Katherine J Baines

Summary

Affiliation: University of Newcastle
Country: Australia

Publications

  1. doi request reprint Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples
    Katherine J Baines
    Centre for Asthma and Respiratory Diseases, Hunter Medical Research Institute, University of Newcastle, Callaghan, Australia
    J Allergy Clin Immunol 127:153-60, 160.e1-9. 2011
  2. doi request reprint Systemic upregulation of neutrophil α-defensins and serine proteases in neutrophilic asthma
    Katherine J Baines
    Priority Research Centre forAsthma and Respiratory Diseases, The University of Newcastle, Callaghan, Australia
    Thorax 66:942-7. 2011
  3. doi request reprint Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes
    Katherine J Baines
    Priority Research Centre for Asthma and Respiratory Diseases, Hunter Medical Research Institute, University of Newcastle, New Lambton Heights, Australia Department of Respiratory and Sleep Medicine, John Hunter Hospital, New Lambton Heights, Australia Electronic address
    J Allergy Clin Immunol 133:997-1007. 2014
  4. pmc Novel immune genes associated with excessive inflammatory and antiviral responses to rhinovirus in COPD
    Katherine J Baines
    Priority Research Centre for Asthma and Respiratory Diseases, The University of Newcastle, Callaghan, NSW, Australia
    Respir Res 14:15. 2013
  5. pmc Innate immune responses are increased in chronic obstructive pulmonary disease
    Katherine Joanne Baines
    Priority Research Centre for Asthma and Respiratory Diseases, The University of Newcastle, Callaghan, New South Wales, Australia
    PLoS ONE 6:e18426. 2011
  6. ncbi request reprint Immune responses of airway neutrophils are impaired in asthma
    Katherine J Baines
    Priority Research Centre for Asthma and Respiratory Diseases, The University of Newcastle, Callaghan, New South Wales, Australia
    Exp Lung Res 35:554-69. 2009
  7. doi request reprint Differential gene expression and cytokine production from neutrophils in asthma phenotypes
    K J Baines
    Level 3, Hunter Medical Research Institute, John Hunter Hospital, Locked Bag 1, Hunter Region Mail Centre, Newcastle, NSW 2310, Australia
    Eur Respir J 35:522-31. 2010
  8. doi request reprint The nutrigenomics of asthma: molecular mechanisms of airway neutrophilia following dietary antioxidant withdrawal
    Katherine J Baines
    Priority Research Centre for Asthma and Respiratory Diseases, University of Newcastle, Callaghan NSW Australia
    OMICS 13:355-65. 2009
  9. doi request reprint Sputum mast cell subtypes relate to eosinophilia and corticosteroid response in asthma
    Gang Wang
    Pneumology Group, Dept of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, P R China Center for Asthma and Respiratory Diseases, Dept of Respiratory and Sleep Medicine, John Hunter Hospital, Hunter Medical Research Institute, University of Newcastle, New Lambton, NSW, Australia
    Eur Respir J 47:1123-33. 2016
  10. doi request reprint The neutrophilic inflammatory phenotype is associated with systemic inflammation in asthma
    Lisa G Wood
    Centre for Asthma and Respiratory Diseases, University of Newcastle, Australia
    Chest 142:86-93. 2012

Detail Information

Publications23

  1. doi request reprint Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples
    Katherine J Baines
    Centre for Asthma and Respiratory Diseases, Hunter Medical Research Institute, University of Newcastle, Callaghan, Australia
    J Allergy Clin Immunol 127:153-60, 160.e1-9. 2011
    ..Previous studies have identified clinical or inflammatory phenotypes of asthma on the basis of clinical and demographic parameters or sputum cell counts; however, few studies have defined transcriptional phenotypes of asthma...
  2. doi request reprint Systemic upregulation of neutrophil α-defensins and serine proteases in neutrophilic asthma
    Katherine J Baines
    Priority Research Centre forAsthma and Respiratory Diseases, The University of Newcastle, Callaghan, Australia
    Thorax 66:942-7. 2011
    ..Systemic inflammation is now recognised as an important part of some airway diseases, but the involvement of systemic inflammation in the pathogenesis of airway inflammatory phenotypes of asthma remains unknown...
  3. doi request reprint Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes
    Katherine J Baines
    Priority Research Centre for Asthma and Respiratory Diseases, Hunter Medical Research Institute, University of Newcastle, New Lambton Heights, Australia Department of Respiratory and Sleep Medicine, John Hunter Hospital, New Lambton Heights, Australia Electronic address
    J Allergy Clin Immunol 133:997-1007. 2014
    ..Airway inflammation is associated with asthma exacerbation risk, treatment response, and disease mechanisms...
  4. pmc Novel immune genes associated with excessive inflammatory and antiviral responses to rhinovirus in COPD
    Katherine J Baines
    Priority Research Centre for Asthma and Respiratory Diseases, The University of Newcastle, Callaghan, NSW, Australia
    Respir Res 14:15. 2013
    ..The objective of this study is to investigate innate immune responses to RV infection in COPD primary BECs (pBECs) in comparison to healthy controls...
  5. pmc Innate immune responses are increased in chronic obstructive pulmonary disease
    Katherine Joanne Baines
    Priority Research Centre for Asthma and Respiratory Diseases, The University of Newcastle, Callaghan, New South Wales, Australia
    PLoS ONE 6:e18426. 2011
    ....
  6. ncbi request reprint Immune responses of airway neutrophils are impaired in asthma
    Katherine J Baines
    Priority Research Centre for Asthma and Respiratory Diseases, The University of Newcastle, Callaghan, New South Wales, Australia
    Exp Lung Res 35:554-69. 2009
    ..Innate immune responses of airway neutrophil cells are impaired in asthmatic subjects on prophylactic therapy and may impact on susceptibility to, and severity of, airway infections...
  7. doi request reprint Differential gene expression and cytokine production from neutrophils in asthma phenotypes
    K J Baines
    Level 3, Hunter Medical Research Institute, John Hunter Hospital, Locked Bag 1, Hunter Region Mail Centre, Newcastle, NSW 2310, Australia
    Eur Respir J 35:522-31. 2010
    ..The mechanisms of non-eosinophilic asthma may involve enhancement of blood neutrophil chemotaxis and survival...
  8. doi request reprint The nutrigenomics of asthma: molecular mechanisms of airway neutrophilia following dietary antioxidant withdrawal
    Katherine J Baines
    Priority Research Centre for Asthma and Respiratory Diseases, University of Newcastle, Callaghan NSW Australia
    OMICS 13:355-65. 2009
    ..A diet low in antioxidants may be contributing to the development of neutrophilic asthma through activation of the innate immune response...
  9. doi request reprint Sputum mast cell subtypes relate to eosinophilia and corticosteroid response in asthma
    Gang Wang
    Pneumology Group, Dept of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, P R China Center for Asthma and Respiratory Diseases, Dept of Respiratory and Sleep Medicine, John Hunter Hospital, Hunter Medical Research Institute, University of Newcastle, New Lambton, NSW, Australia
    Eur Respir J 47:1123-33. 2016
    ..The MCT/CPA3subtype demonstrated increased bronchial sensitivity and reactivity, and signature gene expression, which was associated with airway eosinophilia and greater corticosteroid responsiveness. ..
  10. doi request reprint The neutrophilic inflammatory phenotype is associated with systemic inflammation in asthma
    Lisa G Wood
    Centre for Asthma and Respiratory Diseases, University of Newcastle, Australia
    Chest 142:86-93. 2012
    ..The role of systemic inflammation in asthma is unclear. The aim of this study was to compare systemic inflammation in subjects with stable asthma, categorized by airway inflammatory phenotype, with healthy control subjects...
  11. doi request reprint Systemic inflammation is associated with differential gene expression and airway neutrophilia in asthma
    Juan Juan Fu
    Priority Research Centre for Asthma and Respiratory Diseases, University of Newcastle, Newcastle, Australia
    OMICS 17:187-99. 2013
    ..Our findings suggest that targeting systemic inflammation might provide a novel therapeutic strategy for neutrophilic asthma...
  12. doi request reprint Oncostatin M (OSM) is increased in asthma with incompletely reversible airflow obstruction
    Jodie L Simpson
    Centre for Asthma and Respiratory Disease, School of Medicine and Public Health, The University of Newcastle, Callaghan NSW, Australia
    Exp Lung Res 35:781-94. 2009
    ..Sputum oncostatin M is increased in asthma with irreversible airflow obstruction and is present in airway neutrophils and macrophages. Oncostatin M may link airway inflammation to remodeling in asthma...
  13. doi request reprint Neutrophil extracellular traps are associated with inflammation in chronic airway disease
    Thomas K Wright
    Priority Research Centre for Asthma and Respiratory Diseases, Hunter Medical Research Institute, The University of Newcastle, New Lambton Heights, New South Wales, Australia
    Respirology 21:467-75. 2016
    ..This study aimed to investigate the presence of NETs in sputum from patients with asthma and COPD, and the relationship of NETs with inflammatory phenotype and disease severity...
  14. doi request reprint Differential DNA methylation profiles of infants exposed to maternal asthma during pregnancy
    Lakshitha P Gunawardhana
    Priority Research Centre for Asthma and Respiratory Disease, Hunter Medical Research Institute, The University of Newcastle, Sydney, NSW, Australia
    Pediatr Pulmonol 49:852-62. 2014
    ..We investigated alterations in the DNA methylation profile of peripheral blood from infants exposed to maternal asthma during pregnancy...
  15. doi request reprint Neutrophilic asthma is characterised by increased rhinosinusitis with sleep disturbance and GERD
    Jodie L Simpson
    Centre for Asthma and Respiratory Disease, The University of Newcastle, NSW
    Asian Pac J Allergy Immunol 32:66-74. 2014
    ..While clinically similar to eosinophilic asthma, patients with non-eosinophilic asthma have different responses to treatment and little is known about the triggers of symptoms and inflammation...
  16. pmc Influence of age, past smoking, and disease severity on TLR2, neutrophilic inflammation, and MMP-9 levels in COPD
    Jodie L Simpson
    NHMRC Centre for Respiratory and Sleep Medicine, Faculty of Health, School of Medicine and Public Health, The University of Newcastle, Callaghan, NSW 2308, Australia
    Mediators Inflamm 2013:462934. 2013
    ..TLR2 stimulation activates neutrophils for MMP-9 release. Efforts to understand the mechanisms of TLR2 signalling and subsequent MMP-9 production in COPD may assist in understanding neutrophilic inflammation in COPD...
  17. pmc Airway β-Defensin-1 Protein Is Elevated in COPD and Severe Asthma
    Katherine J Baines
    Priority Research Centre for Asthma and Respiratory Diseases, Hunter Medical Research Institute, The University of Newcastle, New Lambton Heights, NSW 2305, Australia Department of Respiratory and Sleep Medicine, John Hunter Hospital, New Lambton Heights, NSW 2305, Australia
    Mediators Inflamm 2015:407271. 2015
    ..Innate immune antimicrobial peptides, including β-defensin-1, promote the chemotaxis and activation of several immune cells. The role of β-defensin-1 in asthma and chronic obstructive pulmonary disease (COPD) remains unclear...
  18. pmc The effect of azithromycin in adults with stable neutrophilic COPD: a double blind randomised, placebo controlled trial
    Jodie L Simpson
    Centre for Asthma and Respiratory Diseases and Hunter Medical Research Institute, Faculty of Health and Medicine, The University of Newcastle, Callaghan, New South Wales, Australia
    PLoS ONE 9:e105609. 2014
    ..We conducted a randomised, double-blind, placebo-controlled study in COPD participants with stable neutrophilic bronchitis...
  19. doi request reprint IL-27/IFN-γ induce MyD88-dependent steroid-resistant airway hyperresponsiveness by inhibiting glucocorticoid signaling in macrophages
    Jing Jing Li
    Centre for Asthma and Respiratory Disease, University of Newcastle and Hunter Medical Research Institute, Callaghan, New South Wales, Australia
    J Immunol 185:4401-9. 2010
    ....
  20. doi request reprint Elevated expression of the NLRP3 inflammasome in neutrophilic asthma
    Jodie L Simpson
    Centre for Asthma and Respiratory Diseases and Hunter Medical Research Institute, Faculty of Health, School of Medicine and Public Health, The University of Newcastle, Callaghan
    Eur Respir J 43:1067-76. 2014
    ..NLRP3 inflammasome is upregulated in neutrophilic asthma and may regulate the inflammation process observed in this asthma phenotype through production of IL-1β...
  21. pmc Understanding Xeroderma Pigmentosum Complementation Groups Using Gene Expression Profiling after UV-Light Exposure
    Nikola A Bowden
    Hunter Medical Research Institute and the University of Newcastle, Callaghan, NSW 2289, Australia
    Int J Mol Sci 16:15985-96. 2015
    ..This study will assist in furthering our understanding of the different subtypes of XP which will lead to better diagnosis, treatment and management of the disease. ..
  22. doi request reprint Respiratory viral infections in pregnant women with asthma are associated with wheezing in the first 12 months of life
    Vanessa E Murphy
    Centre for Asthma and Respiratory Diseases, University of Newcastle and Hunter Medical Research Institute, Newcastle, NSW, Australia
    Pediatr Allergy Immunol 25:151-8. 2014
    ..Infants of mothers with asthma are more likely to wheeze and have a higher risk of developing asthma than infants of non-asthmatic mothers...
  23. doi request reprint Airway dysbiosis: Haemophilus influenzae and Tropheryma in poorly controlled asthma
    Jodie L Simpson
    Respiratory and Sleep Medicine, School of Medicine and Public Health, Centre for Asthma and Respiratory Disease, The University of Newcastle, Callaghan, Australia
    Eur Respir J 47:792-800. 2016
    ..Reduced bacterial diversity combined with a high prevalence of H. influenzae was observed in neutrophilic asthma, whereas eosinophilic asthma had abundant T. whipplei. ..