Robert G Fassett

Summary

Affiliation: University of Queensland
Country: Australia

Publications

  1. pmc Current and emerging treatment options for the elderly patient with chronic kidney disease
    Robert G Fassett
    The University of Queensland, School of Human Movement Studies, Brisbane, Queensland, Australia
    Clin Interv Aging 9:191-9. 2014
  2. pmc Contrasting approaches to end of life and palliative care in end stage kidney disease
    A N Koshy
    Department of Medicine, Alfred Hospital, Melbourne, Victoria, Australia
    Indian J Nephrol 22:307-9. 2012
  3. doi Astaxanthin in cardiovascular health and disease
    Robert G Fassett
    School of Medicine, The University of Queensland, Brisbane, Queensland 4000, Australia
    Molecules 17:2030-48. 2012
  4. doi Effects of atorvastatin on NGAL and cystatin C in chronic kidney disease: a post hoc analysis of the LORD trial
    Robert G Fassett
    Renal Medicine Department, Royal Brisbane and Women s Hospital, Brisbane, Australia
    Nephrol Dial Transplant 27:182-9. 2012
  5. ncbi Cardiovascular disease in peritoneal dialysis patients
    R G Fassett
    Renal Research, Royal Brisbane and Women s Hospital, Brisbane, Queensland, Australia
    Panminerva Med 51:151-61. 2009
  6. pmc Astaxanthin: a potential therapeutic agent in cardiovascular disease
    Robert G Fassett
    Renal Research Royal Brisbane and Women s Hospital and The University of Queensland School of Medicine, Butterfield Street, Brisbane, Queensland 4029, Australia
    Mar Drugs 9:447-65. 2011
  7. doi Astaxanthin, oxidative stress, inflammation and cardiovascular disease
    Robert G Fassett
    School of Human Movement Studies and School of Medicine, The University of Queensland, Queensland, Australia
    Future Cardiol 5:333-42. 2009
  8. doi Biomarkers in chronic kidney disease: a review
    Robert G Fassett
    Renal Research, Royal Brisbane and Women s Hospital, Brisbane, Queensland, Australia
    Kidney Int 80:806-21. 2011
  9. doi Omega-3 polyunsaturated fatty acids in the treatment of kidney disease
    Robert G Fassett
    Renal Research, Royal Brisbane and Women s Hospital, Brisbane, Queensland, Australia
    Am J Kidney Dis 56:728-42. 2010
  10. doi Effect of atorvastatin on kidney function in chronic kidney disease: a randomised double-blind placebo-controlled trial
    Robert G Fassett
    Renal Medicine, Royal Brisbane and Women s Hospital, Brisbane, Queensland, Australia
    Atherosclerosis 213:218-24. 2010

Collaborators

Detail Information

Publications51

  1. pmc Current and emerging treatment options for the elderly patient with chronic kidney disease
    Robert G Fassett
    The University of Queensland, School of Human Movement Studies, Brisbane, Queensland, Australia
    Clin Interv Aging 9:191-9. 2014
    ..In addition, new therapies to treat and slow CKD progression are needed for all age groups. ..
  2. pmc Contrasting approaches to end of life and palliative care in end stage kidney disease
    A N Koshy
    Department of Medicine, Alfred Hospital, Melbourne, Victoria, Australia
    Indian J Nephrol 22:307-9. 2012
    ....
  3. doi Astaxanthin in cardiovascular health and disease
    Robert G Fassett
    School of Medicine, The University of Queensland, Brisbane, Queensland 4000, Australia
    Molecules 17:2030-48. 2012
    ..On the basis of the promising results of experimental cardiovascular studies and the physicochemical and antioxidant properties and safety profile of astaxanthin, clinical trials should be undertaken...
  4. doi Effects of atorvastatin on NGAL and cystatin C in chronic kidney disease: a post hoc analysis of the LORD trial
    Robert G Fassett
    Renal Medicine Department, Royal Brisbane and Women s Hospital, Brisbane, Australia
    Nephrol Dial Transplant 27:182-9. 2012
    ....
  5. ncbi Cardiovascular disease in peritoneal dialysis patients
    R G Fassett
    Renal Research, Royal Brisbane and Women s Hospital, Brisbane, Queensland, Australia
    Panminerva Med 51:151-61. 2009
    ..Other registry data do not support this. Further long-term studies assessing surrogate and hard endpoint cardiovascular outcomes in peritoneal dialysis are required...
  6. pmc Astaxanthin: a potential therapeutic agent in cardiovascular disease
    Robert G Fassett
    Renal Research Royal Brisbane and Women s Hospital and The University of Queensland School of Medicine, Butterfield Street, Brisbane, Queensland 4029, Australia
    Mar Drugs 9:447-65. 2011
    ..Cardiovascular clinical trials are warranted based on the physicochemical and antioxidant properties, the safety profile and preliminary experimental cardiovascular studies of astaxanthin...
  7. doi Astaxanthin, oxidative stress, inflammation and cardiovascular disease
    Robert G Fassett
    School of Human Movement Studies and School of Medicine, The University of Queensland, Queensland, Australia
    Future Cardiol 5:333-42. 2009
    ..These may lead to large intervention trials assessing cardiovascular morbidity and mortality...
  8. doi Biomarkers in chronic kidney disease: a review
    Robert G Fassett
    Renal Research, Royal Brisbane and Women s Hospital, Brisbane, Queensland, Australia
    Kidney Int 80:806-21. 2011
    ..Although none are ready for use in clinical practice, it is timely to review the role of such biomarkers in predicting CKD progression and/or CVD risk in CKD...
  9. doi Omega-3 polyunsaturated fatty acids in the treatment of kidney disease
    Robert G Fassett
    Renal Research, Royal Brisbane and Women s Hospital, Brisbane, Queensland, Australia
    Am J Kidney Dis 56:728-42. 2010
    ..Well-designed, adequately powered, randomized, controlled clinical trials are required to further investigate the potential benefits of omega-3 polyunsaturated fatty acids on the progression of kidney disease and patient survival...
  10. doi Effect of atorvastatin on kidney function in chronic kidney disease: a randomised double-blind placebo-controlled trial
    Robert G Fassett
    Renal Medicine, Royal Brisbane and Women s Hospital, Brisbane, Queensland, Australia
    Atherosclerosis 213:218-24. 2010
    ..The effect of atorvastatin on kidney function was assessed in patients with stages 2-4 chronic kidney disease...
  11. doi Palliative care in end-stage kidney disease
    Robert G Fassett
    Renal Research, Royal Brisbane and Women s Hospital, School of Medicine, The University of Queensland, Brisbane, St Lucia, Queensland, Australia
    Nephrology (Carlton) 16:4-12. 2011
    ..The objective of this review is to summarize published studies and evidence-based guidelines, core curricula, position statements, standards and tools in palliative care in end-stage kidney disease...
  12. pmc Astaxanthin vs placebo on arterial stiffness, oxidative stress and inflammation in renal transplant patients (Xanthin): a randomised controlled trial
    Robert G Fassett
    Renal Research, Royal Brisbane and Women s Hospital, Herston, Brisbane, Queensland, Australia
    BMC Nephrol 9:17. 2008
    ..The aim of this trial is to investigate the effects of astaxanthin supplementation on arterial stiffness, oxidative stress and inflammation in renal transplant patients...
  13. ncbi Effects of atorvastatin on arterial stiffness in chronic kidney disease: a randomised controlled trial
    Robert G Fassett
    Royal Brisbane and Women s Hospital, Brisbane, Queensland, Australia
    J Atheroscler Thromb 17:235-41. 2010
    ..Hence, the aim of this study was to assess the long-term effects of atorvastatin on arterial stiffness and central blood pressure in patients with CKD...
  14. pmc Comparison of markers of oxidative stress, inflammation and arterial stiffness between incident hemodialysis and peritoneal dialysis patients--an observational study
    Robert G Fassett
    Renal Research, Royal Brisbane and Women s Hospital, Brisbane, Queensland, Australia
    BMC Nephrol 10:8. 2009
    ....
  15. pmc Assessment of arterial stiffness, oxidative stress and inflammation in acute kidney injury
    Robert G Fassett
    Renal Medicine, Royal Brisbane and Women s Hospital, Queensland, Australia
    BMC Nephrol 10:15. 2009
    ..The aim of this study is to elucidate the vascular changes in acute kidney injury. We hypothesise that arterial stiffness will be increased during acute kidney injury and this will return to normal after kidney function recovers...
  16. pmc Pharmacokinetics of intraperitoneal gentamicin in peritoneal dialysis patients with peritonitis (GIPD study)
    Julie M Varghese
    Burns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Australia
    Clin J Am Soc Nephrol 7:1249-56. 2012
    ..This study aimed to describe the plasma and infection site pharmacokinetics of intraperitoneal gentamicin in patients with peritonitis...
  17. pmc CKD.QLD: chronic kidney disease surveillance and research in Queensland, Australia
    Sree K Venuthurupalli
    Renal Medicine, Toowoomba Hospital, Toowoomba, Queensland, Australia
    Nephrol Dial Transplant 27:iii139-45. 2012
    ..However, there is no comprehensive surveillance programme to collect, collate and analyse data on CKD in a systematic way...
  18. doi Variability in oxidative stress biomarkers following a maximal exercise test
    Anna L Mullins
    Exercise and Oxidative Stress Research Group, School of Human Movement Studies, The University of Queensland, Brisbane, Queensland, Australia
    Biomarkers 18:446-54. 2013
    ..Exercise produced significant increases in Isop (27.0%), PC (6.2%) and GPX (7.8%). There were large between-individual coefficients of variation: Isop (152%), PC, (240%), GPX (130%) and TAC (243%)...
  19. doi Performance benefits of rehydration with intravenous fluid and oral glycerol
    Simon P van Rosendal
    Human Performance Laboratory, School of Human Movement Studies, The University of Queensland, Brisbane, Queensland, Australia
    Med Sci Sports Exerc 44:1780-90. 2012
    ..We aimed to examine the effects of rehydrating with four different regimens of IV fluid and oral glycerol on subsequent 40-km cycling time trial performance...
  20. pmc Randomised controlled trial to determine the appropriate time to initiate peritoneal dialysis after insertion of catheter to minimise complications (Timely PD study)
    Dwarakanathan Ranganathan
    Renal Medicine, Royal Brisbane and Women s Hospital, Brisbane, Queensland, 4029, Australia
    BMC Nephrol 11:11. 2010
    ..Previous studies are observational and mostly compare immediate with delayed use. The primary objective is to determine the safest and shortest time interval between surgical placement of a Tenckhoff catheter and starting PD...
  21. doi The effects of dietary fish oil on inflammation, fibrosis and oxidative stress associated with obstructive renal injury in rats
    Jonathan M Peake
    The University of Queensland, School of Human Movement Studies, Brisbane, Australia
    Mol Nutr Food Res 55:400-10. 2011
    ..We examined whether dietary supplementation with fish oil modulates inflammation, fibrosis and oxidative stress following obstructive renal injury...
  22. doi The effect of different volumes of high-intensity interval training on proinsulin in participants with the metabolic syndrome: a randomised trial
    Joyce S Ramos
    Centre for Research on Exercise, Physical Activity and Health, School of Human Movement and Nutrition Sciences, The University of Queensland, Blair Drive, St Lucia, QLD, Australia
    Diabetologia 59:2308-20. 2016
    ..We therefore aimed to investigate the impact of MICT and different volumes of HIIT on circulating intact proinsulin concentration...
  23. doi Fitness Is Independently Associated with Central Hemodynamics in Metabolic Syndrome
    Joyce S Ramos
    1Centre for Research on Exercise, Physical Activity and Health, School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, AUSTRALIA 2Institute of Biomedical Technologies, School of Engineering, Auckland University of Technology, Auckland, NEW ZEALAND 3Recreation, Exercise, and Sport Science Department, Western State Colorado University, Gunnison, CO 4The Institute of Sport Sciences University of Lausanne, University of Lausanne, Lausanne, SWITZERLAND 5Department of Physiology, Faculty of Biology and Medicine, Lausanne University, Lausanne, SWITZERLAND and 6Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia
    Med Sci Sports Exerc 48:1539-47. 2016
    ..To understand the importance of fitness in treating this condition, we examined the association of fitness and fatness with central hemodynamic indices that are known independent predictors of cardiovascular events...
  24. ncbi Effects of antioxidant supplementation on blood cyclosporin A and glomerular filtration rate in renal transplant recipients
    Melanie L Blackhall
    School of Human Movement Studies, The University of Queensland, Queensland, Australia
    Nephrol Dial Transplant 20:1970-5. 2005
    ..However, only a small number of clinical trials have investigated antioxidant supplementation in transplant recipients, with very few data on their effects on patients' immunosuppressive therapy...
  25. ncbi Relationship between antioxidant enzyme genotype and activity and kidney function: a case-control study
    Amanda Crawford
    University of Tasmania, School of Human Life Sciences, Launceston, Tasmania, University of Queensland, School of Medicine, St Lucia, Australia
    Clin Nephrol 78:135-44. 2012
    ..This study compared antioxidant genotypes and activities of CKD patients with population controls, and determined their relationship to kidney function...
  26. doi Antioxidant therapy in hemodialysis patients: a systematic review
    Jeff S Coombes
    School of Human Movement Studies, The University of Queensland, Brisbane, Queensland, Australia
    Kidney Int 81:233-46. 2012
    ..Two intervention trials using different antioxidants have found CVD benefits, suggesting that this line of therapy is effective in this resistant population. These studies require validation in larger, adequately powered trials...
  27. pmc Time course and dose response of alpha tocopherol on oxidative stress in haemodialysis patients
    Ashleigh Reed
    School of Human Movement Studies, The University of Queensland, St Lucia, Queensland, 4072, Australia
    BMC Nephrol 10:32. 2009
    ..Therefore the aim of this study is to investigate the effect of different doses of oral alpha tocopherol on oxidative stress in haemodialysis patients with elevated oxidative stress and the time taken to achieve this effect...
  28. ncbi Dietary intake of patients with chronic kidney disease entering the LORD trial: adjusting for underreporting
    Robert G Fassett
    School of Human Movement Studies, University of Queensland, Brisbane, Australia
    J Ren Nutr 17:235-42. 2007
    ..The study objective was to determine the dietary intake of patients with chronic kidney disease before and after filtering for suspected underreporters and to investigate the impact of underreporting on the interpretation of diet data...
  29. doi Laparoscopic gastric banding surgery performed in obese dialysis patients prior to kidney transplantation
    Anoop N Koshy
    Department of Medicine, Clifford Craig Medical Research Trust, Renal Research Tasmania, University of Tasmania, Launceston General Hospital, Launceston, Tasmania, Australia
    Am J Kidney Dis 52:e15-7. 2008
    ..All these patients subsequently underwent successful uncomplicated kidney transplantations...
  30. doi Effects of exercise training and RhoA/ROCK inhibition on plaque in ApoE-/- mice
    Aya Matsumoto
    School of Human Movement Studies, The University of Queensland, Brisbane, Queensland, Australia
    Int J Cardiol 167:1282-8. 2013
    ..The aim of this study was to compare the effects of a RhoA/ROCK inhibitor (fasudil) and exercise in the Apolipoprotein E knockout (ApoE(-/-)) mouse model of atherosclerosis...
  31. doi Effect of pravastatin on kidney function and urinary protein excretion in autosomal dominant polycystic kidney disease
    Robert G Fassett
    Renal Medicine, Royal Brisbane and Women s Hospital, Brisbane, Queensland, Australia
    Scand J Urol Nephrol 44:56-61. 2010
    ..Experimental and clinical studies have suggested that statins may slow the progression of chronic kidney disease in general and ADPKD specifically...
  32. doi Oxidative stress biomarkers as predictors of cardiovascular disease
    Natalie A Strobel
    Exercise and Oxidative Stress Research Group, School of Human Movement Studies, The University of Queensland, St Lucia, Queensland 4072, Australia
    Int J Cardiol 147:191-201. 2011
    ..Furthermore, it is important to note that the methods used to assess oxidative stress in these studies are indirect, and the evidence that the various methods actually reflect oxidative stress in vivo is limited...
  33. pmc Optimising intraperitoneal gentamicin dosing in peritoneal dialysis patients with peritonitis (GIPD) study
    Dwarakanathan Ranganathan
    Renal Medicine, Royal Brisbane and Women s Hospital, Brisbane, Queensland, 4029 Australia
    BMC Nephrol 10:42. 2009
    ..The aim of this study is to examine a model of gentamicin pharmacokinetics and to develop an intraperitoneal drug dosing regime that maximises bacterial killing and minimises toxicity...
  34. pmc Laparoscopic adjustable gastric band in an obese unrelated living donor prior to kidney transplantation: a case report
    Anoop N Koshy
    School of Human Movement Studies, The University of Queensland, St, Lucia, Queensland, Australia
    J Med Case Rep 4:107. 2010
    ..Many centres exclude obese donors from living donor transplant programs. Diet, exercise and medication are often ineffective weight loss interventions for donors, hence bariatric surgery should be considered...
  35. doi Optimized method for quantification of total F(2)-isoprostanes using gas chromatography-tandem mass spectrometry
    David R Briskey
    Exercise and Oxidative Stress Research Group, School of Human Movement Studies, University of Queensland, Brisbane, Australia School of Medicine, University of Queensland, Brisbane, Australia
    J Pharm Biomed Anal 90:161-6. 2014
    ..Tissue values for healthy mice liver were 50-70 pg/μg protein. This method provides increased ion selectivity and detection capabilities with economical sample through-put...
  36. doi The sustainability of Medical Morning Handover Reporting: adherence in a regional hospital
    Terry J Hannan
    Department of Medicine, Launceston General Hospital, Launceston, TAS 7250, Australia
    Aust Health Rev 34:325-7. 2010
    ..It is considered a significant Quality of Care activity recommended in Australian Medical Association clinical handover guidelines. The sustainability of such activities has not been reported...
  37. doi Effects of exercise and antioxidant supplementation on endothelial gene expression
    Aya Matsumoto
    School of Human Movement Studies, The University of Queensland, Brisbane, Queensland, Australia
    Int J Cardiol 158:59-65. 2012
    ..There is growing evidence that reactive oxygen species may be involved in a number of these adaptations and that antioxidants may be used to investigate this effect...
  38. ncbi Improved resistance to serum oxidation in Gilbert's syndrome: a mechanism for cardiovascular protection
    Andrew C Bulmer
    School of Human Movement Studies, University of Queensland, St Lucia, Queensland 4067, Australia
    Atherosclerosis 199:390-6. 2008
    ..96+/-0.31; control: 0.73+/-0.21; P=0.072). In summary, individuals with GS have an increased circulating antioxidant status and an improved resistance to serum oxidation which may partially explain their reduced prevalence of CVD...
  39. doi 12 min/week of high-intensity interval training reduces aortic reservoir pressure in individuals with metabolic syndrome: a randomized trial
    Joyce S Ramos
    aCentre for Research on Exercise, Physical Activity and Health, School of Human Movement and Nutrition Sciences, The University of Queensland, St Lucia, Queensland, Australia bDepartment of Recreation, Exercise and Sport Science, Western State Colorado University, Gunnison, Colorado, USA cInstitute of Biomedical Technologies, School of Engineering, Auckland University of Technology, Auckland, New Zealand dInstitut des Sciences du Sport de l Universite de Lausanne ISSUL eDepartment of Physiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland fMenzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia
    J Hypertens 34:1977-87. 2016
    ..Therefore, this study compared the effect of different volumes of HIIT and moderate-intensity continuous training (MICT) on aortic reservoir pressure in participants with the metabolic syndrome (MetS)...
  40. pmc Sulforaphane and Other Nutrigenomic Nrf2 Activators: Can the Clinician's Expectation Be Matched by the Reality?
    Christine A Houghton
    School of Human Movement and Nutrition Science, The University of Queensland, Brisbane, Australia
    Oxid Med Cell Longev 2016:7857186. 2016
    ..Both its high bioavailability and significant Nrf2 inducer capacity contribute to the therapeutic potential of sulforaphane-yielding supplements. ..
  41. doi The impact of pre-intervention rate of kidney function change on the assessment of CKD progression
    Robert G Fassett
    The University of Queensland, Brisbane, QLD, Australia
    J Nephrol 27:515-9. 2014
    ..The aim of this analysis was to quantify the effects of a run-in phase on kidney function outcome in CKD patients enrolled in the Lipid Lowering and Onset of Renal Disease (LORD) trial...
  42. doi Sulforaphane: translational research from laboratory bench to clinic
    Christine A Houghton
    School of Human Movement Studies, University of Queensland, Brisbane, Queensland, Australia
    Nutr Rev 71:709-26. 2013
    ..Standardization of sulforaphane nomenclature and assay protocols will be necessary to remove inconsistency and ambiguity in the labeling of currently available broccoli sprout products. ..
  43. doi Exercise training in chronic kidney disease patients
    Erin J Howden
    School of Human Movement Studies, The University of Queensland, Brisbane, QLD, Australia
    Sports Med 42:473-88. 2012
    ..The effects of exercise training on kidney function, cardiovascular disease and quality of life are unknown. Studies are needed to answer these questions and develop evidence-based exercise training guidelines for individuals with CKD...
  44. doi Optimal criteria and sampling interval to detect a V̇O2 plateau at V̇O2max in patients with metabolic syndrome
    Amara C Thomson
    a School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Queensland, Australia
    Res Sports Med 23:337-50. 2015
    ..05]). When conducting maximal stress tests on patients with metabolic syndrome, a 15-b sampling interval and ≤50 mL∙min(-1) criteria should be implemented to increase the likelihood of detecting V̇O2 plateau at V̇O2max. ..
  45. pmc Oxpentifylline versus placebo in the treatment of erythropoietin-resistant anaemia: a randomized controlled trial
    David Wayne Johnson
    Australian Kidney Trials Network, School of Population Health, University of Queensland, Brisbane, Australia
    BMC Nephrol 9:8. 2008
    ..The main hypothesis of this study is that Oxpentifylline administration will effectively treat erythropoietin- or darbepoietin-resistant anaemia in chronic kidney disease patients...
  46. doi "Exercise is Medicine": curbing the burden of chronic disease and physical inactivity
    Jeff S Coombes
    The University of Queensland, Brisbane, QLD, Australia
    Asia Pac J Public Health 27:NP600-5. 2015
    ..This will assist primary care providers in treating their patients. ..
  47. ncbi A national survey of medical morning handover report in Australian hospitals
    Matthew J Fassett
    Department of Medicine, Launceston General Hospital, University of Tasmania, Launceston, TAS, Australia
    Med J Aust 187:164-5. 2007
    ..To investigate the prevalence and format of medical morning handover report (MMHR) in Australian hospitals...
  48. doi Variability of oxidative stress biomarkers in hemodialysis patients
    Rumbidzai Dahwa
    Renal Medicine, Royal Brisbane and Women s Hospital, Brisbane, Queensland, Australia
    Biomarkers 19:154-8. 2014
    ..9-40.2%) and protein carbonyls = 19.5% (15.6-24.5%). There were no significant (p > 0.05) relationships between the oxidative stress biomarkers and dietary antioxidant intake, medications, clinical and demographic parameters...
  49. doi Effects of uric acid-lowering therapy on renal outcomes: a systematic review and meta-analysis
    Bhadran Bose
    Department of Nephrology, University of Queensland at Princess Alexandra Hospital, Brisbane, Australia
    Nephrol Dial Transplant 29:406-13. 2014
    ..The aim of this systematic review is to summarize evidence from randomized controlled trials (RCTs) concerning the benefits and risks of uric acid-lowering therapy on renal outcomes...
  50. doi The effects of immunosuppressants on vascular function, systemic oxidative stress and inflammation in rats
    Cecilia M Shing
    School of Human Life Sciences, University of Tasmania, Launceston, Australia
    Transpl Int 25:337-46. 2012
    ..At the doses administered in this model, the immunosuppressants exerted varying effects on vascular function...
  51. doi Physiological and performance effects of glycerol hyperhydration and rehydration
    Simon P van Rosendal
    The University of Queensland, School of Human Movement Studies, Brisbane, Queensland, Australia
    Nutr Rev 67:690-705. 2009
    ..In summary, while glycerol and fluid ingestion results in hyperhydration, the documented benefits to exercise performance remain inconsistent...