Nikola A Bowden

Summary

Affiliation: University of Newcastle
Country: Australia

Publications

  1. pmc Understanding Xeroderma Pigmentosum Complementation Groups Using Gene Expression Profiling after UV-Light Exposure
    Nikola A Bowden
    Hunter Medical Research Institute and the University of Newcastle, Callaghan, NSW 2289, Australia
    Int J Mol Sci 16:15985-96. 2015
  2. doi request reprint Nucleotide excision repair: why is it not used to predict response to platinum-based chemotherapy?
    Nikola A Bowden
    Centre for Information Based Medicine, University of Newcastle, Australia School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Australia Hunter Medical Research Institute, Newcastle, NSW, Australia Electronic address
    Cancer Lett 346:163-71. 2014
  3. pmc Regulators of global genome repair do not respond to DNA damaging therapy but correlate with survival in melanoma
    Nikola A Bowden
    School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Australia and Hunter Medical Research Institute, Newcastle, NSW, Australia
    PLoS ONE 8:e70424. 2013
  4. pmc The role of altered nucleotide excision repair and UVB-induced DNA damage in melanomagenesis
    Timothy Budden
    Centre for Information Based Medicine, Hunter Medical Research Institute, and School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Newcastle, NSW 2289, Australia
    Int J Mol Sci 14:1132-51. 2013
  5. doi request reprint Nucleotide excision repair gene expression after Cisplatin treatment in melanoma
    Nikola A Bowden
    Centre for Information Based Medicine, University of Newcastle, Newcastle, New South Wales, Australia
    Cancer Res 70:7918-26. 2010
  6. pmc Gene expression profiling of xeroderma pigmentosum
    Nikola A Bowden
    Hunter Medical Research Institute, John Hunter Hospital, Lookout Rd, New Lambton Heights, NSW, 2305, Australia
    Hered Cancer Clin Pract 4:103-10. 2006
  7. pmc Altered gene expression in the superior temporal gyrus in schizophrenia
    Nikola A Bowden
    Neuroscience Institute of Schizophrenia and Allied Disorders, Sydney, NSW, Australia
    BMC Genomics 9:199. 2008
  8. ncbi request reprint Altered expression of regulator of G-protein signalling 4 (RGS4) mRNA in the superior temporal gyrus in schizophrenia
    Nikola A Bowden
    Neuroscience Institute of Schizophrenia and Allied Disorders, Sydney, Australia
    Schizophr Res 89:165-8. 2007
  9. ncbi request reprint Preliminary investigation of gene expression profiles in peripheral blood lymphocytes in schizophrenia
    Nikola A Bowden
    Neuroscience Institute of Schizophrenia and Allied Disorders, Australia
    Schizophr Res 82:175-83. 2006
  10. doi request reprint Low prevalence of germline PALB2 mutations in Australian triple-negative breast cancer
    Michelle W Wong-Brown
    School of Biomedical Sciences and Pharmacy Centre for Information Based Medicine, University of Newcastle, Hunter Medical Research Institute, Newcastle, NSW, Australia
    Int J Cancer 134:301-5. 2014

Collaborators

Detail Information

Publications26

  1. pmc Understanding Xeroderma Pigmentosum Complementation Groups Using Gene Expression Profiling after UV-Light Exposure
    Nikola A Bowden
    Hunter Medical Research Institute and the University of Newcastle, Callaghan, NSW 2289, Australia
    Int J Mol Sci 16:15985-96. 2015
    ..This study will assist in furthering our understanding of the different subtypes of XP which will lead to better diagnosis, treatment and management of the disease. ..
  2. doi request reprint Nucleotide excision repair: why is it not used to predict response to platinum-based chemotherapy?
    Nikola A Bowden
    Centre for Information Based Medicine, University of Newcastle, Australia School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Australia Hunter Medical Research Institute, Newcastle, NSW, Australia Electronic address
    Cancer Lett 346:163-71. 2014
    ..This review summarises the results of previous investigations into NER in cisplatin response and clinical trials where the expression of NER proteins were compared to the response to platinum therapies in treatment. ..
  3. pmc Regulators of global genome repair do not respond to DNA damaging therapy but correlate with survival in melanoma
    Nikola A Bowden
    School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Australia and Hunter Medical Research Institute, Newcastle, NSW, Australia
    PLoS ONE 8:e70424. 2013
    ..Taken together, these findings provide evidence of the mechanisms underlying NER deficiency in melanoma. ..
  4. pmc The role of altered nucleotide excision repair and UVB-induced DNA damage in melanomagenesis
    Timothy Budden
    Centre for Information Based Medicine, Hunter Medical Research Institute, and School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Newcastle, NSW 2289, Australia
    Int J Mol Sci 14:1132-51. 2013
    ..This review discusses the current research surrounding UVB radiation and NER capacity and how further investigation of NER could elucidate the role of NER in avoiding UV-induced cellular death resulting in melanomagenesis...
  5. doi request reprint Nucleotide excision repair gene expression after Cisplatin treatment in melanoma
    Nikola A Bowden
    Centre for Information Based Medicine, University of Newcastle, Newcastle, New South Wales, Australia
    Cancer Res 70:7918-26. 2010
    ..Our findings suggest a possible mechanistic explanation for the limited efficacy of cisplatin treatment and the possible role of UV light in melanoma...
  6. pmc Gene expression profiling of xeroderma pigmentosum
    Nikola A Bowden
    Hunter Medical Research Institute, John Hunter Hospital, Lookout Rd, New Lambton Heights, NSW, 2305, Australia
    Hered Cancer Clin Pract 4:103-10. 2006
    ..Therefore, this analysis has revealed distinct gene expression profiles for the XP complementation groups and the first step towards understanding the neurological symptoms of XP...
  7. pmc Altered gene expression in the superior temporal gyrus in schizophrenia
    Nikola A Bowden
    Neuroscience Institute of Schizophrenia and Allied Disorders, Sydney, NSW, Australia
    BMC Genomics 9:199. 2008
    ..The STG connects to the limbic system (hippocampus and amygdala), the thalamus and neocortical association areas in the prefrontal cortex, all of which have been implicated in schizophrenia...
  8. ncbi request reprint Altered expression of regulator of G-protein signalling 4 (RGS4) mRNA in the superior temporal gyrus in schizophrenia
    Nikola A Bowden
    Neuroscience Institute of Schizophrenia and Allied Disorders, Sydney, Australia
    Schizophr Res 89:165-8. 2007
    ..Altered expression of RGS4 in cortical regions previously implicated in schizophrenia, such as the STG further supports the notion of RGS4 as a potential genetic and functional biological marker of schizophrenia...
  9. ncbi request reprint Preliminary investigation of gene expression profiles in peripheral blood lymphocytes in schizophrenia
    Nikola A Bowden
    Neuroscience Institute of Schizophrenia and Allied Disorders, Australia
    Schizophr Res 82:175-83. 2006
    ..The validity of this approach may lead to better methods of defining this enigmatic disease...
  10. doi request reprint Low prevalence of germline PALB2 mutations in Australian triple-negative breast cancer
    Michelle W Wong-Brown
    School of Biomedical Sciences and Pharmacy Centre for Information Based Medicine, University of Newcastle, Hunter Medical Research Institute, Newcastle, NSW, Australia
    Int J Cancer 134:301-5. 2014
    ..Our study shows that the prevalence of PALB2 germline mutations in individuals with TNBC is ∼1%, similar to the prevalence of PALB2 germline mutation of 1% in familial non-BRCA1/2 breast cancer cohorts...
  11. pmc P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation
    Kelly A Avery-Kiejda
    Oncology and Immunology, Calvary Mater Newcastle Hospital, University of Newcastle, Newcastle, NSW, Australia
    BMC Cancer 11:203. 2011
    ..While mutation of the P53 tumour suppressor gene is a common feature of many types of cancer, mutational inactivation of P53 in melanoma is uncommon; however, its function often appears abnormal...
  12. doi request reprint Repair of UVB-induced DNA damage is reduced in melanoma due to low XPC and global genome repair
    Timothy Budden
    Hunter Medical Research Institute and Faculty of Health, University of Newcastle, Callaghan, NSW, Australia
    Oncotarget . 2016
    ..The same trend was seen in the TCGA melanoma dataset. Reduced GGR in melanoma may contribute to the UV mutation spectrum of the melanoma genome and adds further to the growing evidence of the link between UV, NER and melanoma...
  13. pmc A polymorphic repeat in the IGF1 promoter influences the risk of endometrial cancer
    Katherine A Bolton
    Centre for BioinformaticsBiomarker Discovery and Information Based Medicine, Hunter Medical Research Institute, Newcastle, New South Wales, Australia Priority Research Centre for CancerSchool of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia
    Endocr Connect 5:115-22. 2016
    ..The significant association observed between the CA repeat length and the risk of developing endometrial cancer has not been previously reported. ..
  14. ncbi request reprint Altered gene expression in the amygdala in schizophrenia: up-regulation of genes located in the cytomatrix active zone
    Judith Weidenhofer
    Neuroscience Institute of Schizophrenia and Allied Disorders NISAD, NSW, Australia
    Mol Cell Neurosci 31:243-50. 2006
    ..These results implicate for the first time the dysfunction of the cytomatrix active zone of synapses in the amygdala in the pathophysiology of schizophrenia...
  15. pmc A novel polymorphic repeat in the upstream regulatory region of the estrogen-induced gene EIG121 is not associated with the risk of developing breast or endometrial cancer
    Katherine A Bolton
    Centre for Bioinformatics, Biomarker Discovery and Information Based Medicine, Hunter Medical Research Institute, Newcastle, NSW, Australia
    BMC Res Notes 9:287. 2016
    ..The presence of this STR has not previously been analysed in relation to breast or endometrial cancer risk...
  16. doi request reprint Common genetic variants in the plasminogen activation pathway are not associated with multiple sclerosis
    Mathew B Cox
    Hunter Medical Research Institute, and University of Newcastle, Australia
    Mult Scler 20:489-91. 2014
    ..This suggested there are other potentially modifiable factors influencing gene expression in MS. ..
  17. doi request reprint Altered expression of the plasminogen activation pathway in peripheral blood mononuclear cells in multiple sclerosis: possible pathomechanism of matrix metalloproteinase activation
    Mathew B Cox
    Hunter Medical Research Institute, Australia
    Mult Scler 19:1268-74. 2013
    ..Multiple sclerosis (MS) is an autoimmune disorder where a breakdown in the integrity of the blood-brain barrier is thought to allow lymphocytes to enter the central nervous system...
  18. pmc STaRRRT: a table of short tandem repeats in regulatory regions of the human genome
    Katherine A Bolton
    Centre for Information Based Medicine, Hunter Medical Research Institute, Newcastle, NSW, Australia
    BMC Genomics 14:795. 2013
    ..To study STRs located in regulatory regions, we have performed genome-wide analysis to identify all STRs present in a region that is 2 kilobases upstream and 1 kilobase downstream of the transcription start sites of genes...
  19. pmc Confirmation of childhood acute lymphoblastic leukemia variants, ARID5B and IKZF1, and interaction with parental environmental exposures
    Tiffany Jane Evans
    Centre for Bioinformatics, Biomarker Discovery and Information Based Medicine, Hunter Medical Research Institute, Newcastle, New South Wales, Australia School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia
    PLoS ONE 9:e110255. 2014
    ..If interaction of folic acid supplementation and IKZF1 variants holds, it may be useful to quantify folate levels prior to initiating use of folic acid supplements...
  20. doi request reprint Potential association of vitamin D receptor polymorphism Taq1 with multiple sclerosis
    Mathew B Cox
    University of Newcastle and Hunter Medical Research Institute, Newcastle, Australia
    Mult Scler 18:16-22. 2012
    ..Current evidence based on genetic and epidemiological studies indicate that vitamin D is implicated in the aetiology of this disease...
  21. doi request reprint BRIP1, PALB2, and RAD51C mutation analysis reveals their relative importance as genetic susceptibility factors for breast cancer
    Michelle W Wong
    Discipline of Medical Genetics and Centre for Information Based Medicine, The University of Newcastle, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW 2305, Australia
    Breast Cancer Res Treat 127:853-9. 2011
    ....
  22. pmc Nucleotide excision repair deficiency in melanoma in response to UVA
    Heather C Murray
    School of Biomedical Sciences and Pharmacy, University of Newcastle, Hunter Medical Research Institute, University Dr, Callaghan, NSW 2308 Australia
    Exp Hematol Oncol 5:6. 2015
    ..In this study we aimed to determine if melanoma cells exhibit reduced levels of NER activity in response to UVA...
  23. doi request reprint IL-27/IFN-γ induce MyD88-dependent steroid-resistant airway hyperresponsiveness by inhibiting glucocorticoid signaling in macrophages
    Jing Jing Li
    Centre for Asthma and Respiratory Disease, University of Newcastle and Hunter Medical Research Institute, Callaghan, New South Wales, Australia
    J Immunol 185:4401-9. 2010
    ....
  24. doi request reprint Metastatic melanoma treatment: Combining old and new therapies
    Ryan J Davey
    Hunter Medical Research Institute and School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, NSW, Australia
    Crit Rev Oncol Hematol 98:242-53. 2016
    ..Combining older therapies with the new molecular and immunotherapies will be the most promising way forward for treatment of metastatic melanoma. ..
  25. pmc Whole genome amplification and its impact on CGH array profiles
    Bente A Talseth-Palmer
    School of Biomedical Sciences, Faculty of Health, University of Newcastle and the Hunter Medical Research Institute, NSW, Australia
    BMC Res Notes 1:56. 2008
    ..Four experiments were conducted on amplified DNA compared to unamplified DNA and two experiments on unamplified DNA compared to unamplified DNA...
  26. pmc Gene expression profiling in familial adenomatous polyposis adenomas and desmoid disease
    Nikola A Bowden
    School of Biomedical Sciences, University of Newcastle, Callaghan, NSW, Australia
    Hered Cancer Clin Pract 5:79-96. 2007
    ..This study furthers our understanding of the mechanisms underlying FAP and desmoid tumour formation...