Lyle C Gurrin

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. pmc Leave entitlements, time off work and the household financial impacts of quarantine compliance during an H1N1 outbreak
    Anne M Kavanagh
    Centre for Women s Health, Gender and Society, Melbourne School of Population Health, The University of Melbourne, Melbourne, Victoria, Australia
    BMC Infect Dis 12:311. 2012
  2. pmc A phase I study of daily treatment with a ceramide-dominant triple lipid mixture commencing in neonates
    Adrian J Lowe
    Murdoch Children s Research Institute, Royal Children s Hospital, Flemington Rd, Parkville 3052, Australia
    BMC Dermatol 12:3. 2012
  3. pmc Are Australian immigrants at a risk of being physically inactive?
    Jayantha Dassanayake
    Center for Molecular, Environment, Genetic and Analytical Epidemiology, The University of Melbourne, Australia
    Int J Behav Nutr Phys Act 8:53. 2011
  4. pmc 'The difference in determinants of Chlamydia trachomatis and Mycoplasma genitalium in a sample of young Australian women'
    Jennifer Walker
    Centre for Women s Health, Gender and Society, School of Population Health, University of Melbourne, Victoria 3010, Australia
    BMC Infect Dis 11:35. 2011
  5. pmc Impact of telephone triage on emergency after hours GP Medicare usage: a time-series analysis
    David Dunt
    Centre for Health Policy, Programs and Economics, School of Population Health, University of Melbourne, 3010 VIC Australia
    Aust New Zealand Health Policy 4:21. 2007
  6. ncbi request reprint Using bivariate models to understand between- and within-cluster regression coefficients, with application to twin data
    Lyle C Gurrin
    Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, University of Melbourne, Carlton, Victoria 3053, Australia
    Biometrics 62:745-51. 2006
  7. ncbi request reprint Tutorial in biostatistics: spline smoothing with linear mixed models
    Lyle C Gurrin
    Epidemiology and Biostatistics Unit, University of Melbourne, Australia
    Stat Med 24:3361-81. 2005
  8. doi request reprint Population response to change in infant feeding guidelines for allergy prevention
    Dean Tey
    Department of Allergy and Immunology, Royal Children s Hospital, Parkville, Australia Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Australia Department of Paediatrics, University of Melbourne, Melbourne, Australia
    J Allergy Clin Immunol 133:476-84. 2014
  9. pmc A novel association between a SNP in CYBRD1 and serum ferritin levels in a cohort study of HFE hereditary haemochromatosis
    Clare C Constantine
    Centre for MEGA Epidemiology, School of Population Health, University of Melbourne, Carlton, Victoria, Australia
    Br J Haematol 147:140-9. 2009
  10. pmc Predictors of mammographic density: insights gained from a novel regression analysis of a twin study
    Gillian S Dite
    The University of Melbourne, Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, 723 Swanston Street, Carlton, Victoria 3053, Australia
    Cancer Epidemiol Biomarkers Prev 17:3474-81. 2008

Detail Information

Publications51

  1. pmc Leave entitlements, time off work and the household financial impacts of quarantine compliance during an H1N1 outbreak
    Anne M Kavanagh
    Centre for Women s Health, Gender and Society, Melbourne School of Population Health, The University of Melbourne, Melbourne, Victoria, Australia
    BMC Infect Dis 12:311. 2012
    ....
  2. pmc A phase I study of daily treatment with a ceramide-dominant triple lipid mixture commencing in neonates
    Adrian J Lowe
    Murdoch Children s Research Institute, Royal Children s Hospital, Flemington Rd, Parkville 3052, Australia
    BMC Dermatol 12:3. 2012
    ..We sort to assess the safety and compliance with daily application of a ceramide-dominant triple lipid formula (EpiCeramâ„¢) commencing in the neonatal period for the prevention of eczema...
  3. pmc Are Australian immigrants at a risk of being physically inactive?
    Jayantha Dassanayake
    Center for Molecular, Environment, Genetic and Analytical Epidemiology, The University of Melbourne, Australia
    Int J Behav Nutr Phys Act 8:53. 2011
    ..We examined whether physical activity risk differed between migrant sub-groups and the Australian-born population...
  4. pmc 'The difference in determinants of Chlamydia trachomatis and Mycoplasma genitalium in a sample of young Australian women'
    Jennifer Walker
    Centre for Women s Health, Gender and Society, School of Population Health, University of Melbourne, Victoria 3010, Australia
    BMC Infect Dis 11:35. 2011
    ..Differences in the determinants of Chlamydia trachomatis ('chlamydia') and Mycoplasma genitalium (MG) genital infection in women are not well understood...
  5. pmc Impact of telephone triage on emergency after hours GP Medicare usage: a time-series analysis
    David Dunt
    Centre for Health Policy, Programs and Economics, School of Population Health, University of Melbourne, 3010 VIC Australia
    Aust New Zealand Health Policy 4:21. 2007
    ..Poisson regression analysis was used in analysis...
  6. ncbi request reprint Using bivariate models to understand between- and within-cluster regression coefficients, with application to twin data
    Lyle C Gurrin
    Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, University of Melbourne, Carlton, Victoria 3053, Australia
    Biometrics 62:745-51. 2006
    ..We illustrate these results in a study of female twin pairs from Australia and North America relating mammographic breast density to weight and body mass index...
  7. ncbi request reprint Tutorial in biostatistics: spline smoothing with linear mixed models
    Lyle C Gurrin
    Epidemiology and Biostatistics Unit, University of Melbourne, Australia
    Stat Med 24:3361-81. 2005
    ..The models are fitted in R (a clone of S-plus) and using Markov chain Monte Carlo (MCMC) implemented in the package WinBUGS...
  8. doi request reprint Population response to change in infant feeding guidelines for allergy prevention
    Dean Tey
    Department of Allergy and Immunology, Royal Children s Hospital, Parkville, Australia Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Australia Department of Paediatrics, University of Melbourne, Melbourne, Australia
    J Allergy Clin Immunol 133:476-84. 2014
    ..It is unknown whether population infant feeding practices have changed since recently revised Australian allergy guidelines removed recommendations to delay allergenic solids...
  9. pmc A novel association between a SNP in CYBRD1 and serum ferritin levels in a cohort study of HFE hereditary haemochromatosis
    Clare C Constantine
    Centre for MEGA Epidemiology, School of Population Health, University of Melbourne, Carlton, Victoria, Australia
    Br J Haematol 147:140-9. 2009
    ..004). This putative genetic modifier of iron overload expression accounts for 11% (95% CI 0.4%, 22.6%) of the variance in serum ferritin levels of C282Y homozygotes...
  10. pmc Predictors of mammographic density: insights gained from a novel regression analysis of a twin study
    Gillian S Dite
    The University of Melbourne, Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, 723 Swanston Street, Carlton, Victoria 3053, Australia
    Cancer Epidemiol Biomarkers Prev 17:3474-81. 2008
    ..The associations between mammographic density measures and height are consistent with shared early life environmental factors that predispose to both height and percent mammographic density and possibly breast cancer risk...
  11. doi request reprint The natural history of serum iron indices for HFE C282Y homozygosity associated with hereditary hemochromatosis
    Lyle C Gurrin
    Centre for MEGA Epidemiology, School of Population Health, The University of Melbourne, Melbourne, Australia
    Gastroenterology 135:1945-52. 2008
    ..We characterized the development of elevated iron measures in C282Y homozygotes followed for 12 years...
  12. doi request reprint Childhood wheeze phenotypes show less than expected growth in FEV1 across adolescence
    Caroline J Lodge
    1 Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Australia
    Am J Respir Crit Care Med 189:1351-8. 2014
    ..Better characterization of childhood wheeze phenotypes using newer statistical methods provides a basis for addressing the heterogeneity of childhood asthma. Outcomes of these phenotypes beyond childhood are unknown...
  13. doi request reprint Common genetic variants associated with breast cancer and mammographic density measures that predict disease
    Fabrice Odefrey
    Department of Pathology and Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, University of Melbourne, Melbourne 3053, Australia
    Cancer Res 70:1449-58. 2010
    ..These findings could help elucidate how those variants and mammographic density measures are associated with breast cancer susceptibility...
  14. doi request reprint The natural history and clinical predictors of egg allergy in the first 2 years of life: a prospective, population-based cohort study
    Rachel L Peters
    Murdoch Childrens Research Institute, Parkville, Australia Department of Paediatrics, University of Melbourne, Parkville, Australia
    J Allergy Clin Immunol 133:485-91. 2014
    ..There is a paucity of data examining the natural history of and risk factors for egg allergy persistence, the most common IgE-mediated food allergy in infants...
  15. doi request reprint Does eczema in infancy cause hay fever, asthma, or both in childhood? Insights from a novel regression model of sibling data
    John L Hopper
    Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, University of Melbourne, Melbourne, Australia
    J Allergy Clin Immunol 130:1117-1122.e1. 2012
    ..The atopic march hypothesis proposes that eczema precedes the development of asthma and allergic rhinitis...
  16. ncbi request reprint Childhood infections and the risk of asthma: a longitudinal study over 37 years
    John A Burgess
    Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Carlton, Vic, Australia
    Chest 142:647-54. 2012
    ..Few studies have examined common childhood infections and adult asthma. We examined associations between childhood infectious diseases, childhood pneumonia, and current, persisting, and incident asthma to middle age...
  17. doi request reprint Early-life risk factors for childhood wheeze phenotypes in a high-risk birth cohort
    Caroline J Lodge
    Center for Molecular, Environmental, Genetic, and Analytic Epidemiology, School of Population and Global Health, University of Melbourne, Melbourne, Australia Electronic address
    J Pediatr 164:289-94.e1-2. 2014
    ..To define longitudinal childhood wheeze phenotypes and identify their early-life risk factors...
  18. pmc Natural history of HFE simple heterozygosity for C282Y and H63D: a prospective 12-year study
    Sophie G Zaloumis
    Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia
    J Gastroenterol Hepatol 30:719-25. 2015
    ..The risk of hemochromatosis-related morbidity for HFE simple heterozygosity for either the C282Y or H63D substitutions in the HFE protein was assessed using a prospective community-based cohort study...
  19. pmc The impact of family history of allergy on risk of food allergy: a population-based study of infants
    Jennifer J Koplin
    Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Parkville, Victoria 3052, Australia
    Int J Environ Res Public Health 10:5364-77. 2013
    ..Re-defining "high risk" as two or more allergic family members may be more useful for identification of groups with a significantly increased risk of food allergy both clinically and within research studies. ..
  20. doi request reprint A comparison of self-reported and record-linked blood donation history in an Australian cohort
    Nadine A Bertalli
    Centre for MEGA Epidemiology, School of Population Health, The University of Melbourne, Australia
    Transfusion 51:2189-98. 2011
    ..This study aimed to retrieve electronic records from a national blood donation service and link them to self-reported history of donation to assess agreement between the two sources...
  21. doi request reprint Skin prick test responses and allergen-specific IgE levels as predictors of peanut, egg, and sesame allergy in infants
    Rachel L Peters
    Murdoch Childrens Research Institute, Melbourne, Australia Department of Paediatrics, University of Melbourne, Melbourne, Australia
    J Allergy Clin Immunol 132:874-80. 2013
    ..However, 95% PPVs specific to infants, the age group most likely to present for diagnosis of food allergy, are limited...
  22. doi request reprint Factors influencing asthma remission: a longitudinal study from childhood to middle age
    John A Burgess
    Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Level 2, 723 Swanston Street, Carlton, Victoria 3053, Australia
    Thorax 66:508-13. 2011
    ..To examine asthma remission from childhood to middle age...
  23. doi request reprint Computer reminders for Chlamydia screening in general practice: a randomized controlled trial
    Jennifer Walker
    University of Melbourne, Victoria, Australia
    Sex Transm Dis 37:445-50. 2010
    ..The aim of this trial was to determine the effectiveness of a computer alert in general practice on chlamydia testing in young women...
  24. doi request reprint Polymorphisms affecting vitamin D-binding protein modify the relationship between serum vitamin D (25[OH]D3) and food allergy
    Jennifer J Koplin
    Murdoch Childrens Research Institute, Parkville, Australia School of Population and Global Health, University of Melbourne, Parkville, Australia
    J Allergy Clin Immunol 137:500-506.e4. 2016
    ..Lower vitamin D-binding protein (DBP) levels increase the biological availability of serum vitamin D. Genetic polymorphisms explain almost 80% of the variation in binding protein levels...
  25. doi request reprint House dust mite sensitization in toddlers predicts current wheeze at age 12 years
    Caroline J Lodge
    Centre for MEGA Epidemiology, University of Melbourne, Melbourne, Australia
    J Allergy Clin Immunol 128:782-788.e9. 2011
    ..Identification of children at risk of developing asthma provides a window of opportunity for risk-reducing interventions. Allergen sensitization might identify high-risk children...
  26. doi request reprint Cohort Profile: The HealthNuts Study: Population prevalence and environmental/genetic predictors of food allergy
    Jennifer J Koplin
    Murdoch Childrens Research Institute, Royal Children s Hospital and University of Melbourne, Parkville, Vic, Australia, School of Population and Global Health, University of Melbourne, Carlton, Vic, Australia and
    Int J Epidemiol 44:1161-71. 2015
    ..Biological specimens (blood, cheek swabs) were collected at each wave for ancillary immunological, genetic and epigenetic studies. Applications to access data and/or samples can be submitted to [katrina.allen@mcri.edu.au]. ..
  27. doi request reprint The interplay between the effects of lifetime asthma, smoking, and atopy on fixed airflow obstruction in middle age
    Jennifer L Perret
    Centre for Molecular, Environmental, Genetic, and Analytical Epidemiology, University of Melbourne, Victoria, Australia
    Am J Respir Crit Care Med 187:42-8. 2013
    ..The contribution by asthma to the development of fixed airflow obstruction (AO) and the nature of its effect combined with active smoking and atopy remain unclear...
  28. pmc Comparing the frequency of common genetic variants and haplotypes between carriers and non-carriers of BRCA1 and BRCA2 deleterious mutations in Australian women diagnosed with breast cancer before 40 years of age
    Lidija Turkovic
    Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, The University of Melbourne, Victoria 3010, Australia
    BMC Cancer 10:466. 2010
    ....
  29. doi request reprint Natural history of peanut allergy and predictors of resolution in the first 4 years of life: A population-based assessment
    Rachel L Peters
    Population Health, The Murdoch Childrens Research Institute, Parkville, Australia Department of Paediatrics, University of Melbourne, Parkville, Australia
    J Allergy Clin Immunol 135:1257-66.e1-2. 2015
    ..Previous studies of predictors of tolerance development have been biased by failure to challenge high-risk children when IgE antibody levels are high, therefore potentially introducing bias to persistent allergy...
  30. pmc Maximising retention in a longitudinal study of genital Chlamydia trachomatis among young women in Australia
    Jennifer Walker
    Centre for Women s Health, Gender and Society, School of Population Health, University of Melbourne, Victoria 3010, Australia
    BMC Public Health 11:156. 2011
    ..The aims of this paper are to describe the methods used to recruit and retain young women in a longitudinal study and to explore factors associated with loss to follow up...
  31. ncbi request reprint Mammographic density and candidate gene variants: a twins and sisters study
    Jennifer Stone
    Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, 2 723 Swanston Street, Carlton, Victoria 3053, Australia
    Cancer Epidemiol Biomarkers Prev 16:1479-84. 2007
    ..Little is known about its genetic determinants...
  32. ncbi request reprint Victims of violence among Indigenous mothers living with dependent children
    Kyllie Cripps
    Melbourne School of Population Health, University of Melbourne, Melbourne, Vic, Australia
    Med J Aust 191:481-5. 2009
    ..To identify individual and household factors associated with violence among Australian Indigenous women with dependent children...
  33. pmc VITALITY trial: protocol for a randomised controlled trial to establish the role of postnatal vitamin D supplementation in infant immune health
    Katrina J Allen
    The Murdoch Childrens Research Institute, Parkville, Victoria, Australia The Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia The Department of Allergy and Immunology, Royal Children s Hospital, Parkville, Victoria, Australia
    BMJ Open 5:e009377. 2015
    ....
  34. doi request reprint The predictive value of skin prick testing for challenge-proven food allergy: a systematic review
    Rachel L Peters
    Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Melbourne, Vic, Australia
    Pediatr Allergy Immunol 23:347-52. 2012
    ..Standardization of SPT devices and allergens, OFC protocols including standardized cessation criteria, and population-based samples would all help to improve generalizability of PPVs of SPTs...
  35. pmc HFE C282Y/H63D compound heterozygotes are at low risk of hemochromatosis-related morbidity
    Lyle C Gurrin
    Centre for MEGA Epidemiology, School Population Health, University of Melbourne, Victoria, Australia
    Hepatology 50:94-101. 2009
    ..001). Male and female compound heterozygotes had a similar prevalence of hemochromatosis-related morbidity to wild-types. One of 82 males and zero of 95 females had documented iron overload-related disease...
  36. ncbi request reprint Regression models for twin studies: a critical review
    John B Carlin
    Clinical Epidemiology and Biostatistics Unit, Murdoch Children s Research Institute, Royal Children s Hospital, Melbourne, Australia
    Int J Epidemiol 34:1089-99. 2005
    ..We recommend the use of a general model that includes separate regression coefficients for within-twin-pair and between-pair effects, and provide guidelines for the interpretation of estimates obtained under this model...
  37. doi request reprint Development of the Falls Risk for Older People in the Community (FROP-Com) screening tool
    Melissa A Russell
    National Ageing Research Institute, Preventive and Public Health Division, Parkville, Melbourne, Victoria 3095, Australia
    Age Ageing 38:40-6. 2009
    ..the aim of this study was to develop a brief screening tool for use in the emergency department (ED), to identify people who require further assessment and management...
  38. pmc Incentive payments to general practitioners aimed at increasing opportunistic testing of young women for chlamydia: a pilot cluster randomised controlled trial
    Jade E Bilardi
    Sexual Health Unit, Melbourne School of Population Health, The University of Melbourne, Carlton, Victoria 3053, Australia
    BMC Public Health 10:70. 2010
    ..The aim of this pilot study was to determine if offering general practitioners (GP) a small incentive payment per test would increase chlamydia testing in women aged 16 to 24 years, attending general practice...
  39. doi request reprint Childhood eczema and asthma incidence and persistence: a cohort study from childhood to middle age
    John A Burgess
    Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Carlton, Australia
    J Allergy Clin Immunol 122:280-5. 2008
    ..The association between eczema and asthma is well documented, but the temporal sequence of this association has not been closely examined...
  40. pmc SNP selection for genes of iron metabolism in a study of genetic modifiers of hemochromatosis
    Clare C Constantine
    The Centre for Molecular, Environmental, Genetic and Analytic MEGA Epidemiology, School of Population Health, The University of Melbourne, Melbourne, Australia
    BMC Med Genet 9:18. 2008
    ..We report our experience of selecting tag SNPs in 35 genes involved in iron metabolism in a cohort study seeking to discover genetic modifiers of hereditary hemochromatosis...
  41. doi request reprint Risk factors for female sexual dysfunction in the general population: exploring factors associated with low sexual function and sexual distress
    Richard D Hayes
    School of Population Health, The University of Melbourne, Australia
    J Sex Med 5:1681-93. 2008
    ..No previous population-based studies have used validated instruments to measure female sexual dysfunction (FSD) in Australian women across a broad age range...
  42. doi request reprint Sexual risk factors and bacterial vaginosis: a systematic review and meta-analysis
    Katherine A Fethers
    Melbourne Sexual Health Centre, The Alfred Hospital, Carlton, Victoria, Australia
    Clin Infect Dis 47:1426-35. 2008
    ..Investigation of sexual transmission of BV is limited by the absence of a clear microbiological etiology; however, we have shown that the epidemiological profile of BV is similar to that of established sexually transmitted infections...
  43. pmc Relationship between vehicle emissions laws and incidence of suicide by motor vehicle exhaust gas in Australia, 2001-06: an ecological analysis
    David M Studdert
    Melbourne School of Population Health, University of Melbourne, Melbourne, Australia
    PLoS Med 7:e1000210. 2010
    ..The objective of this ecological study was to test the relationship by investigating whether areas of Australia with fewer noxious vehicles per capita experienced lower rates of MVEG suicide...
  44. doi request reprint Non-proportional odds multivariate logistic regression of ordinal family data
    Sophie G Zaloumis
    Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, 207 Bouverie Street, Carlton, Victoria 3010, Australia
    Biom J 57:286-303. 2015
    ..We applied the proposed methodology to male pattern baldness data from the Victorian Family Heart Study. ..
  45. pmc Identification of doctors at risk of recurrent complaints: a national study of healthcare complaints in Australia
    Marie M Bismark
    Melbourne School of Population and Global Health, University of Melbourne, Parkville, Victoria, Australia
    BMJ Qual Saf 22:532-40. 2013
    ..1) To determine the distribution of formal patient complaints across Australia's medical workforce and (2) to identify characteristics of doctors at high risk of incurring recurrent complaints...
  46. ncbi request reprint Are rates of pathology test ordering higher in general practices co-located with pathology collection centres?
    David M Studdert
    Melbourne School of Population Health, University of Melbourne, Melbourne, Vic, Australia
    Med J Aust 193:114-9. 2010
    ..To determine whether rates of pathology test ordering by general practitioners in general practices co-located with pathology collection centres (PCCs) are higher than those of GPs in practices located apart from PCCs...
  47. doi request reprint Iron-overload-related disease in HFE hereditary hemochromatosis
    Katrina J Allen
    Murdoch Children s Research Institute, University of Melbourne, Melbourne, Australia
    N Engl J Med 358:221-30. 2008
    ..Diseases related to iron overload develop in some C282Y homozygotes, but the extent of the risk is controversial...
  48. ncbi request reprint A note on genetic variance components in mixed models
    Martin L Hazelton
    School of Mathematics and Statistics, University of Western Australia, Crawley, Western Australia, Australia
    Genet Epidemiol 24:297-301. 2003
    ..We illustrate the application of this technique to mixed models for familial data...
  49. ncbi request reprint Uising WinBUGS to fit nonlinear mixed models with an application to pharmacokinetic modelling of insulin response to glucose challenge in sheep exposed antenatally to glucocorticoids
    Lyle C Gurrin
    Women and Infants Research Foundation, King Edward Memorial Hospital, Subiaco, Western Australia, Australia
    J Biopharm Stat 13:117-39. 2003
    ..It is argued that the fitting of an appropriate statistical model to complex physiological data does not necessarily proclude a result that has a clear interpretation for clinical scientists...
  50. ncbi request reprint Effect of vacuum profile on breast milk expression using an electric breast pump
    Leon R Mitoulas
    Faculty of Life and Physical Sciences, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
    J Hum Lact 18:353-60. 2002
    ..Breastfeeding characteristics did not differ between poor and successful expressers. These results show that breast milk expression by an electric breast pump can be influenced by the vacuum pattern...
  51. ncbi request reprint Efficacy of breast milk expression using an electric breast pump
    Leon R Mitoulas
    University of Western Australia, Crawley, Western Australia
    J Hum Lact 18:344-52. 2002
    ..Furthermore, this study is the first to establish protocols that allow for the objective determination of breast pump efficacy...