Genomes and Genes
Gerard F Hoyne
Affiliation: University of Notre Dame
- Genetic and cellular studies highlight that A Disintegrin and Metalloproteinase 19 is a protective biomarker in human prostate cancerGerard Hoyne
School of Health Sciences and Institute of Health Science Research, The University of Notre Dame Australia, Fremantle Campus, Australia
BMC Cancer 16:151. 2016..ADAM19 has been positively associated with numerous diseases, but has not been shown to be a tumor suppressor in the pathogenesis of any human cancers. Our group sought to investigate the role of ADAM19 in human prostate cancer...
- Visualizing the role of Cbl-b in control of islet-reactive CD4 T cells and susceptibility to type 1 diabetesGerard F Hoyne
Department of Immunology, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory 0200, Australia
J Immunol 186:2024-32. 2011..These results reveal a role for peripheral T cell anergy in organ-specific self-tolerance and illuminate the interplay between Cblb-dependent anergy and other mechanisms for preventing organ-specific autoimmunity...
- Mechanisms that regulate peripheral immune responses to control organ-specific autoimmunityGerard F Hoyne
School of Health Sciences, University of Notre Dame Australia, 19 Mouat Street, Fremantle, WA 6959, Australia
Clin Dev Immunol 2011:294968. 2011..This paper will examine the role of a range of E3 ubiquitin ligases and signaling pathways that influence the development of T-cell effector responses and the development of organ-specific autoimmune diseases such as type 1 diabetes...
- A cell autonomous role for the Notch ligand Delta-like 3 in αβ T-cell developmentGerard F Hoyne
The Laboratory of T Cell Development and Regulation, John Curtin School of Medical Research, Australian National University Canberra, Canberra, Australian Capital Territory, Australia
Immunol Cell Biol 89:696-705. 2011....
- Differential requirement for the CD45 splicing regulator hnRNPLL for accumulation of NKT and conventional T cellsMehmet Yabas
Department of Immunology, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia
PLoS ONE 6:e26440. 2011..In both cell subsets it is required as a trans-acting factor to regulate alternative splicing of the Ptprc mRNA, but it is only required for survival of conventional T cells...
- The use of genomewide ENU mutagenesis screens to unravel complex mammalian traits: identifying genes that regulate organ-specific and systemic autoimmunityGerard F Hoyne
Australian Cancer Research Foundation Genetics Laboratory and Australian Phenomics Facility, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia
Immunol Rev 210:27-39. 2006..The successful propagation and identification of the new gene variants will shed light on the various developmental checkpoints in lymphocyte development that are crucial for establishing tolerance to self-antigens...
- Consequences of increased CD45RA and RC isoforms for TCR signaling and peripheral T cell deficiency resulting from heterogeneous nuclear ribonucleoprotein L-like mutationZuopeng Wu
John Curtin School of Medical Research, Australian National University, Canberra, Australia
J Immunol 185:231-8. 2010..In T cells with no CD45 protein, hnRNPLL mutation still diminished peripheral T cell accumulation, demonstrating that hnRNPLL regulates T cell longevity independently from its effects on CD45 splicing...
- Cooperation between somatic Ikaros and Notch1 mutations at the inception of T-ALLYovina Sontani
Immunology Department, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia
Leuk Res 35:1512-9. 2011..These findings illuminate the early stages of leukemogenesis by demonstrating progressive exaggeration of Notch1 responsiveness at the DP thymocyte stage brought about by multiple mutations acting in concert upon the Notch1 pathway...