Peter G Gibson

Summary

Affiliation: University of Newcastle
Country: Australia

Publications

  1. doi request reprint Asthma in older adults
    Peter G Gibson
    School of Medicine and Public Health, Faculty of Health, University of Newcastle, Callaghan, NSW, Australia
    Lancet 376:803-13. 2010
  2. pmc Immunometabolism in obese asthmatics: are we there yet?
    Hashim A Periyalil
    Priority Research Centre for Asthma and Respiratory Diseases, Faculty of Health, University of Newcastle, Callaghan, NSW 2308, Australia
    Nutrients 5:3506-30. 2013
  3. doi request reprint Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes
    Katherine J Baines
    Priority Research Centre for Asthma and Respiratory Diseases, Hunter Medical Research Institute, University of Newcastle, New Lambton Heights, Australia Department of Respiratory and Sleep Medicine, John Hunter Hospital, New Lambton Heights, Australia Electronic address
    J Allergy Clin Immunol 133:997-1007. 2014
  4. pmc Novel immune genes associated with excessive inflammatory and antiviral responses to rhinovirus in COPD
    Katherine J Baines
    Priority Research Centre for Asthma and Respiratory Diseases, The University of Newcastle, Callaghan, NSW, Australia
    Respir Res 14:15. 2013
  5. doi request reprint Manipulating antioxidant intake in asthma: a randomized controlled trial
    Lisa G Wood
    Centre for Asthma and Respiratory Diseases, University of Newcastle, New South Wales, Australia
    Am J Clin Nutr 96:534-43. 2012
  6. doi request reprint Early-life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology
    Jay C Horvat
    Centre for Asthma and Respiratory Disease and Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia
    J Allergy Clin Immunol 125:617-25, 625.e1-625.e6. 2010
  7. doi request reprint Lycopene-rich treatments modify noneosinophilic airway inflammation in asthma: proof of concept
    Lisa G Wood
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW, Australia
    Free Radic Res 42:94-102. 2008
  8. ncbi request reprint Clarithromycin targets neutrophilic airway inflammation in refractory asthma
    Jodie L Simpson
    NHMRC Centre for Respiratory and Sleep Medicine, School of Medicine and Public Health, University of Newcastle, Callaghan, Australia
    Am J Respir Crit Care Med 177:148-55. 2008
  9. ncbi request reprint Inhibition of allergic airways disease by immunomodulatory therapy with whole killed Streptococcus pneumoniae
    Julie A Preston
    Centre for Asthma and Respiratory Diseases, School of Biomedical Sciences, Faculty of Health, The University of Newcastle, Newcastle, Australia
    Vaccine 25:8154-62. 2007
  10. doi request reprint Psychosocial variables are related to future exacerbation risk and perinatal outcomes in pregnant women with asthma
    Heather Powell
    Centre for Asthma and Respiratory Diseases, Hunter Medical Research Institute, Newcastle, NSW, Australia
    J Asthma 50:383-9. 2013

Detail Information

Publications90

  1. doi request reprint Asthma in older adults
    Peter G Gibson
    School of Medicine and Public Health, Faculty of Health, University of Newcastle, Callaghan, NSW, Australia
    Lancet 376:803-13. 2010
    ....
  2. pmc Immunometabolism in obese asthmatics: are we there yet?
    Hashim A Periyalil
    Priority Research Centre for Asthma and Respiratory Diseases, Faculty of Health, University of Newcastle, Callaghan, NSW 2308, Australia
    Nutrients 5:3506-30. 2013
    ..This review examines proposed multilevel interactions between metabolic and immune systems in obese asthmatics that underlie the negative effects of obesity and may offer significant therapeutic promise. ..
  3. doi request reprint Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes
    Katherine J Baines
    Priority Research Centre for Asthma and Respiratory Diseases, Hunter Medical Research Institute, University of Newcastle, New Lambton Heights, Australia Department of Respiratory and Sleep Medicine, John Hunter Hospital, New Lambton Heights, Australia Electronic address
    J Allergy Clin Immunol 133:997-1007. 2014
    ..Airway inflammation is associated with asthma exacerbation risk, treatment response, and disease mechanisms...
  4. pmc Novel immune genes associated with excessive inflammatory and antiviral responses to rhinovirus in COPD
    Katherine J Baines
    Priority Research Centre for Asthma and Respiratory Diseases, The University of Newcastle, Callaghan, NSW, Australia
    Respir Res 14:15. 2013
    ..The objective of this study is to investigate innate immune responses to RV infection in COPD primary BECs (pBECs) in comparison to healthy controls...
  5. doi request reprint Manipulating antioxidant intake in asthma: a randomized controlled trial
    Lisa G Wood
    Centre for Asthma and Respiratory Diseases, University of Newcastle, New South Wales, Australia
    Am J Clin Nutr 96:534-43. 2012
    ..Antioxidant-rich diets are associated with reduced asthma prevalence in epidemiologic studies. We previously showed that short-term manipulation of antioxidant defenses leads to changes in asthma outcomes...
  6. doi request reprint Early-life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology
    Jay C Horvat
    Centre for Asthma and Respiratory Disease and Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia
    J Allergy Clin Immunol 125:617-25, 625.e1-625.e6. 2010
    ..The progression of aberrant T(H)2 cell responses and disease development has been attributed to a lack of infections. However, exposure to specific pathogens such as Chlamydia may alter immunologic programming and predispose to asthma...
  7. doi request reprint Lycopene-rich treatments modify noneosinophilic airway inflammation in asthma: proof of concept
    Lisa G Wood
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW, Australia
    Free Radic Res 42:94-102. 2008
    ..Changing dietary antioxidant intake may be contributing to rising asthma prevalence. Lycopene-rich supplements should be further investigated as a therapeutic intervention...
  8. ncbi request reprint Clarithromycin targets neutrophilic airway inflammation in refractory asthma
    Jodie L Simpson
    NHMRC Centre for Respiratory and Sleep Medicine, School of Medicine and Public Health, University of Newcastle, Callaghan, Australia
    Am J Respir Crit Care Med 177:148-55. 2008
    ..Macrolide antibiotics, such as clarithromycin, have in vitro efficacy against IL-8 and neutrophils, key inflammatory mediators in noneosinophilic asthma...
  9. ncbi request reprint Inhibition of allergic airways disease by immunomodulatory therapy with whole killed Streptococcus pneumoniae
    Julie A Preston
    Centre for Asthma and Respiratory Diseases, School of Biomedical Sciences, Faculty of Health, The University of Newcastle, Newcastle, Australia
    Vaccine 25:8154-62. 2007
    ..This indicates the potential of Spn as an IMT for asthma...
  10. doi request reprint Psychosocial variables are related to future exacerbation risk and perinatal outcomes in pregnant women with asthma
    Heather Powell
    Centre for Asthma and Respiratory Diseases, Hunter Medical Research Institute, Newcastle, NSW, Australia
    J Asthma 50:383-9. 2013
    ..To determine the relationship between psychosocial variables, future exacerbation risk during pregnancy, and perinatal outcomes...
  11. doi request reprint Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples
    Katherine J Baines
    Centre for Asthma and Respiratory Diseases, Hunter Medical Research Institute, University of Newcastle, Callaghan, Australia
    J Allergy Clin Immunol 127:153-60, 160.e1-9. 2011
    ..Previous studies have identified clinical or inflammatory phenotypes of asthma on the basis of clinical and demographic parameters or sputum cell counts; however, few studies have defined transcriptional phenotypes of asthma...
  12. doi request reprint Neutrophilic asthma has different radiographic features to COPD and smokers
    Jodie L Simpson
    Centre for Asthma and Respiratory Diseases, University of Newcastle, Newcastle, Australia
    Respir Med 103:881-7. 2009
    ..The aim of this study was to examine the airway and parenchymal abnormalities using high resolution computed tomographic (HRCT) scanning in participants with neutrophilic asthma, COPD and smoking controls...
  13. doi request reprint Systemic upregulation of neutrophil α-defensins and serine proteases in neutrophilic asthma
    Katherine J Baines
    Priority Research Centre forAsthma and Respiratory Diseases, The University of Newcastle, Callaghan, Australia
    Thorax 66:942-7. 2011
    ..Systemic inflammation is now recognised as an important part of some airway diseases, but the involvement of systemic inflammation in the pathogenesis of airway inflammatory phenotypes of asthma remains unknown...
  14. doi request reprint The neutrophilic inflammatory phenotype is associated with systemic inflammation in asthma
    Lisa G Wood
    Centre for Asthma and Respiratory Diseases, University of Newcastle, Australia
    Chest 142:86-93. 2012
    ..The role of systemic inflammation in asthma is unclear. The aim of this study was to compare systemic inflammation in subjects with stable asthma, categorized by airway inflammatory phenotype, with healthy control subjects...
  15. doi request reprint Potentially pathogenic bacteria cultured from the sputum of stable asthmatics are associated with increased 8-isoprostane and airway neutrophilia
    Lisa G Wood
    Centre for Asthma and Respiratory Disease, University of Newcastle, Callaghan, NSW, Australia
    Free Radic Res 44:146-54. 2010
    ..The role of bacteria in potentiating neutrophilic asthma warrants further investigation. Therapies such as antibiotic and antioxidant treatment may be most effective in this sub-group of patients...
  16. doi request reprint Anti-inflammatory effects of long-chain n-3 PUFA in rhinovirus-infected cultured airway epithelial cells
    Ahmad Saedisomeolia
    Nutraceuticals Research Group, School of Biomedical Sciences, University of Newcastle, Newcastle, NSW, Australia
    Br J Nutr 101:533-40. 2009
    ..EPA and AA did not change the release of inflammatory biomarkers significantly. It is concluded that DHA has a potential role in suppressing RV-induced airway inflammation...
  17. doi request reprint Persistence of rhinovirus RNA and IP-10 gene expression after acute asthma
    Lisa G Wood
    Centre for Asthma and Respiratory Diseases, Hunter Medical Research Institute, University of Newcastle, Newcastle, New South Wales, Australia
    Respirology 16:291-9. 2011
    ..This study investigates the frequency of viral persistence after acute asthma, assesses viral infectivity and determines the host inflammatory responses to viral persistence...
  18. doi request reprint IL-27/IFN-γ induce MyD88-dependent steroid-resistant airway hyperresponsiveness by inhibiting glucocorticoid signaling in macrophages
    Jing Jing Li
    Centre for Asthma and Respiratory Disease, University of Newcastle and Hunter Medical Research Institute, Callaghan, New South Wales, Australia
    J Immunol 185:4401-9. 2010
    ....
  19. doi request reprint Psychosocial outcomes are related to asthma control and quality of life in pregnant women with asthma
    Heather Powell
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW, Australia
    J Asthma 48:1032-40. 2011
    ..Little is known about the psychosocial impact and perceived teratogenic (fetal harm due to medication) risks of asthma treatment (inhaled/oral corticosteroids and β-agonist) during pregnancy...
  20. doi request reprint Sputum mast cell subtypes relate to eosinophilia and corticosteroid response in asthma
    Gang Wang
    Pneumology Group, Dept of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, P R China Center for Asthma and Respiratory Diseases, Dept of Respiratory and Sleep Medicine, John Hunter Hospital, Hunter Medical Research Institute, University of Newcastle, New Lambton, NSW, Australia
    Eur Respir J 47:1123-33. 2016
    ..The MCT/CPA3subtype demonstrated increased bronchial sensitivity and reactivity, and signature gene expression, which was associated with airway eosinophilia and greater corticosteroid responsiveness. ..
  21. doi request reprint Older peoples' perception of tests used in the assessment and management of COPD and asthma
    Vanessa M McDonald
    Centre for Asthma and Respiratory Diseases, The University of Newcastle, Newcastle, NSW, Australia Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute John Hunter Hospital, Newcastle, NSW, Australia School of Nursing and Midwifery, The University of Newcastle, Newcastle, NSW, Australia School of Medicine and Public Health, The University of Newcastle, Newcastle, NSW, Australia
    Clin Respir J 7:367-74. 2013
    ..This study evaluated the patient perception of tests used for the assessment of airways disease in older people...
  22. doi request reprint Characterization of laryngeal dysfunction in chronic persistent cough
    Nicole M Ryan
    Centre for Asthma and Respiratory Diseases, School of Medicine and Public Health, University of Newcastle, Newcastle, 2308, NSW, Australia
    Laryngoscope 119:640-5. 2009
    ....
  23. doi request reprint Systemic inflammation is associated with differential gene expression and airway neutrophilia in asthma
    Juan Juan Fu
    Priority Research Centre for Asthma and Respiratory Diseases, University of Newcastle, Newcastle, Australia
    OMICS 17:187-99. 2013
    ..Our findings suggest that targeting systemic inflammation might provide a novel therapeutic strategy for neutrophilic asthma...
  24. doi request reprint Pneumococcal components induce regulatory T cells that attenuate the development of allergic airways disease by deviating and suppressing the immune response to allergen
    Alison N Thorburn
    Centre for Asthma and Respiratory Disease, University of Newcastle, Newcastle, New South Wales 2300, Australia
    J Immunol 191:4112-20. 2013
    ..Therefore, bacterial components (T+P) drive the differentiation of highly suppressive Tregs, which suppress the Th2 response, prevent the Th17 response and disable the DC response resulting in the effective suppression of AAD. ..
  25. doi request reprint The nutrigenomics of asthma: molecular mechanisms of airway neutrophilia following dietary antioxidant withdrawal
    Katherine J Baines
    Priority Research Centre for Asthma and Respiratory Diseases, University of Newcastle, Callaghan NSW Australia
    OMICS 13:355-65. 2009
    ..A diet low in antioxidants may be contributing to the development of neutrophilic asthma through activation of the innate immune response...
  26. doi request reprint Oncostatin M (OSM) is increased in asthma with incompletely reversible airflow obstruction
    Jodie L Simpson
    Centre for Asthma and Respiratory Disease, School of Medicine and Public Health, The University of Newcastle, Callaghan NSW, Australia
    Exp Lung Res 35:781-94. 2009
    ..Sputum oncostatin M is increased in asthma with irreversible airflow obstruction and is present in airway neutrophils and macrophages. Oncostatin M may link airway inflammation to remodeling in asthma...
  27. doi request reprint Reduced circulating antioxidant defences are associated with airway hyper-responsiveness, poor control and severe disease pattern in asthma
    Lisa G Wood
    Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW, Australia
    Br J Nutr 103:735-41. 2010
    ..This highlights the potential role for antioxidant supplementation in these subjects...
  28. ncbi request reprint Immune responses of airway neutrophils are impaired in asthma
    Katherine J Baines
    Priority Research Centre for Asthma and Respiratory Diseases, The University of Newcastle, Callaghan, New South Wales, Australia
    Exp Lung Res 35:554-69. 2009
    ..Innate immune responses of airway neutrophil cells are impaired in asthmatic subjects on prophylactic therapy and may impact on susceptibility to, and severity of, airway infections...
  29. pmc Influence of age, past smoking, and disease severity on TLR2, neutrophilic inflammation, and MMP-9 levels in COPD
    Jodie L Simpson
    NHMRC Centre for Respiratory and Sleep Medicine, Faculty of Health, School of Medicine and Public Health, The University of Newcastle, Callaghan, NSW 2308, Australia
    Mediators Inflamm 2013:462934. 2013
    ..TLR2 stimulation activates neutrophils for MMP-9 release. Efforts to understand the mechanisms of TLR2 signalling and subsequent MMP-9 production in COPD may assist in understanding neutrophilic inflammation in COPD...
  30. doi request reprint Combined Haemophilus influenzae respiratory infection and allergic airways disease drives chronic infection and features of neutrophilic asthma
    Ama Tawiah Essilfie
    Centre for Asthma and Respiratory Disease and Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia
    Thorax 67:588-99. 2012
    ..The relationship between chronic airway colonisation and the development of steroid-resistant neutrophilic asthma is unclear...
  31. doi request reprint Management of asthma in pregnancy guided by measurement of fraction of exhaled nitric oxide: a double-blind, randomised controlled trial
    Heather Powell
    Centre for Asthma and Respiratory Diseases, University of Newcastle and Hunter Medical Research Institute, Newcastle, NSW, Australia
    Lancet 378:983-90. 2011
    ..We tested the hypothesis that a management algorithm for asthma in pregnancy based on F(E)NO and symptoms would reduce asthma exacerbations...
  32. ncbi request reprint Inflammatory subtypes in asthma: assessment and identification using induced sputum
    Jodie L Simpson
    School of Medical Practice and Population Health, Hunter Medical Research Institute, The University of Newcastle, Callaghan, New South Wales, Australia
    Respirology 11:54-61. 2006
    ..The authors sought to investigate the detection of non-eosinophilic asthma using induced sputum. Although this is an important subtype of clinical asthma, its recognition is not standardized...
  33. pmc Innate immune activation in neutrophilic asthma and bronchiectasis
    Jodie L Simpson
    Department of Respiratory and Sleep Medicine, School of Medicine and Public Health, Hunter Medical Research Institute, The University of Newcastle, Newcastle, Australia
    Thorax 62:211-8. 2007
    ..The inflammatory response in asthma is heterogeneous...
  34. doi request reprint Alterations in inflammatory, antiviral and regulatory cytokine responses in peripheral blood mononuclear cells from pregnant women with asthma
    Rebecca L Vanders
    Centre for Asthma and Respiratory Diseases, School of Medicine and Public Health, The University of Newcastle, Newcastle, New South Wales, Australia
    Respirology 18:827-33. 2013
    ..Asthma exacerbations are caused most frequently by respiratory viruses. A balance between antiviral and inflammatory immune responses is critical during pregnancy; the balance may be altered by asthma and respiratory virus infection...
  35. doi request reprint Impaired type I and III interferon response to rhinovirus infection during pregnancy and asthma
    Rebecca Louise Forbes
    Department of Respiratory Medicine, Centre for Asthma and Respiratory Disease, The University of Newcastle, School of Medicine and Public Health, New Lambton, NSW, Australia, 2350
    Thorax 67:209-14. 2012
    ..Pregnant women have increased susceptibility and disease severity to viral infections like influenza and HRVs, as do asthmatics. Successful pregnancy requires immunological modulation to permit fetal tolerance...
  36. doi request reprint A high-fat challenge increases airway inflammation and impairs bronchodilator recovery in asthma
    Lisa G Wood
    Centre for Asthma and Respiratory Disease, Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia
    J Allergy Clin Immunol 127:1133-40. 2011
    ..Dietary fat activates systemic innate immune responses, but the effect on airway responses is unknown...
  37. ncbi request reprint CICADA: Cough in Children and Adults: Diagnosis and Assessment. Australian cough guidelines summary statement
    Peter G Gibson
    Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, NSW, Australia
    Med J Aust 192:265-71. 2010
    ..In ADULTS, refractory cough that persists after therapy is managed by empirical inhaled corticosteroid therapy and speech pathology techniques...
  38. doi request reprint Lycopene enrichment of cultured airway epithelial cells decreases the inflammation induced by rhinovirus infection and lipopolysaccharide
    Ahmad Saedisomeolia
    Nutraceuticals Research Group, School of Biomedical Sciences, University of Newcastle, NSW 2308, Australia
    J Nutr Biochem 20:577-85. 2009
    ..Lycopene also decreased the release of IL-6 and IP-10 following exposure to lipopolysaccharide. We conclude that lycopene has a potential role in suppressing rhinovirus induced airway inflammation...
  39. doi request reprint Reduced Antiviral Interferon Production in Poorly Controlled Asthma Is Associated With Neutrophilic Inflammation and High-Dose Inhaled Corticosteroids
    Jodie L Simpson
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, New Lambton, NSW, Australia Priority Research Centre for Asthma and Respiratory Disease, The University of Newcastle, Callaghan, NSW, Australia Electronic address
    Chest 149:704-13. 2016
    ..This is a matter of some controversy, with some investigators reporting reduced type I interferon (IFN) synthesis and others suggesting that type I IFN synthesis is relatively normal in asthma...
  40. doi request reprint Macrolide therapy suppresses key features of experimental steroid-sensitive and steroid-insensitive asthma
    Ama Tawiah Essilfie
    Centre for Asthma and Respiratory Disease and Hunter Medical Research Institute, University of Newcastle, Newcastle, New South Wales, Australia
    Thorax 70:458-67. 2015
    ..Macrolide therapy is effective in steroid-insensitive endotypes, such as non-eosinophilic asthma. However, whether the effects of macrolides are due to antimicrobial or anti-inflammatory mechanisms is not known...
  41. ncbi request reprint Persistent airway obstruction after virus infection is not associated with airway inflammation
    Lisa G Wood
    School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia
    Chest 131:415-23. 2007
    ..This study examined the contribution of airway inflammation to the delayed lung function recovery that occurs in some people following virus-induced asthma exacerbations...
  42. ncbi request reprint Neonatal chlamydial infection induces mixed T-cell responses that drive allergic airway disease
    Jay C Horvat
    Priority Research Centre for Asthma and Respiratory Disease, School of Biomedical Sciences, Faculty of Health, University of Newcastle, Newcastle, Australia
    Am J Respir Crit Care Med 176:556-64. 2007
    ..Chlamydial lung infection has been associated with asthma in children and adults. However, how chlamydial infection influences the development of immune responses that promote asthma remains unknown...
  43. ncbi request reprint Airway and circulating levels of carotenoids in asthma and healthy controls
    Lisa G Wood
    Department Respiratory and Sleep Medicine, John Hunter Hospital, Locked Bag 1, Hunter Region Mail Centre, NSW, 2310, Australia
    J Am Coll Nutr 24:448-55. 2005
    ..Elevated oxidative stress and impaired antioxidant defences are increasingly recognised features of asthma. Carotenoids are potent dietary antioxidants that may protect against asthma by reducing oxidative damage...
  44. doi request reprint Identification of novel diagnostic biomarkers for asthma and chronic obstructive pulmonary disease
    Nicole M Verrills
    School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Newcastle, Australia
    Am J Respir Crit Care Med 183:1633-43. 2011
    ..Proteomics may identify a useful panel of biomarkers for identification of asthma and chronic obstructive pulmonary disease (COPD)...
  45. doi request reprint Multidimensional assessment of older people with asthma and COPD: clinical management and health status
    Vanessa M McDonald
    School of Medicine and Public Health, The University of Newcastle, Newcastle, NSW, Australia
    Age Ageing 40:42-9. 2011
    ..the diagnosis and management of obstructive airway diseases (OADs) such as asthma and chronic obstructive pulmonary disease (COPD) can be challenging in older people...
  46. doi request reprint Neutrophil extracellular traps are associated with inflammation in chronic airway disease
    Thomas K Wright
    Priority Research Centre for Asthma and Respiratory Diseases, Hunter Medical Research Institute, The University of Newcastle, New Lambton Heights, New South Wales, Australia
    Respirology 21:467-75. 2016
    ..This study aimed to investigate the presence of NETs in sputum from patients with asthma and COPD, and the relationship of NETs with inflammatory phenotype and disease severity...
  47. doi request reprint Rhinitis in pregnant women with asthma is associated with poorer asthma control and quality of life
    Heather Powell
    a Centre for Asthma and Respiratory Diseases, University of Newcastle and Hunter Medical Research Institute, Newcastle, NSW, Australia
    J Asthma 52:1023-30. 2015
    ..To describe the pattern and severity of rhinitis in pregnancy and the impact rhinitis has on asthma control and quality of life (QoL) in pregnant women with asthma...
  48. doi request reprint Differential DNA methylation profiles of infants exposed to maternal asthma during pregnancy
    Lakshitha P Gunawardhana
    Priority Research Centre for Asthma and Respiratory Disease, Hunter Medical Research Institute, The University of Newcastle, Sydney, NSW, Australia
    Pediatr Pulmonol 49:852-62. 2014
    ..We investigated alterations in the DNA methylation profile of peripheral blood from infants exposed to maternal asthma during pregnancy...
  49. ncbi request reprint Use of omalizumab in a severe asthma clinic
    Peter G Gibson
    Priority Research Centre for Asthma and Respiratory Diseases, University of Newcastle, Callaghan, Australia
    Respirology 12:S35-44; discussion S45-7. 2007
    ....
  50. ncbi request reprint Induced sputum 8-isoprostane concentrations in inflammatory airway diseases
    Lisa G Wood
    Department of Respiratory and Sleep Medicine, John Hunter Hospital, Locked Bag 1, Hunter Region Mail Centre, NSW, 2310, Australia
    Am J Respir Crit Care Med 171:426-30. 2005
    ..Analysis of 8-iso-PGF(2alpha) concentrations in induced sputum provides a useful tool for monitoring oxidative stress and investigating strategies aimed at reducing oxidative stress in airways disease...
  51. doi request reprint Plasmacytoid dendritic cells and CD8 T cells from pregnant women show altered phenotype and function following H1N1/09 infection
    Rebecca L Vanders
    Centre for Asthma and Respiratory Diseases, School of Medicine and Public Health, The University of Newcastle Newcastle, Australia
    J Infect Dis 208:1062-70. 2013
    ..In this study we determined whether plasmacytoid dendritic cells (pDCs) and CD8 T cells from pregnant women display altered activity following in vitro infection with 2009 pandemic swine influenza (H1N1/09)...
  52. doi request reprint Gabapentin for refractory chronic cough: a randomised, double-blind, placebo-controlled trial
    Nicole M Ryan
    Priority Centre for Asthma and Respiratory Diseases, School of Medicine and Public Health, The University of Newcastle, Newcastle, NSW, Australia
    Lancet 380:1583-9. 2012
    ..We established the efficacy of gabapentin in patients with refractory chronic cough...
  53. doi request reprint Clinical and physiological features of postinfectious chronic cough associated with H1N1 infection
    Nicole M Ryan
    Priority Centre for Asthma and Respiratory Diseases, School of Medicine and Public Health, The University of Newcastle, Newcastle, 2308 NSW, Australia
    Respir Med 106:138-44. 2012
    ..This study sought to investigate the prevalence, characteristics and mechanism of chronic cough following laboratory-confirmed H1N1 2009 influenza...
  54. ncbi request reprint Differential proteolytic enzyme activity in eosinophilic and neutrophilic asthma
    Jodie L Simpson
    School of Medical Practice and Population Health, and Medical Genetics, School of Biomedical Science, Hunter Medical Research Institute, The University of Newcastle, Callaghan, Australia
    Am J Respir Crit Care Med 172:559-65. 2005
    ..Asthma is characterized by both chronic inflammation and remodeling of the airways. Proteases are important mediators of inflammation, cytokine activation, and tissue remodeling...
  55. doi request reprint Inflammatory mechanisms and treatment of obstructive airway diseases with neutrophilic bronchitis
    Jodie L Simpson
    Centre for Asthma and Respiratory Disease, The University of Newcastle, Newcastle, NSW, Australia
    Pharmacol Ther 124:86-95. 2009
    ..Studies also show improvements in quality of life and exacerbation rates in airways diseases...
  56. ncbi request reprint Increased plasma fatty acid concentrations after respiratory exacerbations are associated with elevated oxidative stress in cystic fibrosis patients
    Lisa G Wood
    Discipline of Nutrition and Dietetics, The University of Newcastle, Callaghan, New South Wales, Australia
    Am J Clin Nutr 75:668-75. 2002
    ..Oxidative stress and depleted antioxidant defenses occur in stable cystic fibrosis patients. During acute infection, the balance between oxidants and antioxidants may be further disturbed...
  57. pmc Airway β-Defensin-1 Protein Is Elevated in COPD and Severe Asthma
    Katherine J Baines
    Priority Research Centre for Asthma and Respiratory Diseases, Hunter Medical Research Institute, The University of Newcastle, New Lambton Heights, NSW 2305, Australia Department of Respiratory and Sleep Medicine, John Hunter Hospital, New Lambton Heights, NSW 2305, Australia
    Mediators Inflamm 2015:407271. 2015
    ..Innate immune antimicrobial peptides, including β-defensin-1, promote the chemotaxis and activation of several immune cells. The role of β-defensin-1 in asthma and chronic obstructive pulmonary disease (COPD) remains unclear...
  58. pmc The effect of azithromycin in adults with stable neutrophilic COPD: a double blind randomised, placebo controlled trial
    Jodie L Simpson
    Centre for Asthma and Respiratory Diseases and Hunter Medical Research Institute, Faculty of Health and Medicine, The University of Newcastle, Callaghan, New South Wales, Australia
    PLoS ONE 9:e105609. 2014
    ..We conducted a randomised, double-blind, placebo-controlled study in COPD participants with stable neutrophilic bronchitis...
  59. doi request reprint CD8 T cells and dendritic cells: key players in the attenuated maternal immune response to influenza infection
    Rebecca L Vanders
    Centre for Asthma and Respiratory Diseases, The University of Newcastle, Newcastle, NSW, Australia Hunter Medical Research Institute, Newcastle, NSW, Australia Electronic address
    J Reprod Immunol 107:1-9. 2015
    ..This review highlights the role of dendritic cells (DCs) and CD8 T cells during pregnancy, and the changes that occur in these antiviral cells following influenza virus infections. ..
  60. doi request reprint Macrophage activation, age and sex effects of immunometabolism in obese asthma
    Hashim A Periyalil
    Centre for Asthma and Respiratory Diseases, Faculty of Health and Medicine, University of Newcastle, Callaghan, Australia Hunter Medical Research Institute, New Lambton, Australia
    Eur Respir J 45:388-95. 2015
    ..The heterogeneous systemic inflammatory profile across age and sex suggests the existence of sub-phenotypes in obese asthma at the molecular level...
  61. doi request reprint Premenstrual asthma: prevalence, cycle-to-cycle variability and relationship to oral contraceptive use and menstrual symptoms
    Vanessa E Murphy
    Centre for Asthma and Respiratory Diseases, University of Newcastle and Hunter Medical Research Institute, Newcastle, NSW, Australia
    J Asthma 45:696-704. 2008
    ..PMA resulting in increased symptoms and medication use occurred in 57% of subjects studied for 2-4 menstrual cycles. The use of oral contraceptives is not protective and further work is required to elucidate the mechanisms of PMA...
  62. doi request reprint Speech pathology for chronic cough: a new approach
    Peter G Gibson
    Centre for Asthma and Respiratory Diseases, John Hunter Hospital University of Newcastle, Newcastle, NSW, Australia
    Pulm Pharmacol Ther 22:159-62. 2009
    ..Speech pathology intervention can be an effective way to treat refractory chronic cough...
  63. doi request reprint Elevated expression of the NLRP3 inflammasome in neutrophilic asthma
    Jodie L Simpson
    Centre for Asthma and Respiratory Diseases and Hunter Medical Research Institute, Faculty of Health, School of Medicine and Public Health, The University of Newcastle, Callaghan
    Eur Respir J 43:1067-76. 2014
    ..NLRP3 inflammasome is upregulated in neutrophilic asthma and may regulate the inflammation process observed in this asthma phenotype through production of IL-1β...
  64. doi request reprint Managing older patients with coexistent asthma and chronic obstructive pulmonary disease: diagnostic and therapeutic challenges
    Vanessa M McDonald
    Priority Research Centre for Asthma and Respiratory Diseases, University of Newcastle, Newcastle, NSW, Australia
    Drugs Aging 30:1-17. 2013
    ....
  65. doi request reprint Pregnant women have attenuated innate interferon responses to 2009 pandemic influenza A virus subtype H1N1
    Rebecca L Forbes
    Centre for Asthma and Respiratory Diseases, School of Medicine and Public Health, The University of Newcastle, Australia
    J Infect Dis 206:646-53. 2012
    ..Antiviral immunity is critical during influenza virus infection, and understanding the changes that occur during pregnancy and the effect of vaccination is essential for improving health outcomes for mother and baby...
  66. doi request reprint Cough pharmacotherapy: current and future status
    Peter G Gibson
    University of Newcastle, School of Medicine and Public Health, Centre for Asthma and Respiratory Diseases, Newcastle, NSW 2308, Australia
    Expert Opin Pharmacother 12:1745-55. 2011
    ..Neuromodulators for sensory neuropathic cough and new compounds to block transient receptor potential (TRP) receptors hold promise for chronic cough and upper airway hypersensitivity...
  67. ncbi request reprint Migration to a western country increases asthma symptoms but not eosinophilic airway inflammation
    Peter G Gibson
    Hunter Medical Research Institute, University of Newcastle, John Hunter Hospital, Newcastle, New South Wales, Australia
    Pediatr Pulmonol 36:209-15. 2003
    ..The development of wheeze after migration to Australia was independent of eosinophilic inflammation and consistent with noneosinophilic asthma mechanisms...
  68. ncbi request reprint Role of atypical bacterial infection of the lung in predisposition/protection of asthma
    Philip M Hansbro
    Discipline of Immunology and Microbiology, School of Biomedical Sciences, University of Newcastle, Callaghan, New South Wales, Australia
    Pharmacol Ther 101:193-210. 2004
    ....
  69. doi request reprint Asthma in pregnancy
    Vanessa E Murphy
    Centre for Asthma and Respiratory Diseases, University of Newcastle and Hunter Medical Research Institute, Department of Respiratory and Sleep Medicine, John Hunter Hospital, Locked Bag 1, HRMC, Newcastle, New South Wales 2310, Australia
    Clin Chest Med 32:93-110, ix. 2011
    ..Barriers to effective asthma management and opportunities for optimized care and treatment are discussed, and a summary of the clinical guidelines for the management of asthma during pregnancy is presented...
  70. doi request reprint Oxidized vitamin E and glutathione as markers of clinical status in asthma
    Lisa G Wood
    Department of Respiratory and Sleep Medicine, Level 3, Hunter Medical Research Institute, John Hunter Hospital, Locked Bag 1, Hunter Region Mail Centre, Newcastle, 2310 NSW, Australia
    Clin Nutr 27:579-86. 2008
    ....
  71. ncbi request reprint Outpatient monitoring of asthma
    Peter G Gibson
    Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, NSW, Australia
    Curr Opin Allergy Clin Immunol 2:161-6. 2002
    ..Additional monitoring tools are under evaluation, and these include measures of airway responsiveness, airway inflammation, and Internet-based monitoring systems...
  72. doi request reprint Innate immune mechanisms linking non-esterified fatty acids and respiratory disease
    Lisa G Wood
    Department of Respiratory and Sleep Medicine, Level 3, John Hunter Hospital, Hunter Medical Research Institute, Locked Bag 1, Hunter Region Mail Centre, Newcastle, 2310 NSW, Australia
    Prog Lipid Res 48:27-43. 2009
    ..Finally, the review will discuss how the recognition of NEFA as important inflammatory stimulants in respiratory disease, leads to the possibility that pathways involved in lipid metabolism may provide therapeutic targets...
  73. doi request reprint Dietary factors lead to innate immune activation in asthma
    Lisa G Wood
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, 2310 NSW, Australia
    Pharmacol Ther 123:37-53. 2009
    ..Therapeutic strategies aimed at addressing diet-induced innate immune activation are warranted...
  74. ncbi request reprint Asthma education
    Peter G Gibson
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, University of Newcastle, Locked Bag 1, Hunter Region Mail Centre, NSW 2310, Australia
    Respir Med 97:1036-44. 2003
    ..While a structured asthma self-management programme is effective in a hospital setting, attempts to deliver these programmes in primary care have met with varying success...
  75. doi request reprint Respiratory viral infections in pregnant women with asthma are associated with wheezing in the first 12 months of life
    Vanessa E Murphy
    Centre for Asthma and Respiratory Diseases, University of Newcastle and Hunter Medical Research Institute, Newcastle, NSW, Australia
    Pediatr Allergy Immunol 25:151-8. 2014
    ..Infants of mothers with asthma are more likely to wheeze and have a higher risk of developing asthma than infants of non-asthmatic mothers...
  76. doi request reprint Longitudinal changes in clinical outcomes in older patients with asthma, COPD and asthma-COPD overlap syndrome
    Juan Juan Fu
    Priority Research Centre for Asthma and Respiratory Diseases, School of Medicine and Public Health, University of Newcastle, Newcastle, N S W, Australia
    Respiration 87:63-74. 2014
    ..The progression of obstructive airway diseases (OADs) including asthma, chronic obstructive pulmonary disease (COPD) and asthma-COPD overlap syndrome in older adults is not well understood...
  77. ncbi request reprint Differential effects of maintenance long-acting beta-agonist and inhaled corticosteroid on asthma control and asthma exacerbations
    Peter G Gibson
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, University of Newcastle, New Lambton, Australia
    J Allergy Clin Immunol 119:344-50. 2007
    ..Combination therapy with long-acting beta-agonists (LABAs)/inhaled corticosteroids (ICSs) has become established as effective maintenance treatment for asthma...
  78. ncbi request reprint Allergic bronchopulmonary aspergillosis
    Peter G Gibson
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, University of Newcastle, NSW, Australia
    Semin Respir Crit Care Med 27:185-91. 2006
    ..Treatment involves corticosteroids and antifungal therapy with oral azoles. Additional management seeks to monitor and control the other disease components of severe asthma, bronchiectasis, and disease exacerbations...
  79. ncbi request reprint Interleukin-10 gene expression in acute virus-induced asthma
    Terry V Grissell
    School of Medical Practice and Population Health, University of Newcastle, Callaghan, Australia
    Am J Respir Crit Care Med 172:433-9. 2005
    ..Virus-induced asthma is characterized by marked neutrophil influx and eosinophil degranulation, suggesting a mode of immunopathogenesis different from that of allergen-induced asthma...
  80. doi request reprint Insight into older peoples' healthcare experiences with managing COPD, asthma, and asthma-COPD overlap
    Vanessa M McDonald
    School of Medicine and Public Health, Faculty of Health, The University of Newcastle, Callaghan, NSW 2308, Australia
    J Asthma 50:497-504. 2013
    ..The aim of this study was to explore older peoples' experiences of asthma or COPD with reference to their journey in the healthcare system...
  81. pmc Multidimensional assessment and tailored interventions for COPD: respiratory utopia or common sense?
    Vanessa M McDonald
    School of Nursing and Midwifery, University of Newcastle, Newcastle, New South Wales, Australia
    Thorax 68:691-4. 2013
    ..The rising disease burden from chronic obstructive pulmonary disease (COPD) requires new approaches...
  82. doi request reprint Assessment and reproducibility of non-eosinophilic asthma using induced sputum
    Jodie L Simpson
    Centre for Asthma and Respiratory Disease, The University of Newcastle, Callaghan, NSW, Australia
    Respiration 79:147-51. 2010
    ..The stability of airway inflammation in asthma over time is not known, yet this information is crucial to inflammation-based patient management...
  83. ncbi request reprint Reduced toll-like receptor 4 and substance P gene expression is associated with airway bacterial colonization in children
    Terry V Grissell
    Hunter Medical Research Institute, University of Newcastle, John Hunter Hospital, New Lambton, Australia
    Pediatr Pulmonol 42:380-5. 2007
    ..There is evidence for co-regulation of neurokinin (TAC1) and TLR4 gene expression in airway cells from children with airway bacterial colonization and their reduced expression may be associated with an impaired bacterial clearance...
  84. ncbi request reprint Circulating markers to assess nutritional therapy in cystic fibrosis
    Lisa G Wood
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, 2310, NSW, Australia
    Clin Chim Acta 353:13-29. 2005
    ..This article provides an overview of the biomarkers useful in the prediction of the efficacy of nutritional therapy on improvements in quality and quantity of life in CF...
  85. pmc Chronic cough and laryngeal dysfunction improve with specific treatment of cough and paradoxical vocal fold movement
    Nicole M Ryan
    Centre for Asthma and Respiratory Diseases, School of Medicine and Public Health, The University of Newcastle, Newcastle, 2308, NSW, Australia
    Cough 5:4. 2009
    ..Successful treatment for chronic persistent cough leads to improvements in these features of laryngeal dysfunction...
  86. pmc Cough reflex sensitivity improves with speech language pathology management of refractory chronic cough
    Nicole M Ryan
    Centre for Asthma and Respiratory Diseases, School of Medicine and Public Health, The University of Newcastle, Newcastle, 2308, NSW, Australia
    Cough 6:5. 2010
    ..The number of treatments required to effect a response was also assessed...
  87. doi request reprint Obesity and childhood asthma - mechanisms and manifestations
    Megan E Jensen
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW 2310, Australia
    Curr Opin Allergy Clin Immunol 12:186-92. 2012
    ..This review highlights the most recent findings over the past 18 months in understanding the presentation and potential mechanisms of obesity in childhood asthma...
  88. doi request reprint The role of speech pathology in the management of patients with chronic refractory cough
    Anne E Vertigan
    Speech Pathology Department, John Hunter Hospital, Locked Bag 1, Hunter Region Mail Centre, Newcastle, NSW 2310, Australia
    Lung 190:35-40. 2012
    ..This review outlines the potential mechanisms for improvement in cough, indicators for referral to speech pathology for cough, and exclusion criteria...
  89. ncbi request reprint Asthma in older adults: a holistic, person-centred and problem-oriented approach
    Guy B Marks
    Woolcock Institute of Medical Research, Sydney, NSW, Australia
    Med J Aust 191:197-9. 2009
    ..Regardless of how obstructive lung disease is labelled, targeting treatment to components of the problem is the best solution...
  90. ncbi request reprint Reduced 11beta-hydroxysteroid dehydrogenase type 2 activity is associated with decreased birth weight centile in pregnancies complicated by asthma
    Vanessa E Murphy
    Mothers and Babies Research Centre, University of Newcastle, New South Wales, Australia
    J Clin Endocrinol Metab 87:1660-8. 2002
    ....