Vicki L Clifton

Summary

Affiliation: University of Newcastle
Country: Australia

Publications

  1. ncbi request reprint Effect of inhaled glucocorticoid treatment on placental 11beta-hydroxysteroid dehydrogenase type 2 activity and neonatal birthweight in pregnancies complicated by asthma
    Vicki L Clifton
    Mothers and Babies Research Centre, John Hunter Hospital, Hunter Medical Research Institute, University of Newcastle, New South Wales, Australia
    Aust N Z J Obstet Gynaecol 46:136-40. 2006
  2. ncbi request reprint Characterization of human fetal cord blood steroid profiles in relation to fetal sex and mode of delivery using temperature-dependent inclusion chromatography and principal component analysis (PCA)
    Vicki L Clifton
    Mothers and Babies Research Centre, Hunter Medical Research Institute, University of Newcastle, NSW, Australia
    J Chromatogr B Analyt Technol Biomed Life Sci 855:249-54. 2007
  3. ncbi request reprint Maternal asthma during pregnancy and fetal outcomes: potential mechanisms and possible solutions
    Vicki Clifton
    Mothers and Babies Research Centre, John Hunter Hospital, Hunter Medical Research Institute and the University of Newcastle, Newcastle, New South Wales, Australia
    Curr Opin Allergy Clin Immunol 6:307-11. 2006
  4. ncbi request reprint Increased anti-oxidant enzyme activity and biological oxidation in placentae of pregnancies complicated by maternal asthma
    V L Clifton
    Mothers and Babies Research Centre, Hunter Medical Research Institute, Newcastle, NSW 2305, Australia
    Placenta 26:773-9. 2005
  5. ncbi request reprint Sexually dimorphic effects of maternal asthma during pregnancy on placental glucocorticoid metabolism and fetal growth
    Vicki L Clifton
    Mothers and Babies Research Centre, John Hunter Hospital, Locked Bag 1, HRMC, Newcastle, NSW 2310, Australia
    Cell Tissue Res 322:63-71. 2005
  6. ncbi request reprint Placental cytokine expression covaries with maternal asthma severity and fetal sex
    Naomi M Scott
    Mothers and Babies Research Centre, Newcastle, New South Wales, Australia
    J Immunol 182:1411-20. 2009
  7. doi request reprint Psychosocial variables are related to future exacerbation risk and perinatal outcomes in pregnant women with asthma
    Heather Powell
    Centre for Asthma and Respiratory Diseases, Hunter Medical Research Institute, Newcastle, NSW, Australia
    J Asthma 50:383-9. 2013
  8. ncbi request reprint Maternal asthma is associated with reduced female fetal growth
    Vanessa E Murphy
    Mothers and Babies Research Centre, John Hunter Hospital, Hunter Medical Research Institute and University of Newcastle, Newcastle, NSW 2310, Australia
    Am J Respir Crit Care Med 168:1317-23. 2003
  9. ncbi request reprint Endocrine regulation of human fetal growth: the role of the mother, placenta, and fetus
    Vanessa E Murphy
    Mothers and Babies Research Centre, and Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, University of Newcastle, New South Wales, Australia
    Endocr Rev 27:141-69. 2006
  10. ncbi request reprint The effect of maternal asthma on placental and cord blood protein profiles
    Vanessa E Murphy
    Mothers and Babies Research Centre, Hunter Medical Research Institute, Newcastle NSW, Australia
    J Soc Gynecol Investig 12:349-55. 2005

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Effect of inhaled glucocorticoid treatment on placental 11beta-hydroxysteroid dehydrogenase type 2 activity and neonatal birthweight in pregnancies complicated by asthma
    Vicki L Clifton
    Mothers and Babies Research Centre, John Hunter Hospital, Hunter Medical Research Institute, University of Newcastle, New South Wales, Australia
    Aust N Z J Obstet Gynaecol 46:136-40. 2006
    ..One of the main reasons for maternal exacerbations during pregnancy is non-compliance with inhaled glucocorticoid treatment due to the misconception that inhaled glucocorticoids are harmful to the fetus...
  2. ncbi request reprint Characterization of human fetal cord blood steroid profiles in relation to fetal sex and mode of delivery using temperature-dependent inclusion chromatography and principal component analysis (PCA)
    Vicki L Clifton
    Mothers and Babies Research Centre, Hunter Medical Research Institute, University of Newcastle, NSW, Australia
    J Chromatogr B Analyt Technol Biomed Life Sci 855:249-54. 2007
    ..Moreover, we have provided new evidence that despite the absence of testosterone there are number of steroids and low molecular mass compounds that differ between male and female fetuses...
  3. ncbi request reprint Maternal asthma during pregnancy and fetal outcomes: potential mechanisms and possible solutions
    Vicki Clifton
    Mothers and Babies Research Centre, John Hunter Hospital, Hunter Medical Research Institute and the University of Newcastle, Newcastle, New South Wales, Australia
    Curr Opin Allergy Clin Immunol 6:307-11. 2006
    ..This review will examine the recent literature on immune function in pregnant women, immune function in nonpregnant asthma patients and studies conducted on asthma during pregnancy...
  4. ncbi request reprint Increased anti-oxidant enzyme activity and biological oxidation in placentae of pregnancies complicated by maternal asthma
    V L Clifton
    Mothers and Babies Research Centre, Hunter Medical Research Institute, Newcastle, NSW 2305, Australia
    Placenta 26:773-9. 2005
    ....
  5. ncbi request reprint Sexually dimorphic effects of maternal asthma during pregnancy on placental glucocorticoid metabolism and fetal growth
    Vicki L Clifton
    Mothers and Babies Research Centre, John Hunter Hospital, Locked Bag 1, HRMC, Newcastle, NSW 2310, Australia
    Cell Tissue Res 322:63-71. 2005
    ..However, the male fetus continues to grow in response to maternal asthma with no changes in placental function. This response by the male fetus may partially contribute to the increased risk of morbidity and mortality in this sex...
  6. ncbi request reprint Placental cytokine expression covaries with maternal asthma severity and fetal sex
    Naomi M Scott
    Mothers and Babies Research Centre, Newcastle, New South Wales, Australia
    J Immunol 182:1411-20. 2009
    ..These data suggest that placental basal cytokine mRNA expression is sex specifically regulated in pregnancies complicated by asthma, and interestingly these changes are more prevalent in mild rather than severe asthma...
  7. doi request reprint Psychosocial variables are related to future exacerbation risk and perinatal outcomes in pregnant women with asthma
    Heather Powell
    Centre for Asthma and Respiratory Diseases, Hunter Medical Research Institute, Newcastle, NSW, Australia
    J Asthma 50:383-9. 2013
    ..To determine the relationship between psychosocial variables, future exacerbation risk during pregnancy, and perinatal outcomes...
  8. ncbi request reprint Maternal asthma is associated with reduced female fetal growth
    Vanessa E Murphy
    Mothers and Babies Research Centre, John Hunter Hospital, Hunter Medical Research Institute and University of Newcastle, Newcastle, NSW 2310, Australia
    Am J Respir Crit Care Med 168:1317-23. 2003
    ..This study provides evidence that in pregnancies complicated by asthma there is a fetal sex-specific effect on the maternal immune system with adverse effects on placental function and female fetal growth...
  9. ncbi request reprint Endocrine regulation of human fetal growth: the role of the mother, placenta, and fetus
    Vanessa E Murphy
    Mothers and Babies Research Centre, and Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, University of Newcastle, New South Wales, Australia
    Endocr Rev 27:141-69. 2006
    ..Endocrine regulation of fetal growth involves interactions between the mother, placenta, and fetus, and these effects may program long-term physiology...
  10. ncbi request reprint The effect of maternal asthma on placental and cord blood protein profiles
    Vanessa E Murphy
    Mothers and Babies Research Centre, Hunter Medical Research Institute, Newcastle NSW, Australia
    J Soc Gynecol Investig 12:349-55. 2005
    ....
  11. doi request reprint Changes in human placental 5alpha-reductase isoenzyme expression with advancing gestation: effects of fetal sex and glucocorticoid exposure
    Thi T Vu
    Mothers and Babies Research Centre and School of Biomedical Sciences, John Hunter Hospital Campus, University of Newcastle, Callaghan, NSW 2308, Australia
    Reprod Fertil Dev 21:599-607. 2009
    ..These findings suggest that the preterm neonate may have lower developmental exposure to 5alpha-reduced steroids and may lack steroid-mediated neuroprotection depending on fetal sex...
  12. doi request reprint Psychosocial outcomes are related to asthma control and quality of life in pregnant women with asthma
    Heather Powell
    Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW, Australia
    J Asthma 48:1032-40. 2011
    ..Little is known about the psychosocial impact and perceived teratogenic (fetal harm due to medication) risks of asthma treatment (inhaled/oral corticosteroids and β-agonist) during pregnancy...
  13. ncbi request reprint Proteomic study of plasma proteins in pregnant women with asthma
    Vanessa E Murphy
    Mothers and Babies Research Centre, Hunter Medical Research Institute, Newcastle, NWS, Australia
    Respirology 11:41-8. 2006
    ..This study used the novel proteomic technique, surface-enhanced laser desorption ionization-time of flight mass spectrometry to determine if the presence of asthma during pregnancy was associated with alterations in plasma proteins...
  14. ncbi request reprint Reduced 11beta-hydroxysteroid dehydrogenase type 2 activity is associated with decreased birth weight centile in pregnancies complicated by asthma
    Vanessa E Murphy
    Mothers and Babies Research Centre, University of Newcastle, New South Wales, Australia
    J Clin Endocrinol Metab 87:1660-8. 2002
    ....
  15. doi request reprint Management of asthma in pregnancy guided by measurement of fraction of exhaled nitric oxide: a double-blind, randomised controlled trial
    Heather Powell
    Centre for Asthma and Respiratory Diseases, University of Newcastle and Hunter Medical Research Institute, Newcastle, NSW, Australia
    Lancet 378:983-90. 2011
    ..We tested the hypothesis that a management algorithm for asthma in pregnancy based on F(E)NO and symptoms would reduce asthma exacerbations...
  16. doi request reprint Carbon monoxide is a significant mediator of cardiovascular status following preterm birth
    Michael J Stark
    Mother and Babies Research Centre, Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia
    Pediatrics 124:277-84. 2009
    ..With male gender as a strong predictor of cardiovascular instability, we hypothesized that gender-specific differences in circulating carbon monoxide levels contributed to dysregulated microvascular function in preterm male infants...
  17. ncbi request reprint Neonates born to mothers with preeclampsia exhibit sex-specific alterations in microvascular function
    Michael J Stark
    Mother and Babies Research Centre, University of Newcastle, Newcastle, New South Wales 2305, Australia
    Pediatr Res 65:292-5. 2009
    ..001). Altered fetal microvascular structure and function in response to maternal preeclampsia may result in sexually dimorphic patterns of fetal growth and account for alterations in neonatal microvascular adaptation after birth...
  18. doi request reprint Rhinitis in pregnant women with asthma is associated with poorer asthma control and quality of life
    Heather Powell
    a Centre for Asthma and Respiratory Diseases, University of Newcastle and Hunter Medical Research Institute, Newcastle, NSW, Australia
    J Asthma 52:1023-30. 2015
    ..To describe the pattern and severity of rhinitis in pregnancy and the impact rhinitis has on asthma control and quality of life (QoL) in pregnant women with asthma...
  19. doi request reprint Asthma during pregnancy alters immune cell profile and airway epithelial chemokine release
    Annette Osei-Kumah
    Department of Endocrinology, Mothers and Babies Research Centre, Hunter Medical Research Institute, Locked Bag 1, Hunter Regional Mail Centre, Newcastle, NSW, 2310, Australia
    Inflamm Res 59:349-58. 2010
    ..The aim of the present study was to access maternal immune cell profiles in the presence and absence of asthma and to determine the effect of pregnancy-derived factors on epithelial cell function...
  20. doi request reprint Maternal and cord plasma cytokine and chemokine profile in pregnancies complicated by asthma
    Annette Osei-Kumah
    Mothers and Babies Research Centre, Department of Endocrinology, Locked Bag 1, Hunter Medical Research Institute, Newcastle NSW 2310, Australia
    Cytokine 43:187-93. 2008
    ..This is the first study to show increased eotaxin production in the feto-placental unit of asthmatic pregnancies and may be one mechanism by which allergy susceptibility is increased in the offspring of asthmatic women...
  21. doi request reprint Sex-specific differences in peripheral microvascular blood flow in preterm infants
    Michal J Stark
    Mother and Babies Research Centre, University of Newcastle, Newcastle, NSW 2305, Australia
    Pediatr Res 63:415-9. 2008
    ..Sex-specific differences in microvascular blood flow and vasodilatory capacity in the immediate newborn period may affect the transitional circulation, contributing to excess of morbidity and mortality in preterm males...
  22. doi request reprint Altered nociceptive, endocrine, and dorsal horn neuron responses in rats following a neonatal immune challenge
    Ihssane Zouikr
    Laboratory of Neuroimmunology, School of Psychology, University of Newcastle, Newcastle, New South Wales, Australia
    Psychoneuroendocrinology 41:1-12. 2014
    ..These findings highlight the importance of immune activation during the neonatal period in shaping pain sensitivity later in life. This programming involves both spinal cord neurons and the HPA axis. ..
  23. ncbi request reprint Severe asthma exacerbations during pregnancy
    Vanessa E Murphy
    Department of Respiratory and Sleep Medicine, John Hunter Hospital and Hunter Medical Research Institute, University of Newcastle, New South Wales 2310, Australia
    Obstet Gynecol 106:1046-54. 2005
    ..To estimate the frequency of severe asthma exacerbations in pregnant women and to estimate whether there is an association with adverse perinatal outcomes...
  24. ncbi request reprint Corticotropin-releasing hormone causes vasodilation in human skin via mast cell-dependent pathways
    Renee Crompton
    Mothers and Babies Research Centre, Hunter Medical Research Institute, Newcastle NSW, Australia
    J Clin Endocrinol Metab 88:5427-32. 2003
    ..These findings provide novel evidence that CRH-induced vasodilation in human skin occurs via mast cell degranulation and is principally mediated by histamine and, to a lesser extent, by prostacyclin and nitric oxide...
  25. ncbi request reprint Short-term effects of glucocorticoids in the human fetal-placental circulation in vitro
    Vicki L Clifton
    Mothers and Babies Research Centre, Department of Endocrinology, John Hunter Hospital, Hunter Region Mail Center, Newcastle, New South Wales 2310, Australia
    J Clin Endocrinol Metab 87:2838-42. 2002
    ..These data suggest that dexamethasone can cause dilation in the fetal-placental circulation, possibly via an endothelium-independent pathway...
  26. ncbi request reprint Inflammatory mediator release in normal bronchial smooth muscle cells is altered by pregnant maternal and fetal plasma independent of asthma
    A Osei-Kumah
    Department of Endocrinology, Mothers and Babies Research Centre, John Hunter Hospital, Lookout Road, New Lambton Heights, Newcastle, NSW 2310, Australia
    Placenta 27:847-52. 2006
    ..This change in BSM function may be one mechanism that contributes to increased asthma severity during pregnancy...
  27. ncbi request reprint Maternal asthma as a model for examining fetal sex-specific effects on maternal physiology and placental mechanisms that regulate human fetal growth
    V L Clifton
    Department of Endocrinology, Mothers and Babies Research Centre, Hunter Medical Research Institute, John Hunter Hospital, Locked Bag No 1, HRMC, Newcastle, NSW 2310, Australia
    Placenta 25:S45-52. 2004
    ..These findings indicate there may be different mechanisms regulating placental glucocorticoid and immune mechanisms depending on fetal sex in both asthmatic and non-asthmatic pregnancies...
  28. doi request reprint Influence of sympathetic activity in the control of peripheral microvascular tone in preterm infants
    Celine Corbisier de Meautsart
    Mothers and Babies Research Centre, Hunter Medical Research Institute, and Discipline of Paediatrics and Child Health, School of Medicine and Public Health, University of Newcastle, Newcastle, Australia
    Pediatr Res 80:793-799. 2016
    ..Sympathetic nervous vascular regulation is evident in females. We hypothesized that sympathetic dysfunction in male preterm infants may contribute to a failure of peripheral microvascular vasoconstriction...
  29. doi request reprint Programming of formalin-induced nociception by neonatal LPS exposure: Maintenance by peripheral and central neuroimmune activity
    Ihssane Zouikr
    Laboratory of Neuroimmunology, School of Psychology, University of Newcastle, Newcastle, New South Wales, Australia School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia Hunter Medical Research Institute, Newcastle, New South Wales, Australia Electronic address
    Brain Behav Immun 44:235-46. 2015
    ..This is of clinical relevance given the high prevalence of bacterial infection during the neonatal period, particularly in the vulnerable population of preterm infants admitted to neonatal intensive care units. ..
  30. pmc Altered formalin-induced pain and Fos induction in the periaqueductal grey of preadolescent rats following neonatal LPS exposure
    Ihssane Zouikr
    Laboratory of Neuroimmunology, School of Psychology, University of Newcastle, Newcastle, New South Wales, Australia
    PLoS ONE 9:e98382. 2014
    ..These data highlight the importance of neonatal immune priming in programming inflammatory pain sensitivity later in development and highlight the PAG as a possible mediator of this process. ..
  31. ncbi request reprint Column-based method to simultaneously extract DNA, RNA, and proteins from the same sample
    Jorge M Tolosa
    University of Newcastle, New Lambton Heights, NSW, Australia
    Biotechniques 43:799-804. 2007
    ..This technique provides a simple and effective way to analyze protein and nucleic acids simultaneously from the same sample without affecting yield and quality...
  32. doi request reprint Male sex and pre-existing diabetes are independent risk factors for stillbirth
    Patricia J Engel
    Mothers and Babies Research Centre, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
    Aust N Z J Obstet Gynaecol 48:375-83. 2008
    ..To determine whether the risk of stillbirth is associated with male fetal sex, fetal growth and maternal factors in an Australian population...
  33. pmc Low formalin concentrations induce fine-tuned responses that are sex and age-dependent: a developmental study
    Ihssane Zouikr
    Laboratory of Neuroimmunology, School of Psychology, University of Newcastle, Newcastle, New South Wales, Australia
    PLoS ONE 8:e53384. 2013
    ..These data also show that the developing nociceptive system is very sensitive to subtle changes in formalin concentrations...
  34. ncbi request reprint Alterations of placental vascular function in asthmatic pregnancies
    V L Clifton
    Mothers and Babies Research Centre and Respiratory Medicine, John Hunter Hospital, University of Newcastle, Newcastle, New South Wales, Australia
    Am J Respir Crit Care Med 164:546-53. 2001
    ..These changes in vascular function in asthmatic pregnancies may contribute to the low-birthweight outcome observed in this condition...
  35. ncbi request reprint Metabolism of synthetic steroids by the human placenta
    V E Murphy
    Mothers and Babies Research Centre, Hunter Medical Research Institute, University of Newcastle, New South Wales 2310, Australia
    Placenta 28:39-46. 2007
    ..In conclusion, the use of inhaled steroids for asthma treatment does not affect fetal growth, despite differences in placental metabolism by 11beta-HSD2...
  36. pmc Videomicroscopy as a tool for investigation of the microcirculation in the newborn
    Ian M R Wright
    Hunter Medical Research Institute, Newcastle, New South Wales, Australia Discipline of Paediatrics and Child Health, School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia Kaleidoscope Neonatal Intensive Care Unit, John Hunter Children s Hospital, Newcastle, New South Wales, Australia Graduate School of Medicine and Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, New South Wales, Australia
    Physiol Rep 4:. 2016
    ..It is recommended that studies for examining the mature neonatal microvascular structure be delayed until 72 h of life, but studies of the physiology of cardiovascular transition should include the 24-h time point after delivery...
  37. ncbi request reprint Prenatal exposure to a pro-inflammatory stimulus causes delays in the development of the innate immune response to LPS in the offspring
    Nicolette A Hodyl
    Laboratory of Neuroimmunology, School of Psychology, University of Newcastle, Callaghan, NSW 2308, Australia
    J Neuroimmunol 190:61-71. 2007
    ..The developmental profile of immune functioning following prenatal immune activation has not previously been demonstrated. This study highlights the prenatal period as one of importance in determining later immune function...
  38. ncbi request reprint Alterations in human placental 11beta-hydroxysteroid dehydrogenase type 1 and 2 with gestational age and labour
    V E Murphy
    Mothers and Babies Research Centre, Hunter Medical Research Institute, University of Newcastle, New South Wales 2310, Australia
    Placenta 24:739-44. 2003
    ..This decrease in type 2 activity, along with an increase in 11beta-HSD1 gene expression may be a mechanism by which cortisol concentrations rise at term to regulate fetal maturation and activate pathways associated with labour...
  39. ncbi request reprint Asthma self-management skills and the use of asthma education during pregnancy
    V E Murphy
    Mothers and Babies Research Centre, Endocrine Unit, John Hunter Hospital, Locked Bag 1, Hunter Region Mail Centre, Newcastle, New South Wales, 2310, Australia
    Eur Respir J 26:435-41. 2005
    ..In conclusion, during pregnancy, patients with asthma have poor asthma knowledge and skills, and may benefit from self-management education as part of their obstetric care...
  40. pmc Asthma exacerbations during pregnancy: incidence and association with adverse pregnancy outcomes
    V E Murphy
    Department of Respiratory and Sleep Medicine, John Hunter Hospital, Locked Bag 1, Hunter Region Mail Centre, Newcastle, New South Wales 2310, Australia
    Thorax 61:169-76. 2006
    ..Pregnant women may be less likely to receive oral steroids for the emergency management of asthma. The effective management and prevention of asthma exacerbations during pregnancy is important for the health of both the mother and fetus...
  41. ncbi request reprint Asthma during pregnancy: mechanisms and treatment implications
    V E Murphy
    Dept of Respiratory and Sleep Medicine, Hunter Medical Research Institute, University of Newcastle, NSW, Australia
    Eur Respir J 25:731-50. 2005
    ..Asthma treatment, by reducing maternal inflammation and preventing exacerbations, is safe for use in pregnant females and contributes to improved outcomes for both mother and foetus...
  42. ncbi request reprint Microvascular effects of CRH in human skin vary in relation to gender
    V L Clifton
    Mothers and Babies Research Centre, John Hunter Hospital, University of Newcastle, Newcastle, New South Wales 2310, Australia
    J Clin Endocrinol Metab 87:267-70. 2002
    ..The mechanism by which CRH causes dilation in human skin is presently unknown. However, these data suggest that CRH-induced dilation may be one mechanism by which cardiovascular risk is reduced in premenopausal women...
  43. ncbi request reprint Alterations in the maternal peripheral microvascular response in pregnancies complicated by preeclampsia and the impact of fetal sex
    Michael J Stark
    Mother and Babies Research Centre, Hunter Medical Research Institute, University of Newcastle, Newcastle, NSW, Australia
    J Soc Gynecol Investig 13:573-8. 2006
    ..Recent studies suggest that maternal physiology varies with fetal sex. We wanted to examine if there were sex-specific differences in maternal peripheral microvascular function in normal pregnancy and pregnancy complicated by PE...
  44. ncbi request reprint Urocortin: a mechanism for the sustained activation of the HPA axis in the late-gestation ovine fetus?
    Alison C Holloway
    Department of Physiology, Canadian Institute for Health Research Groups in Fetal and Neonatal Health and Development, University of Toronto, Toronto, Ontario M55 1A8, Canada
    Am J Physiol Endocrinol Metab 283:E165-71. 2002
    ..Regulation of urocortin by cortisol suggests a mechanism to override negative feedback and sustain feedforward of fetal hypothalamic-pituitary-adrenal function, leading to birth...
  45. ncbi request reprint Determination of steroids in human plasma using temperature-dependent inclusion chromatography for metabolomic investigations
    Paweł K Zarzycki
    Laboratory of Toxicology, Department of Environmental Biology, Technical University of Koszalin, Sniadeckich 2, 75 453 Koszalin, Poland
    J Chromatogr A 1104:203-8. 2006
    ..This method is simplistic, inexpensive and reproducible with the capabilities of accurate quantification of steroids. Therefore it could have numerous clinical and metabolomic applications...