Genomes and Genes
Leonard Da Silva
Affiliation: University of Queensland
- Molecular and morphological analysis of adenoid cystic carcinoma of the breast with synchronous tubular adenosisLeonard Da Silva
University of Queensland Centre for Clinical Research, The Royal Brisbane and Women s Hospital, Level 6, Building 71 918, Herston, Brisbane, 4029, Australia
Virchows Arch 454:107-14. 2009..These molecular data highlight the genomic instability of TA, a benign florid proliferation intermingled with ACC, and do not provide evidence of molecular evolution from TA to ACC...
- Rare variants in the ATM gene and risk of breast cancerDavid E Goldgar
Department of Dermatology, University of Utah School of Medicine, 30 N 1900 E, Salt Lake City, UT 84132 2101, USA
Breast Cancer Res 13:R73. 2011..However, the magnitude of risk and the subset of variants that are pathogenic for breast cancer remain unresolved...
- Dissecting the transcriptional networks underlying breast cancer: NR4A1 reduces the migration of normal and breast cancer cell linesAnnika N Alexopoulou
University of Oxford Branch, Ludwig Institute for Cancer Research, Old Road Campus, off Roosevelt Drive, Oxford OX3 7DQ, UK
Breast Cancer Res 12:R51. 2010..The purpose of the study was to identify the role of NR4A1 in normal mammary epithelial and breast cancer cell biology...
- Gene expression profiling of formalin-fixed, paraffin-embedded familial breast tumours using the whole genome-DASL assayNic Waddell
The Queensland Institute of Medical Research, Brisbane, Australia
J Pathol 221:452-61. 2010....
- Gene expression profiling of tumour epithelial and stromal compartments during breast cancer progressionAna Cristina Vargas
UQ Centre for Clinical Research, The University of Queensland, Herston, Brisbane, QLD, Australia
Breast Cancer Res Treat 135:153-65. 2012..We propose that these expression changes could be involved in facilitating the transition from in situ disease to invasive cancer and may thus mark a critical point in disease development...
- Subtypes of familial breast tumours revealed by expression and copy number profilingNic Waddell
Queensland Institute of Medical Research, Brisbane, Australia
Breast Cancer Res Treat 123:661-77. 2010..This study highlights the heterogeneity of familial tumours and the clinical consequences for treatment and prognosis...
- HER3 and downstream pathways are involved in colonization of brain metastases from breast cancerLeonard Da Silva
Molecular and Cellular Pathology, The University of Queensland Centre for Clinical Research, and School of Medicine, Building 918 B71, RBWH complex, Brisbane, 4029, Australia
Breast Cancer Res 12:R46. 2010..Metastases to the brain from breast cancer have a high mortality, and basal-like breast cancers have a propensity for brain metastases. However, the mechanisms that allow cells to colonize the brain are unclear...
- Calcium channel TRPV6 as a potential therapeutic target in estrogen receptor-negative breast cancerAmelia A Peters
The University of Queensland, School of Pharmacy, Brisbane, Queensland, Australia, 4072
Mol Cancer Ther 11:2158-68. 2012..Our findings suggest that inhibitors of TRPV6 may offer a novel therapeutic strategy for the treatment of ER-negative breast cancers...
- Tumor heterogeneity in a follicular carcinoma of thyroid: a study by comparative genomic hybridizationLeonard Da Silva
The University of Queensland, UQ Centre for Clinical Research, Herston, Building 918 B71, Royal Brisbane and Women s Hospital, Herston, QLD, 4029, Australia
Endocr Pathol 22:103-7. 2011....
- Expression and function of the protein tyrosine phosphatase receptor J (PTPRJ) in normal mammary epithelial cells and breast tumorsChanel E Smart
School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia
PLoS ONE 7:e40742. 2012..These data indicate that PTPRJ may regulate differentiation of normal mammary epithelia and that dysregulation of protein localisation may be associated with tumorigenesis...
- The calcium pump plasma membrane Ca(2+)-ATPase 2 (PMCA2) regulates breast cancer cell proliferation and sensitivity to doxorubicinAmelia A Peters
School of Pharmacy, The University of Queensland, Brisbane, Queensland, 4072, Australia
Sci Rep 6:25505. 2016..PMCA2 mRNA levels are also a potential tool in identifying poor responders to therapy in women with Basal breast cancer. ..
- Aberrant expression of E-cadherin in lobular carcinomas of the breastLeonard Da Silva
Molecular and Cellular Pathology, Mayne Medical School, University of Queensland, Brisbane, Australia
Am J Surg Pathol 32:773-83. 2008..Misclassification of tumors may lead to mismanagement of patients in clinical practice, particularly in the context of in situ disease at margins...
- An epithelial to mesenchymal transition programme does not usually drive the phenotype of invasive lobular carcinomasAmy E McCart Reed
The University of Queensland, UQ Centre for Clinical Research, Herston, 4029, QLD, Australia
J Pathol 238:489-94. 2016..However, the data overall do not support a role for EMT in defining the phenotypic peculiarities of the majority of ILCs. Copyright © 2015 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. ..
- Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell linesMajid Momeny
University of Queensland, UQ Center for Clinical Research, Herston, QLD, Australia
Oncotarget 6:3932-46. 2015..Collectively these data suggest mechanisms by which the HER3-HER2 dimer promotes development of metastatic tumors in the heregulin-rich brain microenvironment. ..
- The contribution of breast cancer pathology to statistical models to predict mutation risk in BRCA carriersAna Cristina Vargas
Molecular and Cellular Pathology, The University of Queensland Centre for Clinical Research, The Royal Brisbane and Women s Hospital, Building 71 918, Brisbane, QLD 4029, Australia
Fam Cancer 9:545-53. 2010..Here we review the pathology of familial breast cancer and assess the evidence to justify the use of pathology in refining risk assessment models...
- Pathology of hereditary breast cancerLeonard Da Silva
Molecular and Cellular Pathology, The University of Queensland Centre for Clinical Research, The Royal Brisbane and Women s Hospital, Brisbane, QLD, Australia
Mod Pathol 23:S46-51. 2010..A number of low-to-moderate-penetrant genes/loci have also been identified, but their role and contribution in breast cancer development is still under investigation...
- Point Mutations in Exon 1B of APC Reveal Gastric Adenocarcinoma and Proximal Polyposis of the Stomach as a Familial Adenomatous Polyposis VariantJun Li
Department of Genetics and Computational Biology, QIMR Berghofer, Herston, QLD 4029, Australia
Am J Hum Genet 98:830-42. 2016..Our finding that GAPPS is caused by point mutations in the same promoter suggests that families with mutations affecting the promoter 1B are at risk of gastric adenocarcinoma, regardless of whether or not colorectal polyps are present. ..
- Fibroadenoma and intraduct papilloma--a common pathogenesis?Margaret C Cummings
Molecular and Cellular Pathology, Centre for Clinical Research, University of Queensland, Brisbane, Queensland, Australia
Virchows Arch 455:271-5. 2009..That fibroadenoma and intraduct papilloma may have a common pathogenesis is discussed...
- Molecular aspects of breast cancer metastasis to the brainJodi M Saunus
UQ Centre for Clinical Research, The University of Queensland, Herston, QLD 4029, Australia
Genet Res Int 2011:219189. 2011....
- Integrated genomic and transcriptomic analysis of human brain metastases identifies alterations of potential clinical significanceJodi M Saunus
University of Queensland, UQ Centre for Clinical Research, Herston, Queensland, Australia
J Pathol 237:363-78. 2015....
- What's in a cancer syndrome? Genes, phenotype and pathologyNicola Wayte
The Queensland Institute of Medical Research, Brisbane, Australia
Pathology 40:247-59. 2008....