Christopher V Dayas

Summary

Affiliation: University of Newcastle
Country: Australia

Publications

  1. pmc Cocaine- and amphetamine-regulated transcript (CART) signaling within the paraventricular thalamus modulates cocaine-seeking behaviour
    Morgan H James
    Neurobiology of Addiction Laboratory, School of Biomedical Sciences and Pharmacy and the Centre for Brain and Mental Health Research, University of Newcastle and the Hunter Medical Research Institute, Newcastle, New South Wales, Australia
    PLoS ONE 5:e12980. 2010
  2. pmc An emerging role for the Mammalian target of rapamycin in "pathological" protein translation: relevance to cocaine addiction
    Christopher V Dayas
    School of Biomedical Sciences and Pharmacy, Centre for Translational Neuroscience and Mental Health Research, Hunter Medical Research Institute, University of Newcastle Callaghan, NSW, Australia
    Front Pharmacol 3:13. 2012
  3. pmc Cocaine potentiates excitatory drive in the perifornical/lateral hypothalamus
    Jiann Wei Yeoh
    1School of Biomedical Sciences and Pharmacy, and the Centre for Translational Neuroscience and Mental Health Research, University of Newcastle, Callaghan, NSW 2308, Australia
    J Physiol 590:3677-89. 2012
  4. ncbi request reprint Stimuli linked to ethanol availability activate hypothalamic CART and orexin neurons in a reinstatement model of relapse
    Christopher V Dayas
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA, USA
    Biol Psychiatry 63:152-7. 2008
  5. pmc Distinct patterns of neural activation associated with ethanol seeking: effects of naltrexone
    Christopher V Dayas
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California 92037, USA
    Biol Psychiatry 61:979-89. 2007
  6. doi request reprint Down-regulated striatal gene expression for synaptic plasticity-associated proteins in addiction and relapse vulnerable animals
    Amanda L Brown
    Neurobiology of Addiction Laboratory, School of Biomedical Sciences and Pharmacy, Centre for Brain and Mental Health Research, University of Newcastle and the Hunter Medical Research Institute, Newcastle, NSW, Australia
    Int J Neuropsychopharmacol 14:1099-110. 2011
  7. doi request reprint Rapamycin reduces motivated responding for cocaine and alters GluA1 expression in the ventral but not dorsal striatum
    Morgan H James
    Brain Health Institute, Rutgers University, NJ, USA Neurobiology of Addiction Laboratory, School of Biomedical Sciences and Pharmacy and the Centre for Translational Neuroscience and Mental Health Research, University of Newcastle and the Hunter Medical Research Institute, Newcastle, NSW, Australia
    Eur J Pharmacol 784:147-54. 2016
  8. pmc mTORC1 inhibition in the nucleus accumbens 'protects' against the expression of drug seeking and 'relapse' and is associated with reductions in GluA1 AMPAR and CAMKIIα levels
    Morgan H James
    Neurobiology of Addiction Laboratory, School of Biomedical Sciences and Pharmacy and the Centre for Translational Neuroscience and Mental Health Research, University of Newcastle and the Hunter Medical Research Institute, Newcastle, NSW, Australia
    Neuropsychopharmacology 39:1694-702. 2014
  9. ncbi request reprint Activation of group II metabotropic glutamate receptors attenuates both stress and cue-induced ethanol-seeking and modulates c-fos expression in the hippocampus and amygdala
    Yu Zhao
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 26:9967-74. 2006
  10. doi request reprint Orexin-1 receptor signalling within the ventral tegmental area, but not the paraventricular thalamus, is critical to regulating cue-induced reinstatement of cocaine-seeking
    Morgan H James
    Neurobiology of Addiction Laboratory, School of Biomedical Sciences and Pharmacy and the Centre for Brain and Mental Health Research, University of Newcastle and the Hunter Medical Research Institute, Newcastle, NSW, Australia
    Int J Neuropsychopharmacol 14:684-90. 2011

Collaborators

Detail Information

Publications18

  1. pmc Cocaine- and amphetamine-regulated transcript (CART) signaling within the paraventricular thalamus modulates cocaine-seeking behaviour
    Morgan H James
    Neurobiology of Addiction Laboratory, School of Biomedical Sciences and Pharmacy and the Centre for Brain and Mental Health Research, University of Newcastle and the Hunter Medical Research Institute, Newcastle, New South Wales, Australia
    PLoS ONE 5:e12980. 2010
    ....
  2. pmc An emerging role for the Mammalian target of rapamycin in "pathological" protein translation: relevance to cocaine addiction
    Christopher V Dayas
    School of Biomedical Sciences and Pharmacy, Centre for Translational Neuroscience and Mental Health Research, Hunter Medical Research Institute, University of Newcastle Callaghan, NSW, Australia
    Front Pharmacol 3:13. 2012
    ....
  3. pmc Cocaine potentiates excitatory drive in the perifornical/lateral hypothalamus
    Jiann Wei Yeoh
    1School of Biomedical Sciences and Pharmacy, and the Centre for Translational Neuroscience and Mental Health Research, University of Newcastle, Callaghan, NSW 2308, Australia
    J Physiol 590:3677-89. 2012
    ....
  4. ncbi request reprint Stimuli linked to ethanol availability activate hypothalamic CART and orexin neurons in a reinstatement model of relapse
    Christopher V Dayas
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA, USA
    Biol Psychiatry 63:152-7. 2008
    ..However, the potential role of other hypothalamic feeding peptides, such as cocaine- and amphetamine-regulated transcript (CART), in conditioned reinstatement has yet to be explored...
  5. pmc Distinct patterns of neural activation associated with ethanol seeking: effects of naltrexone
    Christopher V Dayas
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California 92037, USA
    Biol Psychiatry 61:979-89. 2007
    ....
  6. doi request reprint Down-regulated striatal gene expression for synaptic plasticity-associated proteins in addiction and relapse vulnerable animals
    Amanda L Brown
    Neurobiology of Addiction Laboratory, School of Biomedical Sciences and Pharmacy, Centre for Brain and Mental Health Research, University of Newcastle and the Hunter Medical Research Institute, Newcastle, NSW, Australia
    Int J Neuropsychopharmacol 14:1099-110. 2011
    ....
  7. doi request reprint Rapamycin reduces motivated responding for cocaine and alters GluA1 expression in the ventral but not dorsal striatum
    Morgan H James
    Brain Health Institute, Rutgers University, NJ, USA Neurobiology of Addiction Laboratory, School of Biomedical Sciences and Pharmacy and the Centre for Translational Neuroscience and Mental Health Research, University of Newcastle and the Hunter Medical Research Institute, Newcastle, NSW, Australia
    Eur J Pharmacol 784:147-54. 2016
    ..Possible caveats of this treatment approach are discussed. ..
  8. pmc mTORC1 inhibition in the nucleus accumbens 'protects' against the expression of drug seeking and 'relapse' and is associated with reductions in GluA1 AMPAR and CAMKIIα levels
    Morgan H James
    Neurobiology of Addiction Laboratory, School of Biomedical Sciences and Pharmacy and the Centre for Translational Neuroscience and Mental Health Research, University of Newcastle and the Hunter Medical Research Institute, Newcastle, NSW, Australia
    Neuropsychopharmacology 39:1694-702. 2014
    ..These effects appear to involve a role for mTORC1 in the regulation of GluA1 AMPARs and CAMKIIα in the NACsh. ..
  9. ncbi request reprint Activation of group II metabotropic glutamate receptors attenuates both stress and cue-induced ethanol-seeking and modulates c-fos expression in the hippocampus and amygdala
    Yu Zhao
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 26:9967-74. 2006
    ..The results implicate group II mGluRs as a shared neuropharmacological substrate for ethanol-seeking elicited by both drug cues and stress and identify group II mGluRs as promising treatment targets for relapse prevention...
  10. doi request reprint Orexin-1 receptor signalling within the ventral tegmental area, but not the paraventricular thalamus, is critical to regulating cue-induced reinstatement of cocaine-seeking
    Morgan H James
    Neurobiology of Addiction Laboratory, School of Biomedical Sciences and Pharmacy and the Centre for Brain and Mental Health Research, University of Newcastle and the Hunter Medical Research Institute, Newcastle, NSW, Australia
    Int J Neuropsychopharmacol 14:684-90. 2011
    ..We hypothesize that blockade of VTA OrxR1 signalling may reduce nucleus accumbens dopamine in response to drug cue presentation...
  11. pmc Purity and enrichment of laser-microdissected midbrain dopamine neurons
    Amanda L Brown
    Neurobiology of Ageing Laboratory, School of Biomedical Sciences and Pharmacy, Centre for Translational Neuroscience and Mental Health Research, University of Newcastle, Newcastle, NSW 2308, Australia
    Biomed Res Int 2013:747938. 2013
    ..This study demonstrates that it is possible to laser-microdissect dopamine neurons to a high degree of cell purity. Therefore gene expression profiles can be precisely attributed to the targeted microdissected cells. ..
  12. doi request reprint Perturbed cholesterol homeostasis in aging spinal cord
    Gemma M Parkinson
    Neurobiology of Aging and Dementia Laboratory, School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia Preclinical Neurobiology Research Program, Centre for Brain and Mental Health Research, University of Newcastle, Callaghan, New South Wales, Australia Hunter Medical Research Institute, New South Wales, Australia
    Neurobiol Aging 45:123-35. 2016
    ..Together, these results suggest that perturbed cholesterol homeostasis, possibly as a result of increased inflammatory activation in spinal cord white matter, may contribute to impaired spinal cord function with aging. ..
  13. ncbi request reprint Increased mitochondrial DNA deletions in substantia nigra dopamine neurons of the aged rat
    Gemma M Parkinson
    School of Biomedical Sciences and Pharmacy, Medical Sciences Building, Room 306C, University of Newcastle, Callaghan, NSW 2308, Australia
    Curr Aging Sci 7:155-60. 2014
    ....
  14. ncbi request reprint Characterisation of mitochondrial DNA deletions by long-PCR in central nervous system regions of young, middle- and old-aged rats
    Ashley Cahif
    School of Biomedical Sciences and Pharmacy, Medical Sciences Building, Room 306C, University of Newcastle, Callaghan, NSW 2308, Australia
    Curr Aging Sci 6:232-8. 2013
    ..These findings are remarkably consistent with previous human brain data and further underscore the value of the rat model for investigation of ageing-related changes in the mitochondrial genome. ..
  15. pmc Altered formalin-induced pain and Fos induction in the periaqueductal grey of preadolescent rats following neonatal LPS exposure
    Ihssane Zouikr
    Laboratory of Neuroimmunology, School of Psychology, University of Newcastle, Newcastle, New South Wales, Australia
    PLoS ONE 9:e98382. 2014
    ..These data highlight the importance of neonatal immune priming in programming inflammatory pain sensitivity later in development and highlight the PAG as a possible mediator of this process. ..
  16. ncbi request reprint Hypothalamic paraventricular nucleus neurons regulate medullary catecholamine cell responses to restraint stress
    Christopher V Dayas
    Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane, Queensland 4072, Australia
    J Comp Neurol 478:22-34. 2004
    ..Considered in concert with previous results, these data suggest that the activation of medullary CA cells in response to psychological stress may involve a critical input from the PVN...