Affiliation: The Walter and Eliza Hall Institute of Medical Research
- Desmoplastic melanoma: comparison of expression of differentiation antigens and cancer testis antigensElgene Lim
Ludwig Institute for Cancer Research Department of Medical Oncology, Austin Health, Heidelberg, Victoria, Australia
Melanoma Res 16:347-55. 2006..Low levels of expression of cancer testis antigen may indicate that they are suboptimal targets for vaccine development in desmoplastic melanoma...
- Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathwaysElgene Lim
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia
Breast Cancer Res 12:R21. 2010..The epithelial cell signatures were used to interrogate mouse models of mammary tumorigenesis and to compare with their normal human counterpart subsets to identify conserved genes and networks...
- ROAST: rotation gene set tests for complex microarray experimentsDi Wu
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, Australia
Bioinformatics 26:2176-82. 2010..Methods that rely on permutation of probes unrealistically assume independence of genes, while those that rely on permutation of sample are suitable only for two-group comparisons with a good number of replicates in each group...
- Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriersElgene Lim
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
Nat Med 15:907-13. 2009..Our findings suggest that an aberrant luminal progenitor population is a target for transformation in BRCA1-associated basal tumors ...
- Sensitization of BCL-2-expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737Samantha R Oakes
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
Proc Natl Acad Sci U S A 109:2766-71. 2012..Our findings provide in vivo evidence that BH3 mimetics can be used to sensitize primary breast tumors to chemotherapy and further suggest that elevated BCL-2 expression constitutes a predictive response marker in breast cancer...