Affiliation: The Children's Hospital at Westmead
- Tape transfer sectioning of tissue microarrays introduces nonspecific immunohistochemical staining artifactsD Catchpoole
Biospecimens Research Group, and Tumour Bank The Children s Cancer Research Unit, The Children s Hospital at Westmead, Westmead, NSW, Australia
Biotech Histochem 86:421-8. 2011..Quantitative image analysis of immunohistochemical staining demonstrated that the tape method produced a higher incidence of nonspecific staining, which raised the potential for false positive staining...
- A genome-wide screen identifies frequently methylated genes in haematological and epithelial cancersThomas Dunwell
Department of Medical and Molecular Genetics, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham B152TT, UK
Mol Cancer 9:44. 2010..High throughput screens are required to identify epigenetic markers that can be useful for diagnostic and prognostic purposes across malignancies...
- The novel RASSF6 and RASSF10 candidate tumour suppressor genes are frequently epigenetically inactivated in childhood leukaemiasLuke B Hesson
Department of Medical and Molecular Genetics, Institute of Biomedical Research, Medical School, University of Birmingham, Edgbaston, B15 2TT, UK
Mol Cancer 8:42. 2009..We also determined the methylation status of CpG islands associated with RASSF1-10 in a series of childhood acute lymphocytic leukaemias (ALL) and normal blood and bone marrow samples...
- MINER: exploratory analysis of gene interaction networks by machine learning from expression dataSidath Randeni Kadupitige
School of Computer Science and Engineering, The University of New South Wales, Sydney, NSW, 2052, Australia
BMC Genomics 10:S17. 2009..Numerous approaches have been proposed, most of which attempt only "one-shot" reconstruction of the whole network with no intervention from the user, or offer only simple correlation analysis to infer gene dependencies...
- Inter-platform comparability of microarrays in acute lymphoblastic leukemiaStephanie A Mitchell
Research Center for Genetic Medicine, Children s National Medical Center, Institute of Biomedical Sciences, George Washington University Medical Center, Washington, D C 20037, USA
BMC Genomics 5:71. 2004..Lists of genes that are differentially expressed in the six major subclasses of ALL have previously been reported in the literature as possible predictors of the subclass...
- cDNA array-CGH profiling identifies genomic alterations specific to stage and MYCN-amplification in neuroblastomaQing Rong Chen
Oncogenomics Section, Pediatric Oncology Branch, Advanced Technology Center, National Cancer Institute, 8717 Grovemont Circle, Gaithersburg, MD 20877, USA
BMC Genomics 5:70. 2004..Recurrent non-random genomic alterations are the hallmarks of cancer and the characterization of these imbalances is critical to our understanding of tumorigenesis and cancer progression...
- Intracellular trafficking as a determinant of AS-DACA cytotoxicity in rhabdomyosarcoma cellsSteven J Wolf
Biospecimens Research and Tumour Bank, Children s Cancer Research Unit, The Children s Hospital at Westmead, Westmead, NSW 2774, Australia
BMC Cell Biol 12:36. 2011..Here, we investigate the basis for this selectivity, and demonstrate in these RMS lines, and in an AS-DACA- resistant subclone of RH30, that AS-DACA-induced cytotoxicity correlates with the induction of DNA double strand breaks...
- The potential tumour suppressor role for caspase-9 (CASP9) in the childhood malignancy, neuroblastomaD R Catchpoole
Children s Cancer Institute Australia for Medical Research, PO Box 81, Randwick, NSW 2031, Australia
Eur J Cancer 37:2217-21. 2001..These polymorphisms did not associate with the clinicopathological stages of disease or the predicted clinical outcomes of the patients. Silencing mutations of CASP9 are therefore unlikely to be causal to neuroblastoma tumorigenesis...
- Gene expression profiles that segregate patients with childhood acute lymphoblastic leukaemia: an independent validation study identifies that endoglin associates with patient outcomeDaniel Catchpoole
The Tumour Bank, The Oncology Research Unit, The Children s Hospital at Westmead, Locked Bag 4001, Westmead, NSW 2145, Australia
Leuk Res 31:1741-7. 2007..An artificial neural network identified endoglin, which was reported in the initial study as a potential lineage marker, was actually better at identifying ALL patients with poor outcome...
- Can Archival Tissue Reveal Answers to Modern Research Questions?: Computer-Aided Histological Assessment of Neuroblastoma Tumours Collected over 60 YearsAlbert Chetcuti
Tumour Bank, The Children s Cancer Research Unit, Kid s Research Institute, The Children s Hospital at Westmead, Westmead, NSW 2145, Australia
Microarrays (Basel) 3:72-88. 2014..The construction and assessment of this neuroblastoma TMA has demonstrated the feasibility of using archival samples for research. ..
- Bilateral Wilms tumor and early presentation in pediatric patients is associated with the truncation of the Wilms tumor 1 proteinMin Hu
Center for Kidney Research, Children s Hospital at Westmead, The University of Sydney, Westmead, NSW, Australia
J Pediatr 163:224-9. 2013..To investigate the frequency of constitutional Wilms tumor 1 gene (WT1) abnormalities in children with bilateral Wilms tumor (WT) and the age of tumor onset in patients with a mutation...
- Expression profiling reveals MSX1 and EphB2 expression correlates with the invasion capacity of Wilms tumorsAlbert Chetcuti
Children s Cancer Research Unit, The Children s Hospital at Westmead, Sydney, Australia
Pediatr Blood Cancer 57:950-7. 2011..The aim of this study was to identify new proteins associated with the invasion capacity of Wilms tumor...
- Predicting outcome in childhood acute lymphoblastic leukemia using gene expression profiling: prognostication or protocol selection?Daniel Catchpoole
Blood 111:2486-7; author reply 2487-8. 2008
- Credentialing preclinical pediatric xenograft models using gene expression and tissue microarray analysisCraig C Whiteford
Oncogenomics Section, Comparative Oncology Program, and Cell and Molecular Biology Section, Pediatric Oncology Branch
Cancer Res 67:32-40. 2007..The database will facilitate the identification of tumor markers predictive of response to tested agents as well as the discovery of new molecular targets...
- High-resolution analysis of chromosomal breakpoints and genomic instability identifies PTPRD as a candidate tumor suppressor gene in neuroblastomaRaymond L Stallings
Children s Cancer Research Institute and Department of Pediatrics, University of Texas Health Science Center at San Antonio, 8403 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
Cancer Res 66:3673-80. 2006..The most frequent microdeletion involved the PTPRD locus, indicating a possible tumor suppressor function for this gene...
- Prediction of clinical outcome using gene expression profiling and artificial neural networks for patients with neuroblastomaJun S Wei
Advanced Technology Center, Oncogenomics Section, Pediatric Oncology Branch, National Cancer Institute, NIH, Gaithersburg, Maryland 20877, USA
Cancer Res 64:6883-91. 2004..0005). Our findings provide evidence of a gene expression signature that can predict prognosis independent of currently known risk factors and could assist physicians in the individual management of patients with high-risk neuroblastoma...