Aven Lee

Summary

Affiliation: University of Queensland
Country: Australia

Publications

  1. doi request reprint Astrocytes: Glutamate transport and alternate splicing of transporters
    Aven Lee
    The University of Queensland, Centre for Clinical Research, Queensland, Australia
    Int J Biochem Cell Biol 42:1901-6. 2010
  2. doi request reprint A novel splice variant of the Excitatory Amino Acid Transporter 5: Cloning, immunolocalization and functional characterization of hEAAT5v in human retina
    A Lee
    UQ Centre for Clinical Research, The University of Queensland, Brisbane, QLD 4029, Australia Electronic address
    Neurochem Int . 2016
  3. pmc Excitatory amino acid transporter 5 is widely expressed in peripheral tissues
    A Lee
    UQ Centre for Clinical Research, The University of Queensland, Brisbane, QLD, Australia, Queensland, Australia
    Eur J Histochem 57:e11. 2013
  4. doi request reprint Alternate splicing and expression of the glutamate transporter EAAT5 in the rat retina
    Aven Lee
    The University of Queensland, UQ Centre for Clinical Research, Queensland 4029, Australia
    Gene 506:283-8. 2012
  5. doi request reprint Exon 4-skipping GLT-1: a new form of an abundantly expressed glutamate transporter
    Aven Lee
    The University of Queensland, Centre for Clinical Research, Queensland, Australia
    Neurosci Lett 504:228-31. 2011
  6. pmc Localisation of novel forms of glutamate transporters and the cystine-glutamate antiporter in the choroid plexus: Implications for CSF glutamate homeostasis
    Aven Lee
    The University of Queensland Centre for Clinical Research, QLD 4029, Australia
    J Chem Neuroanat 43:64-75. 2012
  7. doi request reprint A new splice variant of the glutamate-aspartate transporter: cloning and immunolocalization of GLAST1c in rat, pig and human brains
    Aven Lee
    The University of Queensland, Centre for Clinical Research, Queensland, Australia
    J Chem Neuroanat 43:52-63. 2012
  8. pmc Na+-H+ exchanger regulatory factor 1 is a PDZ scaffold for the astroglial glutamate transporter GLAST
    Aven Lee
    School of Biomedical Sciences, University of Queensland, Brisbane, Queensland 4072, Australia
    Glia 55:119-29. 2007
  9. ncbi request reprint Regulation of albumin endocytosis by PSD95/Dlg/ZO-1 (PDZ) scaffolds. Interaction of Na+-H+ exchange regulatory factor-2 with ClC-5
    Deanne H Hryciw
    School of Biomedical Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia
    J Biol Chem 281:16068-77. 2006
  10. pmc Expression of multiple glutamate transporter splice variants in the rodent testis
    Aven Lee
    Centre for Clinical Research, Royal Brisbane and Women s Hospital, The University of Queensland, Brisbane, QLD 4029, Australia
    Asian J Androl 13:254-65. 2011

Collaborators

Detail Information

Publications19

  1. doi request reprint Astrocytes: Glutamate transport and alternate splicing of transporters
    Aven Lee
    The University of Queensland, Centre for Clinical Research, Queensland, Australia
    Int J Biochem Cell Biol 42:1901-6. 2010
    ..Such coordinate mechanisms may potentially contribute to changes in astrocyte function, especially in pathological contexts...
  2. doi request reprint A novel splice variant of the Excitatory Amino Acid Transporter 5: Cloning, immunolocalization and functional characterization of hEAAT5v in human retina
    A Lee
    UQ Centre for Clinical Research, The University of Queensland, Brisbane, QLD 4029, Australia Electronic address
    Neurochem Int . 2016
    ..The loss of hEAAT5v could, therefore, represent an early pathological change in the development of AMD and might be involved in its aetiology...
  3. pmc Excitatory amino acid transporter 5 is widely expressed in peripheral tissues
    A Lee
    UQ Centre for Clinical Research, The University of Queensland, Brisbane, QLD, Australia, Queensland, Australia
    Eur J Histochem 57:e11. 2013
    ..We conclude that EAAT5 is a widely distributed protein. Whether it functions in all locations as a glutamate transporter, or mainly as a glutamate-gated chloride conductance, remains to be determined...
  4. doi request reprint Alternate splicing and expression of the glutamate transporter EAAT5 in the rat retina
    Aven Lee
    The University of Queensland, UQ Centre for Clinical Research, Queensland 4029, Australia
    Gene 506:283-8. 2012
    ....
  5. doi request reprint Exon 4-skipping GLT-1: a new form of an abundantly expressed glutamate transporter
    Aven Lee
    The University of Queensland, Centre for Clinical Research, Queensland, Australia
    Neurosci Lett 504:228-31. 2011
    ..We conclude that exon-4 skipping GLT 1 is abundantly expressed in the brain and may represent either a functional glutamate transporter or a modulator of glutamate transporter function...
  6. pmc Localisation of novel forms of glutamate transporters and the cystine-glutamate antiporter in the choroid plexus: Implications for CSF glutamate homeostasis
    Aven Lee
    The University of Queensland Centre for Clinical Research, QLD 4029, Australia
    J Chem Neuroanat 43:64-75. 2012
    ....
  7. doi request reprint A new splice variant of the glutamate-aspartate transporter: cloning and immunolocalization of GLAST1c in rat, pig and human brains
    Aven Lee
    The University of Queensland, Centre for Clinical Research, Queensland, Australia
    J Chem Neuroanat 43:52-63. 2012
    ....
  8. pmc Na+-H+ exchanger regulatory factor 1 is a PDZ scaffold for the astroglial glutamate transporter GLAST
    Aven Lee
    School of Biomedical Sciences, University of Queensland, Brisbane, Queensland 4072, Australia
    Glia 55:119-29. 2007
    ..In vitro binding assays showed that GLAST bound directly to the PDZ1 domain of NHERF1 via the C-terminal ETKM motif of GLAST. These findings implicate the GLAST-NHERF1 complex in the regulation of glutamate homeostasis in astrocytes...
  9. ncbi request reprint Regulation of albumin endocytosis by PSD95/Dlg/ZO-1 (PDZ) scaffolds. Interaction of Na+-H+ exchange regulatory factor-2 with ClC-5
    Deanne H Hryciw
    School of Biomedical Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia
    J Biol Chem 281:16068-77. 2006
    ..Thus NHERF1 and NHERF2 differentially regulate albumin uptake by mechanisms that ultimately alter the cell-surface levels of ClC-5...
  10. pmc Expression of multiple glutamate transporter splice variants in the rodent testis
    Aven Lee
    Centre for Clinical Research, Royal Brisbane and Women s Hospital, The University of Queensland, Brisbane, QLD 4029, Australia
    Asian J Androl 13:254-65. 2011
    ..The apparent presence of many of these transporters in the testis and sperm may indicate a need for glutamate transport by such cells...
  11. doi request reprint Chloride channel ClC-5 binds to aspartyl aminopeptidase to regulate renal albumin endocytosis
    Aven Lee
    UQ Centre for Clinical Research, The University of Queensland, Herston, Brisbane, Queensland, Australia
    Am J Physiol Renal Physiol 308:F784-92. 2015
    ..Therefore, we have identified another key molecular component of the albumin endocytic machinery in the renal proximal tubule and describe a new role for DNPEP in stabilizing the actin cytoskeleton. ..
  12. doi request reprint Rapid loss of glutamine synthetase from astrocytes in response to hypoxia: implications for excitotoxicity
    Aven Lee
    The University of Queensland, Centre for Clinical Research, Royal Brisbaneand Womens Hospital, Building 71 Herston, Brisbane, Queensland 4029, Australia
    J Chem Neuroanat 39:211-20. 2010
    ..Loss of GS from astrocytes would plausibly lead to a rise in intracellular glutamate, and could explain why reversal of astrocytic glutamate transport during hypoxia/ischaemia is conceptually possible...
  13. doi request reprint In vivo visualization of albumin degradation in the proximal tubule
    Craig Slattery
    School of Biomedical Sciences, The University of Queensland, St Lucia, Queensland, Australia
    Kidney Int 74:1480-6. 2008
    ..Our study shows that DQ-albumin, together with conventional fluorescent conjugates of intact albumin, can be used to visualize albumin degradation by proximal tubules in vivo...
  14. ncbi request reprint NaSi-1 and Sat-1: structure, function and transcriptional regulation of two genes encoding renal proximal tubular sulfate transporters
    Aven Lee
    School of Biomedical Sciences, University of Queensland, Brisbane, QLD 4072, Australia
    Int J Biochem Cell Biol 37:1350-6. 2005
    ..This review presents the current understanding of the transcriptional regulation of NaSi-1 and Sat-1, and describes possible pathogenetic implications which arise as a consequence of altered SO(4)2- homeostasis...
  15. ncbi request reprint Characterization of the human sulfate anion transporter (hsat-1) protein and gene (SAT1; SLC26A1)
    Ralf R Regeer
    School of Biomedical Sciences, Department of Physiology and Pharmacology, University of Queensland, Brisbane, Queensland 4072, Australia
    DNA Cell Biol 22:107-17. 2003
    ..This study represents the first functional characterization of the human SAT1 gene and protein encoded by the anion transporter hsat-1...
  16. ncbi request reprint Selective modulation of neuronal nicotinic acetylcholine receptor channel subunits by Go-protein subunits
    Harald Fischer
    School of Biomedical Sciences, University of Queensland, Brisbane, Queensland 4072, Australia
    J Neurosci 25:3571-7. 2005
    ....
  17. ncbi request reprint Characterization of the human renal Na(+)-sulphate cotransporter gene ( NAS1) promoter
    Aven Lee
    Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, QLD 4072, Brisbane, Australia
    Pflugers Arch 448:490-9. 2004
    ....
  18. ncbi request reprint Nedd4-2 functionally interacts with ClC-5: involvement in constitutive albumin endocytosis in proximal tubule cells
    Deanne H Hryciw
    School of Biomedical Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia
    J Biol Chem 279:54996-5007. 2004
    ..These data demonstrate that normal constitutive uptake of albumin by the proximal tubule requires Nedd4-2, which may act via ubiquitination to shunt ClC-5 into the endocytic pathway...
  19. ncbi request reprint The mouse sulfate anion transporter gene Sat1 (Slc26a1): cloning, tissue distribution, gene structure, functional characterization, and transcriptional regulation thyroid hormone
    Aven Lee
    Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane, Queensland, Australia
    DNA Cell Biol 22:19-31. 2003
    ..This study represents the first characterization of the structure and regulation of the Sat1 gene encoding a SO(4)(2-)/chloride/oxalate anion transporter...