
    Pär Olsson
    Division of Biomedical Radiation Sciences, Department of Oncology, Radiology and Clinical Immunology, Rudbeck Laboratory, Uppsala University, SE 751 85 Uppsala, Sweden
    Int J Oncol 20:1057-63. 2002
    ..No major differences between the two EGFR expressing cell lines were found and, based on the results in this work, CHO-EGFR cells seem an adequate model for experiments with agents targeting the EGF-receptor...