- Resistance to anti-HCV protease inhibitorsAlexander J Thompson
St Vincent s Hospital Melbourne, Fitzroy, Victoria, Australia
Curr Opin Virol 1:599-606. 2011..This brief review summarizes the current literature concerning resistance to the HCV NS3 protease inhibitors, both experimental and clinical, and identifies the key questions facing the field...
- Toll-like receptors, RIG-I-like RNA helicases and the antiviral innate immune responseAlex J V Thompson
Department of Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, North Melbourne, Victoria, Australia
Immunol Cell Biol 85:435-45. 2007..In the face of such host defence, viruses have developed strategies to evade TLR/RLH signalling. Such host-virus interactions provide the opportunity for manipulation of PRR signalling as a novel therapeutic approach...
- Viral clearance is associated with improved insulin resistance in genotype 1 chronic hepatitis C but not genotype 2/3Alexander J Thompson
Duke Clinical Research Institute, Duke University Medical Center, P O Box 17969, Durham, NC 27715, USA
Gut 61:128-34. 2012..This study investigated the association between a sustained virological response (SVR) and IR after chronic HCV therapy...