Anthony Kicic

Summary

Affiliation: University of Western Australia
Country: Australia

Publications

  1. pmc Successful establishment of primary small airway cell cultures in human lung transplantation
    Balarka Banerjee
    Queensland Centre for Pulmonary Transplantation and Vascular Disease, The Prince Charles Hospital, Brisbane, 4032, Queensland, Australia
    Respir Res 10:99. 2009
  2. pmc Decreased fibronectin production significantly contributes to dysregulated repair of asthmatic epithelium
    Anthony Kicic
    Department of Respiratory Medicine, Princess Margaret Hospital for Children, Perth, 6001, Western Australia, Australia
    Am J Respir Crit Care Med 181:889-98. 2010
  3. ncbi request reprint Intrinsic biochemical and functional differences in bronchial epithelial cells of children with asthma
    Anthony Kicic
    Department of Respiratory Medicine, Princess Margaret Hospital for Children, Perth, 6001, Western Australia, Australia
    Am J Respir Crit Care Med 174:1110-8. 2006
  4. ncbi request reprint Are stem cell characteristics altered by disease state?
    Anthony Kicic
    Stem Cell Unit, Department of Molecular Ophthalmology, Lions Eye Institute and the University of Western Australia, Nedlands, 6009, Western Australia, Australia
    Stem Cells Dev 14:15-28. 2005
  5. ncbi request reprint Marrow stromal cells (MSC): a species comparison
    Anthony Kicic
    Stem Cell Unit, Department of Molecular Ophthalmology, Lions Eye Institute, Centre of Ophthalmology and Visual Science, University of Western Australia, Nedlands, 6009, Western Australia, Australia
    Adv Exp Med Biol 533:407-14. 2003
  6. doi request reprint Bronchial brushings for investigating airway inflammation and remodelling
    Kevin Looi
    School of Paediatrics and Child Health, Centre for Health Research, The University of Western Australia, Nedlands, Australia
    Respirology 16:725-37. 2011
  7. doi request reprint Reduced transforming growth factor β1 (TGF-β1) in the repair of airway epithelial cells of children with asthma
    Kak Ming Ling
    Telethon Kids Institute, Centre for Child Health Research, The University of Western Australia, Nedlands, Western Australia, Australia
    Respirology 21:1219-26. 2016
  8. pmc Regional differences in susceptibiity of bronchial epithelium to mesenchymal transition and inhibition by the macrolide antibiotic azithromycin
    Balarka Banerjee
    School of Paediatrics and Child Health, The University of Western Australia, Nedlands, Western Australia, Australia
    PLoS ONE 7:e52309. 2012
  9. doi request reprint Inflammatory responses to individual microorganisms in the lungs of children with cystic fibrosis
    Catherine Gangell
    Telethon Institute for Child Health Research and the Centre for Child Health Research, University of Western Australia, Perth, Australia
    Clin Infect Dis 53:425-32. 2011
  10. doi request reprint Bronchiectasis in infants and preschool children diagnosed with cystic fibrosis after newborn screening
    Stephen M Stick
    Department of Respiratory Medicine, Princess Margaret Hospital for Children, School of Paediatrics and Child Health, University of Western Australia, Melbourne, Australia
    J Pediatr 155:623-8.e1. 2009

Collaborators

Detail Information

Publications36

  1. pmc Successful establishment of primary small airway cell cultures in human lung transplantation
    Balarka Banerjee
    Queensland Centre for Pulmonary Transplantation and Vascular Disease, The Prince Charles Hospital, Brisbane, 4032, Queensland, Australia
    Respir Res 10:99. 2009
    ..Our aims were to develop robust methods for sampling small airway epithelial cells (SAEC) and to establish submerged SAEC cultures for downstream experimentation...
  2. pmc Decreased fibronectin production significantly contributes to dysregulated repair of asthmatic epithelium
    Anthony Kicic
    Department of Respiratory Medicine, Princess Margaret Hospital for Children, Perth, 6001, Western Australia, Australia
    Am J Respir Crit Care Med 181:889-98. 2010
    ..Damage to airway epithelium is followed by deposition of extracellular matrix (ECM) and migration of adjacent epithelial cells. We have shown that epithelial cells from children with asthma fail to heal a wound in vitro...
  3. ncbi request reprint Intrinsic biochemical and functional differences in bronchial epithelial cells of children with asthma
    Anthony Kicic
    Department of Respiratory Medicine, Princess Margaret Hospital for Children, Perth, 6001, Western Australia, Australia
    Am J Respir Crit Care Med 174:1110-8. 2006
    ..Convincing evidence of epithelial damage and aberrant repair exists in adult asthmatic airways, even in the absence of inflammation. However, comparable studies in children have been limited by access and availability of clinical samples...
  4. ncbi request reprint Are stem cell characteristics altered by disease state?
    Anthony Kicic
    Stem Cell Unit, Department of Molecular Ophthalmology, Lions Eye Institute and the University of Western Australia, Nedlands, 6009, Western Australia, Australia
    Stem Cells Dev 14:15-28. 2005
    ..This investigation has shown the existence of a large pool of undifferentiated stem cells derived from the disease state that have the potential to form the desired cell types when appropriately cued...
  5. ncbi request reprint Marrow stromal cells (MSC): a species comparison
    Anthony Kicic
    Stem Cell Unit, Department of Molecular Ophthalmology, Lions Eye Institute, Centre of Ophthalmology and Visual Science, University of Western Australia, Nedlands, 6009, Western Australia, Australia
    Adv Exp Med Biol 533:407-14. 2003
  6. doi request reprint Bronchial brushings for investigating airway inflammation and remodelling
    Kevin Looi
    School of Paediatrics and Child Health, Centre for Health Research, The University of Western Australia, Nedlands, Australia
    Respirology 16:725-37. 2011
    ..This review attempts to provide an overview of the currently used and recently developed/adapted techniques used to obtain lung tissue with specific reference to the airway epithelium...
  7. doi request reprint Reduced transforming growth factor β1 (TGF-β1) in the repair of airway epithelial cells of children with asthma
    Kak Ming Ling
    Telethon Kids Institute, Centre for Child Health Research, The University of Western Australia, Nedlands, Western Australia, Australia
    Respirology 21:1219-26. 2016
    ..This study tested the hypothesis that the reduced TGF-β1 levels previously observed in paediatric asthmatic airway epithelial cells directly contribute to the dysregulated repair seen in these cells...
  8. pmc Regional differences in susceptibiity of bronchial epithelium to mesenchymal transition and inhibition by the macrolide antibiotic azithromycin
    Balarka Banerjee
    School of Paediatrics and Child Health, The University of Western Australia, Nedlands, Western Australia, Australia
    PLoS ONE 7:e52309. 2012
    ..Here we determined if regional variation in the EMT response to TGFβ1 underlies the bronchiolocentric fibrosis leading to BOS and whether EMT could be inhibited by azithromycin or mycophenolate...
  9. doi request reprint Inflammatory responses to individual microorganisms in the lungs of children with cystic fibrosis
    Catherine Gangell
    Telethon Institute for Child Health Research and the Centre for Child Health Research, University of Western Australia, Perth, Australia
    Clin Infect Dis 53:425-32. 2011
    ..We hypothesized that the inflammatory response in the lungs of children with cystic fibrosis (CF) would vary with the type of infecting organism, being greatest with Pseudomonas aeruginosa and Staphylococcus aureus...
  10. doi request reprint Bronchiectasis in infants and preschool children diagnosed with cystic fibrosis after newborn screening
    Stephen M Stick
    Department of Respiratory Medicine, Princess Margaret Hospital for Children, School of Paediatrics and Child Health, University of Western Australia, Melbourne, Australia
    J Pediatr 155:623-8.e1. 2009
    ..To determine the prevalence of bronchiectasis in young children with cystic fibrosis (CF) diagnosed after newborn screening (NBS) and the relationship of bronchiectasis to pulmonary inflammation and infection...
  11. doi request reprint Matrix metalloproteinase activation by free neutrophil elastase contributes to bronchiectasis progression in early cystic fibrosis
    Luke W Garratt
    School of Paediatrics and Child Health, University of Western Australia, Perth, Australia Telethon Kids Institute, University of Western Australia, Perth, Australia
    Eur Respir J 46:384-94. 2015
    ....
  12. doi request reprint The airway epithelium is a direct source of matrix degrading enzymes in bronchiolitis obliterans syndrome
    Balarka Banerjee
    School of Paediatrics and Child Health, University of Western Australia, Nedlands, Western Australia, Australia
    J Heart Lung Transplant 30:1175-85. 2011
    ..Because matrix metalloproteinase (MMP) -2 and MMP-9 secretion is integral to repair, we hypothesized that airway epithelial cells from patients with BOS would over-express these matrix-degrading enzymes...
  13. doi request reprint Early bronchiectasis in cystic fibrosis detected by surveillance CT
    Naveen Pillarisetti
    Department of Respiratory Medicine, Royal Children s Hospital, Melbourne, Victoria, Australia
    Respirology 15:1009-11. 2010
    ....
  14. doi request reprint Infection, inflammation, and lung function decline in infants with cystic fibrosis
    Naveen Pillarisetti
    Department of Respiratory Medicine, Royal Children s Hospital Melbourne, Flemington Road, Parkville, 3052, Australia
    Am J Respir Crit Care Med 184:75-81. 2011
    ....
  15. doi request reprint Innate inflammatory responses of pediatric cystic fibrosis airway epithelial cells: effects of nonviral and viral stimulation
    Erika N Sutanto
    Division of Clinical Sciences, Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia
    Am J Respir Cell Mol Biol 44:761-7. 2011
    ..The elevated IL-8, together with dampened apoptotic responses by CF cells to HRV, could contribute to augmented airway inflammation in the setting of recurrent viral infections early in life...
  16. ncbi request reprint Effect of human rhinovirus infection on airway epithelium tight junction protein disassembly and transepithelial permeability
    Kevin Looi
    a School of Paediatrics and Child Health, The University of Western Australia, Nedlands, Western Australia, Australia
    Exp Lung Res . 2016
    ..No studies have assessed the effects of human rhinovirus (HRV) infection on epithelial tight junctions (TJs) and resultant barrier function...
  17. doi request reprint Stability of interleukin 8 and neutrophil elastase in bronchoalveolar lavage fluid following long-term storage
    Luke J Berry
    Division of Clinical Sciences, Telethon Institute for Child Health Research, 100 Roberts Road, Subiaco, WA 6155 Australia and Centre for Child Health Research, University of Western Australia, Perth, Australia
    J Cyst Fibros 9:346-50. 2010
    ..Longitudinal analysis assumes uniform stability during storage, however the effect of extended low-temperature storage on these markers remains unclear...
  18. doi request reprint Determinants of culture success in an airway epithelium sampling program of young children with cystic fibrosis
    Luke W Garratt
    1School of Paediatrics and Child Health, University of Western Australia, Nedlands, Perth, Western Australia, Australia
    Exp Lung Res 40:447-59. 2014
    ..However, unique obstacles exist when establishing CF airway epithelial cells (pAECCF). We aimed to identify determinants of culture success through retrospective analysis of a program of routinely brushing children with CF...
  19. ncbi request reprint Differentiation of marrow stromal cells into photoreceptors in the rat eye
    Anthony Kicic
    Stem Cell Unit, Department of Molecular Ophthalmology, Lions Eye Institute, affiliated with the Center of Ophthalmology and Visual Science, University of Western Australia, Nedlands, 6009, Western Australia, Australia
    J Neurosci 23:7742-9. 2003
    ..Our results establish a proof of concept for CD90+ MSC differentiation with autologous transplantation, which may provide a promising therapeutic strategy for the treatment of some forms of genetically inherited retinal degenerations...
  20. pmc The use of non-bronchoscopic brushings to study the paediatric airway
    Catherine Lane
    School of Paediatrics and Child Health, University of Western Australia, Nedlands, 6009, Western Australia, Australia
    Respir Res 6:53. 2005
    ....
  21. doi request reprint Airway epithelial repair in health and disease: Orchestrator or simply a player?
    Thomas Iosifidis
    School of Paediatrics and Child Health, The University of Western Australia, Nedlands, Western Australia, Australia
    Respirology 21:438-48. 2016
    ..This review attempts to highlight migration-specific and cell-extracellular matrix (ECM) aspects of repair used by epithelial cells under normal and disease settings, in the context of human airways. ..
  22. doi request reprint Early life rhinovirus infection exacerbates house-dust-mite induced lung disease more severely in female mice
    Jennifer A Phan
    a Telethon Kids Institute, The University of Western Australia, Subiaco, Western Australia, Australia
    Exp Lung Res 42:24-36. 2016
    ..Recent studies have employed animal models to investigate links between rhinovirus infection and allergic airways disease, however, most do not involve early life infection, and none consider the effects of sex on responses...
  23. doi request reprint Monocytes from children with clinically stable cystic fibrosis show enhanced expression of Toll-like receptor 4
    Nina C Sturges
    Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia
    Pediatr Pulmonol 45:883-9. 2010
    ..930). The increased surface expression of TLR4 seen in young children with CF appears to be related to having CF per se and not related to current pulmonary infection...
  24. doi request reprint Lung disease at diagnosis in infants with cystic fibrosis detected by newborn screening
    Peter D Sly
    Division of Clinical Sciences, Telethon Institute for Child Health Research, PO Box 855, W Perth, WA 6872, Australia
    Am J Respir Crit Care Med 180:146-52. 2009
    ..The promise of newborn screening (NBS) for cystic fibrosis (CF) has not been fully realized, and the extent of improvement in respiratory outcomes is unclear. We hypothesized that significant lung disease was present at diagnosis...
  25. doi request reprint Identification of genes differentially regulated by vitamin D deficiency that alter lung pathophysiology and inflammation in allergic airways disease
    Rachel E Foong
    Telethon Kids Institute, The University of Western Australia, Perth, Western Australia, Australia
    Am J Physiol Lung Cell Mol Physiol 311:L653-63. 2016
    ..Differential regulation of these genes by vitamin D deficiency could determine lung inflammation and pathophysiology and suggest that the effect of vitamin D deficiency on HDM-induced allergic airways disease is complex. ..
  26. doi request reprint Biodiesel exhaust-induced cytotoxicity and proinflammatory mediator production in human airway epithelial cells
    Benjamin J Mullins
    Fluid Dynamics Research Group, Curtin University, GPO Box U1987, Perth, Western Australia, 6845, Australia
    Environ Toxicol 31:44-57. 2016
    ..Exposure to PCO exhaust elicited the greatest loss of cellular viability, but virtually no inflammatory response, likely due to an overall increase in average particle size...
  27. ncbi request reprint Limbal stem cells: the search for a marker
    Kevin Y H Chee
    Stem Cell Unit, Department of Molecular Ophthalmology, Lions Eye Institute, 2 Verdun Street, Nedlands, WA 6009, Australia
    Clin Experiment Ophthalmol 34:64-73. 2006
    ..Such a discovery will have far-reaching implications for the study of ocular surface biology and stratified squamous epithelia in general...
  28. doi request reprint Cells of epithelial lineage are present in blood, engraft the bronchial epithelium, and are increased in human lung transplantation
    Leigh A May
    Telethon Institute for Child Health Research, Subiaco, Western Australia, Australia
    J Heart Lung Transplant 28:550-7. 2009
    ..In this study, in the setting of human lung transplantation, we sought to determine whether exogenous epithelial cells are able to engraft the transplanted organ and if cells of a similar phenotype could be detected in peripheral blood...
  29. pmc Productive Infection of Human Embryonic Stem Cell-Derived NKX2.1+ Respiratory Progenitors with Human Rhinovirus
    Robert A Jenny
    Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia Murdoch Childrens Research Institute, Parkville, Victoria, Australia Telethon Kids Institute, Centre for Health Research, School of Paediatrics and Child Health, Centre for Health Research, and Centre for Cell Therapy and Regenerative Medicine, School of Medicine and Pharmacology, University of Western Australia, Nedlands, Western Australia, Australia Department of Respiratory Medicine, Princess Margaret Hospital for Children, Perth, Western Australia, Australia Richie Centre, Monash Prince Henry s Medical Research Institute, Clayton, Victoria, Australia
    Stem Cells Transl Med 4:603-14. 2015
    ..Our experiments provide proof of principle for the use of PSC-derived respiratory epithelial cells in the study of cell-virus interactions...
  30. pmc Rhinovirus exacerbates house-dust-mite induced lung disease in adult mice
    Jennifer A Phan
    Division of Clinical Sciences, Telethon Institute for Child Health Research, The University of Western Australia, Subiaco, Western Australia, Australia Pharmacology, Pharmacy and Anaesthesiology Unit, School of Medicine and Pharmacology, The University of Western Australia, Crawley, Western Australia, Australia
    PLoS ONE 9:e92163. 2014
    ....
  31. doi request reprint Pressurised metered dose inhaler-spacer technique in young children improves with video instruction
    Nicole Shaw
    Clinical Sciences, Telethon Kids Institute, Subiaco, Western Australia, Australia, 6008
    Eur J Pediatr 175:1007-12. 2016
    ..Additionally, pMDI-spacer technique improved with successive visits over one year for the group overall as evidenced by increases in the proportion of children scoring maximal (p = 0.02) and near-maximal (p = 0.04) scores...
  32. doi request reprint Hypoxia and sterile inflammation in cystic fibrosis airways: mechanisms and potential therapies
    Samuel T Montgomery
    School of Paediatrics and Child Health, The University of Western Australia, Nedlands, Australia
    Eur Respir J 49:. 2017
    ....
  33. doi request reprint Biodiesel exhaust: the need for a systematic approach to health effects research
    Alexander N Larcombe
    Telethon Kids Institute, University of Western Australia, Perth, Australia
    Respirology 20:1034-45. 2015
    ..Such an assessment could inform biodiesel production priorities, drive research and development into new exhaust treatment technologies, and ultimately minimize the health impacts of biodiesel exhaust exposure...
  34. doi request reprint Interpretation of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine is adversely affected by methodological inaccuracies when using a commercial ELISA
    Luke W Garratt
    Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, WA 6008, Australia
    Free Radic Biol Med 48:1460-4. 2010
    ..The implications of these findings for study outcomes add further support for chromatographic techniques, despite their cost and complexity, to remain the gold standard in urinary 8-oxodG assessment...
  35. pmc Desferrithiocin is a more potent antineoplastic agent than desferrioxamine
    Anthony Kicic
    Department of Physiology, University of Western Australia, Nedlands 6907, Western Australia, Australia
    Br J Pharmacol 135:1393-402. 2002
    ..Further investigation into the DFT class of Fe chelators seems warranted, particularly in view of its high activity in relation to DFO, a chelator which is already in clinical trial for neuroblastoma...
  36. ncbi request reprint Using stem cells to repair the degenerate retina. Stem cells in the context of retinal degenerations
    Christine M Hall
    Centre for Ophthalmology and Visual Science, The University of Western Australia, Australia
    Adv Exp Med Biol 572:381-8. 2006