Genomes and Genes
Michele D Binder
Affiliation: University of Melbourne
- TAM receptor signalling and demyelinationMichele D Binder
Florey Neuroscience Institutes and Centre for Neuroscience, The University of Melbourne, Parkville, Vic, Australia
Neurosignals 17:277-87. 2009..A current challenge in this field is to expand our understanding of TAM receptor signalling from rodent models of central demyelination to human disease...
- Gas6 increases myelination by oligodendrocytes and its deficiency delays recovery following cuprizone-induced demyelinationMichele D Binder
Multiple Sclerosis Division, Florey Neuroscience Institutes, University of Melbourne, Parkville, Victoria, Australia
PLoS ONE 6:e17727. 2011..These findings establish Gas6 as an important regulator of both CNS demyelination and remyelination...
- Gas6 deficiency increases oligodendrocyte loss and microglial activation in response to cuprizone-induced demyelinationMichele D Binder
Howard Florey Institute, University of Melbourne, Parkville, Victoria 3010, Australia
J Neurosci 28:5195-206. 2008..Therefore, TAM receptor activation and regulation can independently influence both oligodendrocyte survival and the microglial response after CNS damage...
- Long-term effects of combined neonatal and adolescent stress on brain-derived neurotrophic factor and dopamine receptor expression in the rat forebrainRachel A Hill
Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia
Biochim Biophys Acta 1842:2126-35. 2014..These results elucidate the long-term effects of 'two hit' developmental stress on behaviour. ..
- Galanin is an autocrine myelin and oligodendrocyte trophic signal induced by leukemia inhibitory factorMelissa M Gresle
Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Australia Department of Medicine, University of Melbourne, Australia
Glia 63:1005-20. 2015..These findings suggest a potential role for the use of galanin agonists in the treatment of human demyelinating diseases...
- Leukemia inhibitory factor signaling modulates both central nervous system demyelination and myelin repairMark P Marriott
Howard Florey Institute, The University of Melbourne, Victoria, Australia
Glia 56:686-98. 2008..Thus endogenous LIF receptor signaling is not only protective of oligodendrocytes but can also enhance remyelination, and exogenous LIF has therapeutic potential in limiting the consequences of oligodendrocyte damage...
- Oligodendrocyte positioning in cerebral cortex is independent of projection neuron layeringSeong Seng Tan
Florey Neurosciences Institute and Centre for Neuroscience, The University of Melbourne, Parkville, Victoria, Australia
Glia 57:1024-30. 2009..We conclude that oligodendrocyte positioning is not linked to the layer positions of V/VI projection neurons...
- Role of cytokines as mediators and regulators of microglial activity in inflammatory demyelination of the CNSTobias D Merson
Florey Neuroscience Institutes, Centre for Neuroscience, University of Melbourne, Parkville, Vic, 3010, Australia
Neuromolecular Med 12:99-132. 2010....
- Common and Low Frequency Variants in MERTK Are Independently Associated with Multiple Sclerosis Susceptibility with Discordant Association Dependent upon HLA-DRB1*15:01 StatusMichele D Binder
Multiple Sclerosis Division, The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia
PLoS Genet 12:e1005853. 2016....
- Sex-specific disruptions in spatial memory and anhedonia in a "two hit" rat model correspond with alterations in hippocampal brain-derived neurotrophic factor expression and signalingRachel A Hill
Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia
Hippocampus 24:1197-211. 2014..Alterations to BDNF signaling may mediate the sex-specific effects of developmental stress on anhedonic behaviors...
- Polymorphisms in the receptor tyrosine kinase MERTK gene are associated with multiple sclerosis susceptibilityGerry Z M Ma
Multiple Sclerosis Division, Florey Neuroscience Institutes, University of Melbourne, Melbourne, Victoria, Australia
PLoS ONE 6:e16964. 2011..All 12 replicated SNPs were in strong linkage disequilibrium with each other. In combination, these data suggest the MERTK gene is a novel risk gene for MS susceptibility...
- Brain-derived neurotrophic factor expression is increased in the hippocampus of 5-HT(2C) receptor knockout miceRachel A Hill
Behavioral Neuroscience Laboratory, Mental Health Research Institute, Parkville, Victoria, Australia 3052
Hippocampus 21:434-45. 2011..05). In conclusion, loss of 5-HT(2C) receptor expression leads to a marked and selective increase in levels of the mature form of BDNF in the hippocampus. Despite this marked increase, 5-HT(2C) KO show only subtle behavioral changes...