Stephen L Nutt

Summary

Affiliation: The Walter and Eliza Hall Institute of Medical Research
Country: Australia

Publications

  1. doi Plasma cell development: from B-cell subsets to long-term survival niches
    Kirsten A Fairfax
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Australia
    Semin Immunol 20:49-58. 2008
  2. pmc A non-canonical function of Ezh2 preserves immune homeostasis.
    Ajithkumar Vasanthakumar
    EMBO Rep 18:619-631. 2017
  3. ncbi The transcriptional regulation of B cell lineage commitment
    Stephen L Nutt
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Immunity 26:715-25. 2007
  4. ncbi Interleukin 21: a key player in lymphocyte maturation
    Stephen L Nutt
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville Victoria 3050, Australia
    Crit Rev Immunol 24:239-50. 2004
  5. pmc Dynamic regulation of PU.1 expression in multipotent hematopoietic progenitors
    Stephen L Nutt
    The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia
    J Exp Med 201:221-31. 2005
  6. ncbi Blimp-1 connects the intrinsic and extrinsic regulation of T cell homeostasis
    Stephen L Nutt
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, 3050, Australia
    J Clin Immunol 28:97-106. 2008
  7. ncbi Germinal center B and follicular helper T cells: siblings, cousins or just good friends?
    Stephen L Nutt
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Nat Immunol 12:472-7. 2011
  8. ncbi BLIMP1 guides the fate of effector B and T cells
    Stephen L Nutt
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville Victoria, 3050, Australia
    Nat Rev Immunol 7:923-7. 2007
  9. doi The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells
    Erika Cretney
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Nat Immunol 12:304-11. 2011
  10. ncbi Initiation of plasma-cell differentiation is independent of the transcription factor Blimp-1
    Axel Kallies
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Immunity 26:555-66. 2007

Detail Information

Publications89

  1. doi Plasma cell development: from B-cell subsets to long-term survival niches
    Kirsten A Fairfax
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Australia
    Semin Immunol 20:49-58. 2008
    ..In this review we cover these aspects of plasma cell development with a particular emphasis on the B-cell subsets giving rise to the plasma cells and to their maintenance once formed...
  2. pmc A non-canonical function of Ezh2 preserves immune homeostasis.
    Ajithkumar Vasanthakumar
    EMBO Rep 18:619-631. 2017
    ..Taken together, we have identified a chromatin-independent function of Ezh2 that impacts on the development of the immune system...
  3. ncbi The transcriptional regulation of B cell lineage commitment
    Stephen L Nutt
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Immunity 26:715-25. 2007
    ....
  4. ncbi Interleukin 21: a key player in lymphocyte maturation
    Stephen L Nutt
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville Victoria 3050, Australia
    Crit Rev Immunol 24:239-50. 2004
    ..In these contexts, IL-21 has shown very promising efficacy in a number of antitumor immune responses mediated by NK and or T lymphocytes...
  5. pmc Dynamic regulation of PU.1 expression in multipotent hematopoietic progenitors
    Stephen L Nutt
    The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia
    J Exp Med 201:221-31. 2005
    ..1(lo) CMPs were the immediate precursors of the MEP. Thus, down-regulation of PU.1 expression in the CMP is the first molecularly identified event associated with the restriction of differentiation to erythroid and megakaryocyte lineages...
  6. ncbi Blimp-1 connects the intrinsic and extrinsic regulation of T cell homeostasis
    Stephen L Nutt
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, 3050, Australia
    J Clin Immunol 28:97-106. 2008
    ..Interestingly, Blimp-1 expression is controlled by the same cgammaC cytokines that regulate T cell homeostasis suggesting a direct link between the extrinsic and intrinsic arms of the process...
  7. ncbi Germinal center B and follicular helper T cells: siblings, cousins or just good friends?
    Stephen L Nutt
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Nat Immunol 12:472-7. 2011
    ..Less is known about the memory B cells that arise from the GC pool, as they seem to be distinctly 'programmed' on the basis of their antigen receptor affinity to enter the long-lived memory pool...
  8. ncbi BLIMP1 guides the fate of effector B and T cells
    Stephen L Nutt
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville Victoria, 3050, Australia
    Nat Rev Immunol 7:923-7. 2007
    ..In addition, an important role for BLIMP1 in maintaining the homeostasis of effector T cells is emerging, suggesting intriguing parallels between the control of effector-cell fates in both B and T cells...
  9. doi The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells
    Erika Cretney
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Nat Immunol 12:304-11. 2011
    ..Thus, our study defines a differentiation pathway that leads to the acquisition of T(reg) cell effector functions and requires both IRF4 and Blimp-1...
  10. ncbi Initiation of plasma-cell differentiation is independent of the transcription factor Blimp-1
    Axel Kallies
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Immunity 26:555-66. 2007
    ..Our results indicate that full plasma-cell differentiation but not commitment to the plasma-cell fate requires the expression of functional Blimp-1...
  11. pmc Differential requirement for OBF-1 during antibody-secreting cell differentiation
    Lynn M Corcoran
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    J Exp Med 201:1385-96. 2005
    ..These studies define a new regulatory role for OBF-1 in determining the cell-autonomous capacity of B cells to undergo terminal differentiation in response to different immunological signals...
  12. doi Fas ligand-mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas
    Shoukat Afshar-Sterle
    1 Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia 2 Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia 3
    Nat Med 20:283-90. 2014
    ..Thus, malignant transformation of mature B cells requires mutations that impair intrinsic differentiation processes and permit escape from T cell-mediated tumor surveillance. ..
  13. doi Transcription factor IRF4 regulates germinal center cell formation through a B cell-intrinsic mechanism
    Simon N Willis
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    J Immunol 192:3200-6. 2014
    ..major or influenza virus infection. Taken together, these data demonstrate a B cell-intrinsic requirement for IRF4 for not only the development of Ab secreting plasma cells but also for GC formation. ..
  14. doi The development and fate of follicular helper T cells defined by an IL-21 reporter mouse
    Katja Lüthje
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Nat Immunol 13:491-8. 2012
    ..Thus, we demonstrated that TFH cells were not terminally differentiated but instead retained the flexibility to be recruited into other helper T cell subsets and nonlymphoid tissues...
  15. ncbi Different kinetics of blimp-1 induction in B cell subsets revealed by reporter gene
    Kirsten A Fairfax
    Immunology Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, Australia
    J Immunol 178:4104-11. 2007
    ..Transferred naive Blimp-1(GFP/+) B1 and B2 cells both gave rise to ASCs in the bone marrow, suggesting no intrinsic barriers to B1 cell entry into the long-lived ASC compartment...
  16. doi The transcription factor PU.1 controls dendritic cell development and Flt3 cytokine receptor expression in a dose-dependent manner
    Sebastian Carotta
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Immunity 32:628-41. 2010
    ..1 as a critical regulator of both conventional and plasmacytoid DC development and provide one mechanism how altered PU.1 concentration can have profound functional consequences for hematopoietic cell development...
  17. ncbi Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance
    Axel Kallies
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Nat Immunol 7:466-74. 2006
    ..These data identify Blimp-1 as an essential regulator of T cell homeostasis and suggest that Blimp-1 regulates both B cell and T cell differentiation...
  18. pmc The transcription factors IRF8 and PU.1 negatively regulate plasma cell differentiation
    Sebastian Carotta
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia Department of Medical Biology, Department of Pathology, Department of Microbiology and Immunology, and Department of Computing and Information Systems, University of Melbourne, Parkville, Victoria 3010, Australia
    J Exp Med 211:2169-81. 2014
    ..As the PU.1-IRF8 complex functions in a reciprocal manner to IRF4, we propose that concentration-dependent competition between these factors controls B cell terminal differentiation. ..
  19. pmc Mcl-1 is essential for the survival of plasma cells
    Victor Peperzak
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Nat Immunol 14:290-7. 2013
    ..Our results identify a critical role for Mcl-1 in the maintenance of plasma cells...
  20. pmc IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism
    Dimitra Zotos
    The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia
    J Exp Med 207:365-78. 2010
    ..The absence of IL-21 or IL-21 receptor does not abrogate the appearance of T cells in GCs or the appearance of CD4 T cells with a follicular helper phenotype. IL-21 thus controls fate choices of GC B cells directly...
  21. ncbi Identification of Pax5 target genes in early B cell differentiation
    Clare Pridans
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Immunol 180:1719-28. 2008
    ..These include the repression of the adhesion molecule Embigin, which is expressed in bone marrow progenitors, T cells, and myeloid cells but is specifically repressed by Pax5 in B cells...
  22. doi A molecular threshold for effector CD8(+) T cell differentiation controlled by transcription factors Blimp-1 and T-bet
    Annie Xin
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Nat Immunol 17:422-32. 2016
    ....
  23. doi A role for Blimp1 in the transcriptional network controlling natural killer cell maturation
    Axel Kallies
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Blood 117:1869-79. 2011
    ..We have identified NK cells as the first hematopoietic cell type in which the IRF4-Blimp1-Bcl6 regulatory axis is not in operation, highlighting the distinct nature of the NK-cell gene-regulatory network...
  24. pmc PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis
    Aleksandar Dakic
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    J Exp Med 201:1487-502. 2005
    ..These findings emphasize the distinct nature of adult hematopoiesis and reveal that PU.1 regulates the specification of the multipotent lymphoid and myeloid compartments and restrains, rather than promotes, granulopoiesis...
  25. doi The transcription factor IRF4 is essential for TCR affinity-mediated metabolic programming and clonal expansion of T cells
    Kevin Man
    1 The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia 2 The Department of Medical Biology, University of Melbourne, Parkville, Australia
    Nat Immunol 14:1155-65. 2013
    ..Thus, IRF4 is an indispensable molecular 'rheostat' that 'translates' TCR affinity into the appropriate transcriptional programs that link metabolic function with the clonal selection and effector differentiation of T cells. ..
  26. doi Blimp1 is limiting for transformation in a mouse plasmacytoma model
    Kathy D'Costa
    Division of Immunology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Blood 113:5911-9. 2009
    ..These observations suggest that Blimp1 is limiting for plasma cell transformation and thus has potential as a target for new therapies to combat MM...
  27. ncbi NK cell maturation and peripheral homeostasis is associated with KLRG1 up-regulation
    Nicholas D Huntington
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Immunol 178:4764-70. 2007
    ..These data indicate that NK cells acquire KLRG1 on their surface during development, and this expression correlates with functional distinctions from other peripheral NK cells in vivo...
  28. doi The interactions of multiple cytokines control NK cell maturation
    Jason Brady
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    J Immunol 185:6679-88. 2010
    ....
  29. ncbi The development of functional B lymphocytes in conditional PU.1 knock-out mice
    Matthew Polli
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, Australia 3050
    Blood 106:2083-90. 2005
    ..These findings suggest that PU.1 is not essential for the development of functional B lymphocytes beyond the pre-B stage...
  30. ncbi Transient Notch signaling induces NK cell potential in Pax5-deficient pro-B cells
    Sebastian Carotta
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Eur J Immunol 36:3294-304. 2006
    ..These data indicate that Notch signaling induces T/NK cell differentiation in Pax5(-/-) pro-B cells that is strikingly similar to early thymopoiesis...
  31. ncbi Pax5 maintains cellular identity by repressing gene expression throughout B cell differentiation
    Sebastian Carotta
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Cell Cycle 5:2452-6. 2006
    ..These recent insights into the mechanism of action of Pax5 in controlling B cell identity will be discussed...
  32. pmc Critical roles for c-Myb in lymphoid priming and early B-cell development
    Kylie T Greig
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Blood 115:2796-805. 2010
    ..These data show that c-Myb plays a critical role in the regulatory pathways governing lymphoid specification and early B-cell differentiation...
  33. pmc A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary natural killer cells
    Nicholas D Huntington
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    J Exp Med 201:1421-33. 2005
    ..Thus we identify CD45 as a pivotal enzyme in eliciting a precise subset of NK cell responses...
  34. doi Transcriptional profiling of mouse B cell terminal differentiation defines a signature for antibody-secreting plasma cells
    Wei Shi
    1 The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia 2 Department of Computing and Information Systems, The University of Melbourne, Parkville, Victoria, Australia
    Nat Immunol 16:663-73. 2015
    ..These findings both highlight and expand the core program that guides B cell terminal differentiation and the production of antibodies. ..
  35. pmc Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response
    Julie Tellier
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Nat Immunol 17:323-30. 2016
    ..Thus, Blimp-1 was required for the unique physiological ability of plasma cells that enables the secretion of protective antibody. ..
  36. pmc Peripheral natural killer cell maturation depends on the transcription factor Aiolos
    Melissa L Holmes
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia
    EMBO J 33:2721-34. 2014
    ..These data place Aiolos in the emerging gene regulatory network controlling NK-cell maturation and function...
  37. pmc Early appearance of germinal center-derived memory B cells and plasma cells in blood after primary immunization
    Elizabeth J Blink
    The Walter and Eliza Hall Institute of Medical Research, Parkville 3050, Australia
    J Exp Med 201:545-54. 2005
    ..We find no evidence for a blimp-1-expressing preplasma memory compartment, suggesting germinal center output is restricted to ASCs and B220(+) memory B cells, and this is sufficient to account for the process of affinity maturation...
  38. pmc Plasma cell ontogeny defined by quantitative changes in blimp-1 expression
    Axel Kallies
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, 3050, Australia
    J Exp Med 200:967-77. 2004
    ..Thus, maturation from transient plasmablast to long-lived ASCs in bone marrow is predicated on quantitative increases in Blimp-1 expression...
  39. doi The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15
    Rebecca B Delconte
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia Department of Medical Biology, University of Melbourne, VIC 3010 Australia
    Immunity 44:103-15. 2016
    ....
  40. ncbi High rate of antibody secretion is not integral to plasma cell differentiation as revealed by XBP-1 deficiency
    Nadine Taubenheim
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    J Immunol 189:3328-38. 2012
    ..Thus, XBP-1 deficiency demonstrates that the gene regulatory program controlling plasma cell differentiation can proceed relatively normally in the absence of high rates of Ig secretion...
  41. pmc Mcl-1 is essential for germinal center formation and B cell memory
    Ingela Vikstrom
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia
    Science 330:1095-9. 2010
    ..Our results identify Mcl1 as the main anti-apoptotic regulator of activated B cell survival and suggest distinct mechanisms controlling survival of GC and memory B cells...
  42. doi Blimp-1 transcription factor is required for the differentiation of effector CD8(+) T cells and memory responses
    Axel Kallies
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Immunity 31:283-95. 2009
    ..This study identifies Blimp-1 as a master regulator of the terminal differentiation of CD8(+) effector T cells and uncovers a conservation of the pathways that regulate the terminal differentiation of T and B cells...
  43. pmc Putative IKDCs are functionally and developmentally similar to natural killer cells, but not to dendritic cells
    Irina Caminschi
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, 3050, Australia
    J Exp Med 204:2579-90. 2007
    ..Thus, IKDCs resemble NK cells functionally, and neither cell type could be induced to be effective antigen-presenting cells...
  44. ncbi The regulation of the B-cell gene expression programme by Pax5
    Melissa L Holmes
    Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Immunol Cell Biol 86:47-53. 2008
    ..These target genes reveal a gene regulatory network, with Pax5 at its centre that controls the B-cell gene expression programme...
  45. pmc Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1
    Nicholas D Huntington
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Nat Immunol 8:856-63. 2007
    ..Thus, IL-15 regulates the survival of NK cells at multiple steps, with Bim and Noxa being key antagonists of Mcl-1, the critical survivor factor in this process...
  46. pmc Id2 expression delineates differential checkpoints in the genetic program of CD8α+ and CD103+ dendritic cell lineages
    Jacob T Jackson
    Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    EMBO J 30:2690-704. 2011
    ..Genetic mapping DC subset differentiation using Id2-GFP may have broad implications in understanding the interplay of DC subsets during protective and pathological immune responses...
  47. pmc Dynamic changes in Id3 and E-protein activity orchestrate germinal center and plasma cell development
    Renee Gloury
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia
    J Exp Med 213:1095-111. 2016
    ....
  48. doi Innate immunodeficiency following genetic ablation of Mcl1 in natural killer cells
    Priyanka Sathe
    1 The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia 2 Department of Medical Biology, University of Melbourne, Victoria 3010, Australia 3
    Nat Commun 5:4539. 2014
    ..These results clearly demonstrate a non-redundant pathway linking IL-15 to Mcl1 in the maintenance of NK cells and innate immune responses in vivo. ..
  49. pmc The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway
    Lucille C Rankin
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Nat Immunol 14:389-95. 2013
    ..Our results pinpoint the regulation of Notch signaling by T-bet as a distinct molecular pathway that guides the development of NKp46+ ILCs...
  50. pmc Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation
    Anissa M Jabbour
    Children s Cancer Centre, Murdoch Children s Research Institute, Royal Children s Hospital, Parkville, Vic, Australia
    Blood 115:344-52. 2010
    ..Thus, we conclude that p53 protein is activated after IL-3 deprivation by loss of MDM2. Activated p53 transcriptionally up-regulates Puma, which initiates apoptosis...
  51. pmc Monocytic leukemia zinc finger protein is essential for the development of long-term reconstituting hematopoietic stem cells
    Tim Thomas
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Genes Dev 20:1175-86. 2006
    ....
  52. ncbi Terminal differentiation of lymphocytes depends on Blimp-1
    Axel Kallies
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, Australia
    Curr Opin Immunol 19:156-62. 2007
    ..These new findings suggest that Blimp-1 has a conserved function in the final differentiation of both the cellular and the humoral arm of the adaptive immune response...
  53. doi The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells
    Ajithkumar Vasanthakumar
    1 The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia 2 The Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia
    Nat Immunol 16:276-85. 2015
    ..Human omental adipose tissue Treg cells also showed high ST2 expression, suggesting an evolutionarily conserved requirement for IL-33 in VAT-Treg cell homeostasis. ..
  54. ncbi IL-21 induces the functional maturation of murine NK cells
    Jason Brady
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Immunol 172:2048-58. 2004
    ..These developmental changes suggested that IL-21 functions to induce the terminal differentiation of mouse NK cells, resulting in heightened NK cell-mediated cytotoxicity and immune surveillance...
  55. pmc Langerhans cells are generated by two distinct PU.1-dependent transcriptional networks
    Michael Chopin
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    J Exp Med 210:2967-80. 2013
    ..1 and promoted LC differentiation from PU.1-sufficient progenitors. These findings highlight the dual molecular network underlying LC differentiation, and show the central role of PU.1 in these processes. ..
  56. doi Effector Regulatory T Cell Differentiation and Immune Homeostasis Depend on the Transcription Factor Myb
    Sheila Dias
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia
    Immunity 46:78-91. 2017
    ....
  57. doi Acetylation of the Cd8 Locus by KAT6A Determines Memory T Cell Diversity
    Dane M Newman
    The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia Department of Medical Biology, The University of Melbourne, Parkville, VIC 3010, Australia
    Cell Rep 16:3311-21. 2016
    ..These findings suggest a direct role of CD8αβ co-receptor expression and histone acetylation in shaping functional diversity within the cytotoxic T cell pool. ..
  58. pmc Repression of Flt3 by Pax5 is crucial for B-cell lineage commitment
    Melissa L Holmes
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Genes Dev 20:933-8. 2006
    ..These findings demonstrate that the repression of Flt3 by Pax5 is essential for normal B-lymphopoiesis...
  59. doi RUNX2 Mediates Plasmacytoid Dendritic Cell Egress from the Bone Marrow and Controls Viral Immunity
    Michael Chopin
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia Department of Medical Biology, University of Melbourne, Parkville, VIC 3010, Australia Electronic address
    Cell Rep . 2016
    ....
  60. pmc MOZ regulates B-cell progenitors and, consequently, Moz haploinsufficiency dramatically retards MYC-induced lymphoma development
    Bilal N Sheikh
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia and Department of Medical Biology, and
    Blood 125:1910-21. 2015
    ..Our results suggest that even partial inhibition of MOZ may reduce the proliferative capacity of MEIS1, and HOX-driven lymphoma and leukemia cells. ..
  61. doi Losing B cell identity
    Sebastian Carotta
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Bioessays 30:203-7. 2008
    ..The reliance of B cell identity on a single gene is not without its problems as the loss of Pax5 results in B cell malignancies in mouse models and mutation in human PAX5 is the most-common genetic lesion in acute lymphoblastic leukemia...
  62. doi Surprising new roles for PU.1 in the adaptive immune response
    Sebastian Carotta
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Immunol Rev 238:63-75. 2010
    ..1 in peripheral T-cell differentiation. Here, we review insights derived from these mouse models of PU.1 deficiency, with particular emphasis on these functions of PU.1 in the lymphocyte and dendritic cell lineages...
  63. pmc c-Myb is required for plasma cell migration to bone marrow after immunization or infection
    Kim L Good-Jacobson
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia
    J Exp Med 212:1001-9. 2015
    ..Therefore, c-Myb plays an essential, novel role in establishing the long-lived plasma cell population in the BM via responsiveness to chemokine migration cues. ..
  64. pmc Effect of thymic stimulation of CD4+ T cell expansion on disease onset and progression in mutant SOD1 mice
    Rebecca K Sheean
    The Florey Institute of Neuroscience and Mental Health, University of Melbourne, 30 Royal Parade, Parkville, Victoria, 3052, Australia
    J Neuroinflammation 12:40. 2015
    ..Here, we assessed the effects of augmenting endogenous CD4+ T cell number by stimulating the thymus using surgical castration on the phenotype of transgenic SOD1(G93A) mice...
  65. doi The genetic network controlling plasma cell differentiation
    Stephen L Nutt
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, 3050, Australia
    Semin Immunol 23:341-9. 2011
    ....
  66. doi Transcriptional programming of the dendritic cell network
    Gabrielle T Belz
    Division of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, Victoria 3052, Australia
    Nat Rev Immunol 12:101-13. 2012
    ..In this Review, we discuss new evidence regarding the coordination of the specification and commitment of precursor cells to different DC subsets and highlight the ensemble of transcription factors that control these processes...
  67. ncbi Is PU.1 a dosage-sensitive regulator of haemopoietic lineage commitment and leukaemogenesis?
    Aleksandar Dakic
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Trends Immunol 28:108-14. 2007
    ..1. Here, we will discuss the data that, we believe, argue against the dosage-sensitive model of PU.1-mediated lineage commitment and leukaemogenesis...
  68. doi Identification of the earliest NK-cell precursor in the mouse BM
    Sebastian Carotta
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, Australia
    Blood 117:5449-52. 2011
    ..In vitro differentiation studies demonstrate that pre-pro NK cells are committed to NK-cell lineage and appear to be upstream of the previously identified NK-cell progenitor population...
  69. ncbi Functional subsets of mouse natural killer cells
    Yoshihiro Hayakawa
    Cancer Immunology Program, Sir Donald and Lady Trescowick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Immunol Rev 214:47-55. 2006
    ..Extending our knowledge of mature NK cell heterogeneity between the species will be critical to further our understanding of the pathological role of NK cells in immune responses...
  70. doi Differentiation and function of Foxp3(+) effector regulatory T cells
    Erika Cretney
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Trends Immunol 34:74-80. 2013
    ..Here, we discuss the factors that control the differentiation of eTreg cells and their importance in disease settings...
  71. doi Critical roles for c-Myb in hematopoietic progenitor cells
    Kylie T Greig
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Semin Immunol 20:247-56. 2008
    ..These studies reveal a complex array of functions for c-Myb in multiple hematopoietic cell types that will redefine our understanding of this crucial transcription factor...
  72. ncbi PU.1 is a suppressor of myeloid leukemia, inactivated in mice by gene deletion and mutation of its DNA binding domain
    Wendy D Cook
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Blood 104:3437-44. 2004
    ..1 normally suppresses development of myeloid leukemia by promoting differentiation and that the combination of gene deletion and a point mutation that impairs its ability to bind DNA is particularly leukemogenic...
  73. ncbi Specification of the primitive myeloid precursor pool requires signaling through Alk8 in zebrafish
    Benjamin M Hogan
    Ludwig Institute for Cancer Research, Post Office Box 2008, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Curr Biol 16:506-11. 2006
    ..1 expression, but the role of alk8 was independent of the scl-dependent cell-fate pathway. Furthermore, the role of Alk8 in myelopoiesis was genetically separable from its earlier role in dorsal-ventral embryonic patterning...
  74. ncbi NK cells promote peritoneal xenograft rejection through an IFN-gamma-dependent mechanism
    Ming Lee Lin
    Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Vic, Australia
    Xenotransplantation 13:536-46. 2006
    ..Like cytotoxic T lymphocytes (CTL), they express perforin and are potent secretors of gamma-interferon (IFN-gamma). However, there is conflicting evidence about their role in mediating rejection of xenogeneic tissue...
  75. doi The unique features of follicular T cell subsets
    Julie Tellier
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, Vic, 3052, Australia
    Cell Mol Life Sci 70:4771-84. 2013
    ..In this review we will discuss the function of follicular T cells and interaction of these populations within the GC response. ..
  76. doi Polycomb repressive complex 2 (PRC2) suppresses Eμ-myc lymphoma
    Stanley C W Lee
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia and
    Blood 122:2654-63. 2013
    ..This finding provides new insight regarding the functional contribution of mutations in PRC2 in a range of leukemias. ..
  77. doi B-cell identity--commitment is not forever
    Stephen L Nutt
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    N Engl J Med 358:82-3. 2008
  78. pmc Agm1/Pgm3-mediated sugar nucleotide synthesis is essential for hematopoiesis and development
    Kylie T Greig
    Division of Molecular Medicine, The Walter and Eliza Hall Institute of Medical Research, Victoria, Australia
    Mol Cell Biol 27:5849-59. 2007
    ....
  79. pmc Apaf-1 and caspase-9 do not act as tumor suppressors in myc-induced lymphomagenesis or mouse embryo fibroblast transformation
    Clare L Scott
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Cell Biol 164:89-96. 2004
    ..Moreover, loss of Apaf-1 did not promote oncogene-induced transformation of mouse embryo fibroblasts. Thus, Apaf-1 and caspase-9 do not suppress c-myc-induced lymphomagenesis and embryo fibroblast transformation...
  80. pmc Plasma cell S1P1 expression determines secondary lymphoid organ retention versus bone marrow tropism
    Kenji Kabashima
    Howard Hughes Medical Institute HHMI and Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA
    J Exp Med 203:2683-90. 2006
    ....
  81. ncbi IL-7 and the thymus dictate the NK cell 'labor market'
    Mark J Smyth
    Nat Immunol 7:1134-6. 2006
  82. ncbi Aberrant mast-cell differentiation in mice lacking the stem-cell leukemia gene
    Jessica M Salmon
    Rotary Bone Marrow Research Laboratories, Royal Melbourne Hospital, Melbourne, Australia
    Blood 110:3573-81. 2007
    ..Together, these studies suggest that loss of SCL leads to aberrant mast-cell differentiation of megakaryocyte-erythroid progenitors...
  83. pmc Sequential activation of NKT cells and NK cells provides effective innate immunotherapy of cancer
    Mark J Smyth
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
    J Exp Med 201:1973-85. 2005
    ..Overall, the data suggest that NK cell antitumor function can be enhanced greatly by strategies that are designed to expand and differentiate NK cells via DC activation of NKT cells...
  84. ncbi Blimp1 regulates development of the posterior forelimb, caudal pharyngeal arches, heart and sensory vibrissae in mice
    Elizabeth J Robertson
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Development 134:4335-45. 2007
    ..Collectively, the present experiments demonstrate that Blimp1 requirements in diverse cell types are exquisitely dose dependent...
  85. pmc Targeted gene expression in transgenic Xenopus using the binary Gal4-UAS system
    Katharine O Hartley
    Wellcome CRC Institute, Tennis Court Road, Cambridge CB2 1QR, United Kingdom
    Proc Natl Acad Sci U S A 99:1377-82. 2002
    ..Finally, we exploit this system to characterize the neural and mesodermal defects obtained from early misexpression of Xvent-2. These results emphasize the potential of this system for the controlled analyses of gene function in Xenopus...
  86. ncbi FcgammaRIII-dependent inhibition of interferon-gamma responses mediates suppressive effects of intravenous immune globulin
    Kyung Hyun Park-Min
    Graduate Program in Immunology and Microbial Pathogenesis, Weill Medical College and Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA
    Immunity 26:67-78. 2007
    ....
  87. ncbi Tumor growth need not be driven by rare cancer stem cells
    Priscilla N Kelly
    Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia
    Science 317:337. 2007
    ..We suggest that the low frequency of tumor-sustaining cells observed in xenotransplantation studies may reflect the limited ability of human tumor cells to adapt to growth in a foreign (mouse) milieu...
  88. pmc High affinity germinal center B cells are actively selected into the plasma cell compartment
    Tri Giang Phan
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown NSW 2042, Australia
    J Exp Med 203:2419-24. 2006
    ..Because the body can sustain only limited numbers of plasma cells, this "quality control" over plasma cell differentiation is likely critical for establishing effective humoral immunity...