R J Lewis
Affiliation: University of Queensland
- HPLC/tandem electrospray mass spectrometry for the determination of Sub-ppb levels of Pacific and Caribbean ciguatoxins in crude extracts of fishR J Lewis
Queensland Agricultural Biotechnology Centre QDPI, University of Queensland, Australia
Anal Chem 71:247-50. 1999..25 ppb C-CTX-1 to be established. HPLC/MS/MS provides a sensitive analytical approach, not previously available, for the determination of Pacific and Caribbean ciguatoxins at sub-ppb levels in fish flesh...
- The changing face of ciguateraR J Lewis
Queensland Agricultural Biotechnology Centre DPI, Gehrmann Laboratories, The University of Queensland, QLD 4072, Australia
Toxicon 39:97-106. 2001..Similarities and differences in ciguatera in the Pacific Ocean, Indian Ocean and Caribbean Sea are highlighted, and future research directions are suggested...
- Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypesR J Lewis
Centre for Drug Design and Development 3D Centre, Institute for Molecular Bioscience, Department of Physiology and Pharmacology, CSIRO Tropical Agriculture, and Queensland Agricultural Biotechnology Centre QDPI, Australia
J Biol Chem 275:35335-44. 2000..1)H NMR studies reveal that CVID possesses a combination of unique structural features, including two hydrogen bonds that stabilize loop 2 and place loop 2 proximal to loop 4, creating a globular surface that is rigid and well defined...
- Solution structure and proposed binding mechanism of a novel potassium channel toxin kappa-conotoxin PVIIAM J Scanlon
Centre for Drug Design and Development, University of Queensland, St Lucia, Australia
Structure 5:1585-97. 1997..This study of the solution structure and mode of channel binding of PVIIA forms the basis for mapping the interacting residues at the conotoxin-ion channel interface...
- Two new classes of conopeptides inhibit the alpha1-adrenoceptor and noradrenaline transporterI A Sharpe
Institute for Molecular Bioscience, University of Queensland, Brisbane 4072, Australia
Nat Neurosci 4:902-7. 2001..marmoreus). rho-TIA and chi-MrIA selectively modulate these important membrane-bound proteins. Both peptides act as reversible non-competitive inhibitors and provide alternative avenues for the identification of inhibitor drugs...
- muO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficitsJ Ekberg
Institute for Molecular Bioscience and School of Biomedical Sciences, University of Queensland, QLD 4072, Australia
Proc Natl Acad Sci U S A 103:17030-5. 2006..The actions of MrVIB reveal that VGSC antagonists displaying selectivity toward Na(v)1.8 can alleviate chronic pain behavior with a greater therapeutic index than nonselective antagonists...
- Electrical activity in rat tail artery during asynchronous activation of postganglionic nerve terminals by ciguatoxin-1J A Brock
Department of Physiology and Pharmacology, University of Queensland, Australia
Br J Pharmacol 116:2213-20. 1995..In 100-400 pM CTX-1, the smooth muscle was depolarized to levels resembling those recorded in this artery during ongoing vasoconstrictor discharge in vivo...
- NMDA receptor subunit-dependent modulation by conantokin-G and Ala7-conantokin-GL Ragnarsson
School of Molecular and Microbial Sciences, University of Queensland, Brisbane, Queensland, Australia
J Neurochem 96:283-91. 2006..We conclude that the combinations of subunits that comprise the NMDA receptor complex influence conantokin and glutamate affinities and the nature of the responses to conantokins...
- N-type calcium channel blockers: novel therapeutics for the treatment of painC I Schroeder
Institute for Molecular Bioscience, University of Queensland, St Lucia, QLD 4072, Australia
Med Chem 2:535-43. 2006..2 calcium channel therapeutics, and finally the development of small molecules for the treatment of chronic pain...
- The role of defensive ecological interactions in the evolution of conotoxinsJ R Prashanth
Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia
Mol Ecol 25:598-615. 2016..Thus, our results demonstrate an important role for defence in the evolution of conotoxins. ..
- Re-engineering the μ-conotoxin SIIIA scaffoldK B Akondi
Institute for Molecular Bioscience IMB, The University of Queensland, Brisbane, 4072, Queensland, Australia
Biopolymers 101:347-54. 2014..This minimal functional conotoxin scaffold may allow further development of selective NaV blockers...
- The effects of alanine-substituted conantokin-G and ifenprodil on the human spermine-activated N-methyl-D-aspartate receptorV W W Tsai
School of Molecular and Microbial Sciences, University of Queensland, Brisbane 4072, Australia
Neuroscience 130:457-64. 2005..Both agents were non-competitive in the inhibitory phase. Overall, the data suggest that Con-G(A7) and ifenprodil interact differently with the polyamine modulation of the glutamate-N-methyl-D-aspartate receptor...