Shelley Gorman

Summary

Affiliation: University of Western Australia
Country: Australia

Publications

  1. pmc Reversible control by vitamin D of granulocytes and bacteria in the lungs of mice: an ovalbumin-induced model of allergic airway disease
    Shelley Gorman
    Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth, Australia
    PLoS ONE 8:e67823. 2013
  2. pmc Acute erythemal ultraviolet radiation causes systemic immunosuppression in the absence of increased 25-hydroxyvitamin D3 levels in male mice
    Shelley Gorman
    Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia
    PLoS ONE 7:e46006. 2012
  3. doi request reprint The current state of play of rodent models to study the role of vitamin D in UV-induced immunomodulation
    Shelley Gorman
    Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth, Australia
    Photochem Photobiol Sci 11:1788-96. 2012
  4. doi request reprint Vitamin D(3) deficiency enhances allergen-induced lymphocyte responses in a mouse model of allergic airway disease
    Shelley Gorman
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia
    Pediatr Allergy Immunol 23:83-7. 2012
  5. doi request reprint Gene regulation by 1,25-dihydroxyvitamin D3 in CD4+CD25+ cells is enabled by IL-2
    Shelley Gorman
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia
    J Invest Dermatol 130:2368-76. 2010
  6. doi request reprint Prior infection with murine cytomegalovirus (MCMV) limits the immunocontraceptive effects of an MCMV vector expressing the mouse zona-pellucida-3 protein
    Shelley Gorman
    Discipline of Microbiology and Immunology, M502, School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
    Vaccine 26:3860-9. 2008
  7. pmc 1,25-dihydroxyvitamin D3 enhances the ability of transferred CD4+ CD25+ cells to modulate T helper type 2-driven asthmatic responses
    Shelley Gorman
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia
    Immunology 130:181-92. 2010
  8. doi request reprint Immune-modifying properties of topical vitamin D: Focus on dendritic cells and T cells
    Shelley Gorman
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, West Perth, Western Australia, Australia
    J Steroid Biochem Mol Biol 121:247-9. 2010
  9. ncbi request reprint Mixed infection with multiple strains of murine cytomegalovirus occurs following simultaneous or sequential infection of immunocompetent mice
    Shelley Gorman
    Discipline of Microbiology, School of Biomedical and Chemical Sciences, M502, University of Western Australia, Crawley
    J Gen Virol 87:1123-32. 2006
  10. pmc Topical 1,25-dihydroxyvitamin D3 subverts the priming ability of draining lymph node dendritic cells
    Shelley Gorman
    Telethon Institute for Child Health Research, University of Western Australia, Perth, Western Australia, Australia
    Immunology 131:415-25. 2010

Collaborators

Detail Information

Publications35

  1. pmc Reversible control by vitamin D of granulocytes and bacteria in the lungs of mice: an ovalbumin-induced model of allergic airway disease
    Shelley Gorman
    Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth, Australia
    PLoS ONE 8:e67823. 2013
    ....
  2. pmc Acute erythemal ultraviolet radiation causes systemic immunosuppression in the absence of increased 25-hydroxyvitamin D3 levels in male mice
    Shelley Gorman
    Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia
    PLoS ONE 7:e46006. 2012
    ..Thus, in male mice, UVR-induced 25(OH)D(3) is not essential for mediating the immunosuppressive effects of erythemal UVR...
  3. doi request reprint The current state of play of rodent models to study the role of vitamin D in UV-induced immunomodulation
    Shelley Gorman
    Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth, Australia
    Photochem Photobiol Sci 11:1788-96. 2012
    ..We end with discussion of the epigenetic effects of vitamin D and UVR for immunosuppression...
  4. doi request reprint Vitamin D(3) deficiency enhances allergen-induced lymphocyte responses in a mouse model of allergic airway disease
    Shelley Gorman
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia
    Pediatr Allergy Immunol 23:83-7. 2012
    ..These results suggest that vitamin D(3) deficiency modulates the capacity of lymphocytes to respond to allergens...
  5. doi request reprint Gene regulation by 1,25-dihydroxyvitamin D3 in CD4+CD25+ cells is enabled by IL-2
    Shelley Gorman
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia
    J Invest Dermatol 130:2368-76. 2010
    ..Therefore, 1,25(OH)(2)D(3) enabled by IL-2 can directly enhance the regulatory potential of CD4+CD25+ T cells to control immune disease...
  6. doi request reprint Prior infection with murine cytomegalovirus (MCMV) limits the immunocontraceptive effects of an MCMV vector expressing the mouse zona-pellucida-3 protein
    Shelley Gorman
    Discipline of Microbiology and Immunology, M502, School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
    Vaccine 26:3860-9. 2008
    ..Given that mixed infection of mice with MCMV is common, it is possible that prior immunity acquired by natural mucosal infection may have less a less inhibitory effect on the immunocontraceptive outcome...
  7. pmc 1,25-dihydroxyvitamin D3 enhances the ability of transferred CD4+ CD25+ cells to modulate T helper type 2-driven asthmatic responses
    Shelley Gorman
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia
    Immunology 130:181-92. 2010
    ..This work highlights how local 1,25(OH)(2)D(3) production by lung epithelial cells may modulate the suppressive activity of local regulatory T cells...
  8. doi request reprint Immune-modifying properties of topical vitamin D: Focus on dendritic cells and T cells
    Shelley Gorman
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, West Perth, Western Australia, Australia
    J Steroid Biochem Mol Biol 121:247-9. 2010
    ..Finally, topical 1,25(OH)2D3 also enhanced the number and suppressive activity of CD4+CD25+ regulatory T cells in the lymphatic tissue draining skin...
  9. ncbi request reprint Mixed infection with multiple strains of murine cytomegalovirus occurs following simultaneous or sequential infection of immunocompetent mice
    Shelley Gorman
    Discipline of Microbiology, School of Biomedical and Chemical Sciences, M502, University of Western Australia, Crawley
    J Gen Virol 87:1123-32. 2006
    ..2 % of trapped mice. The observations that mixed infections are common in free-living M. domesticus and are acquired by immunocompetent mice through simultaneous or successive infections are important for vaccine development...
  10. pmc Topical 1,25-dihydroxyvitamin D3 subverts the priming ability of draining lymph node dendritic cells
    Shelley Gorman
    Telethon Institute for Child Health Research, University of Western Australia, Perth, Western Australia, Australia
    Immunology 131:415-25. 2010
    ....
  11. doi request reprint Toward homeostasis: regulatory dendritic cells from the bone marrow of mice with inflammation of the airways and peritoneal cavity
    Naomi M Scott
    Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth, Australia
    Am J Pathol 181:535-47. 2012
    ..Our study represents an important homeostatic process with potential for therapeutic use in the future...
  12. pmc Characterization of regulatory dendritic cells differentiated from the bone marrow of UV-irradiated mice
    Royce L X Ng
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, WA, Australia
    Immunology 140:399-412. 2013
    ..In summary, UV-BMDCs do not express the classical phenotypic or gene expression properties of DCs reported by others as 'regulatory' or 'tolerogenic'...
  13. doi request reprint Altered immunity and dendritic cell activity in the periphery of mice after long-term engraftment with bone marrow from ultraviolet-irradiated mice
    Royce L X Ng
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth 6008, Western Australia, Australia
    J Immunol 190:5471-84. 2013
    ..Erythemal UVR may imprint a long-lasting epigenetic effect on DC progenitors in the BM and alter the function of their terminally differentiated progeny...
  14. ncbi request reprint CD4+ T cells in lymph nodes of UVB-irradiated mice suppress immune responses to new antigens both in vitro and in vivo
    Shelley Gorman
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia
    J Invest Dermatol 127:915-24. 2007
    ..The potential of these regulatory cells poised to regulate responses to incoming antigens at distant non-irradiated sites broadens the biological impact of UVB irradiation of skin on immunity...
  15. ncbi request reprint Topically applied 1,25-dihydroxyvitamin D3 enhances the suppressive activity of CD4+CD25+ cells in the draining lymph nodes
    Shelley Gorman
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Australia
    J Immunol 179:6273-83. 2007
    ..These studies suggest that 1,25(OH)(2)D(3) may be an important mediator by which UVB-irradiation exerts some of its immunomodulatory effects...
  16. doi request reprint Differences in control by UV radiation of inflammatory airways disease in naïve and allergen pre-sensitised mice
    Naomi M Scott
    Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, West Perth, Australia
    Photochem Photobiol Sci 10:1894-901. 2011
    ..The second, associated with administration to pre-sensitised mice, is weaker and is detected when the mice are sensitised with lower levels of allergen and adjuvant...
  17. ncbi request reprint Primary defect in UVB-induced systemic immunomodulation does not relate to immature or functionally impaired APCs in regional lymph nodes
    Shelley Gorman
    Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth
    J Immunol 174:6677-85. 2005
    ....
  18. doi request reprint UV exposure and protection against allergic airways disease
    Shelley Gorman
    Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, PO Box 855, West Perth, Western Australia, Australia 6872
    Photochem Photobiol Sci 9:571-7. 2010
    ..This review gives some scientific understanding to century-old anecdotal reports that beach and mountain resort holidays associated with increased UV exposure are beneficial in asthma treatment...
  19. ncbi request reprint Effect of both ultraviolet B irradiation and histamine receptor function on allergic responses to an inhaled antigen
    Jacqueline P McGlade
    Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, West Perth, WA, Australia
    J Immunol 178:2794-802. 2007
    ....
  20. doi request reprint Modulation of the immune system by UV radiation: more than just the effects of vitamin D?
    Prue H Hart
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, PO Box 855, Perth, Western Australia 6872, Australia
    Nat Rev Immunol 11:584-96. 2011
    ..Here, we compare and contrast the effects of UV radiation and vitamin D on immune function in immunopathological diseases, such as psoriasis, multiple sclerosis and asthma, and during infection...
  21. doi request reprint Ultraviolet irradiation of mice reduces the competency of bone marrow-derived CD11c+ cells via an indomethacin-inhibitable pathway
    Royce L X Ng
    Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth, Australia
    J Immunol 185:7207-15. 2010
    ..These results show that UV irradiation of mice can affect the function of bone marrow-derived CD11c(+) cells via a mechanism inhibitable by indomethacin; this pathway is likely to contribute to systemic UV-induced immunosuppression...
  22. pmc Dietary Vitamin D Increases Percentages and Function of Regulatory T Cells in the Skin-Draining Lymph Nodes and Suppresses Dermal Inflammation
    Shelley Gorman
    Telethon Kids Institute, University of Western Australia, Perth, WA, Australia
    J Immunol Res 2016:1426503. 2016
    ..These data suggest that dietary vitamin D3 increased the percentages and suppressive activity of TReg cells in the SDLN, which are poised to suppress dermal inflammation...
  23. pmc Vitamin D deficiency causes airway hyperresponsiveness, increases airway smooth muscle mass, and reduces TGF-β expression in the lungs of female BALB/c mice
    Rachel E Foong
    Telethon Institute for Child Health Research, The University of Western Australia, Subiaco, Western Australia, Australia
    Physiol Rep 2:e00276. 2014
    ..This study provides a link between vitamin D deficiency and respiratory symptoms in chronic lung disease. ..
  24. doi request reprint Identification of genes differentially regulated by vitamin D deficiency that alter lung pathophysiology and inflammation in allergic airways disease
    Rachel E Foong
    Telethon Kids Institute, The University of Western Australia, Perth, Western Australia, Australia
    Am J Physiol Lung Cell Mol Physiol 311:L653-63. 2016
    ..Differential regulation of these genes by vitamin D deficiency could determine lung inflammation and pathophysiology and suggest that the effect of vitamin D deficiency on HDM-induced allergic airways disease is complex. ..
  25. doi request reprint Low maternal serum vitamin D during pregnancy and the risk for postpartum depression symptoms
    Monique Robinson
    Telethon Kids Institute, The University of Western Australia, PO Box 855, West Perth, Perth, WA, 6872, Australia
    Arch Womens Ment Health 17:213-9. 2014
    ..Low vitamin D during pregnancy is a risk factor for the development of postpartum depression symptoms. ..
  26. pmc A pathogenic role for the integrin CD103 in experimental allergic airways disease
    Vanessa S Fear
    Telethon Kids Institute, Perth, Australia
    Physiol Rep 4:. 2016
    ..These data support a role for CD103 in the pathogenesis of EAAD in BALB/c mice through local control of CD4+ T cell and DC subset recruitment to, and migration from, the airway mucosa during induction of allergic inflammation...
  27. doi request reprint Reduced immune responses in chimeric mice engrafted with bone marrow cells from mice with airways inflammation
    Naomi M Scott
    Telethon Kids Institute, University of Western Australia, PO Box 855, West Perth, WA, 6872, Australia
    Inflamm Res 64:861-73. 2015
    ..Using chimeric mice, the outcomes of airways inflammation on bone marrow progenitor cells were studied...
  28. doi request reprint The effects of in utero vitamin D deficiency on airway smooth muscle mass and lung function
    Rachel E Foong
    1 Telethon Kids Institute, The University of Western Australia, Perth, Western Australia, Australia and
    Am J Respir Cell Mol Biol 53:664-75. 2015
    ..These observations suggest that in utero vitamin D deficiency can alter lung structure and function and increase inflammation, contributing to symptoms in chronic diseases, such as asthma. ..
  29. doi request reprint Vitamin D deficiency causes deficits in lung function and alters lung structure
    Graeme R Zosky
    Telethon Institute for Child Health Research, Subiaco, Western Australia, Australia
    Am J Respir Crit Care Med 183:1336-43. 2011
    ..Thus, causal data confirming a relationship between vitamin D and lung function are lacking...
  30. pmc Sun Exposure and Its Effects on Human Health: Mechanisms through Which Sun Exposure Could Reduce the Risk of Developing Obesity and Cardiometabolic Dysfunction
    Naomi Fleury
    Telethon Kids Institute, University of Western Australia, P O Box 855, Perth 6872, Australia
    Int J Environ Res Public Health 13:. 2016
    ..In this review, we detail the evidence around the cardiometabolic protective effects of UVR and suggest mechanistic pathways through which UVR could be beneficial...
  31. doi request reprint Ultraviolet radiation, vitamin D and the development of obesity, metabolic syndrome and type-2 diabetes
    Shelley Gorman
    Telethon Kids Institute, University of Western Australia, Perth, Western Australia
    Photochem Photobiol Sci . 2016
    ....
  32. pmc Can skin exposure to sunlight prevent liver inflammation?
    Shelley Gorman
    Telethon Kids Institute, University of Western Australia, 100 Roberts Rd, Subiaco, Western Australia 6008, Australia
    Nutrients 7:3219-39. 2015
    ..While there has been a focus on vitamin D, other mediators induced by sun exposure, such as nitric oxide may also play important roles in curtailing liver inflammation. ..
  33. doi request reprint Ultraviolet radiation suppresses obesity and symptoms of metabolic syndrome independently of vitamin D in mice fed a high-fat diet
    Sian Geldenhuys
    Telethon Kids Institute, The University of Western Australia, Perth, Western Australia, Australia
    Diabetes 63:3759-69. 2014
    ....
  34. pmc Response to the Boucher et al. Comments on Fleury et al. Sun Exposure and Its Effects on Human Health: Mechanisms through Which Sun Exposure Could Reduce the Risk of Developing Obesity and Cardiometabolic Dysfunction. Int. J. Environ. Res. Public Health 2
    Naomi Fleury
    Telethon Kids Institute, University of Western Australia, P O Box 855, Perth 6872, Australia
    Int J Environ Res Public Health 13:. 2016
    ..We thank Boucher et al. [1] for their interest in our recently published review [2]. [...]...
  35. pmc Exposure to UV Wavelengths in Sunlight Suppresses Immunity. To What Extent is UV-induced Vitamin D3 the Mediator Responsible?
    Prue H Hart
    Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, West Perth, WA 6872, Australia
    Clin Biochem Rev 34:3-13. 2013
    ..Vitamin D3 levels are a measure of past sun exposure but vitamin D3-dependent and vitamin D3-independent immunosuppressive effects of UVR may play a role in control of autoimmune diseases...