Leon J Worth

Summary

Affiliation: Royal Melbourne Hospital
Country: Australia

Publications

  1. doi request reprint Epidemiology of Clostridium difficile infections in Australia: enhanced surveillance to evaluate time trends and severity of illness in Victoria, 2010-2014
    L J Worth
    Victorian Healthcare Associated Infection Surveillance System Coordinating Centre, Victoria, Australia Department of Medicine, University of Melbourne, Victoria, Australia Electronic address
    J Hosp Infect 93:280-5. 2016
  2. doi request reprint Central line-associated bloodstream infections in Australian intensive care units: Time-trends in infection rates, etiology, and antimicrobial resistance using a comprehensive Victorian surveillance program, 2009-2013
    Leon J Worth
    Victorian Healthcare Associated Infection Surveillance System Coordinating Centre, Victoria, Australia Department of Medicine, University of Melbourne, Victoria, Australia Electronic address
    Am J Infect Control 43:848-52. 2015
  3. ncbi request reprint Staphylococcus aureus bloodstream infection in Australian hospitals: findings from a Victorian surveillance system
    Leon J Worth
    Victorian Healthcare Associated Infection Surveillance System Coordinating Centre, Melbourne, Vic, Australia
    Med J Aust 200:282-4. 2014
  4. doi request reprint Impact of revising the National Nosocomial Infection Surveillance System definition for catheter-related bloodstream infection in ICU: reproducibility of the National Healthcare Safety Network case definition in an Australian cohort of infection control p
    Leon J Worth
    Victorian Hospital Acquired Infection Surveillance System VICNISS Coordinating Centre, North Melbourne, Victoria, Australia
    Am J Infect Control 37:643-8. 2009
  5. doi request reprint Validation of statewide surveillance system data on central line-associated bloodstream infection in intensive care units in Australia
    Emma S McBryde
    Victorian Infectious Diseases Service, Centre for Clinical Research Excellence in Infectious Diseases, Royal Melbourne Hospital, Melbourne, Victoria, Australia
    Infect Control Hosp Epidemiol 30:1045-9. 2009
  6. doi request reprint Surveillance for catheter-associated bloodstream infection in hematology units: quantifying the characteristics of a practical case definition
    Leon J Worth
    Department of Infectious Diseases, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Infect Control Hosp Epidemiol 29:358-60. 2008
  7. doi request reprint Infective and thrombotic complications of central venous catheters in patients with hematological malignancy: prospective evaluation of nontunneled devices
    Leon J Worth
    Centre for Clinical Research Excellence in Infectious Disease, Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Victoria, 3052, Australia
    Support Care Cancer 17:811-8. 2009
  8. doi request reprint Risks, severity and timing of infections in patients with multiple myeloma: a longitudinal cohort study in the era of immunomodulatory drug therapy
    Benjamin W Teh
    Department of Infectious Diseases, Peter MacCallum Cancer Centre, East Melbourne, Vic, Australia
    Br J Haematol 171:100-8. 2015
  9. doi request reprint Bloodstream infections in haematology: risks and new challenges for prevention
    Leon J Worth
    Department of Infectious Diseases, Peter MacCallum Cancer Centre, Victoria, Australia
    Blood Rev 23:113-22. 2009
  10. ncbi request reprint The epidemiology of Clostridium difficile infection in patients with cancer
    Andrew I T Hebbard
    a Department of Infectious Diseases and Infection Prevention, Peter MacCallum Cancer Centre, Melbourne, Australia
    Expert Rev Anti Infect Ther 14:1077-1085. 2016

Collaborators

Detail Information

Publications24

  1. doi request reprint Epidemiology of Clostridium difficile infections in Australia: enhanced surveillance to evaluate time trends and severity of illness in Victoria, 2010-2014
    L J Worth
    Victorian Healthcare Associated Infection Surveillance System Coordinating Centre, Victoria, Australia Department of Medicine, University of Melbourne, Victoria, Australia Electronic address
    J Hosp Infect 93:280-5. 2016
    ..With epidemic strains of Clostridium difficile posing a substantial healthcare burden internationally, there is a need for longitudinal evaluation of Clostridium difficile infection (CDI) events in Australia...
  2. doi request reprint Central line-associated bloodstream infections in Australian intensive care units: Time-trends in infection rates, etiology, and antimicrobial resistance using a comprehensive Victorian surveillance program, 2009-2013
    Leon J Worth
    Victorian Healthcare Associated Infection Surveillance System Coordinating Centre, Victoria, Australia Department of Medicine, University of Melbourne, Victoria, Australia Electronic address
    Am J Infect Control 43:848-52. 2015
    ..We sought to describe time-trends in CLABSI rates, infections by ICU peer-groups, etiology, and antimicrobial susceptibility of pathogens in a large cohort of Australian ICUs for the period January 1, 2009-December 31, 2013...
  3. ncbi request reprint Staphylococcus aureus bloodstream infection in Australian hospitals: findings from a Victorian surveillance system
    Leon J Worth
    Victorian Healthcare Associated Infection Surveillance System Coordinating Centre, Melbourne, Vic, Australia
    Med J Aust 200:282-4. 2014
    ..To determine the burden of disease and trend over time for rates of Staphylococcus aureus bloodstream (SAB) infections in Victorian health care services...
  4. doi request reprint Impact of revising the National Nosocomial Infection Surveillance System definition for catheter-related bloodstream infection in ICU: reproducibility of the National Healthcare Safety Network case definition in an Australian cohort of infection control p
    Leon J Worth
    Victorian Hospital Acquired Infection Surveillance System VICNISS Coordinating Centre, North Melbourne, Victoria, Australia
    Am J Infect Control 37:643-8. 2009
    ..Effective and comparable surveillance for central venous catheter-related bloodstream infections (CLABSIs) in the intensive care unit requires a reproducible case definition that can be readily applied by infection control professionals...
  5. doi request reprint Validation of statewide surveillance system data on central line-associated bloodstream infection in intensive care units in Australia
    Emma S McBryde
    Victorian Infectious Diseases Service, Centre for Clinical Research Excellence in Infectious Diseases, Royal Melbourne Hospital, Melbourne, Victoria, Australia
    Infect Control Hosp Epidemiol 30:1045-9. 2009
    ....
  6. doi request reprint Surveillance for catheter-associated bloodstream infection in hematology units: quantifying the characteristics of a practical case definition
    Leon J Worth
    Department of Infectious Diseases, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Infect Control Hosp Epidemiol 29:358-60. 2008
    ..0% sensitivity and 94.3% specificity. This case definition provides a practical method for effectively excluding CVC-associated bloodstream infection...
  7. doi request reprint Infective and thrombotic complications of central venous catheters in patients with hematological malignancy: prospective evaluation of nontunneled devices
    Leon J Worth
    Centre for Clinical Research Excellence in Infectious Disease, Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Victoria, 3052, Australia
    Support Care Cancer 17:811-8. 2009
    ..The objectives of this study were to determine the natural history and rate of CVC-related complications and risk factors for CR-BSI and to compare device-specific complications in a hematology population...
  8. doi request reprint Risks, severity and timing of infections in patients with multiple myeloma: a longitudinal cohort study in the era of immunomodulatory drug therapy
    Benjamin W Teh
    Department of Infectious Diseases, Peter MacCallum Cancer Centre, East Melbourne, Vic, Australia
    Br J Haematol 171:100-8. 2015
    ..New approaches to prevention and treatment of infection should focus upon identified periods of risk and treatment-related risk factors. ..
  9. doi request reprint Bloodstream infections in haematology: risks and new challenges for prevention
    Leon J Worth
    Department of Infectious Diseases, Peter MacCallum Cancer Centre, Victoria, Australia
    Blood Rev 23:113-22. 2009
    ..To reduce the rate and impact of bloodstream infections multifaceted and customised strategies are required within individual haematology units...
  10. ncbi request reprint The epidemiology of Clostridium difficile infection in patients with cancer
    Andrew I T Hebbard
    a Department of Infectious Diseases and Infection Prevention, Peter MacCallum Cancer Centre, Melbourne, Australia
    Expert Rev Anti Infect Ther 14:1077-1085. 2016
    ..difficile colonisation in cancer patients and the potential impact of dedicated antimicrobial stewardship programs in reducing the burden of CDI in cancer units...
  11. doi request reprint Impact of vancomycin surgical antibiotic prophylaxis on the development of methicillin-sensitive staphylococcus aureus surgical site infections: report from Australian Surveillance Data (VICNISS)
    Ann L Bull
    Victorian Healthcare Associated Surveillance System VICNISS Coordinating Centre, North Melbourne, Australia
    Ann Surg 256:1089-92. 2012
    ..To compare risks for developing surgical site infection (SSI) due to Staphylococcus aureus when vancomycin is used for antibiotic prophylaxis with risks when a β-lactam antibiotic is administered for prophylaxis...
  12. doi request reprint Epidemiology of bloodstream infections in patients with myeloma receiving current era therapy
    Benjamin W Teh
    Department of Infectious Diseases, Peter MacCallum Cancer Centre, Parkville, Victoria, Australia
    Eur J Haematol . 2016
    ..The objective of this study was to define the epidemiology of BSI with current era MM treatment regimens, including immunomodulatory drugs, proteasome inhibitors and autologous haematopoietic stem cell transplantation (ASCT)...
  13. doi request reprint Prevention of viral infections in patients with multiple myeloma: the role of antiviral prophylaxis and immunization
    Benjamin W Teh
    a 1 Department of Infectious Diseases, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Expert Rev Anti Infect Ther 13:1325-36. 2015
    ..Recommended prevention strategies are summarized using a risk-stratified approach. Further studies evaluating preventative measures for newly identified risk periods are required. ..
  14. doi request reprint Risks and burden of viral respiratory tract infections in patients with multiple myeloma in the era of immunomodulatory drugs and bortezomib: experience at an Australian Cancer Hospital
    Benjamin W Teh
    Department of Infectious Diseases, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Support Care Cancer 23:1901-6. 2015
    ..The epidemiology, risk factors and outcomes of viral respiratory tract infections (vRTI) are not well described in patients with multiple myeloma managed with novel agents, the current standard of care...
  15. doi request reprint Diminishing surgical site infections in Australia: time trends in infection rates, pathogens and antimicrobial resistance using a comprehensive Victorian surveillance program, 2002-2013
    Leon J Worth
    Victorian Healthcare Associated Infection Surveillance System VICNISS Coordinating Centre, Melbourne, Victoria, 3000, Australia
    Infect Control Hosp Epidemiol 36:409-16. 2015
    ..To evaluate time trends in surgical site infection (SSI) rates and SSI pathogens in Australia...
  16. ncbi request reprint Catheter-related bloodstream infections in hematology: time for standardized surveillance?
    Leon J Worth
    Centre for Clinical Research Excellence in Infectious Disease, Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Cancer 109:1215-26. 2007
    ..Only when these issues are addressed can a surveillance strategy reliably assess trends and compare data, leading to improved patient outcomes and a reduction in healthcare expenditure for patients with hematologic malignancy...
  17. doi request reprint Late-onset Pneumocystis jirovecii pneumonia post-fludarabine, cyclophosphamide and rituximab: implications for prophylaxis
    Gabrielle M Haeusler
    Department of Infectious Diseases and Infection Control, Peter MacCallum Cancer Centre, East Melbourne, Vic, Australia
    Eur J Haematol 91:157-63. 2013
    ..The objective of this study was to review the incidence of PJP during and post-FCR in the era of highly sensitive molecular diagnostics and (18) F-fluorodeoxyglucose (FDG) positron emission tomography (PET)-computerised tomography (CT)...
  18. doi request reprint Use of FDG PET/CT for investigation of febrile neutropenia: evaluation in high-risk cancer patients
    Stephen D Guy
    Department of Infectious Diseases, Western Health, Private Bag, Footscray, Victoria, Australia 3011
    Eur J Nucl Med Mol Imaging 39:1348-55. 2012
    ..The aim of this study was to prospectively evaluate the clinical utility of FDG PET/CT in patients with cancer and severe neutropenia and five or more days of persistent fever despite antibiotic therapy...
  19. doi request reprint Prophylactic intravenous immunoglobulin during autologous haemopoietic stem cell transplantation for multiple myeloma is not associated with reduced infectious complications
    Piers Blombery
    Division of Cancer Medicine, Peter MacCallum Cancer Centre, East Melbourne, Melbourne, Victoria, Australia
    Ann Hematol 90:1167-72. 2011
    ..4 g/kg) to reduce infectious complications in a large cohort of patients with myeloma undergoing ASCT. In the absence of data supporting efficacy in this context, there appears to be no benefit in the routine use of IVIG for this purpose...
  20. pmc Improving Antimicrobial Stewardship by Antibiotic Allergy Delabeling: Evaluation of Knowledge, Attitude, and Practices Throughout the Emerging Infections Network
    Jason A Trubiano
    Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia Department of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia Department of Medicine, University of Melbourne, Parkville, Victoria, Australia
    Open Forum Infect Dis 3:ofw153. 2016
    ..In this study, we discuss current antibiotic allergy knowledge gaps and the development of AAT practices within antimicrobial stewardship programs, which will potentially improve antimicrobial prescribing...
  21. doi request reprint Is it possible to achieve a target of zero central line associated bloodstream infections?
    Leon J Worth
    Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
    Curr Opin Infect Dis 25:650-7. 2012
    ..Although a zero target is proposed, the feasibility has not been evaluated. The objective of this review is to identify factors contributing to CLABSI and determine whether current evidence supports attainment of a zero infection rate...
  22. doi request reprint Stenotrophomonas maltophilia: emerging disease patterns and challenges for treatment
    Iain J Abbott
    Department of Infectious Diseases, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Expert Rev Anti Infect Ther 9:471-88. 2011
    ..Finally, measures to prevent transmission of S. maltophilia within healthcare facilities are reported, especially in at-risk patient populations...
  23. doi request reprint Infections in Australian Aged-Care Facilities: Evaluating the Impact of Revised McGeer Criteria for Surveillance of Urinary Tract Infections
    Noleen J Bennett
    1Victorian Healthcare Associated Infection Surveillance System VICNISS Coordinating Centre, Melbourne, Victoria, Australia
    Infect Control Hosp Epidemiol 37:610-2. 2016
    ..To estimate the infection burden in these facilities where microbiologic testing is not routine, modified surveillance criteria for UTIs are necessary...
  24. doi request reprint Can mortality of cancer patients with fever and neutropenia be improved?
    Karin A Thursky
    aDepartment of Infectious Diseases and Infection Prevention, Peter MacCallum Cancer Centre bVictorian Infectious Diseases Service, Royal Melbourne Hospital at the Doherty Institute cDepartment of Medicine, University of Melbourne, Victoria, Australia
    Curr Opin Infect Dis 28:505-13. 2015
    ..The objective of this review is to summarize factors associated with reduced mortality in patients with neutropenic fever, highlighting components of clinical care with potential for inclusion in quality improvement programs...