Michael Breakspear

Summary

Affiliation: University of New South Wales
Country: Australia

Publications

  1. pmc Generative models of cortical oscillations: neurobiological implications of the kuramoto model
    Michael Breakspear
    School of Psychiatry, University of New South Wales Sydney, NSW, Australia
    Front Hum Neurosci 4:190. 2010
  2. ncbi request reprint The nonlinear theory of schizophrenia
    Michael Breakspear
    The School of Psychiatry, University of New South Wales and the Black Dog Institute, Australia
    Aust N Z J Psychiatry 40:20-35. 2006
  3. ncbi request reprint The multiscale character of evoked cortical activity
    Michael Breakspear
    The Black Dog Institute, Hospital Rd, Prince of Wales Hospital and The School of Psychiatry, University of New South Wales, Randwick, NSW 2031, Australia
    Neuroimage 30:1230-42. 2006
  4. ncbi request reprint Small-world properties of nonlinear brain activity in schizophrenia
    Mikail Rubinov
    Black Dog Institute and School of Psychiatry, University of New South Wales, Sydney, Australia
    Hum Brain Mapp 30:403-16. 2009
  5. doi request reprint Functional Dysconnection of the Inferior Frontal Gyrus in Young People With Bipolar Disorder or at Genetic High Risk
    Gloria Roberts
    School of Psychiatry, University of New South Wales, Randwick, New South Wales Black Dog Institute, Randwick, New South Wales
    Biol Psychiatry . 2016
  6. doi request reprint What clinical features precede the onset of bipolar disorder?
    Tania Perich
    School of Psychiatry, University of New South Wales, Australia Black Dog Institute, Prince of Wales Hospital, Australia
    J Psychiatr Res 62:71-7. 2015
  7. pmc Neurobiologically realistic determinants of self-organized criticality in networks of spiking neurons
    Mikail Rubinov
    Black Dog Institute and School of Psychiatry, University of New South Wales, Sydney, Australia
    PLoS Comput Biol 7:e1002038. 2011
  8. doi request reprint Effects of mnemonic load on cortical activity during visual working memory: linking ongoing brain activity with evoked responses
    Tjeerd W Boonstra
    School of Psychiatry, University of New South Wales, Sydney, Australia Black Dog Institute, Sydney, Australia Research Institute MOVE, VU University Amsterdam, The Netherlands Electronic address
    Int J Psychophysiol 89:409-18. 2013
  9. doi request reprint Network dysfunction of emotional and cognitive processes in those at genetic risk of bipolar disorder
    Michael Breakspear
    1 QIMR Berghofer, Brisbane, Queensland, Australia 2 Metro North Mental Health Service, Brisbane, Queensland, Australia 3 School of Psychiatry, University of New South Wales, Randwick, NSW, Australia
    Brain 138:3427-39. 2015
  10. doi request reprint Comparing the phenomenology of depressive episodes in bipolar I and II disorder and major depressive disorder within bipolar disorder pedigrees
    Andrew Frankland
    School of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, New South Wales, Australia
    J Clin Psychiatry 76:32-8; quiz 39. 2015

Detail Information

Publications53

  1. pmc Generative models of cortical oscillations: neurobiological implications of the kuramoto model
    Michael Breakspear
    School of Psychiatry, University of New South Wales Sydney, NSW, Australia
    Front Hum Neurosci 4:190. 2010
    ....
  2. ncbi request reprint The nonlinear theory of schizophrenia
    Michael Breakspear
    The School of Psychiatry, University of New South Wales and the Black Dog Institute, Australia
    Aust N Z J Psychiatry 40:20-35. 2006
    ..Only a few studies of brain activity in schizophrenia, however, have used nonlinear methods. This review paper evaluates the contribution of the nonlinear sciences towards understanding schizophrenia...
  3. ncbi request reprint The multiscale character of evoked cortical activity
    Michael Breakspear
    The Black Dog Institute, Hospital Rd, Prince of Wales Hospital and The School of Psychiatry, University of New South Wales, Randwick, NSW 2031, Australia
    Neuroimage 30:1230-42. 2006
    ..It also affords a quantitative means of testing hierarchical and multiscale models of cortical activity...
  4. ncbi request reprint Small-world properties of nonlinear brain activity in schizophrenia
    Mikail Rubinov
    Black Dog Institute and School of Psychiatry, University of New South Wales, Sydney, Australia
    Hum Brain Mapp 30:403-16. 2009
    ..This randomization may underlie the cognitive disturbances characteristic of schizophrenia...
  5. doi request reprint Functional Dysconnection of the Inferior Frontal Gyrus in Young People With Bipolar Disorder or at Genetic High Risk
    Gloria Roberts
    School of Psychiatry, University of New South Wales, Randwick, New South Wales Black Dog Institute, Randwick, New South Wales
    Biol Psychiatry . 2016
    ..Here, we studied resting-state functional connectivity of the left IFG in participants with BD and in those at increased genetic risk...
  6. doi request reprint What clinical features precede the onset of bipolar disorder?
    Tania Perich
    School of Psychiatry, University of New South Wales, Australia Black Dog Institute, Prince of Wales Hospital, Australia
    J Psychiatr Res 62:71-7. 2015
    ....
  7. pmc Neurobiologically realistic determinants of self-organized criticality in networks of spiking neurons
    Mikail Rubinov
    Black Dog Institute and School of Psychiatry, University of New South Wales, Sydney, Australia
    PLoS Comput Biol 7:e1002038. 2011
    ..The central role of these features in our model may reflect their importance for neuronal information processing...
  8. doi request reprint Effects of mnemonic load on cortical activity during visual working memory: linking ongoing brain activity with evoked responses
    Tjeerd W Boonstra
    School of Psychiatry, University of New South Wales, Sydney, Australia Black Dog Institute, Sydney, Australia Research Institute MOVE, VU University Amsterdam, The Netherlands Electronic address
    Int J Psychophysiol 89:409-18. 2013
    ..Analysis of the relationship between event-related changes in slow potentials and cortical rhythms, using partial least squares, is indeed consistent with the notion that the former make a causal contribution to the latter. ..
  9. doi request reprint Network dysfunction of emotional and cognitive processes in those at genetic risk of bipolar disorder
    Michael Breakspear
    1 QIMR Berghofer, Brisbane, Queensland, Australia 2 Metro North Mental Health Service, Brisbane, Queensland, Australia 3 School of Psychiatry, University of New South Wales, Randwick, NSW, Australia
    Brain 138:3427-39. 2015
    ..We thus establish a specific network disturbance suggesting dysfunction in the processes that support hierarchical relationships between emotion and cognitive control in those at high genetic risk for bipolar disorder. ..
  10. doi request reprint Comparing the phenomenology of depressive episodes in bipolar I and II disorder and major depressive disorder within bipolar disorder pedigrees
    Andrew Frankland
    School of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, New South Wales, Australia
    J Clin Psychiatry 76:32-8; quiz 39. 2015
    ..The aim of this retrospective study was to compare the phenomenology of the most severe lifetime depressive episodes between bipolar I (BP-I) and II (BP-II) disorder subtypes and MDD in these pedigrees...
  11. doi request reprint Simulation of neuronal death and network recovery in a computational model of distributed cortical activity
    Mikail Rubinov
    School of Psychiatry, University of New South Wales, Sydney, NSW, Australia
    Am J Geriatr Psychiatry 17:210-7. 2009
    ..The authors utilize a model of activity-dependent neuronal plasticity to study the interplay between synaptogenesis, neuronal death, and neurogenesis on the resulting pattern of neuronal connectivity...
  12. doi request reprint Anxiety, stress and perfectionism in bipolar disorder
    Justine Corry
    School of Psychiatry, University of New South Wales, Randwick, NSW, Australia Black Dog Institute, Prince of Wales Hospital, Randwick, NSW, Australia Electronic address
    J Affect Disord 151:1016-24. 2013
    ..The anxiety disorders are highly comorbid with bipolar disorder but the mechanisms that underpin this comorbidity are yet to be determined...
  13. ncbi request reprint A novel method for the topographic analysis of neural activity reveals formation and dissolution of 'Dynamic Cell Assemblies'
    Michael Breakspear
    Brain Dynamics Centre, Westmead Hospital, Westmead, NSW, 2145, Australia
    J Comput Neurosci 16:49-68. 2004
    ..In particular, the character of transitions between consecutive synchronous epochs may reflect important aspects of information processing and cognitive flexibility...
  14. pmc Symbiotic relationship between brain structure and dynamics
    Mikail Rubinov
    Black Dog Institute and School of Psychiatry, University of New South Wales, Sydney, Australia
    BMC Neurosci 10:55. 2009
    ..We provide further biophysical justification for this model and quantitatively characterize the relationship between structure, function and dynamics that accompanies the ensuing self-organization...
  15. doi request reprint Reduced inferior frontal gyrus activation during response inhibition to emotional stimuli in youth at high risk of bipolar disorder
    Gloria Roberts
    School of Psychiatry, University of New South Wales, NSW, Australia
    Biol Psychiatry 74:55-61. 2013
    ....
  16. pmc Impact of load-related neural processes on feature binding in visuospatial working memory
    Nicole A Kochan
    Brain and Ageing Research Program, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia
    PLoS ONE 6:e23960. 2011
    ..However the neural mechanisms underlying this process, and its modulation by task and load effects, are not well understood...
  17. doi request reprint The organisation of the elderly connectome
    Alistair Perry
    Centre for Healthy Brain Ageing CHeBA, School of Psychiatry, University of New South Wales, Sydney, NSW, Australia School of Psychiatry, University of New South Wales, Sydney, NSW 2052, Australia Systems Neuroscience Group, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, QLD 4006, Australia
    Neuroimage 114:414-26. 2015
    ..These findings provide insights into healthy brain ageing and provide a benchmark for the study of neurodegenerative disorders such as Alzheimer's disease (AD) and frontotemporal dementia (FTD)...
  18. pmc Dynamics of a neural system with a multiscale architecture
    Michael Breakspear
    The Black Dog Institute, Prince of Wales Hospital and School of Psychiatry, University of New South Wales, Randwick, NSW 2031, Australia
    Philos Trans R Soc Lond B Biol Sci 360:1051-74. 2005
    ..A framework for relating the dynamical behaviour of the system to measured observables is presented and further extensions to capture wave phenomena and mode coupling are suggested...
  19. doi request reprint The foveal confluence in human visual cortex
    Mark M Schira
    School of Psychology, University of New South Wales, Sydney, New South Wales 2052, Australia
    J Neurosci 29:9050-8. 2009
    ..75 degrees, the cortical representations for both V2 and V3 are larger than that of V1, indicating that more neuronal processing power is dedicated to second-level analysis in this small but important part of the visual field...
  20. ncbi request reprint Phase-locked cluster oscillations in periodically forced integrate-and-fire-or-burst neuronal populations
    Angela J Langdon
    School of Psychiatry, University of New South Wales, Sydney, Australia
    Phys Rev E Stat Nonlin Soft Matter Phys 86:061903. 2012
    ....
  21. ncbi request reprint Screening for bipolar disorder: the utility and comparative properties of the MSS and MDQ measures
    Gordon Parker
    School of Psychiatry, University of New South Wales, Australia
    J Affect Disord 109:83-9. 2008
    ..Our objective was to further determine the diagnostic utility of the Mood Swings Survey (MSS) in distinguishing bipolar and unipolar disorders, and draw comparisons between this measure and the widely-used Mood Disorder Questionnaire (MDQ)...
  22. doi request reprint The impact of detecting bipolar disorder in previously diagnosed unipolar patients at a specialist depression clinic
    Gordon Parker
    Black Dog Institute, Sydney, Australia
    J Nerv Ment Dis 199:419-22. 2011
    ..Future studies examining the impact of diagnosing a bipolar disorder would therefore benefit from the close consideration of the optimal control group or control strategy...
  23. pmc Modeling magnification and anisotropy in the primate foveal confluence
    Mark M Schira
    School of Psychiatry and The Black Dog Institute, University of New South Wales, Sydney Australia
    PLoS Comput Biol 6:e1000651. 2010
    ..Our models demonstrate that the organization follows clear morphogenetic principles that are essential for our understanding of foveal vision in daily life...
  24. pmc A dendritic mechanism for decoding traveling waves: principles and applications to motor cortex
    Stewart Heitmann
    School of Psychiatry, The University of New South Wales, Sydney, Australia The Black Dog Institute, Sydney, Australia
    PLoS Comput Biol 9:e1003260. 2013
    ..By additionally showing how the nature of the wave patterns can be controlled by modulating the topology of local intra-cortical connections, we hence propose a novel integrated neuronal model of encoding and decoding motor commands. ..
  25. doi request reprint Scale-free bursting in human cortex following hypoxia at birth
    James A Roberts
    Systems Neuroscience Group, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia, Faculty of Health Sciences, School of Medicine, University of Queensland, Brisbane, Queensland 4029, Australia, The University of Queensland Centre for Clinical Research and Perinatal Research Centre, Brisbane, Queensland 4006, Australia, Department of Children s Clinical Neurophysiology, Helsinki University Central Hospital and University of Helsinki, Helsinki HUS 00029, Finland, Royal Brisbane and Women s Hospital, Herston, Queensland 4006, Australia, and School of Psychiatry, University of New South Wales and the Black Dog Institute, Randwick, New South Wales 2031, Australia
    J Neurosci 34:6557-72. 2014
    ....
  26. doi request reprint Multi-frequency phase locking in human somatosensory cortex
    Angela J Langdon
    School of Psychiatry, University of New South Wales, Sydney, Australia
    Prog Biophys Mol Biol 105:58-66. 2011
    ..The existence of n:m phase synchronization demonstrates the contribution of intrinsic cortical dynamics to stimulus encoding and provides a novel phenomenological criteria for the validation of large-scale models of the brain...
  27. pmc Modulation of cortical activity by transcranial direct current stimulation in patients with affective disorder
    Tamara Y Powell
    School of Psychiatry, University of New South Wales, Sydney, Australia Black Dog Institute, Sydney, Australia
    PLoS ONE 9:e98503. 2014
    ..Effects on the N2 and frontal theta activity likely reflect modulated activity in the medial frontal cortex and hence indicate that the after-effects of tDCS extend beyond the direct focal effects to the left DLPFC. ..
  28. doi request reprint Cortical responses to a graded working memory challenge predict functional decline in mild cognitive impairment
    Nicole A Kochan
    Brain and Ageing Research Program, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia
    Biol Psychiatry 70:123-30. 2011
    ..We observed greater deactivation of posteromedial cortex (PMC) under conditions of increased WM load in MCI compared with control subjects. Our objective here is to test whether this paradigm can predict ensuing functional decline...
  29. pmc Scene unseen: Disrupted neuronal adaptation in melancholia during emotional film viewing
    Matthew P Hyett
    School of Psychiatry, University of New South Wales, Black Dog Institute Building, Prince of Wales Hospital, Hospital Road, Randwick, NSW 2031, Australia QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, QLD 4006, Australia
    Neuroimage Clin 9:660-7. 2015
    ....
  30. pmc Intrinsic coupling modes in source-reconstructed electroencephalography
    Saeid Mehrkanoon
    1 School of Psychiatry, University of New South Wales, Sydney, Australia
    Brain Connect 4:812-25. 2014
    ..These results show a relationship between intrinsic coupling modes that is distinct from the effect of volume conduction...
  31. doi request reprint The reorganization of corticomuscular coherence during a transition between sensorimotor states
    Saeid Mehrkanoon
    School of Psychiatry, University of New South Wales, Sydney, Australia Black Dog Institute, Sydney, Australia Electronic address
    Neuroimage 100:692-702. 2014
    ..We interpret the dual-band synchronization in the alpha and gamma bands as parallel streams of corticospinal processing involved in parsing prediction errors and generating new motor predictions...
  32. ncbi request reprint Complex mental activity and the aging brain: molecular, cellular and cortical network mechanisms
    Michael J Valenzuela
    School of Psychiatry, University of New South Wales, Sydney, Australia
    Brain Res Rev 56:198-213. 2007
    ..This paper will explore the neurobiological and clinical implications of this framework, in particular in the context of age-related brain disease...
  33. pmc Prior and present evidence: how prior experience interacts with present information in a perceptual decision making task
    Muhsin Karim
    School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia
    PLoS ONE 7:e37580. 2012
    ..We describe the influence of prior information in relation to the more traditionally studied factors of interest in a classic discrimination task...
  34. doi request reprint Low-dimensional dynamics of resting-state cortical activity
    Saeid Mehrkanoon
    Black Dog Institute, The University of New South Wales, Hospital Rd, Sydney, NSW, 2031, Australia
    Brain Topogr 27:338-52. 2014
    ..These analyses uncover the complex temporal character of endogenous cortical fluctuations and, in particular, offer an opportunity to reconstruct the low dimensional linear subspace in which they unfold...
  35. ncbi request reprint "Dynamic" connectivity in neural systems: theoretical and empirical considerations
    Michael Breakspear
    School of Physics, University of Sydney, NSW, Australia
    Neuroinformatics 2:205-26. 2004
    ..We conclude by suggesting that techniques based on dynamical interdependence--or "dynamical connectivity"--show significant potential for extracting meaningful information from functional neuroimaging data...
  36. ncbi request reprint Synchronous gamma activity: a review and contribution to an integrative neuroscience model of schizophrenia
    Kwang Hyuk Lee
    Cognitive Neuroscience Unit, Department of Psychology, University of Sydney, and The Brain Dynamics Centre, Westmead Hospital, 2145, Sydney, NSW, Australia
    Brain Res Brain Res Rev 41:57-78. 2003
    ..It is concluded that measures of Gamma synchrony offer a valuable window into the core integrative disturbance in schizophrenia cognition...
  37. doi request reprint Neural mechanisms of intermuscular coherence: implications for the rectification of surface electromyography
    Tjeerd W Boonstra
    School of Psychiatry, University of New South Wales, Australia
    J Neurophysiol 107:796-807. 2012
    ..These findings implicate that the shape of MUAPs is an essential parameter to reconcile experimental and computational approaches...
  38. doi request reprint Clinical characteristics and temperament influences on 'happy' euphoric and 'snappy' irritable bipolar hypo/manic mood states
    Rebecca K Graham
    School of Psychiatry, University of New South Wales, Sydney, NSW, Australia Black Dog Institute, Hospital Road, Prince of Wales Hospital, Randwick, Sydney, NSW 2031, Australia
    J Affect Disord 174:144-9. 2015
    ..While mood elevation and euphoria are the most commonly described phenotypic descriptors of hypo/mania, irritability and anger may dominate. This study was designed to pursue possible determinants of such differing states...
  39. doi request reprint Subdiffusive dynamics of bump attractors: mechanisms and functional roles
    Yang Qi
    School of Physics, University of Sydney, Sydney, NSW, 2006, Australia
    Neural Comput 27:255-80. 2015
    ..Based on the probability density function of bump position, we also show that the subdiffusive dynamics result in a long-tailed decay of firing rate, greatly extending the duration of persistent activity. ..
  40. pmc A computational role for bistability and traveling waves in motor cortex
    Stewart Heitmann
    School of Psychiatry, The University of New South Wales Sydney, NSW, Australia
    Front Comput Neurosci 6:67. 2012
    ..We surmise that motor cortex may thus employ state-dependent computation to achieve very rapid changes between bistable motor states when the demand for speed exceeds the demand for accuracy...
  41. pmc Muscle co-contraction modulates damping and joint stability in a three-link biomechanical limb
    Stewart Heitmann
    Systems Neuroscience Group, School of Psychiatry, University of New South Wales Sydney, NSW, Australia
    Front Neurorobot 5:5. 2011
    ..Lastly we verify these analytic findings in the full biomechanical limb model...
  42. doi request reprint Comparison of depressive episodes in bipolar disorder and in major depressive disorder within bipolar disorder pedigrees
    Philip B Mitchell
    UNSW School of Psychiatry, Prince of Wales Hospital, Randwick, Australia
    Br J Psychiatry 199:303-9. 2011
    ....
  43. doi request reprint Inching toward Bethlehem: mapping melancholia
    Gordon Parker
    School of Psychiatry, University of New South Wales, Sydney, Australia
    J Affect Disord 123:291-8. 2010
    ..Analyses then examined the capacity of both the refined symptom and validator sets to discriminate the assigned melancholic and non-melancholic subjects...
  44. ncbi request reprint An improved algorithm for the detection of dynamical interdependence in bivariate time-series
    John R Terry
    Department of Mathematical Sciences, Loughborough University, Leices, LEII 3TU, UK
    Biol Cybern 88:129-36. 2003
    ..Such an improvement may assist an understanding of the role of large-scale nonlinear processes in normal brain function...
  45. ncbi request reprint Nonlinear synchronization in EEG and whole-head MEG recordings of healthy subjects
    Cornelis J Stam
    Department of Clinical Neurophysiology, VU University Medical Centre, Amsterdam, The Netherlands
    Hum Brain Mapp 19:63-78. 2003
    ..The spatial scale and physical properties of MEG acquisition may increase the sensitivity of the data to underlying nonlinear structure...
  46. ncbi request reprint Modulation of excitatory synaptic coupling facilitates synchronization and complex dynamics in a biophysical model of neuronal dynamics
    Michael Breakspear
    Brain Dynamics Centre, Westmead Hospital, Westmead, NSW 2145, Australia
    Network 14:703-32. 2003
    ..The paper concludes with a discussion of the putative relevance of such processes in the brain, including the role of neuromodulatory systems and the mechanisms underlying sensory perception, adaptation, computation and complexity...
  47. ncbi request reprint Wavelets and functional magnetic resonance imaging of the human brain
    Ed Bullmore
    Brain Mapping Unit and Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Neuroimage 23:S234-49. 2004
    ..We conclude that the wavelet domain is a rich source of new concepts and techniques to enhance the power of statistical analysis of human fMRI data...
  48. ncbi request reprint Small-world networks and disturbed functional connectivity in schizophrenia
    Sifis Micheloyannis
    University of Crete, Medical Division, 71409 Iraklion Crete, Greece
    Schizophr Res 87:60-6. 2006
    ..This method could be helpful for diagnosis and evaluation of the severity of the disease, as well as understanding the pathophysiologic mechanisms underlying cognitive dysfunction in schizophrenia...
  49. pmc Network structure of cerebral cortex shapes functional connectivity on multiple time scales
    Christopher J Honey
    Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA
    Proc Natl Acad Sci U S A 104:10240-5. 2007
    ....
  50. ncbi request reprint Nonlinear phase desynchronization in human electroencephalographic data
    Michael Breakspear
    Brain Dynamics Centre, Department of Psychological Medicine, Westmead Hospital, Darcy Road, Westmead, Sydney, NSW 2048, Australia
    Hum Brain Mapp 15:175-98. 2002
    ..Statistical analysis reveals that this null hypothesis can be robustly rejected in a small number (approximately 4%) of EEG epochs. These findings are discussed with reference to the adaptive function and complex dynamics of the brain...
  51. ncbi request reprint Multivariate time-frequency analysis of electromagnetic brain activity during bimanual motor learning
    Tjeerd W Boonstra
    Research Institute MOVE, VU University Amsterdam, The Netherlands
    Neuroimage 36:370-7. 2007
    ..These electrophysiological findings support the view that activity in motor cortex co-varies closely with behavioral changes over the course of learning...
  52. ncbi request reprint Possibilities for the prevention and treatment of cognitive impairment and dementia
    David Burke
    Br J Psychiatry 190:371-2. 2007
    ....
  53. ncbi request reprint Spatiotemporal wavelet resampling for functional neuroimaging data
    Michael Breakspear
    Brain Dynamics Centre, Westmead Hospital and University of Sydney, Sydney, Australia
    Hum Brain Mapp 23:1-25. 2004
    ..The limitations and possible extensions of the proposed technique are discussed...