Murray J Cairns

Summary

Affiliation: University of Newcastle
Country: Australia

Publications

  1. doi request reprint Optimal consistency in microRNA expression analysis using reference-gene-based normalization
    Xi Wang
    School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, NSW 2308, Australia
    Mol Biosyst 11:1235-40. 2015
  2. pmc Ontogeny of small RNA in the regulation of mammalian brain development
    Sharon L Hollins
    School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, University Drive, Callaghan, NSW 2308, Australia
    BMC Genomics 15:777. 2014
  3. pmc Imprinted DLK1-DIO3 region of 14q32 defines a schizophrenia-associated miRNA signature in peripheral blood mononuclear cells
    E Gardiner
    School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia
    Mol Psychiatry 17:827-40. 2012
  4. pmc Schizophrenia is associated with an increase in cortical microRNA biogenesis
    N J Beveridge
    Schizophrenia Research Institute, Sydney, NSW, Australia
    Mol Psychiatry 15:1176-89. 2010
  5. pmc Maturation of the human dorsolateral prefrontal cortex coincides with a dynamic shift in microRNA expression
    Natalie J Beveridge
    To whom correspondence should be addressed School of Biomedical Sciences and Pharmacy, The University of Newcastle, University Drive, Callaghan, NSW 2308, Australia tel 61 2 4921 8670, fax 61 2 4921 7903, E mail
    Schizophr Bull 40:399-409. 2014
  6. pmc Identifying miRNAs, targets and functions
    Bing Liu
    School of Biomedical Sciences and Pharmacy, The University of Newcastle, University Drive, Callaghan NSW 2308, Australia
    Brief Bioinform 15:1-19. 2014
  7. pmc Primer fabrication using polymerase mediated oligonucleotide synthesis
    Murray J Cairns
    Schizophrenia Research Institute, Sydney, NSW 2006, Australia
    BMC Genomics 10:344. 2009
  8. doi request reprint Altered neural signaling and immune pathways in peripheral blood mononuclear cells of schizophrenia patients with cognitive impairment: A transcriptome analysis
    Jing Qin Wu
    School of Biomedical Sciences and Pharmacy, Faculty of Health, The University of Newcastle, University Drive, Callaghan, NSW 2308, Australia Schizophrenia Research Institute, Sydney, Australia Centre for Translational Neuroscience and Mental Health, Hunter Medical Research Institute, Newcastle, NSW 2305, Australia
    Brain Behav Immun 53:194-206. 2016
  9. doi request reprint Gene expression analysis reveals schizophrenia-associated dysregulation of immune pathways in peripheral blood mononuclear cells
    Erin J Gardiner
    Schizophrenia Research Institute, Sydney, NSW, Australia
    J Psychiatr Res 47:425-37. 2013
  10. pmc Transcriptome sequencing revealed significant alteration of cortical promoter usage and splicing in schizophrenia
    Jing Qin Wu
    Schizophrenia Research Institute, Sydney, Australia
    PLoS ONE 7:e36351. 2012

Collaborators

Detail Information

Publications40

  1. doi request reprint Optimal consistency in microRNA expression analysis using reference-gene-based normalization
    Xi Wang
    School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, NSW 2308, Australia
    Mol Biosyst 11:1235-40. 2015
    ....
  2. pmc Ontogeny of small RNA in the regulation of mammalian brain development
    Sharon L Hollins
    School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, University Drive, Callaghan, NSW 2308, Australia
    BMC Genomics 15:777. 2014
    ..Accordingly, in the current study we have examined the contribution of miRNA in the developing rat telencephalon and mesencephalon from just after neural tube closure till birth using a genome-wide microarray strategy...
  3. pmc Imprinted DLK1-DIO3 region of 14q32 defines a schizophrenia-associated miRNA signature in peripheral blood mononuclear cells
    E Gardiner
    School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW, Australia
    Mol Psychiatry 17:827-40. 2012
    ..This pattern of differentially expressed miRNA in PBMCs may be indicative of significant underlying genetic or epigenetic alteration associated with schizophrenia...
  4. pmc Schizophrenia is associated with an increase in cortical microRNA biogenesis
    N J Beveridge
    Schizophrenia Research Institute, Sydney, NSW, Australia
    Mol Psychiatry 15:1176-89. 2010
    ..Given the magnitude of microRNA changes and their wide sphere of influence, this phenomenon could represent an important dimension in the pathogenesis of schizophrenia...
  5. pmc Maturation of the human dorsolateral prefrontal cortex coincides with a dynamic shift in microRNA expression
    Natalie J Beveridge
    To whom correspondence should be addressed School of Biomedical Sciences and Pharmacy, The University of Newcastle, University Drive, Callaghan, NSW 2308, Australia tel 61 2 4921 8670, fax 61 2 4921 7903, E mail
    Schizophr Bull 40:399-409. 2014
    ....
  6. pmc Identifying miRNAs, targets and functions
    Bing Liu
    School of Biomedical Sciences and Pharmacy, The University of Newcastle, University Drive, Callaghan NSW 2308, Australia
    Brief Bioinform 15:1-19. 2014
    ..We also briefly introduce the research in miRNA discovery and miRNA-target identification with an emphasis on the challenges to computational biology. ..
  7. pmc Primer fabrication using polymerase mediated oligonucleotide synthesis
    Murray J Cairns
    Schizophrenia Research Institute, Sydney, NSW 2006, Australia
    BMC Genomics 10:344. 2009
    ..PMOS can be used to generate primers directly in the end-users laboratory within the context of any DNA polymerase chemistry such as in PCR or sequencing reactions..
  8. doi request reprint Altered neural signaling and immune pathways in peripheral blood mononuclear cells of schizophrenia patients with cognitive impairment: A transcriptome analysis
    Jing Qin Wu
    School of Biomedical Sciences and Pharmacy, Faculty of Health, The University of Newcastle, University Drive, Callaghan, NSW 2308, Australia Schizophrenia Research Institute, Sydney, Australia Centre for Translational Neuroscience and Mental Health, Hunter Medical Research Institute, Newcastle, NSW 2305, Australia
    Brain Behav Immun 53:194-206. 2016
    ....
  9. doi request reprint Gene expression analysis reveals schizophrenia-associated dysregulation of immune pathways in peripheral blood mononuclear cells
    Erin J Gardiner
    Schizophrenia Research Institute, Sydney, NSW, Australia
    J Psychiatr Res 47:425-37. 2013
    ....
  10. pmc Transcriptome sequencing revealed significant alteration of cortical promoter usage and splicing in schizophrenia
    Jing Qin Wu
    Schizophrenia Research Institute, Sydney, Australia
    PLoS ONE 7:e36351. 2012
    ..By contrast, sequencing technology can provide un-biased analysis of transcription at nucleotide resolution. Here we use this approach to investigate schizophrenia-associated cortical gene expression...
  11. doi request reprint Upregulation of dicer and microRNA expression in the dorsolateral prefrontal cortex Brodmann area 46 in schizophrenia
    Danielle M Santarelli
    Schizophrenia Research Institute, Sydney, Australia
    Biol Psychiatry 69:180-7. 2011
    ..We hypothesize that abnormal miRNA levels contribute to the complex global changes in gene expression that underlie the pathophysiology of schizophrenia...
  12. pmc Expression of NPAS3 in the human cortex and evidence of its posttranscriptional regulation by miR-17 during development, with implications for schizophrenia
    Jenny Wong
    Schizophrenia Research Institute, Sydney, Australia
    Schizophr Bull 39:396-406. 2013
    ..Further studies into how changes in NPAS3 or its miRNA regulator may influence the development of schizophrenia are warranted...
  13. pmc Gene-microRNA interactions associated with antipsychotic mechanisms and the metabolic side effects of olanzapine
    Danielle M Santarelli
    School of Biomedical Sciences and Pharmacy, The University of Newcastle, University Drive, Callaghan, NSW, 2308, Australia
    Psychopharmacology (Berl) 227:67-78. 2013
    ..MicroRNA regulate numerous genes involved in brain development and function. It is therefore plausible to question whether miRNA expression is also altered and hence whether they take part in the neuroleptic mechanism of action...
  14. doi request reprint Context-specific microRNA function in developmental complexity
    Adam P Carroll
    School of Biomedical Sciences and Pharmacy, Faculty of Health and Hunter Medical Research Institute, University of Newcastle, Callaghan, NSW, Australia
    J Mol Cell Biol 5:73-84. 2013
    ..Moreover, by establishing the timing, location, and mechanism of these regulatory events, we may ultimately understand the true biological function of a specific miRNA in a given cellular environment...
  15. pmc Alternative mRNA fates identified in microRNA-associated transcriptome analysis
    Adam P Carroll
    School of Biomedical Sciences and Pharmacy, Faculty of Health and Hunter Medical Research Institute, University of Newcastle, Callaghan, NSW, Australia
    BMC Genomics 13:561. 2012
    ....
  16. pmc MicroRNAs miR-17 and miR-20a inhibit T cell activation genes and are under-expressed in MS whole blood
    Mathew B Cox
    Hunter Medical Research Institute, The University of Newcastle, Newcastle, New South Wales, Australia
    PLoS ONE 5:e12132. 2010
    ..The same T cell activation genes are also up-regulated in MS whole blood mRNA, suggesting these miRNAs or their analogues may provide useful targets for new therapeutic approaches...
  17. doi request reprint Down-regulation of miR-17 family expression in response to retinoic acid induced neuronal differentiation
    Natalie J Beveridge
    Schizophrenia Research Institute, Sydney, NSW 2006, Australia
    Cell Signal 21:1837-45. 2009
    ..This suggests that the miR-17 family have an integral role in fine-tuning the pathways involved in the regulation of neuronal differentiation...
  18. doi request reprint Dysregulation of miRNA 181b in the temporal cortex in schizophrenia
    Natalie J Beveridge
    Schizophrenia Research Institute, Sydney, NSW 2006, Australia
    Hum Mol Genet 17:1156-68. 2008
    ..This study suggests altered miRNA levels could be a significant factor in the dysregulation of cortical gene expression in schizophrenia...
  19. doi request reprint Design and interpretation of microRNA-reporter gene activity
    Adam P Carroll
    School of Biomedical Sciences and Pharmacy, Faculty of Health and Hunter Medical Research Institute, University of Newcastle, Callaghan, NSW 2308, Australia
    Anal Biochem 437:164-71. 2013
    ....
  20. pmc Gene set enrichment analysis of RNA-Seq data: integrating differential expression and splicing
    Xi Wang
    School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, New South Wales, Australia
    BMC Bioinformatics 14:S16. 2013
    ..However, existing functional analysis methods can only account for differential expression, leaving differential splicing out altogether...
  21. doi request reprint MicroRNA dysregulation in schizophrenia
    Natalie J Beveridge
    Faculty of Health and the Hunter Medical Research Institute, School of Biomedical Sciences and Pharmacy, The University of Newcastle, University Drive, Callaghan, NSW 2308, Australia
    Neurobiol Dis 46:263-71. 2012
    ..These developments have tremendous potential and highlight the significance of this avenue of research...
  22. doi request reprint Discovering functional microRNA-mRNA regulatory modules in heterogeneous data
    Bing Liu
    University of New South Wales, Randwick, NSW, Australia
    Adv Exp Med Biol 774:267-90. 2013
    ....
  23. doi request reprint Catechol-O-methyltransferase (COMT) genotype moderates the effects of childhood trauma on cognition and symptoms in schizophrenia
    Melissa J Green
    School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia Schizophrenia Research Institute, Darlinghurst, NSW, Australia Electronic address
    J Psychiatr Res 49:43-50. 2014
    ....
  24. doi request reprint Antipsychotic drug-associated gene-miRNA interaction in T-lymphocytes
    Erin Gardiner
    School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, NSW, Australia
    Int J Neuropsychopharmacol 17:929-43. 2014
    ..These results indicate that APDs have a significant effect on expression in peripheral tissue that relate to both known mechanisms as well as poorly characterized side effects...
  25. pmc MicroRNA-16 is down-regulated in mutated FLT3 expressing murine myeloid FDC-P1 cells and interacts with Pim-1
    Kyu Tae Kim
    School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia
    PLoS ONE 7:e44546. 2012
    ....
  26. pmc A parallel genome-wide mRNA and microRNA profiling of the frontal cortex of HIV patients with and without HIV-associated dementia shows the role of axon guidance and downstream pathways in HIV-mediated neurodegeneration
    Li Zhou
    Retroviral Genetics Division, Center for Virus Research, Westmead Millennium Institute, Westmead Hospital, The University of Sydney, Westmead, NSW 2145, Sydney, Australia
    BMC Genomics 13:677. 2012
    ..Therefore, identifying HIV fingerprints on the host gene machinery and its regulation by microRNA holds a great promise and potential for improving our understanding of HAD pathogenesis, its diagnosis and therapy...
  27. pmc Proteotranscriptomic Profiling of 231-BR Breast Cancer Cells: Identification of Potential Biomarkers and Therapeutic Targets for Brain Metastasis
    Matthew D Dun
    From the School of Biomedical Sciences and Pharmacy and Hunter Medical Research Institute, Faculty of Health and Medicine, University of Newcastle, Callaghan, New South Wales 2308, Australia
    Mol Cell Proteomics 14:2316-30. 2015
    ..The clinicopathological significance of these major proteomic changes to predict the occurrence of brain metastases, and their potential value as therapeutic targets, warrants further investigation...
  28. pmc Post-transcriptional trafficking and regulation of neuronal gene expression
    Belinda J Goldie
    School of Biomedical Sciences and Pharmacy, Faculty of Health and the Hunter Medical Research Institute, The University of Newcastle, University Drive, Callaghan, NSW 2308, Australia
    Mol Neurobiol 45:99-108. 2012
    ..In this review we examine post-synaptic gene regulation, mRNA trafficking and the emerging role of post-transcriptional gene silencing in synaptic plasticity...
  29. pmc RNA modulators of complex phenotypes in mammalian cells
    Angela Lai
    Johnson and Johnson Research Pty Ltd, Australian Technology Park, Eveleigh, New South Wales, Australia
    PLoS ONE 4:e4758. 2009
    ..The technology described has the potential to identify both functional RNA modulators capable of altering physiological systems and the cellular target genes altered by these modulators...
  30. doi request reprint Alteration of transcriptional networks in the entorhinal cortex after maternal immune activation and adolescent cannabinoid exposure
    Sharon L Hollins
    School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW, Australia Schizophrenia Research Institute, Sydney, NSW, Australia Centre for Brain and Mental Health Research, Hunter Medical Research Institute, Newcastle, NSW 2305, Australia
    Brain Behav Immun 56:187-96. 2016
    ....
  31. doi request reprint MicroRNA: Small RNA mediators of the brains genomic response to environmental stress
    Sharon L Hollins
    School of Biomedical Sciences and Pharmacy and the Hunter Medical Research Institute, The University of Newcastle, Callaghan, NSW 2308, Australia
    Prog Neurobiol 143:61-81. 2016
    ..A greater understanding of the dynamics that mediate an individual's predisposition to stress-induced neuropathology has major human health benefits and is an important area of research. ..
  32. pmc Regulation of gene expression by microRNA in HCV infection and HCV-mediated hepatocellular carcinoma
    Priyanka Gupta
    Centre for Virus Research, Westmead Millennium Institute, Darcy Road, Sydney, Westmead NSW 2145, Australia
    Virol J 11:64. 2014
    ..Here, we review the current knowledge on the role of miRNA and gene expression on HCV infection and hepatocellular carcinoma, in addition to the possible role of miRNA as future therapeutic targets. ..
  33. pmc Activity-associated miRNA are packaged in Map1b-enriched exosomes released from depolarized neurons
    Belinda J Goldie
    School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia Schizophrenia Research Institute, Sydney, Australia Centre for Translational Neuroscience and Mental Health, Hunter Medical Research Institute, University of Newcastle, Callaghan, NSW 2308, Australia
    Nucleic Acids Res 42:9195-208. 2014
    ..These findings further support a role for miRNA as neural plasticity regulators, as they are compartmentalized in neurons and undergo activity-associated redistribution or release into the extracellular matrix. ..
  34. doi request reprint Understanding complex transcriptome dynamics in schizophrenia and other neurological diseases using RNA sequencing
    Xi Wang
    School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, Callaghan, New South Wales, Australia
    Int Rev Neurobiol 116:127-52. 2014
    ....
  35. pmc Multivariate neuroanatomical classification of cognitive subtypes in schizophrenia: a support vector machine learning approach
    Ian C Gould
    Schizophrenia Research Institute, Darlinghurst, NSW, Australia School of Psychiatry, University of New South Wales, Australia
    Neuroimage Clin 6:229-36. 2014
    ..Consideration of sex-specific differences in brain organization is thus likely to assist future attempts to distinguish subgroups of schizophrenia patients on the basis of neuroanatomical features. ..
  36. doi request reprint A comparative examination of the anti-inflammatory effects of SSRI and SNRI antidepressants on LPS stimulated microglia
    Ross J Tynan
    School of Biomedical Sciences and Pharmacy, The University of Newcastle, University Drive, Callaghan, NSW 2308, Australia
    Brain Behav Immun 26:469-79. 2012
    ..These findings suggest that antidepressants may owe at least some of their therapeutic effectiveness to their anti-inflammatory properties...
  37. doi request reprint SeqGSEA: a Bioconductor package for gene set enrichment analysis of RNA-Seq data integrating differential expression and splicing
    Xi Wang
    School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Newcastle, Hunter Medical Research Institute, New Lambton, and Schizophrenia Research Institute, Sydney, NSW, AustraliaSchool of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Newcastle, Hunter Medical Research Institute, New Lambton, and Schizophrenia Research Institute, Sydney, NSW, Australia
    Bioinformatics 30:1777-9. 2014
    ..Real applications show that SeqGSEA detects more biologically meaningful gene sets without biases toward long or highly expressed genes. SeqGSEA can be set up to run in parallel to reduce the analysis time...
  38. ncbi request reprint Recent patents in antiviral siRNAs
    Edward G Saravolac
    School of Biomedical Science, Faculty of Health, and Hunter Medical Research Institute, The University of Newcastle, University Drive, Callagham, NSW 2308, Australia
    Recent Pat Antiinfect Drug Discov 5:44-57. 2010
    ....
  39. doi request reprint The DNA sequence selectivity of maltolato-containing cisplatin analogues in purified plasmid DNA and in intact human cells
    Murray J Cairns
    University of New South Wales, Sydney, Australia
    J Inorg Biochem 103:1151-5. 2009
    ..This study indicated that maltolato can be utilised as the leaving group to increase the aqueous solubility of cisplatin analogues without reducing their biological activity...