Affiliation: University of Melbourne
- Relevant assay to study the adhesion of Plasmodium falciparum-infected erythrocytes to the placental epitheliumPhilippe Boeuf
Department of Medicine RMH WH, The University of Melbourne, Royal Melbourne Hospital, Melbourne, Australia
PLoS ONE 6:e21126. 2011..This demonstrates the power of this assay to advance our understanding of epithelial adhesion of infected erythrocytes and in the design of intervention strategies...
- Insights into deregulated TNF and IL-10 production in malaria: implications for understanding severe malarial anaemiaPhilippe S Boeuf
Institut Pasteur, Unité d Immunologie Moléculaire des Parasites URA CNRS 2581, Paris, France
Malar J 11:253. 2012..Monocytes and T cells are recognized as the main sources of TNF and IL-10 in vivo, but little is known about the activation status of those cells in SMA patients...
- Plasmodium falciparum malaria elicits inflammatory responses that dysregulate placental amino acid transportPhilippe Boeuf
The University of Melbourne, Department of Medicine RMH, Parkville, Victoria, Australia
PLoS Pathog 9:e1003153. 2013..However, IV more profoundly compromises placental amino acid transport function, leading to FGR. Our study offers the first pathogenetic explanation for FGR in PM...
- Placental hypoxia during placental malariaPhilippe Boeuf
Department of Medicine, University of Melbourne, Parkville, Victoria, Australia
J Infect Dis 197:757-65. 2008..We investigated whether parasite or monocyte infiltrates were associated with placental hypoxia, as a potential mechanism underlying malarial FGR...
- V beta profiles in African children with acute cerebral or uncomplicated malaria: very focused changes among a remarkable global stabilitySéverine Loizon
Unité d Immunologie Moléculaire des Parasites, CNRS URA 2581, Departement de Parasitologie, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
Microbes Infect 9:1252-9. 2007..The significance of the reproducible increase of the CD4+V beta 21.3T cell subset deserves further investigations...
- High numbers of circulating pigmented polymorphonuclear neutrophils as a prognostic marker for decreased birth weight during malaria in pregnancyCaroline Lin Lin Chua
Department of Medicine, The Doherty Institute, The University of Melbourne, Australia
Int J Parasitol 45:107-11. 2015..04), suggesting these cells may have a pathogenic role in, and could serve as prognostic markers for, malaria-associated low birth weight. ..
- Insight into the pathogenesis of fetal growth restriction in placental malaria: decreased placental glucose transporter isoform 1 expressionUpeksha P Chandrasiri
Department of Medicine, University of Melbourne
J Infect Dis 209:1663-7. 2014..43; P = .003) and positively with birth weight (r = 0.28; P = .06). These findings suggest that intervillositis, more than placental malaria per se, might cause fetal growth restriction, through impaired transplacental glucose transport. ..
- Monocytes and macrophages in malaria: protection or pathology?Caroline Lin Lin Chua
The University of Melbourne, Department of Medicine Royal Melbourne Hospital, Parkville, Australia
Trends Parasitol 29:26-34. 2013..Knowledge of the factors influencing the balance between protection and pathology can assist in the design of therapeutics aimed at modulating monocyte and macrophage functions to improve outcomes...
- Soluble CD163, a product of monocyte/macrophage activation, is inversely associated with haemoglobin levels in placental malariaCaroline Lin Lin Chua
Department of Medicine Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia
PLoS ONE 8:e64127. 2013..259, p = 0.0001). These inverse relationships suggest a potential role for monocyte/macrophage activation in the pathogenesis of malaria in pregnancy, particularly in relation to malaria-associated anaemia...
- Inhibition of placental mTOR signaling provides a link between placental malaria and reduced birthweightKris Genelyn Dimasuay
Department of Medicine at Royal Melbourne Hospital, The University of Melbourne, Parkville, 3004, Vic, Australia
BMC Med 15:1. 2017..Here, we tested the hypothesis that mechanistic target of rapamycin (mTOR) signaling, a pathway known to regulate amino acid transport, is inhibited in placental malaria-associated intervillositis, contributing to lower birthweight...
- Placental malaria-associated inflammation disturbs the insulin-like growth factor axis of fetal growth regulationAlexandra J Umbers
Department of Medicine, University of Melbourne, Royal Melbourne Hospital, Royal Parade, Parkville Victoria 3050, Australia
J Infect Dis 203:561-9. 2011..We sought to determine whether placental malaria and related inflammation were associated with disturbances in the insulin-like growth factor (IGF) axis, a major regulator of fetal growth...
- Azithromycin-containing intermittent preventive treatment in pregnancy affects gestational weight gain, an important predictor of birthweight in Papua New Guinea - an exploratory analysisHolger W Unger
Department of Medicine, The University of Melbourne, Melbourne, Victoria, Australia
Matern Child Nutr 12:699-712. 2016..Future trials of SPAZ-IPTp must incorporate detailed anthropometric evaluations to investigate mechanisms of effects on maternal and child health. ..
- A Robust Phagocytosis Assay to Evaluate the Opsonic Activity of Antibodies against Plasmodium falciparum-Infected ErythrocytesAndrew Teo
Department of Medicine, The University of Melbourne, The Doherty Institute Level 5, Parkville, Vic, 3010, Australia
Methods Mol Biol 1325:145-52. 2015....
- Immunity to malaria in an era of declining malaria transmissionFreya J I Fowkes
Burnet Institute, Melbourne, Australia
Parasitology 143:139-53. 2016..Lastly we identify research priorities which will increase our understanding of how changing transmission will impact on malarial immunity. ..
- Maximizing antimalarial efficacy and the importance of dosing strategiesJames G Beeson
Burnet Institute, 85 Commercial Road, Melbourne, Victoria, 3004, Australia
BMC Med 13:110. 2015..This highlights the benefits of fixed-dose combinations as a practical strategy for ensuring optimal antimalarial dosing and maximizing efficacy. Please see related article: http://www.biomedcentral.com/1741-7015/13/66...
- CyProQuant-PCR: a real time RT-PCR technique for profiling human cytokines, based on external RNA standards, readily automatable for clinical usePhilippe Boeuf
Unité d Immunologie Moléculaire des Parasites, URA CNRS 2581, Département de Parasitologie et de Médecine Moléculaire, Institut Pasteur, 28 rue du Dr, Roux, 75724 Paris Cedex 15, France
BMC Immunol 6:5. 2005..The techniques currently used for "absolute quantification" of cytokine mRNA are based on a DNA standard curve and do not take into account the critical impact of RT efficiency...