N Ahmed

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. ncbi request reprint Ceramides that mediate apoptosis reduce glucose uptake and transporter affinity for glucose in human leukaemic cell lines but not in neutrophils
    N Ahmed
    Malaghan Institute of Medical Research, Wellington School of Medicine, Wellington South, New Zealand
    Pharmacol Toxicol 86:114-21. 2000
  2. ncbi request reprint N-glycosylation of glucose transporter-1 (Glut-1) is associated with increased transporter affinity for glucose in human leukemic cells
    N Ahmed
    Malaghan Institute of Medical Research, Wellington School of Medicine, Wellington South, New Zealand
    Leuk Res 23:395-401. 1999
  3. ncbi request reprint Transforming oncogenes regulate glucose transport by increasing transporter affinity for glucose: contrasting effects of oncogenes and heat stress in a murine marrow-derived cell line
    N Ahmed
    Malaghan Institute of Medical Research, Wellington School of Medicine, Wellington South, New Zealand
    Life Sci 63:1887-903. 1998
  4. ncbi request reprint Distinct regulation of glucose transport by interleukin-3 and oncogenes in a murine bone marrow-derived cell line
    N Ahmed
    Malaghan Institute of Medical Research, Wellington School of Medicine, Wellington South, New Zealand
    Biochem Pharmacol 57:387-96. 1999
  5. pmc An immunohistochemical perspective of PPAR beta and one of its putative targets PDK1 in normal ovaries, benign and malignant ovarian tumours
    N Ahmed
    Women s Cancer Research Centre, Royal Women s Hospital, Melbourne, Victoria, Australia
    Br J Cancer 98:1415-24. 2008
  6. pmc Enhanced expression of peroxisome proliferator-activated receptor gamma in epithelial ovarian carcinoma
    G Y Zhang
    Department of Obstetrics and Gynaecology, Qilu Hospital of Shandong University, 107 Wenhuaxi Road, Jinan 250012, PR China
    Br J Cancer 92:113-9. 2005
  7. pmc Proteomic-based identification of haptoglobin-1 precursor as a novel circulating biomarker of ovarian cancer
    N Ahmed
    Gynaecological Cancer Research Centre, Royal Women s Hospital, 132 Grattan Street, Carlton, Victoria 3053, Australia
    Br J Cancer 91:129-40. 2004
  8. pmc Downregulation of urokinase plasminogen activator receptor expression inhibits Erk signalling with concomitant suppression of invasiveness due to loss of uPAR-beta1 integrin complex in colon cancer cells
    N Ahmed
    Department of Obstetrics and Gynaecology, Gynaecological Cancer Research Centre, Royal Women s Hospital, University of Melbourne, Melbourne 3053, Australia
    Br J Cancer 89:374-84. 2003
  9. ncbi request reprint Overexpression of alpha(v)beta6 integrin in serous epithelial ovarian cancer regulates extracellular matrix degradation via the plasminogen activation cascade
    N Ahmed
    Gynaecological Cancer Research Centre, Royal Women s Hospital, Melbourne, Australia
    Carcinogenesis 23:237-44. 2002
  10. pmc Ascites induces modulation of alpha6beta1 integrin and urokinase plasminogen activator receptor expression and associated functions in ovarian carcinoma
    N Ahmed
    Gynaecological Cancer Research Centre, Royal Women s Hospital, Melbourne, Australia
    Br J Cancer 92:1475-85. 2005

Collaborators

  • M V Berridge
  • H Zhang
  • Takashi Ueda
  • B E Kemp
  • Y Wang
  • Hidenori Ito
  • M Quinn
  • G E Rice
  • Y Shigeta
  • G Y Zhang
  • S K Tiwari
  • P Murphy
  • E Durante-Mangoni
  • A V Pereboev
  • J Niu
  • H M Georgiou
  • G Kruppa
  • Y Kanai
  • D K Kim
  • A Chairoungdua
  • H Matsuo
  • K Akakura
  • K Mizoguchi
  • T Ichikawa
  • H Endou
  • M Fujimura
  • N Anzai
  • G Shi
  • S Sakamoto
  • F Kauser
  • S M Ali
  • Z Abid
  • M A Hussain
  • C Riley
  • A Alvi
  • I Ahmed
  • K S Ahmed
  • A Habeeb
  • C M Habibullah
  • A A Khan
  • G Barker
  • K Oliva
  • G Ruggiero
  • K Michaelides
  • H T Hassan
  • G J Davies
  • R Bates
  • X Gu
  • M Agrez
  • J Turton
  • S Andrews
  • N thi Man
  • G E Morris
  • V Manne
  • H F Kung
  • C Meyers
  • A Tobin
  • M de Virgilio
  • D Roberts
  • B Kurz
  • E O'Rourke
  • M Resh

Detail Information

Publications23

  1. ncbi request reprint Ceramides that mediate apoptosis reduce glucose uptake and transporter affinity for glucose in human leukaemic cell lines but not in neutrophils
    N Ahmed
    Malaghan Institute of Medical Research, Wellington School of Medicine, Wellington South, New Zealand
    Pharmacol Toxicol 86:114-21. 2000
    ..This is the first study which describes ceramide-induced early physiological/biochemical events leading to cell death in human cells...
  2. ncbi request reprint N-glycosylation of glucose transporter-1 (Glut-1) is associated with increased transporter affinity for glucose in human leukemic cells
    N Ahmed
    Malaghan Institute of Medical Research, Wellington School of Medicine, Wellington South, New Zealand
    Leuk Res 23:395-401. 1999
    ..These results suggest that in leukemic cells N-glycosylation of Glut-1 plays an important role in maintaining its structure and functional integration...
  3. ncbi request reprint Transforming oncogenes regulate glucose transport by increasing transporter affinity for glucose: contrasting effects of oncogenes and heat stress in a murine marrow-derived cell line
    N Ahmed
    Malaghan Institute of Medical Research, Wellington School of Medicine, Wellington South, New Zealand
    Life Sci 63:1887-903. 1998
    ..These results provide evidence for intrinsic activation of glucose transporters by the transforming oncogenes ras and abl, and indicate that oncogenes and 'heat stress' regulate glucose transport by different mechanisms...
  4. ncbi request reprint Distinct regulation of glucose transport by interleukin-3 and oncogenes in a murine bone marrow-derived cell line
    N Ahmed
    Malaghan Institute of Medical Research, Wellington School of Medicine, Wellington South, New Zealand
    Biochem Pharmacol 57:387-96. 1999
    ....
  5. pmc An immunohistochemical perspective of PPAR beta and one of its putative targets PDK1 in normal ovaries, benign and malignant ovarian tumours
    N Ahmed
    Women s Cancer Research Centre, Royal Women s Hospital, Melbourne, Victoria, Australia
    Br J Cancer 98:1415-24. 2008
    ..However, overexpression of PDK1 was evident in borderline and low- to high-grade ovarian tumours and is consistent with its known role in tumorigenesis...
  6. pmc Enhanced expression of peroxisome proliferator-activated receptor gamma in epithelial ovarian carcinoma
    G Y Zhang
    Department of Obstetrics and Gynaecology, Qilu Hospital of Shandong University, 107 Wenhuaxi Road, Jinan 250012, PR China
    Br J Cancer 92:113-9. 2005
    ..01). These findings suggest an involvement of PPARgamma in the onset and development of ovarian carcinoma and provide an insight into the regulation of this molecule in the progression of the disease...
  7. pmc Proteomic-based identification of haptoglobin-1 precursor as a novel circulating biomarker of ovarian cancer
    N Ahmed
    Gynaecological Cancer Research Centre, Royal Women s Hospital, 132 Grattan Street, Carlton, Victoria 3053, Australia
    Br J Cancer 91:129-40. 2004
    ..These data highlight the need to assess circulating concentration of HAP1 in the serum of ovarian cancer patients and evaluate its potential as a biomarker in the early diagnosis of ovarian cancer...
  8. pmc Downregulation of urokinase plasminogen activator receptor expression inhibits Erk signalling with concomitant suppression of invasiveness due to loss of uPAR-beta1 integrin complex in colon cancer cells
    N Ahmed
    Department of Obstetrics and Gynaecology, Gynaecological Cancer Research Centre, Royal Women s Hospital, University of Melbourne, Melbourne 3053, Australia
    Br J Cancer 89:374-84. 2003
    ..This novel paradigm of uPAR-integrin signalling may afford opportunities for alternative therapeutic strategies for the treatment of cancer...
  9. ncbi request reprint Overexpression of alpha(v)beta6 integrin in serous epithelial ovarian cancer regulates extracellular matrix degradation via the plasminogen activation cascade
    N Ahmed
    Gynaecological Cancer Research Centre, Royal Women s Hospital, Melbourne, Australia
    Carcinogenesis 23:237-44. 2002
    ....
  10. pmc Ascites induces modulation of alpha6beta1 integrin and urokinase plasminogen activator receptor expression and associated functions in ovarian carcinoma
    N Ahmed
    Gynaecological Cancer Research Centre, Royal Women s Hospital, Melbourne, Australia
    Br J Cancer 92:1475-85. 2005
    ..Based on these findings, we conclude that ascites can induce selective upregulation of integrin and uPA/uPAR in ovarian cancer cells and these changes may modulate the functions of ovarian carcinomas...
  11. ncbi request reprint Epitopes in the interacting regions of beta-dystroglycan (PPxY motif) and dystrophin (WW domain)
    A V Pereboev
    MRIC Biochemistry Group, North East Wales Institute, Mold Road, LL11 2AW, Wrexham, UK
    Biochim Biophys Acta 1527:54-60. 2001
    ....
  12. ncbi request reprint The alphaVbeta6 integrin regulates its own expression with cell crowding: implications for tumour progression
    J Niu
    Discipline of Surgical Science, Faculty of Medicine and Health Sciences, University of Newcastle, New South Wales, Australia
    Int J Cancer 92:40-8. 2001
    ..The alphavbeta6-mediated induction of gelatinase B secretion facilitates peri-cellular matrix degradation, which helps overcome crowding and restores cell proliferation...
  13. ncbi request reprint A novel missense mutation of SLC7A9 frequent in Japanese cystinuria cases affecting the C-terminus of the transporter
    Y Shigeta
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Shinkawa, Mitaka, Tokyo, Japan
    Kidney Int 69:1198-206. 2006
    ..The results of the present study contribute toward understanding the distribution and frequency of cystinuria-related mutations of SLC7A9...
  14. ncbi request reprint Translational proteomics: developing a predictive capacity -- a review
    G E Rice
    Department of Translational Proteomics, Baker Heart Research Institute, 75 Commercial Road, Melbourne 3004, Victoria, Australia
    Placenta 27:S76-86. 2006
    ....
  15. ncbi request reprint Rapid diagnosis of Helicobacter pylori infection in dyspeptic patients using salivary secretion: a non-invasive approach
    S K Tiwari
    Centre for Liver Research and Diagnostics, Deccan College of Medical Sciences, Kanchanbagh, Hyderabad 500058, Andhra Pradesh, India
    Singapore Med J 46:224-8. 2005
    ..The accuracy of saliva as a non-invasive specimen was compared with that of invasive tests in pretreatment diagnosis of H. pylori infection...
  16. ncbi request reprint Advanced glycation endproducts: what is their relevance to diabetic complications?
    N Ahmed
    Department of Biological Sciences, University of Essex, Central Campus, Wivenhoe Park, Colchester, Essex, CO4 3SQ, UK
    Diabetes Obes Metab 9:233-45. 2007
    ..Increasing expression of enzymes of the enzymatic defence against glycation provides a novel and potentially effective future therapeutic strategy to suppress protein glycation...
  17. ncbi request reprint Role of cardiac troponin I in staging and prognosis of congestive heart failure subjects
    N Ahmed
    Department of Biochemistry, Rangpur Medical College, Rangpur
    Mymensingh Med J 16:12-6. 2007
    ..Cardiac troponin I could also be used as a very important marker for the prognosis of the patients with congestive heart failure...
  18. ncbi request reprint The prothrombin G20210A polymorphism in patients with myocardial infarction
    E Durante-Mangoni
    Institute of Medical Therapy, 2nd University of Naples, Italy
    Blood Coagul Fibrinolysis 13:603-8. 2002
    ..009 in the group without myocardial infarction (P = 0.622). The results of this study suggest that the single nucleotide polymorphism at position 20210 of the prothrombin gene is unlikely to be a risk factor for coronary thrombosis...
  19. ncbi request reprint Increased serum levels of vascular endothelial growth factor correlate with splenomegaly in polycythemia vera
    P Murphy
    Department of Haematology, Royal Shrewsbury Hospital and Institute for Health, University of Lincoln, Lincoln, UK
    Leuk Res 26:1007-1010. 2002
    ..Further studies with large number of polycythemia cases are warranted to explore the role of these cytokines in the pathogenesis, diagnosis and/or therapy of polycythemia...
  20. ncbi request reprint Buffalo plasma fibronectin: a physico-chemical study
    N Ahmed
    Dr B R Ambedkar Center for Biomedical Research, University of Delhi, India
    Indian J Biochem Biophys 38:384-92. 2001
    ..4 nm) as revealed by rotary shadowing electron microscopy further supported the extended conformation of buffalo plasma FN. These results show that buffalo plasma FN has similar properties as that of human plasma FN...
  21. ncbi request reprint Ajoene, a garlic-derived natural compound, enhances chemotherapy-induced apoptosis in human myeloid leukaemia CD34-positive resistant cells
    N Ahmed
    Division of Biomedical Sciences, School of Health Sciences, University of Wolverhampton, England, UK
    Anticancer Res 21:3519-23. 2001
    ..Further studies are warranted to evaluate a similar enhancing effect for ajoene in blast cells from AML patients in primary cultures...
  22. ncbi request reprint Effect of bone morphogenetic protein-6 on haemopoietic stem cells and cytokine production in normal human bone marrow stroma
    N Ahmed
    Division of Biomedical Sciences, School of Health Sciences, University of Wolverhampton, U K
    Cell Biol Int 25:429-35. 2001
    ..Further in vitro tests are required to evaluate this potential mobilising role of BMP-6 in human long-term bone marrow culture...
  23. pmc Identification and preliminary characterization of protein-cysteine farnesyltransferase
    V Manne
    Department of Molecular Biology, Squibb Institute for Medical Research, Princeton, NJ 08543 4000
    Proc Natl Acad Sci U S A 87:7541-5. 1990
    ..Availability of an in vitro protein farnesyltransferase assay should be useful in screening for potential inhibitors of ras oncogene function that will not interfere with other aspects of the mevalonate pathway...