Ronald R Grunstein

Summary

Affiliation: University of Sydney
Country: Australia

Publications

  1. ncbi The case of "Judge Nodd" and other sleeping judges--media, society, and judicial sleepiness
    Ronald R Grunstein
    Sleep and Circadian Research Group and NHMRC Centre for Respiratory and Sleep Medicine, Woolcock Institute of Medical Research, Royal Prince Alfred Hospital, Camperdown, Sydney, NSW, Australia
    Sleep 30:625-32. 2007
  2. pmc The heavy vehicle study: a case-control study investigating risk factors for crash in long distance heavy vehicle drivers in Australia
    Mark Stevenson
    The George Institute, The University of Sydney, Sydney, Australia
    BMC Public Health 10:162. 2010
  3. pmc Two year reduction in sleep apnea symptoms and associated diabetes incidence after weight loss in severe obesity
    Ronald R Grunstein
    Department of Puhnlmonary and Sleep Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    Sleep 30:703-10. 2007
  4. doi Modafinil effects during acute continuous positive airway pressure withdrawal: a randomized crossover double-blind placebo-controlled trial
    Shaun C Williams
    Sleep and Circadian Research Group NHMRC Centre for Sleep Medicine, Woolcock Institute, University of Sydney and Royal Prince Alfred Hospital, Sydney, Australia
    Am J Respir Crit Care Med 181:825-31. 2010
  5. pmc Snoring is not associated with all-cause mortality, incident cardiovascular disease, or stroke in the Busselton Health Study
    Nathaniel S Marshall
    NHMRC Centre for Integrated Research and Understanding of Sleep, Woolcock Institute of Medical Research, University of Sydney, Australia
    Sleep 35:1235-40. 2012
  6. pmc Assessment of sleep and breathing in adults with prader-willi syndrome: a case control series
    Brendon J Yee
    Sleep and Circadian Research Group, Woolcock Institute of Medical Research, Sydney, Australia
    J Clin Sleep Med 3:713-8. 2007
  7. doi Slow wave sleep in patients with respiratory failure
    David Wang
    Woolcock Institute of Medical Research, University of Sydney, Glebe Point Rd, Glebe, NSW 2037, Australia
    Sleep Med 12:378-83. 2011
  8. ncbi The effect of short-term withdrawal from continuous positive airway pressure therapy on sympathetic activity and markers of vascular inflammation in subjects with obstructive sleep apnoea
    Craig L Phillips
    Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia
    J Sleep Res 16:217-25. 2007
  9. doi Cardiometabolic changes after continuous positive airway pressure for obstructive sleep apnoea: a randomised sham-controlled study
    Camilla M Hoyos
    Endocrine and Cardiometabolic Research Group, Woolcock Institute of Medical Research, University of Sydney, Glebe, Australia
    Thorax 67:1081-9. 2012
  10. doi Comparing the neurocognitive effects of 40 h sustained wakefulness in patients with untreated OSA and healthy controls
    Keith K H Wong
    Woolcock Institute of Medical Research, Australia
    J Sleep Res 17:322-30. 2008

Collaborators

Detail Information

Publications94

  1. ncbi The case of "Judge Nodd" and other sleeping judges--media, society, and judicial sleepiness
    Ronald R Grunstein
    Sleep and Circadian Research Group and NHMRC Centre for Respiratory and Sleep Medicine, Woolcock Institute of Medical Research, Royal Prince Alfred Hospital, Camperdown, Sydney, NSW, Australia
    Sleep 30:625-32. 2007
    ..Review cases of judicial sleepiness and subsequent outcomes, including media and community attitudes...
  2. pmc The heavy vehicle study: a case-control study investigating risk factors for crash in long distance heavy vehicle drivers in Australia
    Mark Stevenson
    The George Institute, The University of Sydney, Sydney, Australia
    BMC Public Health 10:162. 2010
    ....
  3. pmc Two year reduction in sleep apnea symptoms and associated diabetes incidence after weight loss in severe obesity
    Ronald R Grunstein
    Department of Puhnlmonary and Sleep Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    Sleep 30:703-10. 2007
    ..To evaluate the effect of bariatric surgery on sleep apnea symptoms and obesity-associated morbidity in patients with severe obesity...
  4. doi Modafinil effects during acute continuous positive airway pressure withdrawal: a randomized crossover double-blind placebo-controlled trial
    Shaun C Williams
    Sleep and Circadian Research Group NHMRC Centre for Sleep Medicine, Woolcock Institute, University of Sydney and Royal Prince Alfred Hospital, Sydney, Australia
    Am J Respir Crit Care Med 181:825-31. 2010
    ..However, interruption of CPAP therapy is common and is associated with a decline in daytime function...
  5. pmc Snoring is not associated with all-cause mortality, incident cardiovascular disease, or stroke in the Busselton Health Study
    Nathaniel S Marshall
    NHMRC Centre for Integrated Research and Understanding of Sleep, Woolcock Institute of Medical Research, University of Sydney, Australia
    Sleep 35:1235-40. 2012
    ..To ascertain whether objectively measured snoring increases mortality, cardiovascular disease, or stroke risk over the effects of obstructive sleep apnea and other established risk factors...
  6. pmc Assessment of sleep and breathing in adults with prader-willi syndrome: a case control series
    Brendon J Yee
    Sleep and Circadian Research Group, Woolcock Institute of Medical Research, Sydney, Australia
    J Clin Sleep Med 3:713-8. 2007
    ....
  7. doi Slow wave sleep in patients with respiratory failure
    David Wang
    Woolcock Institute of Medical Research, University of Sydney, Glebe Point Rd, Glebe, NSW 2037, Australia
    Sleep Med 12:378-83. 2011
    ..SWS is reduced in obstructive sleep apnea (OSA) patients, but SWS has not been specifically studied in respiratory failure patients. The aim of this study is to investigate SWS in predominantly hypercapnic respiratory failure patients...
  8. ncbi The effect of short-term withdrawal from continuous positive airway pressure therapy on sympathetic activity and markers of vascular inflammation in subjects with obstructive sleep apnoea
    Craig L Phillips
    Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia
    J Sleep Res 16:217-25. 2007
    ..1). In conclusion, 1 week of CPAP withdrawal was associated with a return of OSA and a marked increase in sympathetic activity without a concomitant elevation of vascular inflammatory markers...
  9. doi Cardiometabolic changes after continuous positive airway pressure for obstructive sleep apnoea: a randomised sham-controlled study
    Camilla M Hoyos
    Endocrine and Cardiometabolic Research Group, Woolcock Institute of Medical Research, University of Sydney, Glebe, Australia
    Thorax 67:1081-9. 2012
    ..The reversibility of these observed changes with continuous positive airway pressure (CPAP) treatment in men with OSA has not been systematically studied in a randomised sham-controlled fashion...
  10. doi Comparing the neurocognitive effects of 40 h sustained wakefulness in patients with untreated OSA and healthy controls
    Keith K H Wong
    Woolcock Institute of Medical Research, Australia
    J Sleep Res 17:322-30. 2008
    ..Patients with OSA did not respond differently to sleep deprivation than healthy controls. As expected, total sleep deprivation led to significant worsening in performance and subjective sleepiness in both groups...
  11. pmc Changes in regional adiposity and cardio-metabolic function following a weight loss program with sibutramine in obese men with obstructive sleep apnea
    Craig L Phillips
    NHMRC Centre for Sleep Medicine, Woolcock Institute of Medical Research, University of Sydney, Camperdown, Sydney, NSW, Australia
    J Clin Sleep Med 5:416-21. 2009
    ..The aim of this study was to evaluate cardiovascular and metabolic changes, including compartment-specific fat loss in obese OSA subjects undergoing a weight loss program...
  12. doi Effect of weight loss on upper airway size and facial fat in men with obstructive sleep apnoea
    Kate Sutherland
    NHMRC Centre for Sleep Health CIRUS, Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia
    Thorax 66:797-803. 2011
    ..This study aimed to assess changes in upper airway size and regional facial and abdominal fat with weight loss and their association with OSA improvement...
  13. doi Modafinil improves daytime sleepiness in patients with mild to moderate obstructive sleep apnoea not using standard treatments: a randomised placebo-controlled crossover trial
    Julia L Chapman
    The NHMRC Centre for Integrated Research and Understanding of Sleep CIRUS, The University of Sydney, Sydney, New South Wales, Australia
    Thorax 69:274-9. 2014
    ..Modafinil is a wake-promoting drug licensed to treat residual sleepiness in CPAP-treated OSA. We hypothesised that modafinil may effectively treat sleepiness in untreated mild to moderate OSA...
  14. doi The effects of testosterone on ventilatory responses in men with obstructive sleep apnea: a randomised, placebo-controlled trial
    Roo Killick
    NHMRC Centre for Integrated Research and Understanding of Sleep CIRUS, Woolcock Institute of Medical Research, University of Sydney, Sydney, NSW, Australia
    J Sleep Res 22:331-6. 2013
    ..57, P = 0.03) at 6-7 weeks, but not at 18 weeks. Time-dependent alterations in ventilatory recruitment threshold may therefore mediate the time-dependent changes in sleep breathing observed with testosterone...
  15. doi A new EEG biomarker of neurobehavioural impairment and sleepiness in sleep apnea patients and controls during extended wakefulness
    Angela L D'Rozario
    Sleep and Circadian Research Group and NHMRC Centre for Integrated Research and Understanding of Sleep, Woolcock Institute of Medical Research, The University of Sydney, Australia
    Clin Neurophysiol 124:1605-14. 2013
    ..To explore the use of detrended fluctuation analysis (DFA) scaling exponent of the awake electroencephalogram (EEG) as a new alternative biomarker of neurobehavioural impairment and sleepiness in obstructive sleep apnea (OSA)...
  16. doi The effect of modafinil following acute CPAP withdrawal: a preliminary study
    Shaun C Williams
    Sleep and Circadian Research Group, Woolcock Institute of Medical Research, Sydney, Australia
    Sleep Breath 12:359-64. 2008
    ..04) compared to placebo. These data do not support the use of modafinil for the maintenance of daytime functioning in patients with OSA who are acutely withdrawn from CPAP...
  17. pmc Is sleep apnea an independent risk factor for prevalent and incident diabetes in the Busselton Health Study?
    Nathaniel S Marshall
    Woolcock Institute of Medical Research, University of Sydney, Australia
    J Clin Sleep Med 5:15-20. 2009
    ..However, this observation has yet to be replicated outside the USA or be observed lonigitudinally...
  18. pmc Prediction of obstructive sleep apnea with craniofacial photographic analysis
    Richard W W Lee
    Centre for Sleep Health and Research, Department of Respiratory Medicine, Royal North Shore Hospital, NSW, Australia
    Sleep 32:46-52. 2009
    ..To develop models based on craniofacial photographic analysis for the prediction of obstructive sleep apnea (OSA)...
  19. doi Altered positional regulation of nasal patency in patients with obstructive sleep apnoea syndrome
    Johan Hellgren
    Sleep and Circadian Research Group, Woolcock Institute of Medical Research, University of Sydney, Royal Prince Alfred Hospital, Missenden Road, Camperdown, Sydney, 2050, Australia
    Eur Arch Otorhinolaryngol 266:83-7. 2009
    ..01. This study showed that the normal decrease in nasal patency following a change in body position from sitting to supine is absent in patients with OSAS. The results indicate that there is an active regulation of supine nasal patency...
  20. doi Prevalence of patent foramen ovale and its impact on oxygen desaturation in obstructive sleep apnea
    Edmund M T Lau
    Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia
    Int J Cardiol 165:35-40. 2013
    ..However, the interaction between these two conditions has not been well characterised...
  21. doi Body compositional and cardiometabolic effects of testosterone therapy in obese men with severe obstructive sleep apnoea: a randomised placebo-controlled trial
    Camilla M Hoyos
    Endocrine and Cardiometabolic Research Group, NHMRC Centre for Integrated Research and Understanding of Sleep CIRUS, Woolcock Institute of Medical Research, University of Sydney, Glebe, Australia
    Eur J Endocrinol 167:531-41. 2012
    ..There has been no systematic study evaluating whether testosterone therapy can improve cardiometabolic health in obese men with OSA by improving body composition, visceral abdominal fat and insulin sensitivity...
  22. doi Phenotyping interindividual variability in obstructive sleep apnoea response to temazepam using ventilatory chemoreflexes during wakefulness
    David Wang
    Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Camperdown, Sydney, NSW, Australia
    J Sleep Res 20:526-32. 2011
    ..Relatively simple daytime tests of respiratory control may provide a method of determining the effect of sedative-hypnotic medication on breathing during sleep in OSA patients...
  23. pmc Zopiclone Increases the Arousal Threshold without Impairing Genioglossus Activity in Obstructive Sleep Apnea
    Sophie G Carter
    Neuroscience Research Australia NeuRA and the University of New South Wales, Randwick, Sydney, New South Wales, Australia
    Sleep 39:757-66. 2016
    ....
  24. doi Snoring is not associated with adverse effects on blood pressure, arterial structure or function in 8-year-old children: the Childhood Asthma Prevention Study (CAPS)
    Nathaniel S Marshall
    Woolcock Institute of Medical Research, New South Wales, Australia
    J Paediatr Child Health 47:518-23. 2011
    ..To study the association between childhood snoring and cardiovascular risk factors...
  25. doi Short-term hypoxia reduces arterial stiffness in healthy men
    Hima Vedam
    Woolcock Institute of Medical Research, Sydney, NSW, 2050, Australia
    Eur J Appl Physiol 105:19-25. 2009
    ..During hypoxia AIx decreased by 12% following saline but increased by 14% after L-NMMA and Tr did not change. These findings suggest that hypoxia may induce NO-mediated vasodilatation of small muscular arteries but not the aorta...
  26. doi Reply to Taheri and Thomas: is sleep duration associated with obesity-U cannot be serious
    Nathaniel S Marshall
    Sleep and Circadian Group, Woolcock Institute of Medical Research, University of Sydney, Australia
    Sleep Med Rev 12:303-5. 2008
  27. pmc Sleep apnea as an independent risk factor for all-cause mortality: the Busselton Health Study
    Nathaniel S Marshall
    Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia
    Sleep 31:1079-85. 2008
    ..However, it is unknown whether sleep apnea is an independent risk factor for all-cause mortality in a community-based sample free from clinical referral bias...
  28. pmc Clusters of Insomnia Disorder: An Exploratory Cluster Analysis of Objective Sleep Parameters Reveals Differences in Neurocognitive Functioning, Quantitative EEG, and Heart Rate Variability
    Christopher B Miller
    CIRUS, Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research, University of Sydney, Australia
    Sleep 39:1993-2004. 2016
    ..We hypothesized that clusters would differ on neurocognitive performance, sleep-onset measures of quantitative (q)-EEG and heart rate variability (HRV)...
  29. doi An automated algorithm to identify and reject artefacts for quantitative EEG analysis during sleep in patients with sleep-disordered breathing
    Angela L D'Rozario
    Sleep and Circadian Research Group, Woolcock Institute of Medical Research and NHMRC Centre for Integrated Research and Understanding of Sleep CIRUS, The University of Sydney, Sydney, NSW, Australia
    Sleep Breath 19:607-15. 2015
    ....
  30. doi Comparing the effect of hypercapnia and hypoxia on the electroencephalogram during wakefulness
    David Wang
    Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Sydney, Australia Woolcock Institute of Medical Research, University of Sydney, Australia Electronic address
    Clin Neurophysiol 126:103-9. 2015
    ..Hypoxia has been postulated as a key mechanism for neurocognitive impairment in sleep-disordered breathing. However, the effect of hypoxia on the electroencephalogram (EEG) is not clear...
  31. pmc Hypercapnia is a key correlate of EEG activation and daytime sleepiness in hypercapnic sleep disordered breathing patients
    David Wang
    Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Sydney, Australia work performed Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia
    J Clin Sleep Med 10:517-22. 2014
    ..To overcome this limitation, we studied predominantly hypercapnic SDB patients to investigate the role of hypercapnia on EEG activation and daytime sleepiness...
  32. pmc Detecting insomnia in patients with low back pain: accuracy of four self-report sleep measures
    Saad M Alsaadi
    The George Institute for Global Health, Sydney Medical School, University of Sydney, Missenden Road, P O Box M201, Sydney, New South Wales, Australia
    BMC Musculoskelet Disord 14:196. 2013
    ..The study also aimed to determine the clinical optimal cut-off scores of the questionnaires to detect insomnia in the LBP population...
  33. doi The effects of a single mild dose of morphine on chemoreflexes and breathing in obstructive sleep apnea
    David Wang
    Woolcock Institute of Medical Research, University of Sydney, Glebe Point Rd, Glebe, NSW 2037, Australia
    Respir Physiol Neurobiol 185:526-32. 2013
    ..There is a large inter-individual variability in the responses, which may relate to individual morphine metabolism...
  34. doi Sleep-deprived young drivers and the risk for crash: the DRIVE prospective cohort study
    Alexandra L C Martiniuk
    The George Institute for Global Health, University of Sydney, Sydney, NSW, Australia
    JAMA Pediatr 167:647-55. 2013
    ..Short sleep duration is common in adolescents and young adults, and short sleep duration is a risk factor for motor vehicle crash...
  35. ncbi Effects of 8 weeks of continuous positive airway pressure on abdominal adiposity in obstructive sleep apnoea
    Sheila Sivam
    Sleep and Circadian Research Group, Woolcock Institute of Medical Research, PO Box M77, Missenden Road, NSW 2050, Australia
    Eur Respir J 40:913-8. 2012
    ..Longer duration of CPAP use may be necessary to demonstrate a difference...
  36. doi Effects of testosterone therapy on sleep and breathing in obese men with severe obstructive sleep apnoea: a randomized placebo-controlled trial
    Camilla M Hoyos
    Endocrine and Cardiometabolic Research Group, NHMRC Centre for Integrated Research and Understanding of Sleep CIRUS, Woolcock Institute of Medical Research, University of Sydney, Sydney, NSW, Australia
    Clin Endocrinol (Oxf) 77:599-607. 2012
    ..We assessed sleep and breathing effects of near-conventional testosterone treatment as an adjunct to weight loss in obese men with severe OSA...
  37. doi The effect of continuous positive airway pressure usage on sleepiness in obstructive sleep apnoea: real effects or expectation of benefit?
    Megan R Crawford
    NHMRC Centre for Integrated Research and Understanding of Sleep, Woolcock Institute of Medical Research, Sydney Medical School, University of Sydney, Sydney, Australia
    Thorax 67:920-4. 2012
    ..However, these open-label studies have not controlled for patient expectation of benefit derived from their knowledge of hours of device use...
  38. doi Residual sleep-disordered breathing during autotitrating continuous positive airway pressure therapy
    Angela L Denotti
    Woolcock Institute of Medical Research, PO Box M77, Missenden Road, Sydney 2050, NSW, Australia
    Eur Respir J 39:1391-7. 2012
    ..In some patients, autoCPAP fails to detect and/or respond to sleep apnoea. Clinicians should consider limitations of each device and use caution when using autoCPAP report statistics to verify effective treatment...
  39. ncbi Effects of short-term CPAP withdrawal on neurobehavioral performance in patients with obstructive sleep apnea
    Qiao Yang
    Sleep and Circadian Research Group, Woolcock Institute of Medical Research, University of Sydney Australia, Sydney, Australia
    Sleep 29:545-52. 2006
    ....
  40. pmc Prevalence of treatment choices for snoring and sleep apnea in an Australian population
    Nathaniel S Marshall
    Woolcock Institute of Medical Research, University of Sydney, NSW, Australia
    J Clin Sleep Med 3:695-9. 2007
    ..To assess the prevalence of treatment and diagnosis of snoring and sleep apnea in the population of New South Wales Australia...
  41. doi Continuous positive airway pressure reduces postprandial lipidemia in obstructive sleep apnea: a randomized, placebo-controlled crossover trial
    Craig L Phillips
    Sleep and Circadian Research Group, Woolcock Institute of Medical Research, Sydney, New South Wales, Australia
    Am J Respir Crit Care Med 184:355-61. 2011
    ..Dyslipidemia is common in Obstructive Sleep Apnea (OSA). Postprandial lipidemia (PPL) is a strong marker of cardiovascular risk. Evidence that OSA treatment improves PPL is lacking...
  42. pmc The validity of wrist actimetry assessment of sleep with and without sleep apnea
    David Wang
    Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia
    J Clin Sleep Med 4:450-5. 2008
    ..We compared polysomnography (PSG) with actimetric assessment of sleep on an epoch-by-epoch basis in subjects with and without OSA...
  43. pmc A randomized crossover trial of the effect of a novel method of pressure control (SensAwake) in automatic continuous positive airway pressure therapy to treat sleep disordered breathing
    George C Dungan
    Woolcock Institute of Medical Research, Sydney Medical School, University of Sydney, Australia
    J Clin Sleep Med 7:261-7. 2011
    ..To study the acute effect of the new SensAwake CPAP modality (reducing pressure on awakenings) on wake after sleep onset (WASO) and other polysomnographic measures in patients with obstructive sleep apnea (OSA)...
  44. pmc Modafinil Increases Awake EEG Activation and Improves Performance in Obstructive Sleep Apnea during Continuous Positive Airway Pressure Withdrawal
    David Wang
    Sleep and Circadian Group, Woolcock Institute of Medical Research, University of Sydney, Australia
    Sleep 38:1297-303. 2015
    ....
  45. doi Ethics, consent and blinding: lessons from a placebo/sham controlled CPAP crossover trial
    Yasaman Djavadkhani
    NHMRC Centre for Integrated Research and Understanding of Sleep CIRUS, Woolcock Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia
    Thorax 70:265-9. 2015
    ..We assessed rates of staff unblinding, the likelihood of patient unblinding and obtained patient perceptions on lack of full disclosure...
  46. pmc Sleep habits, insomnia, and daytime sleepiness in a large and healthy community-based sample of New Zealanders
    Bradley R Wilsmore
    Sleep and Circadian Research Group, Woolcock Institute of Medical Research, Royal Prince Alfred Hospital, University of Sydney, NSW 2006, Australia
    J Clin Sleep Med 9:559-66. 2013
    ..To determine the relationship between sleep complaints, primary insomnia, excessive daytime sleepiness, and lifestyle factors in a large community-based sample...
  47. ncbi Ethnicity and obstructive sleep apnoea
    Anna Tessa C Villaneuva
    Sleep Research Group, Woolcock Institute of Medical Research, University of Sydney, Australia
    Sleep Med Rev 9:419-36. 2005
    ..The limited number of studies with inter-ethnic comparative data suggest cephalometric variables and their degree of contribution to OSA vary across ethnic groups...
  48. pmc Craniofacial phenotyping in obstructive sleep apnea--a novel quantitative photographic approach
    Richard W W Lee
    Centre for Sleep Health and Research, Department ofRespiratory Medicine, Royal North Shore Hospital, NSW, Australia
    Sleep 32:37-45. 2009
    ..To compare the craniofacial morphological phenotype of subjects with and without obstructive sleep apnea (OSA) using a quantitative photographic analysis technique...
  49. ncbi Diagnostic test evaluation of a nasal flow monitor for obstructive sleep apnea detection in sleep apnea research
    Keith K H Wong
    University of Sydney, Sydney, New South Wales, Australia
    Behav Res Methods 40:360-6. 2008
    ..85. With knowledge of appropriate thresholds and the pretest risk of OSA, the flow monitor can be used to detect or exclude OSA for sleep-related research, as well as to identify severe cases needing priority for further evaluation...
  50. ncbi Electroencephalographic arousals during sleep do not alter the pressor response to Cheyne-Stokes respiration in subjects with chronic heart failure
    Grant N Willson
    Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Missenden Road, Camperdown, Sydney, NSW 2050, Australia
    J Sleep Res 16:421-7. 2007
    ..44, P = 0.22]. This study showed that EEG-defined arousal does not amplify the pressor response to CSR in CHF...
  51. doi Chronotherapy for hypertension in obstructive sleep apnoea (CHOSA): a randomised, double-blind, placebo-controlled crossover trial
    Yasmina Serinel
    NHMRC Centre for Integrated Research and Understanding of Sleep CIRUS, and NHMRC Neurosleep Centre Woolcock Institute of Medical Research, The University of Sydney, Sydney, New South Wales, Australia
    Thorax . 2016
    ..We evaluated the efficacy of this technique in patients with OSA with stage I/II hypertension, both before and after the addition of CPAP...
  52. pmc Maxillomandibular Volume Influences the Relationship between Weight Loss and Improvement in Obstructive Sleep Apnea
    Kate Sutherland
    Centre for Sleep Health and Research, Department of Respiratory Medicine, Royal North Shore Hospital, Sydney, Sydney Medical School, University of Sydney, Sydney, Australia
    Sleep 39:43-9. 2016
    ..Obesity is the major risk factor for OSA; however, weight loss reduces OSA to a variable extent. We aimed to assess whether size of the maxillomandibular skeletal enclosure influences the relationship between weight loss and OSA reduction...
  53. doi Treatment of Sleep Apnea With CPAP Lowers Central and Peripheral Blood Pressure Independent of the Time-of-Day: A Randomized Controlled Study
    Camilla M Hoyos
    Sleep and Circadian Group, Centre for Integrated Research and Understanding of Sleep, Woolcock Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia Discipline of Sleep Medicine, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia
    Am J Hypertens 28:1222-8. 2015
    ..Currently, it is unclear whether the reduction in blood pressure with CPAP is similar between central and peripheral sites. It is also unknown whether there are any time-of-day influences on central blood pressure changes after CPAP...
  54. doi Effects of 8 weeks of CPAP on lipid-based oxidative markers in obstructive sleep apnea: a randomized trial
    Sheila Sivam
    Sleep and Circadian Research Group, Woolcock Institute of Medical Research, University of Sydney, Sydney, NSW, Australia
    J Sleep Res 24:339-45. 2015
    ..5 nm, P > 0.05; and lipid-soluble antioxidant vitamin E 0.03 μm, P > 0.05]. In this study, accumulating CE-O(O)H, a marker of lipid oxidation, does not appear to play a role in oxidative stress in obstructive sleep apnea...
  55. doi Does obstructive sleep apnea cause endothelial dysfunction? A critical review of the literature
    Camilla M Hoyos
    NHMRC Centre for Integrated Research and Understanding of Sleep CIRUS, Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia Electronic address
    Sleep Med Rev 20:15-26. 2015
    ..This review aims to provide a critical appraisal of the cross-sectional and interventional studies which have investigated micro- and macro-vascular endothelial dysfunction in OSA with emphasis on randomised controlled studies. ..
  56. doi To ED or not to ED--is erectile dysfunction in obstructive sleep apnea related to endothelial dysfunction?
    Camilla M Hoyos
    NHMRC Centre for Integrated Research and Understanding of Sleep CIRUS, Woolcock Institute of Medical Research, Sydney Medical School, University of Sydney, Sydney, Australia Electronic address
    Sleep Med Rev 20:5-14. 2015
    ..In both ErectD and OSA clinics, identifying both conditions could improve overall cardiovascular risk stratification whilst treatment of OSA could reduce both ErectD and cardiovascular risk. ..
  57. pmc Sleep apnea and 20-year follow-up for all-cause mortality, stroke, and cancer incidence and mortality in the Busselton Health Study cohort
    Nathaniel S Marshall
    NHMRC Centre for Integrated Research and Understanding of Sleep CIRUS, Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia Sydney Nursing School, University of Sydney, Sydney, Australia
    J Clin Sleep Med 10:355-62. 2014
    ..To ascertain whether objectively measured obstructive sleep apnea (OSA) independently increases the risk of all cause death, cardiovascular disease (CVD), coronary heart disease (CHD), stroke or cancer...
  58. pmc Assessing sleepiness and sleep disorders in Australian long-distance commercial vehicle drivers: self-report versus an "at home" monitoring device
    Lisa N Sharwood
    The George Institute for Global Health, Sydney, Australia
    Sleep 35:469-75. 2012
    ..This study aimed to determine the relationship between subjective versus objective assessment of OSA in CMV drivers...
  59. doi Is sleep duration related to obesity? A critical review of the epidemiological evidence
    Nathaniel S Marshall
    Sleep and Circadian Group, Woolcock Institute of Medical Research, University of Sydney, Australia
    Sleep Med Rev 12:289-98. 2008
    ....
  60. ncbi The utility of the AusEd driving simulator in the clinical assessment of driver fatigue
    Anup V Desai
    Woolcock Institute of Medical Research, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia
    Behav Res Methods 39:673-81. 2007
    ..However, more research is still needed to correlate laboratory based simulator performance with real world driving performance and outcomes...
  61. ncbi A systematic review of the neurobehavioural and physiological effects of shiftwork systems
    Timothy R Driscoll
    School of Public Health, University of Sydney NSW 2006, Australia
    Sleep Med Rev 11:179-94. 2007
    ..There are many unanswered questions in shift design. For these questions to be answered, it is important that the methodological shortcomings present in most of the studies published to date be overcome...
  62. ncbi Medical devices for the diagnosis and treatment of obstructive sleep apnea
    Peter A Cistulli
    Royal North Shore Hospital, Department of Respiratory Medicine, St Leonards, NSW 2065, Australia
    Expert Rev Med Devices 2:749-63. 2005
    ..Advances in our understanding of the neurobiology of sleep and respiration herald the prospect of pharmacologic treatment in the longer term...
  63. ncbi The effect of infective exacerbations on sleep and neurobehavioral function in cystic fibrosis
    Catherine J Dobbin
    Department of Respiratory Medicine, E 11 West, Royal Prince Alfred Hospital, Missenden Road, Sydney, NSW 2050, Australia
    Am J Respir Crit Care Med 172:99-104. 2005
    ..Adults with cystic fibrosis (CF) are susceptible to hypoxemia, hypercapnia, arousal from sleep, and neurobehavioral impairment...
  64. ncbi Sequential use of oxygen and bi-level ventilation for respiratory failure in cystic fibrosis
    Catherine J Dobbin
    Department of Respiratory Medicine, E 11 West, Royal Prince Alfred Hospital, Missenden Road, NSW 2050, Australia
    J Cyst Fibros 3:237-42. 2004
    ..Supplemental nocturnal oxygen is widely used for hypoxaemic respiratory failure in adults with CF...
  65. pmc Subjective daytime sleepiness and daytime function in patients on stable methadone maintenance treatment: possible mechanisms
    David Wang
    Department of Respiratory and Sleep Disorders Medicine, Western Hospital, Department of Medicine RMH and WH, The University of Melbourne, Melbourne, Australia
    J Clin Sleep Med 4:557-62. 2008
    ....
  66. ncbi Sleep disordered breathing in cystic fibrosis
    Maree A Milross
    Department of Respiratory Medicine, Royal Prince Alfred Hospital, Camperdown, Sydney NSW, Australia
    Sleep Med Rev 8:295-308. 2004
    ..Most importantly, we review what is needed from future research in this challenging area of care in patients with CF...
  67. pmc Adolescent sleep patterns and night-time technology use: results of the Australian Broadcasting Corporation's Big Sleep Survey
    Amanda L Gamble
    NHMRC Centre for Integrated Research and Understanding of Sleep CIRUS, The University of Sydney, Sydney, NSW, Australia
    PLoS ONE 9:e111700. 2014
    ..This study investigated whether there is a dose-response relationship between use of electronic devices (computers, cellphones, televisions and radios) in bed prior to sleep and adolescent sleep patterns...
  68. doi Drug effects on ventilatory control and upper airway physiology related to sleep apnea
    David Wang
    Woolcock Institute of Medical Research, University of Sydney, Glebe Point Road, Glebe, 2037 NSW, Australia Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2050, Australia Electronic address
    Respir Physiol Neurobiol 188:257-66. 2013
    ..Practical ways to assess an individual's ventilatory control and how it interacts with upper airway physiology is required for future targeted pharmacotherapy in sleep apnea. ..
  69. doi Effects of continuous positive airway pressure on coagulability in obstructive sleep apnoea: a randomised, placebo-controlled crossover study
    Craig L Phillips
    Department of Respiratory and Sleep Medicine, Royal North Shore Hospital, St Leonards, New South Wales, Australia
    Thorax 67:639-44. 2012
    ..Obstructive sleep apnoea (OSA) is associated with increased cardiovascular risk, however the mechanisms are not well established...
  70. doi Spontaneous adverse event reports associated with zolpidem in Australia 2001-2008
    Monsif Ben-Hamou
    Faculty of Pharmacy, University of Sydney, Australia
    J Sleep Res 20:559-68. 2011
    ..However, the extant literature and the limitations of these spontaneously reported adverse drug reaction data do not allow us to conclude that these events are related causally to zolpidem...
  71. ncbi Treatment of obesity hypoventilation syndrome and serum leptin
    Brendon J Yee
    Sleep Research Group, Woolcock Institute of Medical Research, Royal Prince Alfred Hospital, Camperdown, Sydney, Australia
    Respiration 73:209-12. 2006
    ..This suggests that central leptin resistance may promote the development of OHS in humans. We speculated that the reversal of OHS by regular non-invasive ventilation (NIV) therapy decreases leptin levels...
  72. doi Patent foramen ovale and obstructive sleep apnea: a new association?
    Edmund M T Lau
    Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Camperdown NSW 2050, Australia
    Sleep Med Rev 14:391-5. 2010
    ..We will review the current state of knowledge in the relationship between PFO and OSA, with emphasis on the pathophysiological interactions and clinical implications of this association...
  73. ncbi Association between ventilatory response to hypercapnia and obstructive sleep apnea-hypopnea index in asymptomatic subjects
    David Wang
    Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia
    Sleep Breath 11:103-8. 2007
    ..The mechanism can be applied to asymptomatic subjects with even minimal sleep-disordered breathing...
  74. ncbi Increased adherence to CPAP with a group cognitive behavioral treatment intervention: a randomized trial
    Dianne Richards
    Royal North Shore Hospital, St Leonards, Sydney, Australia
    Sleep 30:635-40. 2007
    ..To improve adherence to continuous positive airway pressure (CPAP) treatment in participants with obstructive sleep apnea (OSA) using a cognitive behavioral therapy (CBT) intervention...
  75. pmc Polysomnography in Australia--trends in provision
    Nathaniel S Marshall
    Woolcock Institute of Medical Research, University of Sydney, NSW, Australia
    J Clin Sleep Med 3:281-4. 2007
    ..To describe the growth in the use of state-funded (Medicare) polysomnography (PSG) in Australia since 1990 and to compare PSG growth to other common diagnostic procedures and growth in total Medicare payments...
  76. doi Big breathing: the complex interaction of obesity, hypoventilation, weight loss, and respiratory function
    Amanda J Piper
    Sleep Unit, Level 11, E Block, Royal Prince Alfred Hospital, Missenden Rd, Camperdown, NSW 2050, Australia
    J Appl Physiol (1985) 108:199-205. 2010
    ..Attention to this residual abnormality is important given the high incidence of cardiovascular abnormalities, including pulmonary hypertension, in individuals with OHS...
  77. doi Obesity hypoventilation syndrome: mechanisms and management
    Amanda J Piper
    Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
    Am J Respir Crit Care Med 183:292-8. 2011
    ..The review outlines the major mechanisms believed to underlie the development of hypoventilation in this subgroup of obese patients, their clinical presentation, and current therapy options...
  78. ncbi Management of acute hypoxemia during flexible bronchoscopy with insertion of a nasopharyngeal tube in lung transplant recipients
    Prashant N Chhajed
    Heart Lung Transplant Unit, St Vincent s Hospital, Darlinghurst, Sydney, Australia
    Chest 121:1350-4. 2002
    ....
  79. ncbi Fatal distraction: a case series of fatal fall-asleep road accidents and their medicolegal outcomes
    Anup V Desai
    Sleep Research Group, Woolcock Institute of Medical Research, Sydney, NSW, Australia
    Med J Aust 178:396-9. 2003
    ..More research is needed to understand the relation between sleep disorders and awareness of sleepiness. Medical practitioners need to be aware of current advice and guidelines with respect to obstructive sleep apnoea and driving...
  80. ncbi Current perspectives on the obesity hypoventilation syndrome
    Amanda J Piper
    Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Camperdown, and Sleep and Circadian Group, Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia
    Curr Opin Pulm Med 13:490-6. 2007
    ..This implies that complex interplay between a number of known and unknown mechanisms is needed to produce daytime respiratory failure in this patient population...
  81. ncbi Brain function in obstructive sleep apnea: results from the Brain Resource International Database
    Keith K H Wong
    Sleep and Circadian Group, Woolcock Institute of Medical Research, University of Sydney, Camperdown, NSW 2050, Australia
    J Integr Neurosci 5:111-21. 2006
    ..We have demonstrated that a diagnostic algorithm based on apnea symptoms and demographic factors can be used to select a group with likely OSA manifesting deficits in information processing and executive function...
  82. ncbi 24/7 Health. Second annual Sleep Loss Symposium: working and sleeping around the clock
    Naomi L Rogers
    Sleep and Circadian Research Group, Woolcock Institute of Medical Research, University of Sydney, and Royal Prince Alfred Hospital, Sydney, NSW, Australia
    Med J Aust 182:444-5. 2005
  83. pmc Assessment and management of patients with obesity hypoventilation syndrome
    Babak Mokhlesi
    Section of Pulmonary and Critical Care Medicine, and Sleep Disorders Center, University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA
    Proc Am Thorac Soc 5:218-25. 2008
    ..In this review we define the clinical characteristics of the syndrome and review the pathophysiology, morbidity, and mortality associated with it. Last, we discuss currently available treatment modalities...
  84. doi Sleep-disordered breathing before and after lung transplantation
    Monique A Malouf
    Lung Transplant Unit, St Vincent s Hospital, Darlinghurst, Australia
    J Heart Lung Transplant 27:540-6. 2008
    ..We sought to determine the prevalence and impact of SDB before and after lung transplantation...
  85. ncbi Sleepiness, sleep-disordered breathing, and accident risk factors in commercial vehicle drivers
    Mark E Howard
    Institute of Breathing and Sleep, Bowen Centre, Austin Health and University of Melbourne, Heidelberg, Victoria, Australia
    Am J Respir Crit Care Med 170:1014-21. 2004
    ..44, p = 0.04). Chronic excessive sleepiness and sleep-disordered breathing are common in Australian commercial vehicle drivers. Accident risk was related to increasing chronic sleepiness and antihistamine and narcotic analgesic use...
  86. pmc Two randomized placebo-controlled trials to evaluate the efficacy and tolerability of mirtazapine for the treatment of obstructive sleep apnea
    Nathaniel S Marshall
    NHMRC Centre for Sleep Medicine, Woolcock Institute of Medical Research, University of Sydney, NSW Australia
    Sleep 31:824-31. 2008
    ..5 and 15 mg. We aimed to confirm and extend these findings in 2 randomized placebo-controlled, proof-of-concept trials...
  87. ncbi Obesity hypoventilation syndrome: hypoxemia during continuous positive airway pressure
    Dev Banerjee
    Sleep and Ventilation Unit, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham, B9 5SS, UK
    Chest 131:1678-84. 2007
    ....
  88. ncbi The short-term effects of high-dose testosterone on sleep, breathing, and function in older men
    Peter Y Liu
    Department of Andrology, ANZAC Research Institute and Concord Hospital, University of Sydney, Sydney, 2139 Australia
    J Clin Endocrinol Metab 88:3605-13. 2003
    ..These changes did not appear to be due to upper airway narrowing. Further study of longer-term lower-dose androgen therapy on sleep and breathing is needed to evaluate its safety in older men...
  89. pmc Adherence to continuous positive airway pressure therapy: the challenge to effective treatment
    Terri E Weaver
    Division of Biobehavioral and Health Sciences, School of Nursing, University of Pennsylvania, Philadelphia, PA 19104 6096, USA
    Proc Am Thorac Soc 5:173-8. 2008
    ..Emerging data suggest that various behavioral interventions may be effective in improving CPAP adherence...
  90. pmc Predictive value of Kushida index and acoustic pharyngometry for the evaluation of upper airway in subjects with or without obstructive sleep apnea
    Dae Gun Jung
    Department of Otolaryngology Head and Neck Surgery, St Paul Hospital, The Catholic University Medical College, Seoul, Korea
    J Korean Med Sci 19:662-7. 2004
    ..Acoustic pharyngometry can be a clinically useful tool for localizing the narrowed portion of the upper airway and predicting obstructive sleep apnea...
  91. ncbi Pharmacotherapy for excessive daytime sleepiness
    Dev Banerjee
    Sleep and Ventilation Unit, Department of Respiratory Medicine, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham B9 5SS, UK
    Sleep Med Rev 8:339-54. 2004
    ..However, until adequately powered randomised-controlled trials confirm long-term efficacy and safety, the recommendation of wakefulness promoters in healthy adults cannot be justified...
  92. ncbi Obstructive sleep apnoea--getting to the heart of the matter?
    Ronald R Grunstein
    Med J Aust 188:324-5. 2008
  93. doi Sleep apnea--past, present, future
    Ronald R Grunstein
    Sleep Med Rev 12:1-4. 2008
  94. ncbi Androgens, obesity, and sleep-disordered breathing in men
    Peter Y Liu
    Department of Andrology, ANZAC Research Institute, Concord Hospital C64, University of Sydney, Sydney NSW 2139, Australia
    Endocrinol Metab Clin North Am 36:349-63. 2007
    ..In addition, avoiding excessive weight may maintain optimal male reproductive health...