Uwe Ackermann

Summary

Affiliation: University of Melbourne
Country: Australia

Publications

  1. ncbi Synthesis, 11C labeling and biological properties of derivatives of the tyrphostin AG957
    Uwe Ackermann
    Centre for PET, Austin Health, Heidelberg, VIC 3084, Australia
    Nucl Med Biol 32:323-8. 2005
  2. doi Dopamine D(1) receptor binding in the anterior cingulate cortex of patients with obsessive-compulsive disorder
    James S Olver
    Department of Psychiatry, University of Melbourne, Heidelberg, Victoria, Australia
    Psychiatry Res 183:85-8. 2010
  3. doi In vivo assessment of vesicular monoamine transporter type 2 in dementia with lewy bodies and Alzheimer disease
    Victor L Villemagne
    Department of Nuclear Medicine, Centre for Positron Emission Tomography, Austin Hospital, Austin Health, Heidelber, Australia
    Arch Neurol 68:905-12. 2011
  4. doi In vivo measurement of vesicular monoamine transporter type 2 density in Parkinson disease with (18)F-AV-133
    Nobuyuki Okamura
    Department of Nuclear Medicine and Centre for PET, Austin Health, Victoria, Australia
    J Nucl Med 51:223-8. 2010
  5. doi Improved synthesis of [(18)F]FLETT via a fully automated vacuum distillation method for [(18)F]2-fluoroethyl azide purification
    Uwe Ackermann
    Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Vic, Australia The University of Melbourne, Parkville, Vic, Australia Ludwig Institute for Cancer Research, Melbourne Branch, Vic, Australia
    Appl Radiat Isot 94:72-6. 2014
  6. pmc Longitudinal assessment of Aβ and cognition in aging and Alzheimer disease
    Victor L Villemagne
    Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Australia
    Ann Neurol 69:181-92. 2011
  7. doi Fully automated synthesis and coupling of [(18) F]FBEM to glutathione using the iPHASE FlexLab module
    Uwe Ackermann
    Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Melbourne, Australia The University of Melbourne, Parkville, Melbourne, Australia Ludwig Institute for Cancer Research, Melbourne Branch, Melbourne, Australia
    J Labelled Comp Radiopharm 57:115-20. 2014
  8. doi Dopamine D1 receptor binding in the striatum of patients with obsessive-compulsive disorder
    James S Olver
    Department of Psychiatry, University of Melbourne, Heidelberg, Victoria, Australia
    J Affect Disord 114:321-6. 2009
  9. pmc Fully automated synthesis of [(18) F]fluoro-dihydrotestosterone ([(18) F]FDHT) using the FlexLab module
    Uwe Ackermann
    Department of Molecular Imaging and Therapy, Austin Health, Heidelberg, Australia
    J Labelled Comp Radiopharm 59:424-8. 2016
  10. doi L-Tyrosine Confers Residualizing Properties to a d-Amino Acid-Rich Residualizing Peptide for Radioiodination of Internalizing Antibodies
    Fook T Lee
    Tumour Targeting Program, Ludwig Institute for Cancer Research and Olivia Newton John Cancer Research Institute, Heidelberg, Victoria, Australia
    Mol Imaging 15:. 2016

Collaborators

Detail Information

Publications11

  1. ncbi Synthesis, 11C labeling and biological properties of derivatives of the tyrphostin AG957
    Uwe Ackermann
    Centre for PET, Austin Health, Heidelberg, VIC 3084, Australia
    Nucl Med Biol 32:323-8. 2005
    ..3+/-2.1% (n=3; not decay corrected) and an average specific radioactivity of 40 GBq/micromol (1.1 Ci/micromol) at the end of synthesis. The total synthesis time from EOB including HPLC purification and formulation was 45 min...
  2. doi Dopamine D(1) receptor binding in the anterior cingulate cortex of patients with obsessive-compulsive disorder
    James S Olver
    Department of Psychiatry, University of Melbourne, Heidelberg, Victoria, Australia
    Psychiatry Res 183:85-8. 2010
    ..These findings suggest mesocortical dopamine inputs via D(1) receptors may play a role in the aetiology of OCD...
  3. doi In vivo assessment of vesicular monoamine transporter type 2 in dementia with lewy bodies and Alzheimer disease
    Victor L Villemagne
    Department of Nuclear Medicine, Centre for Positron Emission Tomography, Austin Hospital, Austin Health, Heidelber, Australia
    Arch Neurol 68:905-12. 2011
    ....
  4. doi In vivo measurement of vesicular monoamine transporter type 2 density in Parkinson disease with (18)F-AV-133
    Nobuyuki Okamura
    Department of Nuclear Medicine and Centre for PET, Austin Health, Victoria, Australia
    J Nucl Med 51:223-8. 2010
    ..PET provides a noninvasive means to evaluate the functional integrity of the presynaptic monoaminergic system in the living human brain...
  5. doi Improved synthesis of [(18)F]FLETT via a fully automated vacuum distillation method for [(18)F]2-fluoroethyl azide purification
    Uwe Ackermann
    Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Vic, Australia The University of Melbourne, Parkville, Vic, Australia Ludwig Institute for Cancer Research, Melbourne Branch, Vic, Australia
    Appl Radiat Isot 94:72-6. 2014
    ..18)F]FLETT was produced in higher overall yield (41.3±6.5%) and shorter synthesis time (67min) than with our previously reported manual method (32.5±2.5% in 130min). ..
  6. pmc Longitudinal assessment of Aβ and cognition in aging and Alzheimer disease
    Victor L Villemagne
    Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Australia
    Ann Neurol 69:181-92. 2011
    ..Assess Aβ deposition longitudinally and explore its relationship with cognition and disease progression...
  7. doi Fully automated synthesis and coupling of [(18) F]FBEM to glutathione using the iPHASE FlexLab module
    Uwe Ackermann
    Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Melbourne, Australia The University of Melbourne, Parkville, Melbourne, Australia Ludwig Institute for Cancer Research, Melbourne Branch, Melbourne, Australia
    J Labelled Comp Radiopharm 57:115-20. 2014
    ..4 in quantitative yields. This fully automated method does not require any manual intervention and therefore reduces the radiation exposure to the operator. ..
  8. doi Dopamine D1 receptor binding in the striatum of patients with obsessive-compulsive disorder
    James S Olver
    Department of Psychiatry, University of Melbourne, Heidelberg, Victoria, Australia
    J Affect Disord 114:321-6. 2009
    ..The authors used positron emission tomography (PET) to examine the binding of the dopamine D(1) receptor antagonist [(11)C]-SCH23390 to D(1) receptors in the striatum of drug-free OCD patients compared with healthy controls...
  9. pmc Fully automated synthesis of [(18) F]fluoro-dihydrotestosterone ([(18) F]FDHT) using the FlexLab module
    Uwe Ackermann
    Department of Molecular Imaging and Therapy, Austin Health, Heidelberg, Australia
    J Labelled Comp Radiopharm 59:424-8. 2016
    ..The synthesis has now been validated at Austin Health and is currently used for [(18) F]FDHT studies in patients. We believe that this method can easily adapted by other modules to further widen the availability of [(18) F]FDHT. ..
  10. doi L-Tyrosine Confers Residualizing Properties to a d-Amino Acid-Rich Residualizing Peptide for Radioiodination of Internalizing Antibodies
    Fook T Lee
    Tumour Targeting Program, Ludwig Institute for Cancer Research and Olivia Newton John Cancer Research Institute, Heidelberg, Victoria, Australia
    Mol Imaging 15:. 2016
    ..The aims of the study were to develop and evaluate a novel residualizing peptide for labeling internalizing antibodies with (124)I to support clinical development using immuno-positron emission tomography (PET)...
  11. ncbi Visual assessment versus quantitative assessment of 11C-PIB PET and 18F-FDG PET for detection of Alzheimer's disease
    Steven Ng
    Department of Nuclear Medicine, Centre for PET, Austin Health, Heidelberg, Victoria, Australia
    J Nucl Med 48:547-52. 2007
    ..The aim of this study was to explore the clinical potential of Abeta imaging for the diagnosis of AD by comparison of the accuracy of visual reading of (11)C-PIB images with quantitative analysis and (18)F-FDG...