G J Lindeman

Summary

Affiliation: The Walter and Eliza Hall Institute of Medical Research
Country: Australia

Publications

  1. pmc Jekyll or Hyde: does Matrigel provide a more or less physiological environment in mammary repopulating assays?
    Francois Vaillant
    Breast Cancer Res 13:108. 2011
  2. pmc The future of mammary stem cell biology: the power of in vivo transplants
    Geoffrey J Lindeman
    Breast Cancer Res 10:402; author reply 403. 2008
  3. pmc Mutation analysis of FANCD2, BRIP1/BACH1, LMO4 and SFN in familial breast cancer
    Aaron G Lewis
    Department of Cancer Genetics, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Breast Cancer Res 7:R1005-16. 2005
  4. pmc Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways
    Elgene Lim
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia
    Breast Cancer Res 12:R21. 2010
  5. pmc Nipple aspiration and ductal lavage in women with a germline BRCA1 or BRCA2 mutation
    Gillian Mitchell
    Division of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia
    Breast Cancer Res 7:R1122-31. 2005
  6. pmc Resident macrophages influence stem cell activity in the mammary gland
    David E Gyorki
    VBCRC Laboratory, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia
    Breast Cancer Res 11:R62. 2009
  7. pmc Deaf-1 regulates epithelial cell proliferation and side-branching in the mammary gland
    Holly E Barker
    The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3050, Australia
    BMC Dev Biol 8:94. 2008
  8. ncbi request reprint Familial cancer 2003 - research and practice, Couran Cove, Queensland, Australia, 3-6 September 2003
    Geoffrey J Lindeman
    Familial Cancer Centre, Royal Melbourne Hospital, Australia
    Fam Cancer 3:75-7. 2004
  9. pmc Frequency of the ATM IVS10-6T-->G variant in Australian multiple-case breast cancer families
    Geoffrey J Lindeman
    Familial Cancer Centre, Royal Melbourne Hospital, Melbourne, Australia
    Breast Cancer Res 6:R401-7. 2004
  10. pmc Cell fate takes a slug in BRCA1-associated breast cancer
    Geoffrey J Lindeman
    Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia
    Breast Cancer Res 13:306. 2011

Detail Information

Publications68

  1. pmc Jekyll or Hyde: does Matrigel provide a more or less physiological environment in mammary repopulating assays?
    Francois Vaillant
    Breast Cancer Res 13:108. 2011
    ..This caveat should be considered when interpreting mammary reconstitution assays that incorporate Matrigel, particularly when transplanting high cell numbers...
  2. pmc The future of mammary stem cell biology: the power of in vivo transplants
    Geoffrey J Lindeman
    Breast Cancer Res 10:402; author reply 403. 2008
  3. pmc Mutation analysis of FANCD2, BRIP1/BACH1, LMO4 and SFN in familial breast cancer
    Aaron G Lewis
    Department of Cancer Genetics, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Breast Cancer Res 7:R1005-16. 2005
    ..We hypothesized that germline mutations in FANCD2, BRIP1/BACH1, LMO4 and SFN may account for some of the unexplained multiple-case breast cancer families...
  4. pmc Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways
    Elgene Lim
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia
    Breast Cancer Res 12:R21. 2010
    ..The epithelial cell signatures were used to interrogate mouse models of mammary tumorigenesis and to compare with their normal human counterpart subsets to identify conserved genes and networks...
  5. pmc Nipple aspiration and ductal lavage in women with a germline BRCA1 or BRCA2 mutation
    Gillian Mitchell
    Division of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia
    Breast Cancer Res 7:R1122-31. 2005
    ..The aim of this study was to collect serial samples of nipple aspirate (NA) and ductal lavage (DL) fluid from women with germline BRCA1/2 mutations in order to create a biorepository for use in identifying biomarkers of breast cancer risk...
  6. pmc Resident macrophages influence stem cell activity in the mammary gland
    David E Gyorki
    VBCRC Laboratory, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia
    Breast Cancer Res 11:R62. 2009
    ..Here we have explored a role for macrophages in regulating mammary stem cell (MaSC) activity, by assessing the ability of MaSCs to reconstitute a mammary gland in a macrophage-depleted fat pad...
  7. pmc Deaf-1 regulates epithelial cell proliferation and side-branching in the mammary gland
    Holly E Barker
    The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3050, Australia
    BMC Dev Biol 8:94. 2008
    ..Here we investigated the influence of DEAF-1 on human and mouse mammary epithelial cells both in vitro and in vivo and identified a potential target gene...
  8. ncbi request reprint Familial cancer 2003 - research and practice, Couran Cove, Queensland, Australia, 3-6 September 2003
    Geoffrey J Lindeman
    Familial Cancer Centre, Royal Melbourne Hospital, Australia
    Fam Cancer 3:75-7. 2004
  9. pmc Frequency of the ATM IVS10-6T-->G variant in Australian multiple-case breast cancer families
    Geoffrey J Lindeman
    Familial Cancer Centre, Royal Melbourne Hospital, Melbourne, Australia
    Breast Cancer Res 6:R401-7. 2004
    ..Although this variant can result in a truncated ATM product, its clinical significance as a high-penetrance breast cancer allele or its role as a low-penetrance risk-modifier is controversial...
  10. pmc Cell fate takes a slug in BRCA1-associated breast cancer
    Geoffrey J Lindeman
    Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia
    Breast Cancer Res 13:306. 2011
    ....
  11. ncbi request reprint Shedding light on mammary stem cells and tumorigenesis
    Geoffrey J Lindeman
    The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 350, Australia
    Cell Cycle 5:671-2. 2006
  12. doi request reprint Insights into the cell of origin in breast cancer and breast cancer stem cells
    Geoffrey J Lindeman
    Breast Cancer Laboratory, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Asia Pac J Clin Oncol 6:89-97. 2010
    ..Although many unresolved questions on CSCs remain, ongoing efforts to identify and characterize CSCs continue to be an important area of investigation, with the potential to identify novel tumor targeting strategies...
  13. doi request reprint Delineating the epithelial hierarchy in the mouse mammary gland
    M L Asselin-Labat
    VBCRC Laboratory, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3050, Australia
    Cold Spring Harb Symp Quant Biol 73:469-78. 2008
    ..Here, we review the known characteristics of mammary stem and progenitor cells, their steroid receptor status, and the pathways that have thus far been implicated in regulating their self-renewal and differentiation...
  14. doi request reprint Predictors of the use of complementary and alternative medicine (CAM) by women at high risk for breast cancer
    K M Field
    Division of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, Locked Bag No 1, A Beckett St, Melbourne, Victoria 8006, Australia
    Eur J Cancer 45:551-60. 2009
    ..Few data exist regarding the use of complementary and alternative medicine (CAM) by unaffected women at high risk of breast cancer...
  15. doi request reprint Gene methylation in breast ductal fluid from BRCA1 and BRCA2 mutation carriers
    Yoland C Antill
    Victorian Breast Cancer Research Consortium Cancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
    Cancer Epidemiol Biomarkers Prev 19:265-74. 2010
    ....
  16. doi request reprint Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers
    Elgene Lim
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Nat Med 15:907-13. 2009
    ..Our findings suggest that an aberrant luminal progenitor population is a target for transformation in BRCA1-associated basal tumors ...
  17. ncbi request reprint The emerging picture of the mouse mammary stem cell
    Francois Vaillant
    Victorian Breast Cancer Research Consortium Laboratory, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3050, Australia
    Stem Cell Rev 3:114-23. 2007
    ..This review will summarize the strategy used in the identification of mouse mammary stem cells and their characterisation...
  18. ncbi request reprint Risk-reducing surgery, screening and chemoprevention practices of BRCA1 and BRCA2 mutation carriers: a prospective cohort study
    K A Phillips
    Division of Hematology and Medical Oncology, Peter MacCallum Cancer Centre, University of Melbourne Department of Medicine, St Vincent s Hospital, Victoria, NSW, Australia
    Clin Genet 70:198-206. 2006
    ..In this cohort, the minority of mutation carriers utilized risk-reducing surgery or chemoprevention and a substantial minority were not undergoing regular cancer-screening tests...
  19. pmc Tumour morphology predicts PALB2 germline mutation status
    Z L Teo
    Genetic Epidemiology Laboratory, The University of Melbourne, Melbourne, Victoria 3010, Australia
    Br J Cancer 109:154-63. 2013
    ..We sought to determine whether morphological features of breast tumours can predict PALB2 germline mutation status...
  20. pmc The LIM domain gene LMO4 inhibits differentiation of mammary epithelial cells in vitro and is overexpressed in breast cancer
    J E Visvader
    The Walter and Eliza Hall Institute of Medical Research and Bone Marrow Research Laboratories, Melbourne, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 98:14452-7. 2001
    ..These studies imply a role for LMO4 in maintaining proliferation of mammary epithelium and suggest that deregulation of this gene may contribute to breast tumorigenesis...
  21. ncbi request reprint Steroid hormone receptor status of mouse mammary stem cells
    Marie Liesse Asselin-Labat
    VBCRC Laboratory, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    J Natl Cancer Inst 98:1011-4. 2006
    ..Thus, mouse mammary stem cells were negative for ERalpha, PR, and ErbB2 and appeared to share common properties with poor-prognosis basal breast cancer...
  22. ncbi request reprint The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity
    Eleanor Y M Sum
    Walter and Eliza Hall Institute of Medical Research and Bone Marrow Research Laboratories, Melbourne, Victoria 3050, Australia
    J Biol Chem 277:7849-56. 2002
    ..These findings reveal a novel complex between BRCA1, LMO4, and CtIP and indicate a role for LMO4 as a repressor of BRCA1 activity in breast tissue...
  23. doi request reprint The mammary progenitor marker CD61/beta3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis
    Francois Vaillant
    VBCRC Laboratory, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Cancer Res 68:7711-7. 2008
    ..Overall, our findings show the utility of the progenitor marker CD61 in the identification of CSCs that sustain specific mammary tumors...
  24. doi request reprint Notch signaling regulates mammary stem cell function and luminal cell-fate commitment
    Toula Bouras
    VBCRC Laboratory, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Cell Stem Cell 3:429-41. 2008
    ..These findings reveal key roles for Notch signaling in MaSCs and luminal cell commitment and further suggest that inappropriate Notch activation promotes the self-renewal and transformation of luminal progenitor cells...
  25. ncbi request reprint The LIM domain protein Lmo4 is highly expressed in proliferating mouse epithelial tissues
    Eleanor Y M Sum
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3050, Australia
    J Histochem Cytochem 53:475-86. 2005
    ..The expression profile of Lmo4 suggests that this cofactor is an important regulator of epithelial proliferation and has implications for its role in the pathogenicity of cancer...
  26. ncbi request reprint Transcriptional regulators in mammary gland development and cancer
    Jane E Visvader
    VBCRC Laboratory, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Vic Parkville 3050, Australia
    Int J Biochem Cell Biol 35:1034-51. 2003
    ..This review will discuss recent insights into the transcriptional networks important for mammary gland development and consider how deregulation of specific transcription factors contributes to the pathogenesis of breast cancer...
  27. ncbi request reprint Mammary stem cells and mammopoiesis
    Jane E Visvader
    The Victorian Breast Cancer Research Consortium Laboratory, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Cancer Res 66:9798-801. 2006
    ..Here we review the characteristics of mouse mammary stem cells, their estrogen receptor status, and the potential cellular hierarchy that exists within the mammary gland...
  28. ncbi request reprint Differential hypermethylation of SOCS genes in ovarian and breast carcinomas
    Kate D Sutherland
    The Walter and Eliza Hall Institute of Medical Research and Bone Marrow Research Laboratories, Royal Melbourne Hospital, Parkville, VIC 3050, Australia
    Oncogene 23:7726-33. 2004
    ..Hypermethylation and silencing of specific SOCS genes in the ovary, and to a lesser extent in breast, may augment cytokine responsiveness in these tissues, thereby contributing to oncogenesis...
  29. ncbi request reprint Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas
    Kate D Sutherland
    The Walter and Eliza Hall Institute of Medical Research and Bone Marrow Research Laboratories, Parkville, Australia
    Int J Cancer 107:155-8. 2003
    ..Thus, the primary mechanism by which LMO4 is deregulated in breast cancers appears to reflect overexpression of the gene rather than the acquisition of activating genetic mutations...
  30. doi request reprint Cancer stem cells in solid tumours: accumulating evidence and unresolved questions
    Jane E Visvader
    VBCRC Laboratory, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia
    Nat Rev Cancer 8:755-68. 2008
    ..The clinical relevance of CSCs remains a fundamental issue but preliminary findings indicate that specific targeting may be possible...
  31. doi request reprint Pro-apoptotic Bim suppresses breast tumor cell metastasis and is a target gene of SNAI2
    D Merino
    1 ACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia 2 Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia
    Oncogene 34:3926-34. 2015
    ..Taken together, our findings suggest that SNAI2-driven BIM-induced apoptosis may temper metastasis by governing the survival of disseminating breast tumor cells. ..
  32. doi request reprint Control of mammary stem cell function by steroid hormone signalling
    Marie Liesse Asselin-Labat
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    Nature 465:798-802. 2010
    ..These findings further indicate that breast cancer chemoprevention may be achieved, in part, through suppression of MaSC function...
  33. ncbi request reprint Generation of a functional mammary gland from a single stem cell
    Mark Shackleton
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Nature 439:84-8. 2006
    ..Our data establish that single cells within the Lin-CD29hiCD24+ population are multipotent and self-renewing, properties that define them as MaSCs...
  34. ncbi request reprint "Cancer in the family" and genetic testing: implications for life insurance
    Elly L Lynch
    Familial Cancer Centre, Royal Melbourne Hospital, Parkville, Vic, Australia
    Med J Aust 179:480-3. 2003
    ..Health practitioners should balance the potential benefits of appropriate genetic testing against potential restriction to life and income-protection insurance when advising people about genetic testing...
  35. ncbi request reprint The phosphoprotein StarD10 is overexpressed in breast cancer and cooperates with ErbB receptors in cellular transformation
    Monilola A Olayioye
    The Walter and Eliza Hall Institute of Medical Research and Bone Marrow Research Laboratories, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Cancer Res 64:3538-44. 2004
    ..Taken together, these data suggest that overexpression of this lipid-binding protein contributes to breast oncogenesis...
  36. ncbi request reprint MMTV-trBrca1 mice display strain-dependent abnormalities in vaginal development
    Kaylene J Simpson
    Department of Biochemistry and Molecular Biology, University of Melbourne, Victoria, Australia
    Int J Dev Biol 48:675-8. 2004
    ..This is the first time that BRCA1 has been implicated in an apoptosis-mediated normal developmental process...
  37. doi request reprint Macrophages, more than just scavengers: their role in breast development and cancer
    David E Gyorki
    VBCRC Laboratory, The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Melbourne, Victoria, Australia
    ANZ J Surg 78:432-6. 2008
    ..Intriguingly, macrophages are often found in the stroma of breast tumours, where they may promote tumour growth and metastasis. In this review we discuss this emerging area of developmental and tumour biology...
  38. doi request reprint Targeting BCL-2 to enhance vulnerability to therapy in estrogen receptor-positive breast cancer
    D Merino
    Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Oncogene 35:1877-87. 2016
    ....
  39. ncbi request reprint Cancer risk management practices of noncarriers within BRCA1/2 mutation positive families in the Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer
    Sarah Jane Dawson
    Division of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, Locked Bag No 1, A Beckett St, Victoria, 8006, Australia
    J Clin Oncol 26:225-32. 2008
    ..Women from BRCA mutation-positive families who do not carry the family-specific mutation are generally at average cancer risk and therefore do not require intensive risk management...
  40. doi request reprint Grhl3 and Lmo4 play coordinate roles in epidermal migration
    Nikki R Hislop
    Rotary Bone Marrow Research Laboratories, Melbourne Health Research Directorate, c o Royal Melbourne Hospital Post Office, Parkville, VIC 3050, Australia
    Dev Biol 321:263-72. 2008
    ..Keratinocytes from mutant mice fail to "heal" in in vitro scratch assays, consistent with a general epidermal migratory defect that is dependent on ERK activation and actin cable formation...
  41. ncbi request reprint Breast cancer protein StarD10 identified by three-dimensional separation using free-flow electrophoresis, reversed-phase high-performance liquid chromatography, and sodium dodecyl sulfate-polyacrylamide gel electrophoresis
    Peter Hoffmann
    St Vincent s Institute and CSIRO Health Sciences and Nutrition, Victoria, Australia
    Electrophoresis 26:1029-37. 2005
    ..Thus, free-flow electrophoresis is a powerful high-capacity complementary technique to RP-HPLC and SDS-PAGE for the purification of proteins from complex cell lysates...
  42. doi request reprint Lineage enforcement by inductive mesenchyme on adult epithelial stem cells across developmental germ layers
    Renea A Taylor
    Centre for Urological Research, Monash Institute of Medical Research, Monash University, Melbourne, Victoria 3168, Australia
    Stem Cells 27:3032-42. 2009
    ..In order to use adult epithelial SCs in regenerative medicine, we must additionally regulate their intrinsic properties to prevent (or enable) transdifferentiation in specified SC niches...
  43. ncbi request reprint Loss of the LIM domain protein Lmo4 in the mammary gland during pregnancy impedes lobuloalveolar development
    Eleanor Y M Sum
    The Walter and Eliza Hall Institute of Medical Research and Bone Marrow Research Laboratories, 1G Royal Parade, Parkville, VIC 3050, Australia
    Oncogene 24:4820-8. 2005
    ..Thus, the use of a conditional targeting strategy has revealed that Lmo4 is required for proper development of the mammary gland during pregnancy and indicated that Lmo4 acts as a positive regulator of alveolar epithelial proliferation...
  44. ncbi request reprint Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation
    Marie Liesse Asselin-Labat
    VBCRC Laboratory, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Nat Cell Biol 9:201-9. 2007
    ..These studies provide evidence for the existence of an epithelial hierarchy within the mammary gland and establish Gata-3 as a critical regulator of luminal differentiation...
  45. ncbi request reprint Identification of Taxreb107 as a lactogenic hormone responsive gene in mammary epithelial cells
    Sergio Wittlin
    VBCRC Breast Cancer Laboratory, The Walter and Eliza Hall Institute of Medical Research and Bone Marrow Research Laboratories, 1G Royal Parade, VIC 3050, Parkville, Australia
    Biochim Biophys Acta 1642:139-47. 2003
    ..These findings indicate a role for Taxreb107 as a lactogenic hormone-responsive gene during differentiation of the mammary gland...
  46. pmc Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation
    Jiong Zhou
    Centre for Functional Genomics and Human Disease, Monash Institute of Reproduction and Development, Monash University, Melbourne, Victoria, Australia
    EMBO J 24:635-44. 2005
    ..Our data demonstrate that Elf5 is essential for developmental processes in the embryo and in the mammary gland during pregnancy...
  47. pmc The proapoptotic BH3-only protein bim is expressed in hematopoietic, epithelial, neuronal, and germ cells
    L A O'Reilly
    Walter and Eliza Hall Institute and the Rotary Bone Marrow Research Laboratories, Royal Melbourne Hospital, Melbourne, Australia
    Am J Pathol 157:449-61. 2000
    ..These results are discussed in the context of the phenotype of Bim-deficient mice and the post-translational regulation of Bim's pro-apoptotic activity...
  48. ncbi request reprint Bfk: a novel weakly proapoptotic member of the Bcl-2 protein family with a BH3 and a BH2 region
    L Coultas
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Cell Death Differ 10:185-92. 2003
    ..Low amounts of Bfk were found in stomach, ovary, bone marrow and spleen, but its level in the mammary gland rose markedly during pregnancy, suggesting that Bfk may play a role in mammary development...
  49. doi request reprint The beliefs, and reported and intended behaviors of unaffected men in response to their family history of prostate cancer
    Ruth Cowan
    Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia
    Genet Med 10:430-8. 2008
    ....
  50. ncbi request reprint Two promoters within the human LMO4 gene contribute to its overexpression in breast cancer cells
    Sergio Wittlin
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, 3050, Parkville, Victoria, Australia
    Genomics 82:280-7. 2003
    ..Thus, overexpression of the LMO4 gene in breast cancer cells reflects increased promoter activity and appears to involve aberrant activation of the second promoter in a subset of these cells...
  51. ncbi request reprint The molecular culprits underlying precocious mammary gland involution
    Kate D Sutherland
    VBCRC Laboratory, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3050, Australia
    J Mammary Gland Biol Neoplasia 12:15-23. 2007
    ..The accumulating data point to a complex network of signal transduction pathways that synergize to regulate apoptosis in the involuting mammary gland...
  52. pmc c-myc as a mediator of accelerated apoptosis and involution in mammary glands lacking Socs3
    Kate D Sutherland
    VBCRC Laboratory, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    EMBO J 25:5805-15. 2006
    ..Our data establish Socs3 as a critical attenuator of pro-apoptotic pathways that act in the developing mammary gland and provide evidence that c-myc regulates apoptosis during involution...
  53. ncbi request reprint StarD10, a START domain protein overexpressed in breast cancer, functions as a phospholipid transfer protein
    Monilola A Olayioye
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Victoria 3050, Australia
    J Biol Chem 280:27436-42. 2005
    ..Interestingly, these lipid binding and transfer specificities distinguish StarD10 from the related START domain proteins Pctp and CERT, suggesting a distinct biological function...
  54. pmc SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor-deficient mice
    G J Lindeman
    The Walter and Eliza Hall Institute of Medical Research, Bone Marrow Research Laboratories, PO Royal Melbourne Hospital, VIC 3050, Australia
    Genes Dev 15:1631-6. 2001
    ..These findings establish a role for SOCS1 as a negative regulator of prolactin signaling and suggest that SOCS1 is required for the prevention of lactation prior to parturition...
  55. ncbi request reprint Accuracy and completeness in reporting family history of prostate cancer by unaffected men
    Clara L Gaff
    Familial Cancer Centre, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Urology 63:1111-6. 2004
    ..However, the accuracy of prostate cancer reports and completeness of the family history provided by unaffected men is poorly understood...
  56. doi request reprint Impaired lactation in mice expressing dominant-negative FADD in mammary epithelium
    Mark Shackleton
    Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia
    Dev Dyn 238:1010-6. 2009
    ..These findings suggest a role for FADD in maintaining the survival of mammary secretory alveolar cells after the establishment of lactation...
  57. ncbi request reprint Germline BRCA1 promoter deletions in UK and Australian familial breast cancer patients: Identification of a novel deletion consistent with BRCA1:psiBRCA1 recombination
    Melissa A Brown
    Department of Medical and Molecular Genetics, King s College London Guy s Campus, Guy s Hospital, London, UK
    Hum Mutat 19:435-42. 2002
    ..These findings indicate that germline BRCA1 promoter deletions are a rare and yet significant mutation event and that they could arise via a novel genetic mechanism...
  58. pmc The Ets transcription factor Elf5 specifies mammary alveolar cell fate
    Samantha R Oakes
    Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia
    Genes Dev 22:581-6. 2008
    ..Thus Elf5 specifies the differentiation of CD61+ progenitors to establish the secretory alveolar lineage during pregnancy, providing a link between prolactin, transcriptional events, and alveolar development...
  59. ncbi request reprint BARD1 variants are not associated with breast cancer risk in Australian familial breast cancer
    Kylie L Gorringe
    Peter MacCallum Cancer Centre, East Melbourne, Vic, 8006, Australia
    Breast Cancer Res Treat 111:505-9. 2008
    ....
  60. ncbi request reprint Predictors of participation in clinical and psychosocial follow-up of the kConFab breast cancer family cohort
    Kelly Anne Phillips
    Department of Hematology and Medical Oncology, Peter MacCallum Cancer Centre, Locked Bag No 1, A Beckett St, Victoria 8006, Australia
    Fam Cancer 4:105-13. 2005
    ..Prospective collection of epidemiological, psychosocial and outcome data in large breast cancer family cohorts should provide less biased data than retrospective studies regarding penetrance of breast cancer and modifiers of genetic risk...
  61. pmc Overexpression of LMO4 induces mammary hyperplasia, promotes cell invasion, and is a predictor of poor outcome in breast cancer
    Eleanor Y M Sum
    The Walter and Eliza Hall Institute of Medical Research and Bone Marrow Research Laboratories, 1G Royal Parade, Parkville VIC 3050, Australia
    Proc Natl Acad Sci U S A 102:7659-64. 2005
    ..Together, these findings suggest that deregulation of LMO4 in breast epithelium contributes directly to breast neoplasia by altering the rate of cellular proliferation and promoting cell invasion...
  62. ncbi request reprint Socs2 and elf5 mediate prolactin-induced mammary gland development
    Jessica Harris
    Garvan Institute of Medical Research, St Vincent s Hospital, Darlinghurst, New South Wales 2010, Australia
    Mol Endocrinol 20:1177-87. 2006
    ..Thus, Socs2 and Elf5 are key members of the set of prolactin-regulated genes that mediate prolactin-driven mammary development...
  63. ncbi request reprint Dimerization of CtIP, a BRCA1- and CtBP-interacting protein, is mediated by an N-terminal coiled-coil motif
    Manu J Dubin
    School of Molecular and Microbial Biosciences, University of Sydney, New South Wales 2006, Australia
    J Biol Chem 279:26932-8. 2004
    ..These results suggest a specific model for CtIP homodimerization via its N terminus and contribute to an improved understanding of how this protein might assemble other factors required for its role as a transcriptional corepressor...
  64. ncbi request reprint Investigation of the transcriptional changes underlying functional defects in the mammary glands of prolactin receptor knockout mice
    Christopher J Ormandy
    Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst Sydney, NSW 2010, Australia
    Recent Prog Horm Res 58:297-323. 2003
    ..Such profiling has identified a number of genes with well-characterized roles in mammary development, in addition to a number of novel transcripts...
  65. ncbi request reprint Threonine 391 phosphorylation of the human prolactin receptor mediates a novel interaction with 14-3-3 proteins
    Monilola A Olayioye
    Walter and Eliza Hall Institute of Medical Research and Bone Marrow Research Laboratories, 1G Royal Parade, Victoria 3050, Australia
    J Biol Chem 278:32929-35. 2003
    ..This was accompanied by a ligand-induced increase in protein kinase B and Erk activation but not that of Stat5a. Phosphorylation of the receptor on Thr391 may therefore provide a new mechanism by which prolactin signaling is attenuated...
  66. ncbi request reprint Knocking off SOCS genes in the mammary gland
    Kate D Sutherland
    Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Cell Cycle 6:799-803. 2007
    ..Perturbation of this pathway leads to an increase in the levels of c-myc and its likely target genes, p53, bax and E2F-1, providing evidence that c-myc is a central effector of apoptosis during involution...
  67. ncbi request reprint CPAP is a novel stat5-interacting cofactor that augments stat5-mediated transcriptional activity
    Benjamin Peng
    The Walter and Eliza Hall Institute of Medical Research and Rotary Bone Marrow Research Laboratories, Post Office Royal Melbourne Hospital, Victoria 3050, Australia
    Mol Endocrinol 16:2019-33. 2002
    ..Furthermore, CPAP was found to augment Stat5-mediated transcription. Thus, we have identified CPAP as a novel coactivator of Stat5 proteins in the PRL (and probably other) pathways...
  68. pmc Defective neural tube closure and anteroposterior patterning in mice lacking the LIM protein LMO4 or its interacting partner Deaf-1
    Kyungmin Hahm
    Division of Hematology Oncology, Department of Pediatrics, Children s Hospital and Dana Farber Cancer Institute, Boston, MA 02115, USA
    Mol Cell Biol 24:2074-82. 2004
    ..Our data indicate an important role for these two transcriptional regulators in pathways affecting neural tube closure and skeletal patterning, most likely reflecting their presence in a functional complex in vivo...