U A Bommer
Affiliation: University of Wollongong
- Growth-factor dependent expression of the translationally controlled tumour protein TCTP is regulated through the PI3-K/Akt/mTORC1 signalling pathwayUlrich Axel Bommer
Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong 2522 NSW, Australia Graduate School of Medicine, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong 2522 NSW, Australia Electronic address
Cell Signal 27:1557-68. 2015..This explains why TCTP levels are frequently increased in cancers, since mTORC1 signalling is hyperactive in ~80% of tumours. ..
- Roles of the translationally controlled tumour protein (TCTP) and the double-stranded RNA-dependent protein kinase, PKR, in cellular stress responsesU A Bommer
Division of Basic Medical Sciences, St George s, University of London, London, UK
Oncogene 29:763-73. 2010..Our results imply that cellular TCTP levels influence sensitivity to apoptosis and that PKR may exert its proapoptotic effects at least in part through downregulation of TCTP via eIF2alpha phosphorylation...
- The growth-related, translationally controlled protein P23 has properties of a tubulin binding protein and associates transiently with microtubules during the cell cycleY Gachet
Divisions of Biochemistry and Immunology, St George s Hospital Medical School, London, UK
J Cell Sci 112:1257-71. 1999..4) Overexpression of P23 results in cell growth retardation and in alterations of cell morphology. Moreover, elevation of P23 levels leads to microtubule rearrangements and to an increase in microtubule mass and stability...
- Translational control: the cancer connectionM J Clemens
Department of Biochemistry, St George s Hospital Medical School, London, UK
Int J Biochem Cell Biol 31:1-23. 1999..The purpose of this article is to give an overview of the field and to indicate where we may expect developments to occur in the next few years...