L A Chahl
Affiliation: University of Newcastle
- Neurons expressing calcium-binding proteins in the prefrontal cortex in schizophreniaPaul A Tooney
Neuroscience Institute of Schizophrenia and Allied Disorders, Darlinghurst, Australia
Prog Neuropsychopharmacol Biol Psychiatry 28:273-8. 2004....
- TRP channels and psychiatric disordersLoris A Chahl
School of Biomedical Science and Pharmacy, University of Newcastle, Newcastle, NSW 2308, Australia
Adv Exp Med Biol 704:987-1009. 2011..Investigation of TRP channels in psychiatric disorders holds the promise of yielding further understanding of the aetiology of psychiatric disorders and the development of new drug treatments...
- TRP's: links to schizophrenia?Loris A Chahl
Centre for Mental Health Studies and Schizophrenia Research Institute, James Fletcher Hospital, University of Newcastle, New South Wales, 2308 Australia
Biochim Biophys Acta 1772:968-77. 2007..Investigation of these links holds the prospect of a new understanding of schizophrenia with resultant therapeutic advances...
- Hydrogen sulphide: an endogenous stimulant of capsaicin-sensitive primary afferent neurons?L A Chahl
School of Biomedical Sciences, University of Newcastle, NSW 2308, Australia
Br J Pharmacol 142:1-2. 2004..present evidence that H(2)S stimulates capsaicin-sensitive primary afferent neurons to release tachykinins in the rat urinary bladder. The possible significance of this finding is discussed in this commentary...
- Tachykinins and neuropsychiatric disordersLoris A Chahl
School of Biomedical Sciences, University of Newcastle, and Neuroscience Institute of Schizophrenia and Allied Disorders, NSW, Australia
Curr Drug Targets 7:993-1003. 2006..Thus specific therapeutic strategies may be required to enable NK1 receptor antagonists to be introduced for treatment of neuropsychiatric disorders...
- Tachykinin NK1 and NK3 receptors in the prefrontal cortex of the human brainP A Tooney
Neuroscience Institute of Schizophrenia and Allied Disorders and School of Biomedical Sciences, Faculty of Medicine and Health Sciences, The University of Newcastle, Callaghan, New South Wales, Australia
Clin Exp Pharmacol Physiol 27:947-9. 2000..Dots of NK3 receptor immunoreactivity were scattered across all cortical layers. In the white matter, astrocytes and beaded fibres displayed NK3 receptor immunoreactivity, particularly in areas surrounding blood vessels...
- Localisation of tachykinin NK1 and NK3 receptors in the human prefrontal and visual cortexP A Tooney
Neuroscience Institute of Schizophrenia and Allied Disorders and School of Biomedical Sciences, Faculty of Medicine and Health Sciences, The University of, Newcastle, Australia
Neurosci Lett 283:185-8. 2000..The NK(3)-LI was more abundant and widespread than the NK(1)-LI. This is the first report of the distribution of the NK(1) receptor in the prefrontal and visual cortex of the human brain by immunohistochemistry...
- The effects of haloperidol treatment on the distribution of NK1 receptor immunoreactive neurons in guinea-pig brainPaul A Tooney
NISAD, Neuroscience Institute of Schizophrenia and Allied Disorders NISAD, Sydney, Australia
Neurosci Lett 383:155-9. 2005..Whether these changes are related to the therapeutic effects or to the side effects of haloperidol in individuals with schizophrenia, remains to be determined...
- Intrinsic sensory deprivation induced by neonatal capsaicin treatment induces changes in rat brain and behaviour of possible relevance to schizophreniaPenny Newson
School of Biomedical Sciences, University of Newcastle, Callaghan, NSW, Australia
Br J Pharmacol 146:408-18. 2005..It is concluded that neonatal capsaicin treatment of rats produces brain changes that are similar to those found in brains of subjects with schizophrenia...
- Localization of NK1 and NK3 receptors in guinea-pig brainJ Yip
Experimental Pharmacology Unit, School of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Newcastle, Newcastle, Australia
Regul Pept 98:55-62. 2001..The present study revealed that tachykinin receptors are widely distributed in the guinea-pig central nervous system...
- Receptor changes in brain tissue of rats treated as neonates with capsaicinKaterina Zavitsanou
Radiopharmaceutical Research Institute, Australian Nuclear Science and Technology Organization ANSTO, Menai, New South Wales, Australia
J Chem Neuroanat 39:248-55. 2010....
- Sensitization to morphine withdrawal in guinea-pigsAkiko Mizutani
School of Biomedical Sciences, Faculty of Health, University of Newcastle, Newcastle, NSW 2308, Australia
Eur J Pharmacol 509:135-43. 2005..It is concluded that sensitization to morphine withdrawal occurs in guinea-pigs...
- The acute effects of capsaicin on the cardiovascular systemL A Chahl
Faculty of Medicine, University of Newcastle, N S W, Australia
Acta Physiol Hung 69:413-9. 1987..Capsaicin induces complex effects on the cardiovascular system, the nature of which varies with the dose and speed of administration...
- The effect of clonidine on the naltrexone-induced withdrawal response in morphine-treated guinea-pigsSebastian Jungnickel
Experimental Pharmacology Unit, School of Biomedical Sciences, University of Newcastle, NSW, Australia
J Pharm Pharmacol 54:127-32. 2002..In conclusion, the modest effect of clonidine in the present experiments suggests that the efficacy of clonidine in humans undergoing naltrexone-induced opioid withdrawal requires further investigation...
- Immunohistochemical localisation of the NK1 receptor in the human amygdala: preliminary investigation in schizophreniaJudith Weidenhofer
Neuroscience Institute of Schizophrenia and Allied Disorders, Sydney, Australia
Prog Neuropsychopharmacol Biol Psychiatry 30:1313-21. 2006....