D J Torpy
Affiliation: South Australia
- Glucocorticoid receptor polymorphisms and post-traumatic stress disorderAnthony W Bachmann
Department of Medicine, University of Queensland, Greenslopes Private Hospital, Brisbane, QLD 4120, Australia
Psychoneuroendocrinology 30:297-306. 2005..Our PTSD group did not display GC hypersensitivity, as measured by the LD-DST and DVVA. In a subset of PTSD patients with the BclI GG genotype, CAPS scores and basal cortisol levels were negatively correlated...
- Value of free cortisol measurement in systemic infectionD J Torpy
Endocrine and Metabolic Unit, Royal Adelaide Hospital, North Terrace, Adelaide SA Australia
Horm Metab Res 39:439-44. 2007..Studies directed at determining if free cortisol is a better guide than total cortisol to the need for hydrocortisone supplementation may be of value...
- Corticosteroid-binding globulin gene polymorphisms: clinical implications and links to idiopathic chronic fatigue disordersD J Torpy
Endocrine and Metabolic Unit, and the Hanson Institute, Royal Adelaide Hospital, Adelaide, South Australia, Australia
Clin Endocrinol (Oxf) 67:161-7. 2007..A mechanism for the effect of CBG mutations on fatigue is not readily apparent because free cortisol levels are normal, although we speculate that CBG may have an effect on cortisol-brain transport...
- Association between chronic fatigue syndrome and the corticosteroid-binding globulin gene ALA SER224 polymorphismDavid J Torpy
University of Queensland Department of Medicine, Greenslopes Hospital, Brisbane, Queensland, Australia
Endocr Res 30:417-29. 2004..Homozygosity for the serine allele of the CBG gene may predispose to CFS, perhaps due to an effect on hypothalamic-pituitary-adrenal axis function related to altered CBG-cortisol transport function or immune-cortisol interactions...
- Early rise in blood pressure following administration of adrenocorticotropic hormone-[1-24] in humansR V Jackson
Neuroendocrine Research Unit, Department of Medicine, University of Queensland, Greenslopes Private Hospital, Brisbane, Queensland 4120, Australia
Clin Exp Pharmacol Physiol 28:773-5. 2001..5. The cardiovascular consequences of therapeutic use of ACTH are well recognized. This results of the present study suggest that even diagnostic administration of ACTH, delivered over a few hours, may raise blood pressure...
- The insulin hypoglycemia test: hypoglycemic criteria and reproducibilityE J Nye
Neuroendocrine Research Unit, Department of Medicine, Brisbane, The University of Queensland, Queensland, Australia
J Neuroendocrinol 13:524-30. 2001..Overall, the cortisol response to hypoglycemia is more reproducible than the ACTH response but, in an individual subject, the difference in peak cortisol between two IHTs may exceed 100 nmol/l...
- Familial corticosteroid-binding globulin deficiency due to a novel null mutation: association with fatigue and relative hypotensionD J Torpy
Department of Medicine, University of Queensland, Greenslopes Private Hospital, Brisbane, Queensland 4120, Australia
J Clin Endocrinol Metab 86:3692-700. 2001..As idiopathic fatigue disorders are associated with relatively low plasma cortisol, abnormalities of corticosteroid-binding globulin may be pathogenic...
- Characteristics of plasma NOx levels in severe sepsis: high interindividual variability and correlation with illness severity, but lack of correlation with cortisol levelsJ T Ho
Hanson Institute, Endocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide, Australia
Clin Endocrinol (Oxf) 73:413-20. 2010..NOx levels were not suppressed reproducibly by hydrocortisone. High interindividual variability of NOx levels suggests that absolute NOx levels may not be a suitable target for individualized hydrocortisone therapy...
- Septic shock and sepsis: a comparison of total and free plasma cortisol levelsJ T Ho
Hanson Institute, The University of Adelaide, Adelaide, Australia
J Clin Endocrinol Metab 91:105-14. 2006....
- Moderate weight loss reduces renin and aldosterone but does not influence basal or stimulated pituitary-adrenal axis functionJ T Ho
Royal Adelaide Hospital, Adelaide, South Australia, Australia
Horm Metab Res 39:694-9. 2007..There may be a threshold effect of weight loss/energy restriction required to alter HPA axis function, or moderate weight loss may lead to a counterbalanced effect of stimulatory and inhibitory influences on HPA axis function...
- CBG Santiago: a novel CBG mutationD J Torpy
Endocrine and Metabolic Unit, Royal Adelaide Hospital, North Terrace, Adelaide 5000, South Australia, Australia
J Clin Endocrinol Metab 97:E151-5. 2012..Corticosteroid-binding globulin (CBG; SERPIN A6) gene mutations are rare; only four mutations have been described, often in association with fatigue and chronic pain, albeit with incomplete penetrance...
- Adrenocorticotropin stimulation tests in patients with hypothalamic-pituitary disease: low dose, standard high dose and 8-h infusion testsE J Nye
Department of Medicine, The University of Queensland, Brisbane, Australia
Clin Endocrinol (Oxf) 55:625-33. 2001..1 microg) or a high dose prolonged infusion does not greatly improve the sensitivity of ACTH [1-24] testing. Dynamic tests that provide a central stimulus remain preferable in the assessment of patients with suspected ACTH deficiency...
- Familial vasopressin-sensitive ACTH-independent macronodular adrenal hyperplasia (VPs-AIMAH): clinical studies of three kindredsLucia Gagliardi
Endocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
Clin Endocrinol (Oxf) 70:883-91. 2009....
- Corticosteroid-binding globulin: the clinical significance of altered levels and heritable mutationsLucia Gagliardi
School of Medicine, University of Adelaide, Adelaide, SA 5005, Australia
Mol Cell Endocrinol 316:24-34. 2010..Further studies may clarify the functions of CBG, and clinical observations may validate and/or extend the phenotypic features of various CBG mutations...
- Reduced maternal corticosteroid-binding globulin and cortisol levels in pre-eclampsia and gamete recipient pregnanciesJui T Ho
Hanson Institute, University of Adelaide, and Endocrine and Metabolic Unit of the Royal Adelaide Hospital, Adelaide, South Australia, Australia
Clin Endocrinol (Oxf) 66:869-77. 2007..To measure and contrast maternal cortisol and corticosteroid-binding globulin (CBG) levels in pregnancies with normal outcomes, pre-eclampsia, intrauterine growth restriction (IUGR) and in gamete recipients...
- Depletion of high-affinity corticosteroid-binding globulin corresponds to illness severity in sepsis and septic shock; clinical implicationsM A Nenke
Endocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide, SA, Australia
Clin Endocrinol (Oxf) 82:801-7. 2015..Our objective was to determine whether CBG cleavage alters circulating levels of haCBG and laCBG in vivo in proportion to sepsis severity...
- Pregnancy-associated corticosteroid-binding globulin: high resolution separation of glycan isoformsE Mitchell
The Hanson Institute, Frome Road, Adelaide, SA 5000, Australia
Horm Metab Res 36:357-9. 2004..The pregnancy-specific CBG previously defined probably represents a subset of the acidic and high molecular weight glycoforms we have resolved by two-dimensional electrophoresis and now describe as pregnancy-associated CBG...
- Screening for subclinical Cushing's syndrome in type 2 diabetes mellitus: low false-positive rates with nocturnal salivary cortisolL Gagliardi
School of Medicine, University of Adelaide, Adelaide, South Australia, Australia
Horm Metab Res 42:280-4. 2010..The NSC and DST should be compared directly in metabolic disorder patients; although our data suggest the patient group will need to be substantially larger to definitively determine the optimal screening test...
- Association of hypertension and hypokalemia with Cushing's syndrome caused by ectopic ACTH secretion: a series of 58 casesDavid J Torpy
University of Queensland, Department of Medicine, Greenslopes Hospital, Newdegate Street, Brisbane, Queensland 4120, Australia
Ann N Y Acad Sci 970:134-44. 2002....
- Plasma free cortisol fraction reflects levels of functioning corticosteroid-binding globulinJohn G Lewis
Steroid and Immunobiochemistry Laboratory, Canterbury Health Laboratories, PO Box 151 Christchurch, New Zealand
Clin Chim Acta 359:189-94. 2005..However little is known about the distribution of free cortisol in plasma where CBG is inactivated or in congenital CBG deficiency...