Janet E Holt

Summary

Affiliation: University of Newcastle
Country: Australia

Publications

  1. pmc APC(FZR1) prevents nondisjunction in mouse oocytes by controlling meiotic spindle assembly timing
    Janet E Holt
    School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Mol Biol Cell 23:3970-81. 2012
  2. doi request reprint The control of meiotic maturation in mammalian oocytes
    Janet E Holt
    Center for Reproductive Sciences and School of Biomedical Sciences, University of Newcastle, Callaghan, New South Wales, Australia
    Curr Top Dev Biol 102:207-26. 2013
  3. doi request reprint Control of homologous chromosome division in the mammalian oocyte
    Janet E Holt
    University of Newcastle, Callaghan, NSW, Australia
    Mol Hum Reprod 15:139-47. 2009
  4. doi request reprint The APC/C activator FZR1 coordinates the timing of meiotic resumption during prophase I arrest in mammalian oocytes
    Janet E Holt
    School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Development 138:905-13. 2011
  5. doi request reprint Reduced chromosome cohesion measured by interkinetochore distance is associated with aneuploidy even in oocytes from young mice
    Julie A Merriman
    School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia
    Biol Reprod 88:31. 2013
  6. doi request reprint The APC/C activator FZR1 is essential for meiotic prophase I in mice
    Janet E Holt
    School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia
    Development 141:1354-65. 2014
  7. doi request reprint The microRNA signature of mouse spermatozoa is substantially modified during epididymal maturation
    Brett Nixon
    Reproductive Science Group, School of Environmental and Life Sciences, Faculty of Science and IT, University of Newcastle, Callaghan, New South Wales, Australia
    Biol Reprod 93:91. 2015
  8. doi request reprint Spatial regulation of APCCdh1-induced cyclin B1 degradation maintains G2 arrest in mouse oocytes
    Janet E Holt
    School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Development 137:1297-304. 2010
  9. pmc Characterisation of mouse epididymosomes reveals a complex profile of microRNAs and a potential mechanism for modification of the sperm epigenome
    Jackson N Reilly
    Priority Research Centre for Reproduction, School of Environmental and Life Sciences, Discipline of Biological Sciences, University of Newcastle, Callaghan, New South Wales 2308, Australia
    Sci Rep 6:31794. 2016
  10. doi request reprint The APC activator fizzy-related-1 (FZR1) is needed for preimplantation mouse embryo development
    Michelle K Y Seah
    School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    J Cell Sci 125:6030-7. 2012

Collaborators

  • Keith T Jones
  • Brett Nixon
  • E A McLaughlin
  • Adam McCluskey
  • JOSE M TEIXEIRA
  • Patrick S Western
  • Thomas Graf
  • Peter Koopman
  • R J Aitken
  • Pradeep S Tanwar
  • Nicole J Camlin
  • Bettina P Mihalas
  • Jessie M Sutherland
  • Julie A Merriman
  • Manish Kumar
  • Jackson N Reilly
  • Kate A Redgrove
  • Alexander P Sobinoff
  • Ilana R Bernstein
  • Yan Yun
  • Simon I R Lane
  • Sergio Moreno
  • Irene Garcia-Higuera
  • Michelle K Y Seah
  • Benjamin J Curry
  • Daniel G Blackmore
  • Amanda L Anderson
  • Emma L Beckett
  • Kate Hutcheon
  • Philip M Hansbro
  • Phillip J Robinson
  • Victoria J Pye
  • Sonika Tyagi
  • Rebecca L Vanders
  • Kiralee Church
  • Andrew G Jarnicki
  • Simone J Stanger
  • Andrew L Eamens
  • Luisa I De Andres
  • Victoria Pye
  • Nicole A Siddall
  • Kara M Gunter
  • Evan Boon
  • Kate L Loveland
  • Barbara A Fraser
  • Gary R Hime
  • Phoebe C Jennings
  • Lucan R Baillie
  • Lynda Dierkx

Detail Information

Publications24

  1. pmc APC(FZR1) prevents nondisjunction in mouse oocytes by controlling meiotic spindle assembly timing
    Janet E Holt
    School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Mol Biol Cell 23:3970-81. 2012
    ..This study implicates FZR1 as a major regulator of prometaphase whose activity helps to prevent chromosome nondisjunction...
  2. doi request reprint The control of meiotic maturation in mammalian oocytes
    Janet E Holt
    Center for Reproductive Sciences and School of Biomedical Sciences, University of Newcastle, Callaghan, New South Wales, Australia
    Curr Top Dev Biol 102:207-26. 2013
    ..This is achieved by APC(CDC20), whose activity is critically regulated by the spindle assembly checkpoint, and which induces both a loss in CDK1 activity as well as the cohesive ties holding chromosomes together...
  3. doi request reprint Control of homologous chromosome division in the mammalian oocyte
    Janet E Holt
    University of Newcastle, Callaghan, NSW, Australia
    Mol Hum Reprod 15:139-47. 2009
    ..In particular, we examine the role played by the spindle assembly checkpoint in controlling the APC/C activity, and in so doing ensuring accurate disjunction of homologs...
  4. doi request reprint The APC/C activator FZR1 coordinates the timing of meiotic resumption during prophase I arrest in mammalian oocytes
    Janet E Holt
    School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Development 138:905-13. 2011
    ..Thus, APC/C(FZR1) activity is required to repress cyclin B1 levels in oocytes during prophase I arrest in the ovary, thereby maintaining meiotic quiescence until hormonal cues trigger resumption...
  5. doi request reprint Reduced chromosome cohesion measured by interkinetochore distance is associated with aneuploidy even in oocytes from young mice
    Julie A Merriman
    School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia
    Biol Reprod 88:31. 2013
    ..Based on these results, we propose that individual oocytes undergo loss in chromosomal cohesion at different rates and that the greater this loss, the greater the risk for becoming aneuploid...
  6. doi request reprint The APC/C activator FZR1 is essential for meiotic prophase I in mice
    Janet E Holt
    School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia
    Development 141:1354-65. 2014
    ....
  7. doi request reprint The microRNA signature of mouse spermatozoa is substantially modified during epididymal maturation
    Brett Nixon
    Reproductive Science Group, School of Environmental and Life Sciences, Faculty of Science and IT, University of Newcastle, Callaghan, New South Wales, Australia
    Biol Reprod 93:91. 2015
    ....
  8. doi request reprint Spatial regulation of APCCdh1-induced cyclin B1 degradation maintains G2 arrest in mouse oocytes
    Janet E Holt
    School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Development 137:1297-304. 2010
    ..We propose a simple spatial model of G2 arrest in which nuclear APC(Cdh1)-proteasomal activity guards against any cyclin B1 accumulation mediated by nuclear import...
  9. pmc Characterisation of mouse epididymosomes reveals a complex profile of microRNAs and a potential mechanism for modification of the sperm epigenome
    Jackson N Reilly
    Priority Research Centre for Reproduction, School of Environmental and Life Sciences, Discipline of Biological Sciences, University of Newcastle, Callaghan, New South Wales 2308, Australia
    Sci Rep 6:31794. 2016
    ....
  10. doi request reprint The APC activator fizzy-related-1 (FZR1) is needed for preimplantation mouse embryo development
    Michelle K Y Seah
    School of Biomedical Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    J Cell Sci 125:6030-7. 2012
    ....
  11. pmc Dynamin 2 is essential for mammalian spermatogenesis
    Kate A Redgrove
    School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Sci Rep 6:35084. 2016
    ..We also demonstrate that DNM2 activity may be temporally regulated by phosphorylation of DNM2 via the kinase CDK1 in spermatogonia, and dephosphorylation by phosphatase PPP3CA during meiotic and post-meiotic spermatogenesis...
  12. doi request reprint Time-lapse epifluorescence imaging of expressed cRNA to cyclin B1 for studying meiosis I in mouse oocytes
    Janet E Holt
    School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia
    Methods Mol Biol 957:91-106. 2013
    ..Here we describe the process of microinjecting cRNA to proteins of interest that have been coupled to a fluorescent protein using cyclin B1 as an example...
  13. doi request reprint Maternal Smoke Exposure Impairs the Long-Term Fertility of Female Offspring in a Murine Model
    Nicole J Camlin
    School of Environmental and Life Sciences, University of Newcastle, Callaghan, New South Wales, Australia
    Biol Reprod 94:39. 2016
    ..In conclusion, our results demonstrate that in utero and lactational exposure to cigarette smoke can have long-lasting effects on the fertility of the next generation of females. ..
  14. pmc Reduced ability to recover from spindle disruption and loss of kinetochore spindle assembly checkpoint proteins in oocytes from aged mice
    Yan Yun
    School of Biomedical Sciences and Pharmacy University of Newcastle Callaghan, NSW, Australia
    Cell Cycle 13:1938-47. 2014
    ..These findings have an impact clinically regarding the handling of human oocytes ex vivo during assisted reproductive techniques and suggest there is a genetic basis to aneuploidy susceptibility. ..
  15. ncbi request reprint Identification and characterization of a novel Mt-retrotransposon highly represented in the female mouse germline
    Janet E Holt
    Reproductive Science Group, Discipline of Biological Science, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Genomics 87:490-9. 2006
    ..Together with in silico data, we predict Mtfull plays an essential role in folliculogenesis through regulation of gene expression...
  16. pmc Germ cell specific overactivation of WNT/╬▓catenin signalling has no effect on folliculogenesis but causes fertility defects due to abnormal foetal development
    Manish Kumar
    Gynaecology Oncology Group, School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia
    Sci Rep 6:27273. 2016
    ....
  17. doi request reprint The use of C57Bl/6xCBA F1 hybrid cross as a model for human age-related oocyte aneuploidy
    Nicole J Camlin
    School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW, 2308, Australia
    Mol Reprod Dev . 2016
    ..Human oocytes are particularly error prone, with reports of aneuploidy rates as high as 50-60% (Fragouli et al. 2011; Kuliev et al. 2011). This article is protected by copyright. All rights reserved...
  18. doi request reprint Changing expression and subcellular distribution of karyopherins during murine oogenesis
    Bettina P Mihalas
    School of Biomedical Sciences and PharmacyUniversity of Newcastle, Callaghan, New South Wales 2308, AustraliaHudson Institute of Medical ResearchClayton, Victoria 3168, AustraliaSchool of Environmental and Life SciencesUniversity of Newcastle, Callaghan, New South Wales 2308, AustraliaSchool of Clinical Sciences and Department of Anatomy and Developmental BiologyMonash University, Clayton, Victoria 3800, Australia School of Biomedical Sciences and PharmacyUniversity of Newcastle, Callaghan, New South Wales 2308, AustraliaHudson Institute of Medical ResearchClayton, Victoria 3168, AustraliaSchool of Environmental and Life SciencesUniversity of Newcastle, Callaghan, New South Wales 2308, AustraliaSchool of Clinical Sciences and Department of Anatomy and Developmental BiologyMonash University, Clayton, Victoria 3800, Australia
    Reproduction 150:485-96. 2015
    ..Thus, we propose that KPNAs, by targeting specific cargoes, are likely to be key regulators of oocyte development...
  19. pmc Next Generation Sequencing Analysis Reveals Segmental Patterns of microRNA Expression in Mouse Epididymal Epithelial Cells
    Brett Nixon
    Reproductive Science Group, School of Environmental and Life Sciences, Faculty of Science and IT, University of Newcastle, Callaghan, NSW, Australia
    PLoS ONE 10:e0135605. 2015
    ..Overall these data provide novel insights into the sophistication of the miRNA network that regulates the function of the male reproductive tract. ..
  20. pmc Knockout of RNA Binding Protein MSI2 Impairs Follicle Development in the Mouse Ovary: Characterization of MSI1 and MSI2 during Folliculogenesis
    Jessie M Sutherland
    School of Environmental and Life Sciences, University of Newcastle, Callaghan NSW 2308, Australia
    Biomolecules 5:1228-44. 2015
    ..1% reduction to controls, p < 0.05). Our findings indicate that MSI1 and MSI2 display distinct expression profiles during mammalian folliculogenesis and that MSI2 is required for pre-antral follicle development. ..
  21. doi request reprint Through the smoke: use of in vivo and in vitro cigarette smoking models to elucidate its effect on female fertility
    Nicole J Camlin
    School of Environment and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Toxicol Appl Pharmacol 281:266-75. 2014
    ..We summarise key findings and highlight the strengths and weaknesses of each model system, and link these to the molecular mechanisms identified in smoke-induced fertility changes. ..
  22. ncbi request reprint CXCR4/SDF1 interaction inhibits the primordial to primary follicle transition in the neonatal mouse ovary
    Janet E Holt
    Reproductive Science Group, Discipline of Biological Science, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Dev Biol 293:449-60. 2006
    ..By retaining follicles in an unactivated state, SDF1/CXCR4 signaling may play an important role in maintaining the size and longevity of the primordial follicle pool...
  23. ncbi request reprint Characterization of structure and expression of the Dzip1 gene in the rat and mouse
    Benjamin J Curry
    Reproductive Science Group, Discipline of Biological Science, School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Genomics 87:275-85. 2006
    ....
  24. ncbi request reprint Biosynthesis of the canine zona pellucida requires the integrated participation of both oocytes and granulosa cells
    Daniel G Blackmore
    Reproductive Science Group, Discipline of Biological Sciences, School of Environmental and Life Sciences, University of Newcastle, Callaghan, New South Wales 2308, Australia
    Biol Reprod 71:661-8. 2004
    ....