Hong He

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. doi request reprint P-21 activated kinase 1 knockdown inhibits β-catenin signalling and blocks colorectal cancer growth
    Hong He
    Department of Surgery, University of Melbourne, Austin Health, Melbourne, Victoria 3084, Australia
    Cancer Lett 317:65-71. 2012
  2. doi request reprint PAK1 interacts with beta-catenin and is required for the regulation of the beta-catenin signalling pathway by gastrins
    Hong He
    Department of Surgery, University of Melbourne, Austin Health, Studley Road, Heidelberg, Melbourne, Victoria 3084, Australia
    Biochim Biophys Acta 1783:1943-54. 2008
  3. ncbi request reprint Involvement of G proteins of the Rho family in the regulation of Bcl-2-like protein expression and caspase 3 activation by Gastrins
    Hong He
    Department of Surgery, University of Melbourne, Austin Health, Melbourne, Victoria 3084, Australia
    Cell Signal 20:83-93. 2008
  4. ncbi request reprint Glycine-extended gastrin stimulates cell proliferation and migration through a Rho- and ROCK-dependent pathway, not a Rac/Cdc42-dependent pathway
    Hong He
    Dept of Surgery, Univ of Melbourne, Austin Health, Studley Rd, Heidelberg, Victoria 3084, Australia
    Am J Physiol Gastrointest Liver Physiol 289:G478-88. 2005
  5. doi request reprint Glaucarubinone and gemcitabine synergistically reduce pancreatic cancer growth via down-regulation of P21-activated kinases
    Dannel Yeo
    Department of Surgery, University of Melbourne, Austin Health, Melbourne, Victoria 3084, Australia
    Cancer Lett 346:264-72. 2014
  6. pmc p-21-Activated kinase 1 mediates gastrin-stimulated proliferation in the colorectal mucosa via multiple signaling pathways
    Nhi Huynh
    Department of Surgery, University of Melbourne, Austin Health, Victoria, Australia
    Am J Physiol Gastrointest Liver Physiol 304:G561-7. 2013
  7. doi request reprint P21-activated kinase 1 promotes colorectal cancer survival by up-regulation of hypoxia-inducible factor-1α
    Kevin H Liu
    Department of Surgery, University of Melbourne, Austin Health, Heidelberg, Victoria 3084, Australia
    Cancer Lett 340:22-9. 2013
  8. doi request reprint P21-activated kinase 1 stimulates colon cancer cell growth and migration/invasion via ERK- and AKT-dependent pathways
    Nhi Huynh
    Department of Surgery, University of Melbourne, Austin Health, Melbourne, Victoria 3084, Australia
    Biochim Biophys Acta 1803:1106-13. 2010
  9. ncbi request reprint Biological activity and ferric ion binding of fragments of glycine-extended gastrin
    Hong He
    The University of Melbourne Department of Surgery, Austin Health, Heidelberg, Victoria 3084, Australia
    Biochemistry 43:11853-61. 2004
  10. pmc FRAX597, a PAK1 inhibitor, synergistically reduces pancreatic cancer growth when combined with gemcitabine
    Dannel Yeo
    Department of Surgery, Austin Health, University of Melbourne, Heidelberg, Vic, Australia
    BMC Cancer 16:24. 2016

Collaborators

Detail Information

Publications36

  1. doi request reprint P-21 activated kinase 1 knockdown inhibits β-catenin signalling and blocks colorectal cancer growth
    Hong He
    Department of Surgery, University of Melbourne, Austin Health, Melbourne, Victoria 3084, Australia
    Cancer Lett 317:65-71. 2012
    ..In mouse models PAK1 knockdown suppressed the growth and metastasis of human CRC cells by decreasing proliferation and increasing apoptosis. Our findings demonstrate for the first time the crucial role of PAK1 in CRC progression in vivo...
  2. doi request reprint PAK1 interacts with beta-catenin and is required for the regulation of the beta-catenin signalling pathway by gastrins
    Hong He
    Department of Surgery, University of Melbourne, Austin Health, Studley Road, Heidelberg, Melbourne, Victoria 3084, Australia
    Biochim Biophys Acta 1783:1943-54. 2008
    ..The results indicate that gastrins regulate beta-catenin signalling through a PAK1-dependent pathway. PAK1 seems to be the point of convergence of multiple signalling pathways activated by gastrins...
  3. ncbi request reprint Involvement of G proteins of the Rho family in the regulation of Bcl-2-like protein expression and caspase 3 activation by Gastrins
    Hong He
    Department of Surgery, University of Melbourne, Austin Health, Melbourne, Victoria 3084, Australia
    Cell Signal 20:83-93. 2008
    ..The findings offer potential targets for blocking the growth-stimulating effects of these gastrins...
  4. ncbi request reprint Glycine-extended gastrin stimulates cell proliferation and migration through a Rho- and ROCK-dependent pathway, not a Rac/Cdc42-dependent pathway
    Hong He
    Dept of Surgery, Univ of Melbourne, Austin Health, Studley Rd, Heidelberg, Victoria 3084, Australia
    Am J Physiol Gastrointest Liver Physiol 289:G478-88. 2005
    ..These results demonstrate that Ggly stimulates IMGE-5 cell proliferation and migration through a Rho/ROCK-dependent pathway but not via Rac- or Cdc42-dependent pathways...
  5. doi request reprint Glaucarubinone and gemcitabine synergistically reduce pancreatic cancer growth via down-regulation of P21-activated kinases
    Dannel Yeo
    Department of Surgery, University of Melbourne, Austin Health, Melbourne, Victoria 3084, Australia
    Cancer Lett 346:264-72. 2014
    ..The synergistic inhibition by glaucarubinone and gemcitabine observed both in vitro and in vivo suggests that glaucarubinone may be a useful adjunct to current regimes of chemotherapy. ..
  6. pmc p-21-Activated kinase 1 mediates gastrin-stimulated proliferation in the colorectal mucosa via multiple signaling pathways
    Nhi Huynh
    Department of Surgery, University of Melbourne, Austin Health, Victoria, Australia
    Am J Physiol Gastrointest Liver Physiol 304:G561-7. 2013
    ..These results indicate that PAK1 mediates the stimulation of colorectal proliferation by gastrins via multiple signaling pathways involving activation of ERK, AKT, and β-catenin...
  7. doi request reprint P21-activated kinase 1 promotes colorectal cancer survival by up-regulation of hypoxia-inducible factor-1α
    Kevin H Liu
    Department of Surgery, University of Melbourne, Austin Health, Heidelberg, Victoria 3084, Australia
    Cancer Lett 340:22-9. 2013
    ..These findings indicate that PAK1 stimulates CRC survival by up-regulation of HIF-1α. ..
  8. doi request reprint P21-activated kinase 1 stimulates colon cancer cell growth and migration/invasion via ERK- and AKT-dependent pathways
    Nhi Huynh
    Department of Surgery, University of Melbourne, Austin Health, Melbourne, Victoria 3084, Australia
    Biochim Biophys Acta 1803:1106-13. 2010
    ..Instead of simultaneously inhibiting both ERK and AKT, the PAK1 convergence point could be an alternative target for CRC therapy...
  9. ncbi request reprint Biological activity and ferric ion binding of fragments of glycine-extended gastrin
    Hong He
    The University of Melbourne Department of Surgery, Austin Health, Heidelberg, Victoria 3084, Australia
    Biochemistry 43:11853-61. 2004
    ..These observations indicate that extensive proteolytic processing may not completely inactivate Ggly and that bioactive forms that are not detected by current radioimmunoassays may be present in tissues and/or plasma...
  10. pmc FRAX597, a PAK1 inhibitor, synergistically reduces pancreatic cancer growth when combined with gemcitabine
    Dannel Yeo
    Department of Surgery, Austin Health, University of Melbourne, Heidelberg, Vic, Australia
    BMC Cancer 16:24. 2016
    ..This study aimed to characterise the expression and functional relevance of PAK1 in pancreatic cancer...
  11. ncbi request reprint Glaucarubinone Combined with Gemcitabine Improves Pancreatic Cancer Survival in an Immunocompetent Orthotopic Murine Model
    Dannel Yeo
    a Department of Surgery, University of Melbourne, Austin Health, Melbourne, Victoria, Australia
    J Invest Surg 29:366-372. 2016
    ..Glaucarubinone, a natural product first isolated from the seeds of the tree Simarouba glauca, has recently been recognized as having anti-cancer properties that may be particularly applicable to pancreatic cancer...
  12. ncbi request reprint ARAP3 is transiently tyrosine phosphorylated in cells attaching to fibronectin and inhibits cell spreading in a RhoGAP-dependent manner
    Stacey T T I
    Department of Surgery, University of Melbourne, Level 5 Clinical Sciences Building, Royal Melbourne Hospital, VIC 3050, Australia
    J Cell Sci 117:6071-84. 2004
    ..These results implicate ARAP3 in integrin-mediated tyrosine kinase signalling pathways controlling Rho GTPases and cell spreading...
  13. doi request reprint Glaucarubinone inhibits colorectal cancer growth by suppression of hypoxia-inducible factor 1α and β-catenin via a p-21 activated kinase 1-dependent pathway
    Nhi Huynh
    Department of Surgery, University of Melbourne, Austin Health, Melbourne, Victoria 3084, Australia
    Biochim Biophys Acta 1853:157-65. 2015
    ..Our findings indicate that glaucarubinone inhibited CRC growth by down-regulation of HIF-1α and β-catenin via a PAK1-dependent pathway. ..
  14. doi request reprint Rho GTPases and p21-activated kinase in the regulation of proliferation and apoptosis by gastrins
    Hong He
    Department of Surgery, University of Melbourne, Austin Health, Studley Road, Heidelberg, Victoria 3084, Australia
    Int J Biochem Cell Biol 40:2018-22. 2008
    ..The central role of the beta-catenin pathway in carcinogenesis suggests that specific inhibitors of p21-activated kinase 1 may in the future provide novel therapies for gastrointestinal malignancies...
  15. pmc Up-regulation of stem cell markers by P21-activated kinase 1 contributes to 5-fluorouracil resistance of colorectal cancer
    Nhi Huynh
    a Department of Surgery, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
    Cancer Biol Ther 17:813-23. 2016
    ..Our findings lay the foundation for a combination therapy in which PAK1 inhibitors targeting CSCs may be combined with conventional 5-FU-based chemotherapy for the treatment of CRC. ..
  16. doi request reprint Inhibition of Group 1 p21-activated Kinases Suppresses Pancreatic Stellate Cell Activation and Increases Survival of Mice with Pancreatic Cancer
    Dannel Yeo
    Department of Surgery, University of Melbourne Austin Health, Melbourne, Victoria, Australia
    Int J Cancer . 2017
    ..Targeting stromal PAK1 could increase therapeutic response and survival of patients with pancreatic cancer. This article is protected by copyright. All rights reserved. © 2014 Wiley Periodicals, Inc...
  17. doi request reprint The role of p21-activated kinases in pancreatic cancer
    Dannel Yeo
    From the Department of Surgery, University of Melbourne, Austin Health, Heidelberg, Melbourne, Victoria, Australia
    Pancreas 44:363-9. 2015
    ..This review highlights the potential role of PAKs in pancreatic cancer and provides a foundation for more effective therapeutics to improve our current treatment of pancreatic cancer. ..
  18. doi request reprint Comparison of two syngeneic orthotopic murine models of pancreatic adenocarcinoma
    Mehrdad Nikfarjam
    1 Department of Surgery, Austin Health, University of Melbourne, Austin Health, LTB8, Heidleberg, Victoria, Australia
    J Invest Surg 26:352-9. 2013
    ..Pancreatic adenocarcinoma has an extremely poor prognosis. The use of appropriate in vivo models is essential in devising methods to improve treatment outcomes...
  19. doi request reprint Total pancreatectomy for the treatment of pancreatic neoplasms
    Mehrdad Nikfarjam
    Department of Surgery, Austin Health, University of Melbourne, Melbourne, Victoria, Australia
    ANZ J Surg 84:823-6. 2014
    ..Because of the improvements in diabetes management, there has been renewed interest in TP for treatment of pancreatic neoplasm, with a need to reassess outcomes...
  20. doi request reprint p21-activated kinases and gastrointestinal cancer
    Hong He
    Department of Surgery, University of Melbourne, Austin Health, Melbourne, Victoria, Australia
    Biochim Biophys Acta 1833:33-9. 2013
    ..Here we summarise recent findings from biological and clinical research on the role of PAKs in gastrointestinal cancer, and discuss the current status of PAK-targeted anticancer therapies...
  21. ncbi request reprint Interfering with Ras signaling using membrane-permeable peptides or drugs
    Hiroshi Maruta
    Tumor Suppressor Laboratory, Ludwig Institute for Cancer Research, Melbourne, Australia
    Methods Mol Biol 189:75-85. 2002
  22. ncbi request reprint Rho family-associated kinases PAK1 and rock
    Hiroshi Maruta
    Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital, Parkville Melbourne, Australia 3050
    Prog Cell Cycle Res 5:203-10. 2003
    ....
  23. ncbi request reprint PAK is essential for RAS-induced upregulation of cyclin D1 during the G1 to S transition
    Thao Nheu
    Ludwig Institute for Cancer Research, Parkville Melbourne, Australia
    Cell Cycle 3:71-4. 2004
    ....
  24. pmc Role of integrin alphav beta6 in acute lung injury induced by Pseudomonas aeruginosa
    Yuanlin Song
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California, USA
    Infect Immun 76:2325-32. 2008
    ..aeruginosa-induced lung injury. However, these therapies also did not increase the lung injury, suggesting that host defense was not compromised by this promising new therapy...
  25. ncbi request reprint Cell proliferation and apoptosis in human uterine leiomyomas and myometria
    Darlene Dixon
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, National Institutes of Health, P O Box 12233, MDC2 09, Research Triangle Park, NC 27709, USA
    Virchows Arch 441:53-62. 2002
    ..We conclude that increased cell proliferation is the most significant contributor to growth and that the proliferative state is autonomous for each tumor in a given patient and is independent of tumor size...
  26. ncbi request reprint [Quantity and apoptosis-related protein level of B lymphocyte in patients with immunorelated pancytopenia]
    Rong Fu
    Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, Tianjin 300020, China
    Zhonghua Xue Ye Xue Za Zhi 23:236-8. 2002
    ..To examine the quantity and apoptosis-related protein level of B lymphocyte in the patients with immunorelated pancytopenia (IRP) and explore the role of B lymphocyte in the pathogenetic mechanism of IRP...
  27. ncbi request reprint The K252a derivatives, inhibitors for the PAK/MLK kinase family selectively block the growth of RAS transformants
    Thao V Nheu
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville, Australia
    Cancer J 8:328-36. 2002
    ..Thus, we have explored such a PAK1 inhibitor(s) among synthetic derivatives of an adenosine triphosphate antagonist...
  28. pmc Uterine natural killer cells: insights into their cellular and molecular biology from mouse modelling
    B Anne Croy
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, ON, N1G 2W1, Canada
    Reproduction 126:149-60. 2003
    ..Decidual maintenance and uNK cell death are additional effects of uNK cell-derived IFN-gamma. Thus, during the first half of gestation, uNK cells contribute to and sustain important changes in the maternal placental bed...
  29. ncbi request reprint Update on pathways regulating the activation of uterine Natural Killer cells, their interactions with decidual spiral arteries and homing of their precursors to the uterus
    B Anne Croy
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Ont N1G 2W1, Guelph, Canada
    J Reprod Immunol 59:175-91. 2003
    ..These approaches maybe applicable to studies in women. Our studies show that complex immuno-physiological events contribute to spiral artery modification by mid-gestation in mice...
  30. ncbi request reprint The Tyr-kinase inhibitor AG879, that blocks the ETK-PAK1 interaction, suppresses the RAS-induced PAK1 activation and malignant transformation
    Hong He
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville Melbourne, Australia
    Cancer Biol Ther 3:96-101. 2004
    ....
  31. ncbi request reprint Caveolin-1, Id3a and two LIM protein genes are upregulated by estrogen in vascular smooth muscle cells
    Tokumitsu Watanabe
    Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo 7 3 1 Hongo, Bunkyo, Tokyo 113 8655, Japan
    Life Sci 75:1219-29. 2004
    ..Addition of 100 nmol/L estradiol for 24 hours increased the mRNA levels of all four genes. Although the precise mechanism remains unclear, regulation of these genes by estrogen might contribute to its effect on VSMC...
  32. ncbi request reprint Analysis of the contributions of L-selectin and CXCR3 in mediating leukocyte homing to pregnant mouse uterus
    Xuemei Xie
    Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada
    Am J Reprod Immunol 53:1-12. 2005
    ....
  33. ncbi request reprint Effects of raloxifene on caveolin-1 mRNA and protein expressions in vascular smooth muscle cells
    Fa Lin Yang
    Institute of Biochemistry and Molecular Biology, Medical College, Shandong University, Jinan 250012, China
    Acta Biochim Biophys Sin (Shanghai) 38:747-52. 2006
    ..These increases were inhibited by estrogen receptor antagonist ICI 182780 (10(5-) M). Results of this study suggest that raloxifene stimulates caveolin-1 transcription and translation through estrogen receptor mediated mechanisms...
  34. pmc Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in human uterine leiomyomas
    Linda Yu
    Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences NIEHS, National Institutes of Health NIH, Department of Health and Human Services DHHS, Research Triangle Park, North Carolina, United States of America
    Mol Med 14:264-75. 2008
    ..These data may provide new anti-tumor targets for noninvasive treatment of fibroids...
  35. doi request reprint Peroxisome proliferator-activated receptor-gamma1 gene therapy attenuates atherosclerosis and stabilizes plaques in apolipoprotein E-deficient mice
    Qin Hu
    Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, Shandong 250012, China
    Hum Gene Ther 19:287-299. 2008
    ..Thus, PPARgamma1 might offer a promising gene therapeutic target against atherosclerosis...
  36. ncbi request reprint Isolation of streptonigrin and its novel derivative from Micromonospora as inducing agents of p53-dependent cell apoptosis
    Haishan Wang
    Medicinal and Combinatorial Chemistry Laboratory, Lead Discovery Group, Microbial Collection, Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609, Singapore
    J Nat Prod 65:721-4. 2002
    ..6 cells that overexpress a dominant negative mutant of p53, thus suggesting that they induce apoptosis through a p53-dependent pathway...