Changhai Ding

Summary

Affiliation: University of Tasmania
Country: Australia

Publications

  1. ncbi request reprint Do NSAIDs affect the progression of osteoarthritis?
    Changhai Ding
    Menzies Centre for Population Health Research, University of Tasmania, Australia
    Inflammation 26:139-42. 2002
  2. ncbi request reprint Lumiracoxib (Novartis)
    Changhai Ding
    Menzies Centre for Population Health Research, University of Tasmania, 17 Liverpool Street, Hobart 7000, Tasmania, Australia
    IDrugs 5:1168-72. 2002
  3. pmc Genetic mechanisms of knee osteoarthritis: a population-based longitudinal study
    Changhai Ding
    Menzies Research Institute, University of Tasmania, Hobart, Australia
    Arthritis Res Ther 8:R8. 2006
  4. pmc Oral administration of type II collagen suppresses pro-inflammatory mediator production by synoviocytes in rats with adjuvant arthritis
    C H Ding
    Institute of Clinical Pharmacology, Anhui Medical University, Hefei, China
    Clin Exp Immunol 132:416-23. 2003
  5. pmc Knee meniscal extrusion in a largely non-osteoarthritic cohort: association with greater loss of cartilage volume
    Changhai Ding
    Menzies Research Institute, University of Tasmania, 199 Macquarie Street, Hobart 7000, Australia
    Arthritis Res Ther 9:R21. 2007
  6. pmc Familial, structural, and environmental correlates of MRI-defined bone marrow lesions: a sibpair study
    Guangju Zhai
    Menzies Research Institute, University of Tasmania, Level 2, Surrey House, 199 Macquarie Street, Hobart, TAS 7000, Australia
    Arthritis Res Ther 8:R137. 2006
  7. ncbi request reprint Meniscal tear as an osteoarthritis risk factor in a largely non-osteoarthritic cohort: a cross-sectional study
    Changhai Ding
    Menzies Research Institute, University of Tasmania, Hobart, Australia
    J Rheumatol 34:776-84. 2007
  8. doi request reprint Subchondral bone and cartilage damage: a prospective study in older adults
    Dawn Dore
    Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia
    Arthritis Rheum 62:1967-73. 2010
  9. ncbi request reprint Correlates of knee pain in younger subjects
    Guangju Zhai
    Menzies Research Institute, University of Tasmania, Hobart, Tasmania, 7001, Australia
    Clin Rheumatol 26:75-80. 2007
  10. ncbi request reprint The genetic contribution and relevance of knee cartilage defects: case-control and sib-pair studies
    Changhai Ding
    Menzies Research Institute, University of Tasmania, Hobart, Tasmania 7000, Australia
    J Rheumatol 32:1937-42. 2005

Collaborators

Detail Information

Publications94

  1. ncbi request reprint Do NSAIDs affect the progression of osteoarthritis?
    Changhai Ding
    Menzies Centre for Population Health Research, University of Tasmania, Australia
    Inflammation 26:139-42. 2002
    ..Therefore, it is necessary and valuable to clarify the effects of these NSAIDs on cartilage in patients with OA using validated non-invasive methods such as MRI...
  2. ncbi request reprint Lumiracoxib (Novartis)
    Changhai Ding
    Menzies Centre for Population Health Research, University of Tasmania, 17 Liverpool Street, Hobart 7000, Tasmania, Australia
    IDrugs 5:1168-72. 2002
    ..By late December 2000, phase III trials had been initiated and were ongoing in December 2001...
  3. pmc Genetic mechanisms of knee osteoarthritis: a population-based longitudinal study
    Changhai Ding
    Menzies Research Institute, University of Tasmania, Hobart, Australia
    Arthritis Res Ther 8:R8. 2006
    ..Importantly, the cartilage changes are largely dependent on baseline differences in cartilage volume, tibial bone area, BMI and knee pain, suggesting that these factors might have a role in their initiation...
  4. pmc Oral administration of type II collagen suppresses pro-inflammatory mediator production by synoviocytes in rats with adjuvant arthritis
    C H Ding
    Institute of Clinical Pharmacology, Anhui Medical University, Hefei, China
    Clin Exp Immunol 132:416-23. 2003
    ..Bystander active suppression may be the main mechanism of oral CII in the suppression of synoviocyte function...
  5. pmc Knee meniscal extrusion in a largely non-osteoarthritic cohort: association with greater loss of cartilage volume
    Changhai Ding
    Menzies Research Institute, University of Tasmania, 199 Macquarie Street, Hobart 7000, Australia
    Arthritis Res Ther 9:R21. 2007
    ....
  6. pmc Familial, structural, and environmental correlates of MRI-defined bone marrow lesions: a sibpair study
    Guangju Zhai
    Menzies Research Institute, University of Tasmania, Level 2, Surrey House, 199 Macquarie Street, Hobart, TAS 7000, Australia
    Arthritis Res Ther 8:R137. 2006
    ..They commonly coexist with chondral defects and ROA but only share common genetic mechanisms to a limited degree. They are also more common with increasing age, male sex, and increasing BMI...
  7. ncbi request reprint Meniscal tear as an osteoarthritis risk factor in a largely non-osteoarthritic cohort: a cross-sectional study
    Changhai Ding
    Menzies Research Institute, University of Tasmania, Hobart, Australia
    J Rheumatol 34:776-84. 2007
    ..To examine the associations between meniscal tear, knee structure, osteoarthritis (OA) risk factors, radiographic change, and symptoms in a largely non-osteoarthritic cohort...
  8. doi request reprint Subchondral bone and cartilage damage: a prospective study in older adults
    Dawn Dore
    Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia
    Arthritis Rheum 62:1967-73. 2010
    ..The aim of this study was to describe the association between baseline tibial bone area and tibial subchondral bone mineral density (BMD) with tibial cartilage defect development and cartilage volume loss...
  9. ncbi request reprint Correlates of knee pain in younger subjects
    Guangju Zhai
    Menzies Research Institute, University of Tasmania, Hobart, Tasmania, 7001, Australia
    Clin Rheumatol 26:75-80. 2007
    ..MRI and biochemical measures can add to radiographs in defining unexplained knee pain in younger subjects...
  10. ncbi request reprint The genetic contribution and relevance of knee cartilage defects: case-control and sib-pair studies
    Changhai Ding
    Menzies Research Institute, University of Tasmania, Hobart, Tasmania 7000, Australia
    J Rheumatol 32:1937-42. 2005
    ....
  11. doi request reprint Associations between serum levels of inflammatory markers and change in knee pain over 5 years in older adults: a prospective cohort study
    Oliver P Stannus
    Menzies Research Institute, Private Bag 23, Hobart, Tasmania 7000, Australia
    Ann Rheum Dis 72:535-40. 2013
    ..To determine the association between inflammatory markers and change in knee pain over 5 years...
  12. pmc The association between leptin, interleukin-6, and hip radiographic osteoarthritis in older people: a cross-sectional study
    Oliver P Stannus
    Menzies Research Institute, University of Tasmania, Private Bag 23, Hobart, Tasmania 7000, Australia
    Arthritis Res Ther 12:R95. 2010
    ..The aim of this study was to describe the associations between leptin, IL-6, and hip radiographic osteoarthritis (ROA) in older adults...
  13. ncbi request reprint Natural history of knee cartilage defects and factors affecting change
    Changhai Ding
    Menzies Research Institute, University of Tasmania, Hobart
    Arch Intern Med 166:651-8. 2006
    ..Knee cartilage defects may play an important role in early osteoarthritis, but little is known about their natural history...
  14. doi request reprint The association between objectively measured physical activity and knee structural change using MRI
    Dawn A Doré
    Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia
    Ann Rheum Dis 72:1170-5. 2013
    ..This study describes the longitudinal association between objectively assessed physical activity (PA) and knee structural change measured using MRI...
  15. pmc Bone marrow lesions predict site-specific cartilage defect development and volume loss: a prospective study in older adults
    Dawn Dore
    Menzies Research Institute Tasmania, University of Tasmania, Private Bag 23, Hobart, 7000, Australia
    Arthritis Res Ther 12:R222. 2010
    ....
  16. ncbi request reprint Knee structural alteration and BMI: a cross-sectional study
    Changhai Ding
    Menzies Research Institute, University of Tasmania, Private Bag 23, Hobart, Tasmania 7000, Australia
    Obes Res 13:350-61. 2005
    ..To describe the associations among BMI, knee cartilage morphology, and bone size in adults...
  17. ncbi request reprint The genetic contribution to longitudinal changes in knee structure and muscle strength: a sibpair study
    Guangju Zhai
    Menzies Research Institute, University of Tasmania, Tasmania, Australia
    Arthritis Rheum 52:2830-4. 2005
    ..To estimate the heritability of longitudinal changes in knee cartilage volume, chondral defects, subchondral bone size, and lower limb muscle strength...
  18. ncbi request reprint A longitudinal study of the association between knee alignment and change in cartilage volume and chondral defects in a largely non-osteoarthritic population
    Guangju Zhai
    Menzies Research Institute, University of Tasmania, Hobart, Australia
    J Rheumatol 34:181-6. 2007
    ..We investigated whether baseline malalignment of the knee predicts subsequent change in knee cartilage volume and chondral defects in subjects with and without radiographic knee osteoarthritis (OA)...
  19. pmc Natural history and clinical significance of MRI-detected bone marrow lesions at the knee: a prospective study in community dwelling older adults
    Dawn Dore
    Menzies Research Institute Tasmania, University of Tasmania, Private Bag 23, Hobart, 7000, Australia
    Arthritis Res Ther 12:R223. 2010
    ....
  20. ncbi request reprint Knee cartilage defects: association with early radiographic osteoarthritis, decreased cartilage volume, increased joint surface area and type II collagen breakdown
    Changhai Ding
    Menzies Research Institute, University of Tasmania, Hobart, Australia
    Osteoarthritis Cartilage 13:198-205. 2005
    ..To generate hypotheses regarding the associations between knee cartilage defects and knee radiographic osteoarthritis (ROA), cartilage volume, bone size and type II collagen breakdown in adults...
  21. ncbi request reprint Smoking interacts with family history with regard to change in knee cartilage volume and cartilage defect development
    Changhai Ding
    Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia
    Arthritis Rheum 56:1521-8. 2007
    ..To describe the effects of smoking on change in knee cartilage volume and increases in knee cartilage defects, and to test for interaction between smoking and family history of osteoarthritis (OA)...
  22. pmc Correlates of knee bone marrow lesions in younger adults
    Benny Antony
    Menzies Institute for Medical Research, University of Tasmania, 17 Liverpool Street, Hobart, TAS 7000, Australia
    Arthritis Res Ther 18:31. 2016
    ....
  23. doi request reprint Moderate vitamin D deficiency is associated with changes in knee and hip pain in older adults: a 5-year longitudinal study
    Laura L Laslett
    Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia
    Ann Rheum Dis 73:697-703. 2014
    ..Vitamin D is important for bone, cartilage and muscle function but there are few studies on its association with joint pain...
  24. doi request reprint Do NSAIDs affect longitudinal changes in knee cartilage volume and knee cartilage defects in older adults?
    Changhai Ding
    Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia
    Am J Med 122:836-42. 2009
    ..The aim of this longitudinal study was to determine the associations between use of NSAIDs and changes in knee cartilage volume and knee cartilage defects over 2.9 years in older adults...
  25. doi request reprint Knee and hip radiographic osteoarthritis predict total hip bone loss in older adults: a prospective study
    Changhai Ding
    Menzies Research Institute, University of Tasmania, Hobart, Australia
    J Bone Miner Res 25:858-65. 2010
    ..In conclusion, older subjects with radiographic hip and knee OA have higher total hip bone loss over 2.6 years regardless of symptoms, suggesting that consideration should be given to the monitoring of bone mass in these subjects...
  26. doi request reprint Serum levels of vitamin D, sunlight exposure, and knee cartilage loss in older adults: the Tasmanian older adult cohort study
    Changhai Ding
    Menzies Research Institute, University of Tasmania, Hobart, Tasmania
    Arthritis Rheum 60:1381-9. 2009
    ..To determine the associations between serum levels of vitamin D, sunlight exposure, and knee cartilage loss cross-sectionally and longitudinally in older adults...
  27. ncbi request reprint Association of prevalent and incident knee cartilage defects with loss of tibial and patellar cartilage: a longitudinal study
    Changhai Ding
    University of Tasmania, Hobart, Tasmania, Australia
    Arthritis Rheum 52:3918-27. 2005
    ..To describe the association between prevalent and incident knee cartilage defects and loss of knee cartilage in male and female adults...
  28. ncbi request reprint A longitudinal study of the effect of sex and age on rate of change in knee cartilage volume in adults
    Changhai Ding
    Menzies Research Institute, Private Bag 23, Hobart, Tasmania 7000, Australia
    Rheumatology (Oxford) 46:273-9. 2007
    ..To describe the association between sex, age and rate of change in knee cartilage volume in adults...
  29. ncbi request reprint Correlates of knee pain in older adults: Tasmanian Older Adult Cohort Study
    Guangju Zhai
    Menzies Research Institute, University of Tasmania, Hobart, Tasmania 7001, Australia
    Arthritis Rheum 55:264-71. 2006
    ..To describe the association between chondral defects, bone marrow lesions, knee and hip radiographic osteoarthritis (OA), and knee pain...
  30. doi request reprint Association between MRI-detected osteophytes and changes in knee structures and pain in older adults: A cohort study
    Zhaohua Zhu
    Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia
    Osteoarthritis Cartilage . 2017
    ..To describe cross-sectional and longitudinal associations between magnetic resonance imaging (MRI)-detected osteophytes (OPs) and knee structural abnormalities and knee pain in older adults...
  31. doi request reprint Correlation Between Changes in Global Knee Structures Assessed by Magnetic Resonance Imaging and Radiographic Osteoarthritis Changes Over Ten Years in a Midlife Cohort
    Hussain Ijaz Khan
    Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia
    Arthritis Care Res (Hoboken) 68:958-64. 2016
    ..The aim of this study was to describe the correlation between changes in structural abnormalities assessed on magnetic resonance imaging (MRI) and change in radiographic osteoarthritis (OA) over 10 years in a midlife cohort...
  32. pmc Hypointense signals in the infrapatellar fat pad assessed by magnetic resonance imaging are associated with knee symptoms and structure in older adults: a cohort study
    Weiyu Han
    Menzies Institute for Medical Research, University of Tasmania, Private Bag 23, Hobart, TAS, 7000, Australia
    Arthritis Res Ther 18:234. 2016
    ..This study aims to describe the associations between hypointense signals in the infrapatellar fat pad (IPFP) and knee structural change and symptoms in older adults...
  33. doi request reprint Signal intensity alteration in the infrapatellar fat pad at baseline for the prediction of knee symptoms and structure in older adults: a cohort study
    Weiyu Han
    Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia Department of Orthopaedics, 3rd Affiliated Hospital of Southern Medical University, Guangzhou, China
    Ann Rheum Dis 75:1783-8. 2016
    ..To describe the associations between infrapatellar fat pad (IPFP) signal intensity alteration at baseline and knee symptoms and structural changes in older adults...
  34. doi request reprint Cross-Sectional and Longitudinal Associations Between Serum Levels of High-Sensitivity C-Reactive Protein, Knee Bone Marrow Lesions, and Knee Pain in Patients With Knee Osteoarthritis
    Zhaohua Zhu
    Zhaohua Zhu, MD Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia, and Arthritis Research Institute, Anhui Medical University, Hefei, Anhui, China
    Arthritis Care Res (Hoboken) 68:1471-7. 2016
    ..To describe associations between serum high-sensitivity C-reactive protein (hsCRP), knee bone marrow lesions (BMLs), and knee pain, cross-sectionally and longitudinally, in patients with knee osteoarthritis (OA)...
  35. doi request reprint Childhood Physical Performance Measures and Adulthood Knee Cartilage Volume and Bone Area: A 25-Year Cohort Study
    Benny Antony
    University of Tasmania, Hobart, Tasmania, Australia
    Arthritis Care Res (Hoboken) 67:1263-71. 2015
    ..We aimed to determine the associations between childhood physical performance measures and tibial cartilage volume and tibial bone area in adults 25 years later...
  36. doi request reprint Association of Body Composition and Hormonal and Inflammatory Factors With Tibial Cartilage Volume and Sex Difference in Cartilage Volume in Young Adults
    Benny Antony
    Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia
    Arthritis Care Res (Hoboken) 68:517-25. 2016
    ....
  37. doi request reprint Cross-sectional and Longitudinal Associations between Knee Joint Effusion Synovitis and Knee Pain in Older Adults
    Xia Wang
    From the Menzies Institute for Medical Research, University of Tasmania Department of Radiology, Royal Hobart Hospital, Hobart, Australia Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia Department of Orthopedics, 3rd Affiliated Hospital of Southern Medical University, Guangzhou, China Research Institute of Orthopedics, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China Department of Epidemiology and Biostatistics, School of Public Health, and the Arthritis Research Institute, 1st Affiliated Hospital, Anhui Medical University, Hefei, China X Wang, PhD, Student, Menzies Institute for Medical Research, University of Tasmania X Jin, PhD, Student, Menzies Institute for Medical Research, University of Tasmania W Han, MD, Menzies Institute for Medical Research, University of Tasmania, and Department of Orthopedics, 3rd Affiliated Hospital of Southern Medical University Y Cao, MD, Menzies Institute for Medical Research, University of Tasmania, and Research Institute of Orthopedics, Shuguang Hospital
    J Rheumatol 43:121-30. 2016
    ..To describe the cross-sectional and longitudinal associations between knee regional effusion synovitis and knee pain in older adults...
  38. pmc Association of physical activity and physical performance with tibial cartilage volume and bone area in young adults
    Benny Antony
    Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia
    Arthritis Res Ther 17:298. 2015
    ..The aim of this study was to describe the associations between physical activity and performance measured 5 years prior and tibial cartilage volume and bone area in young adults...
  39. doi request reprint Effect of Vitamin D Supplementation on Tibial Cartilage Volume and Knee Pain Among Patients With Symptomatic Knee Osteoarthritis: A Randomized Clinical Trial
    Xingzhong Jin
    Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia
    JAMA 315:1005-13. 2016
    ..Observational studies suggest that vitamin D supplementation is associated with benefits for knee osteoarthritis, but current trial evidence is contradictory...
  40. doi request reprint Quantitative Assessment of Knee Effusion-Synovitis in Older Adults: Association With Knee Structural Abnormalities
    Xia Wang
    Menzies Institute for Medical Research and University of Tasmania, Hobart, Tasmania, Australia
    Arthritis Rheumatol 68:837-44. 2016
    ....
  41. doi request reprint Association between hip and knee cartilage measured using radiographs and magnetic resonance imaging: the Tasmanian Older Adult Cohort Study
    Hussain I Khan
    Musculoskeletal Unit, Menzies Research Institute, Medical Science 1 Building, Private Bag 23, 17 Liverpool Street, Hobart, Tasmania 7000, Australia
    Rheumatology (Oxford) 52:2009-15. 2013
    ..The aim of this study was to examine the association of hip and knee cartilage measured by both radiography and MRI...
  42. ncbi request reprint Physical activity and knee structural change: a longitudinal study using MRI
    Stella Foley
    Menzies Research Institute, University of Tasmania, Hobart, Australia
    Med Sci Sports Exerc 39:426-34. 2007
    ..Exercise therapy is effective in improving symptoms of knee osteoarthritis, but its effect on structural change remains unclear...
  43. pmc Optimal sampling of MRI slices for the assessment of knee cartilage volume for cross-sectional and longitudinal studies
    Guangju Zhai
    Menzies Research Institute, University of Tasmania, Hobart, Australia
    BMC Musculoskelet Disord 6:10. 2005
    ..The aim of this study was to determine the optimal sampling of 1.5 mm thick slices of MRI scans to estimate knee cartilage volume in males and females for cross-sectional and longitudinal studies...
  44. doi request reprint Patellofemoral Bone Marrow Lesions: Natural History and Associations With Pain and Structure
    Zhaohua Zhu
    Zhaohua Zhu, PhD, Xingzhong Jin, PhD, Benny Antony, PhD, Weiyu Han, PhD, Laura L Laslett, PhD, Graeme Jones, MD, PhD Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia
    Arthritis Care Res (Hoboken) 68:1647-1654. 2016
    ..To describe the natural history of patellofemoral (PF) joint bone marrow lesions (BMLs) over 2.6 years and associations between changes in PF joint BMLs, knee pain, and knee cartilage morphology in older adults over 5 years...
  45. doi request reprint Association between MRI-detected knee joint regional effusion-synovitis and structural changes in older adults: a cohort study
    Xia Wang
    Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia
    Ann Rheum Dis 75:519-25. 2016
    ..To describe the cross-sectional and longitudinal associations between knee regional effusion-synovitis and structural changes in older adults...
  46. pmc Does cartilage volume measurement or radiographic osteoarthritis at baseline independently predict ten-year cartilage volume loss?
    Andrew McBride
    Menzies Institute for Medical Research, University of Tasmania, Medical Science 1 Building, Private Bag 23 17 Liverpool Street, Hobart, 7000, Australia
    BMC Musculoskelet Disord 17:54. 2016
    ..The aim of this study was to examine whether cartilage volume as measured by MRI and radiographic osteoarthritis (OA) at baseline predict cartilage volume loss over ten years independent of each other and other structural co-pathologies...
  47. doi request reprint Longitudinal associations between adiposity and change in knee pain: Tasmanian older adult cohort study
    Xingzhong Jin
    Menzies Institute for Medical Research, University of Tasmania, Private Bag 23, Hobart, Tasmania 7000, Australia
    Semin Arthritis Rheum 45:564-9. 2016
    ..The aim of this study was to describe the longitudinal relationship between adiposity and change in knee pain...
  48. pmc Natural history and clinical significance of meniscal tears over 8 years in a midlife cohort
    Hussain Ijaz Khan
    Musculoskeletal Unit, Menzies Institute for Medical Research, University of Tasmania, Medical Science 1 Building, Private Bag 23, 17 Liverpool Street, Hobart, TAS, 7000, Australia
    BMC Musculoskelet Disord 17:4. 2016
    ..The aim of this study was to describe the natural history of meniscal tears over 8 years and the relationship with change in knee pain and structures...
  49. doi request reprint Association between childhood overweight measures and adulthood knee pain, stiffness and dysfunction: a 25-year cohort study
    Benny Antony
    Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia
    Ann Rheum Dis 74:711-7. 2015
    ..To describe the associations between overweight measures in childhood and knee pain, stiffness and dysfunction among adults 25 years later...
  50. doi request reprint Cross-sectional and longitudinal associations between circulating leptin and knee cartilage thickness in older adults
    Oliver P Stannus
    Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia
    Ann Rheum Dis 74:82-8. 2015
    ..To investigate cross-sectional and longitudinal associations between serum leptin levels and knee cartilage thickness in older adults...
  51. doi request reprint Body fat predicts an increase and limb muscle strength predicts a decrease in leptin in older adults over 2·6 years
    Benny Antony
    Menzies Research Institute, University of Tasmania, Hobart, Australia
    Clin Endocrinol (Oxf) 79:652-60. 2013
    ..The aim of this study was to determine if body fat and muscle measures predict the natural increase in leptin over 2·6 years in older adults...
  52. doi request reprint Association between serum levels of 25-hydroxyvitamin D and osteoarthritis: a systematic review
    Yuelong Cao
    Menzies Research Institute Tasmania, University of Tasmania, Private Bag 23, Hobart, Tasmania 7000, Australia
    Rheumatology (Oxford) 52:1323-34. 2013
    ..To systematically review the evidence for association between serum 25-hydroxyvitamin D (25-(OH)D) and OA and the effect of vitamin D therapy on OA...
  53. pmc A longitudinal study of the association between dietary factors, serum lipids, and bone marrow lesions of the knee
    Dawn Dore
    Menzies Research Institute Tasmania, University of Tasmania, Private Bag 23, Hobart, Tasmania, 7000, Australia
    Arthritis Res Ther 14:R13. 2012
    ..Bone marrow lesions (BMLs) play an important role in knee osteoarthritis, but their etiology is not well understood. The aim of this longitudinal study was to describe the association between dietary factors, serum lipids, and BMLs...
  54. doi request reprint Association of baseline knee bone size, cartilage volume, and body mass index with knee cartilage loss over time: a longitudinal study in younger or middle-aged adults
    Benny Antony
    Menzies Research Institute, Private Bag 23, Hobart, Tasmania 7000, Australia
    J Rheumatol 38:1973-80. 2011
    ..To determine the association of knee bone size, cartilage volume, and body mass index (BMI) at baseline with knee cartilage loss over 2 years in younger or middle-aged adults...
  55. ncbi request reprint Factors associated with hip cartilage volume measured by magnetic resonance imaging: the Tasmanian Older Adult Cohort Study
    Guangju Zhai
    University of Tasmania, Hobart, Tasmania, Australia
    Arthritis Rheum 52:1069-76. 2005
    ....
  56. doi request reprint Pain at sites outside the knee predicts knee cartilage volume loss in elderly people without knee osteoarthritis: A prospective study
    Feng Pan
    Menzies Institute for Medical Research, University of Tasmania, Private Bag 23, Hobart, Tasmania, 7000, Australia
    Arthritis Care Res (Hoboken) . 2016
    ..This study, therefore, aimed to determine whether pain at multiple sites predicts knee cartilage volume loss amongst community-dwelling older adults, and if so, to explore potential mechanisms...
  57. pmc Serum levels of interleukin-17 and adiponectin are associated with infrapatellar fat pad volume and signal intensity alteration in patients with knee osteoarthritis
    Kang Wang
    Department of Rheumatology and Immunology, Arthritis Research Institute, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Street, Hefei, China
    Arthritis Res Ther 18:193. 2016
    ....
  58. doi request reprint Associations between fat mass and multi-site pain: A 5-year longitudinal study
    Feng Pan
    Menzies Institute for Medical Research, University of Tasmania, Private Bag 23, Hobart, Tasmania, 7000, Australia
    Arthritis Care Res (Hoboken) . 2016
    ..Obesity is an important risk factor in the pathogenesis of pain and multi-site pain (MSP). This study aimed to examine longitudinal associations between fat mass and MSP, and to explore the potential mechanisms of any associations...
  59. doi request reprint The offspring of people with a total knee replacement for severe primary knee osteoarthritis have a higher risk of worsening knee pain over 8 years
    Feng Pan
    Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia
    Ann Rheum Dis 75:368-73. 2016
    ....
  60. doi request reprint History of knee injury and MRI-assessed knee structures in middle- and older-aged adults: a cross-sectional study
    Hussain Ijaz Khan
    Menzies Research Institute, Medical Science 1 Building Private Bag 23, 17 Liverpool Street, Hobart, TAS, 7000, Australia
    Clin Rheumatol 34:1463-72. 2015
    ..The association between knee injury and MRI-assessed structural pathology in the knee joint is moderate and appears to be stronger in older adults compared to middle-aged adults...
  61. doi request reprint Cross-sectional and longitudinal associations between systemic, subchondral bone mineral density and knee cartilage thickness in older adults with or without radiographic osteoarthritis
    Yuelong Cao
    Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia Research Institute of Orthopaedics, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China
    Ann Rheum Dis 73:2003-9. 2014
    ..To investigate cross-sectional and longitudinal associations between systemic bone mineral density (BMD), subchondral BMD (sBMD) and knee cartilage thickness in older adults with or without radiographic osteoarthritis (ROA)...
  62. pmc Vitamin D supplementation in the management of knee osteoarthritis: study protocol for a randomized controlled trial
    Yuelong Cao
    Menzies Research Institute Tasmania, University of Tasmania, Private Bag 23, Hobart, TAS, 7000, Australia
    Trials 13:131. 2012
    ....
  63. doi request reprint The association between parity and knee cartilage in young women
    Shuying Wei
    Menzies Research Institute Tasmania, 17 Liverpool Street, Hobart, Tasmania 7001, Australia
    Rheumatology (Oxford) 51:2039-45. 2012
    ..The aim of this study was to describe the association between parity, cartilage volume and cartilage defects in women aged 31-41 years...
  64. doi request reprint Correlates of subchondral BMD: a cross-sectional study
    Dawn Dore
    Menzies Research Institute, University of Tasmania, Hobart, Australia
    J Bone Miner Res 24:2007-15. 2009
    ..10, p < 0.01). In conclusion, this study identified a large number of factors associated with sBMD, of which the most novel is cartilage defects. Longitudinal studies are required to address causality...
  65. ncbi request reprint Anti-interleukin-6 receptor antibody treatment in inflammatory autoimmune diseases
    Changhai Ding
    Menzies Research Institute, Hobart, Tasmania, Australia
    Rev Recent Clin Trials 1:193-200. 2006
    ..Like other anti-cytokine immunotherapies, caution and close monitoring for the adverse events, especially infection, are necessary in subsequent clinical trials...
  66. ncbi request reprint The genetic contribution to muscle strength, knee pain, cartilage volume, bone size, and radiographic osteoarthritis: a sibpair study
    Guangju Zhai
    University of Tasmania, Hobart, Tasmania, Australia
    Arthritis Rheum 50:805-10. 2004
    ..To estimate the heritability of muscle strength, knee pain, cartilage volume, bone size, and radiographic osteoarthritis (ROA), and to assess whether heritability of the knee structural components is independent of ROA...
  67. doi request reprint A longitudinal study of the association between infrapatellar fat pad maximal area and changes in knee symptoms and structure in older adults
    Faming Pan
    Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China Arthritis Research Institute, 1st Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China
    Ann Rheum Dis 74:1818-24. 2015
    ..The aim of this study was to describe the longitudinal associations between baseline IPFP maximal area and changes in knee pain, knee cartilage volume and cartilage defects in older adults...
  68. ncbi request reprint Drug evaluation: VX-702, a MAP kinase inhibitor for rheumatoid arthritis and acute coronary syndrome
    Changhai Ding
    Menzies Research Institute, University of Tasmania, Hobart, Tasmania 7000, Australia
    Curr Opin Investig Drugs 7:1020-5. 2006
    ..In June 2005, a phase II clinical trial of VX-702 was initiated in rheumatoid arthritis. In July 2006, Vertex was planning to file an IND in the second half of 2006...
  69. doi request reprint A prospective study of the associations between 25-hydroxy-vitamin D, sarcopenia progression and physical activity in older adults
    David Scott
    Menzies Research Institute, University of Tasmania, Hobart School of Human Life Sciences, University of Tasmania, Launceston, TAS, Australia
    Clin Endocrinol (Oxf) 73:581-7. 2010
    ..Our objective was to describe prospective associations between 25OHD, muscle parameters, and PA in community-dwelling older adults...
  70. ncbi request reprint ABT-874, a fully human monoclonal anti-IL-12/IL-23 antibody for the potential treatment of autoimmune diseases
    Changhai Ding
    University of Tasmania, Menzies Research Institute, 199 Macquarie Street, Hobart, Tasmania 7000, Australia
    Curr Opin Investig Drugs 9:515-22. 2008
    ..ABT-87 was previously being developed for the potential treatment of multiple sclerosis; however, by May 2007, development for this indication was discontinued...
  71. doi request reprint Responsiveness of magnetic resonance imaging-derived measures over 2.7 years
    Dawn Aitken
    From the Menzies Research Institute Tasmania, University of Tasmania, Hobart the Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia Osteoarthritis Research Unit, University of Montreal Hospital Research Centre CRCHUM, Notre Dame Hospital, Montreal, Quebec, Canada D Aitken née Doré, PhD G Jones, MD, Menzies Research Institute Tasmania, University of Tasmania F Cicuttini, PhD, Department of Epidemiology and Preventive Medicine, Monash University C Ding, MD, Menzies Research Institute Tasmania, University of Tasmania, Department of Epidemiology and Preventive Medicine, Monash University J P Pelletier, MD J Martel Pelletier, PhD, Osteoarthritis Research Unit, CRCHUM, Notre Dame Hospital
    J Rheumatol 41:2060-7. 2014
    ..To compare the responsiveness of magnetic resonance imaging (MRI)-derived measures of knee osteoarthritis over 2.7 years...
  72. doi request reprint Circulating C reactive protein in osteoarthritis: a systematic review and meta-analysis
    Xingzhong Jin
    Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia
    Ann Rheum Dis 74:703-10. 2015
    ..C reactive protein (CRP), a systemic marker for inflammation, may be elevated in OA patients but the evidence is conflicting...
  73. ncbi request reprint How important is MRI for detecting early osteoarthritis?
    Changhai Ding
    Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia
    Nat Clin Pract Rheumatol 4:4-5. 2008
  74. ncbi request reprint B-cell-targeted therapy for systemic lupus erythematosus: an update
    Changhai Ding
    Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia
    BioDrugs 22:239-49. 2008
    ..g. ocrelizumab) and agents that interrupt B-cell/T-cell interactions also have potential, and the efficacy of these, along with rituximab, belimumab and epratuzumab, needs to be determined by randomized controlled trials...
  75. doi request reprint Circulating levels of inflammatory markers predict change in bone mineral density and resorption in older adults: a longitudinal study
    Changhai Ding
    Menzies Research Institute, University of Tasmania, Hobart, Tasmania 7000, Australia
    J Clin Endocrinol Metab 93:1952-8. 2008
    ..IL-1, IL-6, and TNF-alpha play an important role in the pathogenesis of osteoporosis in animals; however, evidence that these play a similar role in bone loss in human studies is limited...
  76. ncbi request reprint Early radiographic osteoarthritis is associated with substantial changes in cartilage volume and tibial bone surface area in both males and females
    G Jones
    Menzies Centre for Population Health Research, GPO Box 252 23, Tasmania 7000, Hobart, Australia
    Osteoarthritis Cartilage 12:169-74. 2004
    ..To describe the association between early radiographic osteoarthritis of the knee (ROA), knee cartilage volume and tibial bone surface area...
  77. ncbi request reprint Knee articular cartilage development in children: a longitudinal study of the effect of sex, growth, body composition, and physical activity
    Graeme Jones
    Menzies Centre for Population Health Research, GPO Box 252 23, Hobart, Tasmania, Australia 7000
    Pediatr Res 54:230-6. 2003
    ..These results provide novel data on articular cartilage development in humans. The long-term significance of these results with regard to osteoarthritis of the knee in later life remains hypothetical...
  78. doi request reprint Targeting IL-6 in the treatment of inflammatory and autoimmune diseases
    Changhai Ding
    Monash University, Central and Eastern Clinical School, Department of Epidemiology and Preventive Medicine, Commercial Road, Melbourne 3004, Australia
    Expert Opin Investig Drugs 18:1457-66. 2009
    ....
  79. ncbi request reprint Technology evaluation: MRA, Chugai
    Changhai Ding
    Menzies Centre for Population Health Research, University of Tasmania, 17 Liverpool Street, Hobart, 7000 TAS, Australia
    Curr Opin Mol Ther 5:64-9. 2003
    ..MRA is currently undergoing phase II clinical trials for these indications...
  80. doi request reprint The association between oral contraceptive use, bone mineral density and fractures in women aged 50-80 years
    Shuying Wei
    Menzies Research Institute, University of Tasmania, Hobart, TAS 7001, Australia
    Contraception 84:357-62. 2011
    ..The associations between oral contraceptive (OC) use, bone mineral density (BMD) and the risk of fractures remain controversial...
  81. ncbi request reprint Bertilimumab Cambridge Antibody Technology Group
    Changhai Ding
    Menzies Research Institute, University of Tasmania, Hobart 7000, Tasmania, Australia
    Curr Opin Investig Drugs 5:1213-8. 2004
    ..By September 2003, CAT had released results from phase I/II trials, and was seeking to outlicense rights for bertilimumab...
  82. ncbi request reprint Belimumab Human Genome Sciences/Cambridge Antibody Technology/GlaxoSmithKline
    Changhai Ding
    Menzies Research Institute, University of Tasmania, Hobart 7000, Tasmania, Australia
    Curr Opin Investig Drugs 7:464-72. 2006
    ..By January 2006, belimumab had completed phase II clinical trials in SLE and RA; a phase III clinical SLE trial is scheduled to begin later this year...
  83. ncbi request reprint Belimumab, an anti-BLyS human monoclonal antibody for potential treatment of inflammatory autoimmune diseases
    Changhai Ding
    University of Tasmania, Menzies Research Institute, Private Bag 23, Hobart, Tasmania 7000, Australia
    Expert Opin Biol Ther 8:1805-14. 2008
    ..Belimumab (LymphoStat-B), a human monoclonal antibody that inhibits BlyS, was developed for the treatment of these diseases...
  84. ncbi request reprint Licofelone (Merckle)
    Changhai Ding
    Menzies Centre for Population Health Research, University of Tasmania, Hobart 7000, Tasmania, Australia
    IDrugs 6:802-8. 2003
    ..EuroAlliance (a consortium of Alfa Wassermann SpA, Lacer SA and Merckle GmbH) is developing licofelone, a dual cyclooxygenase and 5-lipoxygenase inhibitor for the potential treatment of inflammatory disorders including osteoarthritis...
  85. doi request reprint Associations between serum 25-hydroxyvitamin D and disease activity, inflammatory cytokines and bone loss in patients with rheumatoid arthritis
    Qiong Hong
    Department of Rheumatology and Immunology, First Affiliated Hospital of Anhui Medical University, Department of Endocrinology, 105 Hospital of People s Liberation Army, Arthritis Research Institute, First Affiliated Hospital of Anhui Medical University, Hefei, China and Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia Department of Rheumatology and Immunology, First Affiliated Hospital of Anhui Medical University, Department of Endocrinology, 105 Hospital of People s Liberation Army, Arthritis Research Institute, First Affiliated Hospital of Anhui Medical University, Hefei, China and Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia
    Rheumatology (Oxford) 53:1994-2001. 2014
    ..The aim of this study was to describe the associations between serum levels of 25-hydroxyvitamin D [25(OH)D] and disease activity, inflammatory cytokines and bone loss/erosions in patients with RA...
  86. pmc Association between GDF5 rs143383 polymorphism and knee osteoarthritis: an updated meta-analysis based on 23,995 subjects
    Feng Pan
    Menzies Research Institute Tasmania, University of Tasmania, Private Bag 23, Hobart, Tasmania 7000, Australia
    BMC Musculoskelet Disord 15:404. 2014
    ..Given the availability of more recent data, the aim of this meta-analysis was to determine the overall association between GDF5 rs143383 polymorphism and knee OA and whether the association varies by ethnicity...
  87. doi request reprint Cartilage signal intensity on T1-weighted MRI: association with risk factors and measures of knee osteoarthritis
    Oliver Patrick Stannus
    Menzies Research Institute, University of Tasmania, Private Bag 23, Hobart, Tasmania, 7000, Australia
    Clin Rheumatol 33:359-68. 2014
    ....
  88. ncbi request reprint Association of ACE gene polymorphism with genetic susceptibility to systemic lupus erythematosus in a Chinese population: a family-based association study
    Jianhua Xu
    Department of Rheumatology, First Affiliated Hospital, Hefei, China
    J Rheumatol 34:2408-11. 2007
    ..Family-based association analysis was performed to investigate whether the angiotensin-converting enzyme (ACE)-G261T and ACE-A592G polymorphisms are risk factors for systemic lupus erythematosus (SLE) in a Chinese population...
  89. pmc Tocilizumab: a review of its safety and efficacy in rheumatoid arthritis
    Graeme Jones
    Menzies Research Institute, University of Tasmania, Hobart, Tasmania 7000, Australia
    Clin Med Insights Arthritis Musculoskelet Disord 3:81-9. 2010
    ..In summary, there is sufficient evidence to make TCZ a first line biologic therapy for rheumatoid arthritis especially for those who are unable to take methotrexate or who fail anti-TNF therapy...
  90. ncbi request reprint Association of cartilage defects with loss of knee cartilage in healthy, middle-age adults: a prospective study
    Flavia Cicuttini
    Department of Epidemiology and Preventive Medicine, Monash University Medical School, Alfred Hospital, Prahran, Victoria, Australia
    Arthritis Rheum 52:2033-9. 2005
    ..The aim of this study was to examine the association between cartilage defects in the knee and cartilage volume both cross-sectionally and longitudinally in healthy, middle-age adults...
  91. ncbi request reprint Static knee alignment is associated with the risk of unicompartmental knee cartilage defects
    Neela Janakiramanan
    Department of Epidemiology and Preventative Medicine, Monash University, Central and Eastern Clinical School, Alfred Hospital, Melbourne, VIC 3004, Australia
    J Orthop Res 26:225-30. 2008
    ....
  92. ncbi request reprint Predictors of clinical response to intraarticular Hylan injections -- a prospective study using synovial fluid measures, clinical outcomes, and magnetic resonance imaging
    Ananthila Anandacoomarasamy
    Institute of Bone and Joint Research, Royal North Shore Hospital, University of Sydney, Sydney, Australia
    J Rheumatol 35:685-90. 2008
    ..To evaluate synovial fluid (SF) and clinical and imaging predictors of clinical response in patients receiving intraarticular Hylan GF-20 injections...
  93. ncbi request reprint Does diclofenac induce accelerated progression of hip and knee radiographic osteoarthritis? Comment on the article by Reijman et al
    Changhai Ding
    Arthritis Rheum 54:1027; author reply 1028. 2006
  94. ncbi request reprint Leflunomide, a new disease-modifying drug for treating active rheumatoid arthritis in methotrexate-controlled phase II clinical trial
    Chunde Bao
    Department of Clinical Immunology, Shanghai Renji Hospital, Shanghai Second Medical University, Shanghai 200001, China
    Chin Med J (Engl) 116:1228-34. 2003
    ..To evaluate the efficacy and safety of leflunomide in comparison with methotrexate (MTX) on patients with rheumatoid arthritis (RA) in China...