Joseph J Smolich

Summary

Affiliation: Royal Children's Hospital
Country: Australia

Publications

  1. doi request reprint Major contribution of central pulmonary reservoir discharge to increased pulmonary arterial diastolic blood flow after birth in near-term lambs
    Joseph J Smolich
    Heart Research, Clinical Sciences, Murdoch Childrens Research Institute and Department of Paediatrics, University of Melbourne, Melbourne, Australia
    Am J Physiol Regul Integr Comp Physiol 311:R702-R709. 2016
  2. doi request reprint Retrograde lower body arterial reservoir discharge underlies rapid reversal of ductus arteriosus shunting after early cord clamping at birth in preterm lambs
    Joseph J Smolich
    Heart Research Group, Murdoch Childrens Research Institute, Victoria, Australia and Department of Paediatrics, University of Melbourne, Melbourne, Australia
    J Appl Physiol (1985) 120:399-407. 2016
  3. doi request reprint Onset of asphyxial state in nonrespiring interval between cord clamping and ventilation increases hemodynamic lability of birth transition in preterm lambs
    Joseph J Smolich
    Heart Research Group, Murdoch Childrens Research Institute, Parkville, Australia Department of Paediatrics, University of Melbourne, Parkville, Australia
    J Appl Physiol (1985) 118:675-83. 2015
  4. doi request reprint Increased right ventricular output and central pulmonary reservoir function support rise in pulmonary blood flow during adenosine infusion in the ovine fetus
    Joseph J Smolich
    Heart Research Group, Murdoch Childrens Research Institute, Flemington Road, Parkville, Victoria 3052, Australia
    Am J Physiol Regul Integr Comp Physiol 302:R1450-7. 2012
  5. doi request reprint Enhanced central and conduit pulmonary arterial reservoir function offsets reduced ductal systolic outflow during constriction of the fetal ductus arteriosus
    Joseph J Smolich
    Heart Research Group, Murdoch Childrens Research Institute, Melbourne, Australia
    Am J Physiol Regul Integr Comp Physiol 302:R175-83. 2012
  6. doi request reprint Pulmonary trunk, ductus arteriosus, and pulmonary arterial phasic blood flow interactions during systole and diastole in the fetus
    Joseph J Smolich
    Heart Research Group, Murdoch Children s Research Institute, Melbourne, Australia
    J Appl Physiol (1985) 110:1362-73. 2011
  7. doi request reprint Wave intensity analysis of right ventricular and pulmonary vascular contributions to higher pulmonary than aortic blood pressure in fetal lambs
    Joseph J Smolich
    Heart Research Group, Murdoch Children s Research Institute, Royal Children s Hospital, Melbourne, Victoria, Australia
    Am J Physiol Heart Circ Physiol 299:H890-7. 2010
  8. doi request reprint Ductus arteriosus wave intensity analysis in fetal lambs: midsystolic ductal flow augmentation is due to antegrade pulmonary arterial wave transmission
    Joseph J Smolich
    Department of Paediatrics, Heart Research Group, Murdoch Children s Research Institute, University of Melbourne, Melbourne, Australia
    Am J Physiol Regul Integr Comp Physiol 297:R1171-9. 2009
  9. doi request reprint Simultaneous pulmonary trunk and pulmonary arterial wave intensity analysis in fetal lambs: evidence for cyclical, midsystolic pulmonary vasoconstriction
    Joseph J Smolich
    Australia and New Zealand Children s Heart Research Centre, Murdoch Children s Research Institute, Melbourne, Australia
    Am J Physiol Regul Integr Comp Physiol 294:R1554-62. 2008
  10. doi request reprint Dynamic characterization and hemodynamic effects of pulmonary waves in fetal lambs using cardiac extrasystoles and beat-by-beat wave intensity analysis
    Joseph J Smolich
    Heart Research Group, Murdoch Children s Research Institute, Melbourne, Australia
    Am J Physiol Regul Integr Comp Physiol 297:R428-36. 2009

Collaborators

Detail Information

Publications32

  1. doi request reprint Major contribution of central pulmonary reservoir discharge to increased pulmonary arterial diastolic blood flow after birth in near-term lambs
    Joseph J Smolich
    Heart Research, Clinical Sciences, Murdoch Childrens Research Institute and Department of Paediatrics, University of Melbourne, Melbourne, Australia
    Am J Physiol Regul Integr Comp Physiol 311:R702-R709. 2016
    ..These findings suggest that enhanced diastolic central pulmonary reservoir discharge plays a major role in supporting an increased pulmonary perfusion after birth...
  2. doi request reprint Retrograde lower body arterial reservoir discharge underlies rapid reversal of ductus arteriosus shunting after early cord clamping at birth in preterm lambs
    Joseph J Smolich
    Heart Research Group, Murdoch Childrens Research Institute, Victoria, Australia and Department of Paediatrics, University of Melbourne, Melbourne, Australia
    J Appl Physiol (1985) 120:399-407. 2016
    ..These results suggest that retrograde lower body arterial reservoir discharge plays a key role in rapid reversal and a systolic-to-diastolic shift of ductal shunting after cord clamping and early ventilation at birth. ..
  3. doi request reprint Onset of asphyxial state in nonrespiring interval between cord clamping and ventilation increases hemodynamic lability of birth transition in preterm lambs
    Joseph J Smolich
    Heart Research Group, Murdoch Childrens Research Institute, Parkville, Australia Department of Paediatrics, University of Melbourne, Parkville, Australia
    J Appl Physiol (1985) 118:675-83. 2015
    ..5 min) cord clamp-to-ventilation interval. ..
  4. doi request reprint Increased right ventricular output and central pulmonary reservoir function support rise in pulmonary blood flow during adenosine infusion in the ovine fetus
    Joseph J Smolich
    Heart Research Group, Murdoch Childrens Research Institute, Flemington Road, Parkville, Victoria 3052, Australia
    Am J Physiol Regul Integr Comp Physiol 302:R1450-7. 2012
    ....
  5. doi request reprint Enhanced central and conduit pulmonary arterial reservoir function offsets reduced ductal systolic outflow during constriction of the fetal ductus arteriosus
    Joseph J Smolich
    Heart Research Group, Murdoch Childrens Research Institute, Melbourne, Australia
    Am J Physiol Regul Integr Comp Physiol 302:R175-83. 2012
    ....
  6. doi request reprint Pulmonary trunk, ductus arteriosus, and pulmonary arterial phasic blood flow interactions during systole and diastole in the fetus
    Joseph J Smolich
    Heart Research Group, Murdoch Children s Research Institute, Melbourne, Australia
    J Appl Physiol (1985) 110:1362-73. 2011
    ....
  7. doi request reprint Wave intensity analysis of right ventricular and pulmonary vascular contributions to higher pulmonary than aortic blood pressure in fetal lambs
    Joseph J Smolich
    Heart Research Group, Murdoch Children s Research Institute, Royal Children s Hospital, Melbourne, Victoria, Australia
    Am J Physiol Heart Circ Physiol 299:H890-7. 2010
    ....
  8. doi request reprint Ductus arteriosus wave intensity analysis in fetal lambs: midsystolic ductal flow augmentation is due to antegrade pulmonary arterial wave transmission
    Joseph J Smolich
    Department of Paediatrics, Heart Research Group, Murdoch Children s Research Institute, University of Melbourne, Melbourne, Australia
    Am J Physiol Regul Integr Comp Physiol 297:R1171-9. 2009
    ..These results suggest that the fetal PA BCW(ms) undergoes retrograde transmission into the PT as a BCW(ms), but antegrade transmission into the DA as a FCW(ms) that augments midsystolic DA flow...
  9. doi request reprint Simultaneous pulmonary trunk and pulmonary arterial wave intensity analysis in fetal lambs: evidence for cyclical, midsystolic pulmonary vasoconstriction
    Joseph J Smolich
    Australia and New Zealand Children s Heart Research Centre, Murdoch Children s Research Institute, Melbourne, Australia
    Am J Physiol Regul Integr Comp Physiol 294:R1554-62. 2008
    ....
  10. doi request reprint Dynamic characterization and hemodynamic effects of pulmonary waves in fetal lambs using cardiac extrasystoles and beat-by-beat wave intensity analysis
    Joseph J Smolich
    Heart Research Group, Murdoch Children s Research Institute, Melbourne, Australia
    Am J Physiol Regul Integr Comp Physiol 297:R428-36. 2009
    ..77) with slopes of 0.23-0.64 (P < 0.001). These results indicate that the fetal PA BCW(ms) contributes to beat-to-beat regulation of not only PA but also PT hemodynamics...
  11. ncbi request reprint Aortic wave intensity analysis of ventricular-vascular interaction during incremental dobutamine infusion in adult sheep
    Daniel J Penny
    Department of Cardiology, Royal Children s Hospital, Flemington Road, Parkville, Victoria 3052, Australia
    Am J Physiol Heart Circ Physiol 294:H481-9. 2008
    ..001) that produced earlier and enhanced aortic blood deceleration. These findings provide new insights into the ventricular-vascular interaction of dobutamine...
  12. doi request reprint Accurate automatic detection of end-diastole from left ventricular pressure using peak curvature
    Jonathan P Mynard
    Heart Research Group, Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Victoria 3052, Australia
    IEEE Trans Biomed Eng 55:2651-7. 2008
    ..2) ms. By contrast, ED was often detected early with dP/dt(0) and dP/dt(100) , and late with d(2)P/dt(2)(p) and ECG(R). These results indicate that the peak curvature algorithm using LVP provides accurate and reliable detection of ED...
  13. doi request reprint Enhanced ventricular pump function and decreased reservoir backflow sustain rise in pulmonary blood flow after reduction of lung liquid volume in fetal lambs
    Joseph J Smolich
    Heart Research Group, Murdoch Childrens Research Institute, Melbourne, Australia
    Am J Physiol Regul Integr Comp Physiol 306:R273-80. 2014
    ....
  14. doi request reprint Robustness of the P-U and lnD-U loop wave speed estimation methods: effects of the diastolic pressure decay and vessel wall non-linearities
    Jonathan P Mynard
    Departmentof Paediatrics, Heart Research Group, Murdoch Childrens Research Institute, University of Melbourne, Parkville, Vic, Australia
    Conf Proc IEEE Eng Med Biol Soc 2011:6446-9. 2011
    ....
  15. doi request reprint Non-linear separation of pressure, velocity and wave intensity into forward and backward components
    Jonathan P Mynard
    Heart Research Group, Murdoch Childrens Research Institute, Department of Paediatrics, University of Melbourne, Melbourne, Australia
    Med Biol Eng Comput 50:641-8. 2012
    ..Consideration of linear separation errors may therefore be important in some physiological settings...
  16. doi request reprint The reservoir-wave paradigm introduces error into arterial wave analysis: a computer modelling and in-vivo study
    Jonathan P Mynard
    Heart Research Group, Murdoch Childrens Research Institute, Melbourne, Victoria, Australia
    J Hypertens 30:734-43. 2012
    ..This new approach has led to controversial conclusions about the nature and significance of arterial wave reflection. Our aim was to assess whether WI or WI(RW) more accurately represent wave phenomena...
  17. doi request reprint Urotensin-II contributes to pulmonary vasoconstriction in a perinatal model of persistent pulmonary hypertension of the newborn secondary to meconium aspiration syndrome
    Catherine M Simpson
    Heart Research Group, Murdoch Children s Research Institute, Parkville, Victoria 3052, Australia
    Pediatr Res 67:150-7. 2010
    ..001). These findings suggest that U-II normally acts as a pulmonary vasodilator after birth, but in the presence of MAS, it assumes a vasoconstrictor role. U-II receptor blockade also improves pulmonary hemodynamics in this model...
  18. doi request reprint Wave intensity amplification and attenuation in non-linear flow: implications for the calculation of local reflection coefficients
    Jonathan Mynard
    Heart Research Group, Murdoch Children s Heart Research Institute, Flemington Road, Parkville, Victoria 3052, Australia
    J Biomech 41:3314-21. 2008
    ..Conversely, R(Delta)(P) is unaffected by the degree of non-linearity and is thus more accurate than R(PI) and R(CI)...
  19. doi request reprint Scalability and in vivo validation of a multiscale numerical model of the left coronary circulation
    Jonathan P Mynard
    Heart Research Group, Murdoch Childrens Research Institute, Parkville, Victoria, Australia
    Am J Physiol Heart Circ Physiol 306:H517-28. 2014
    ..This multiscale model is likely to be useful for investigating wave phenomena and phasic aspects of coronary flow in adults and during development. ..
  20. ncbi request reprint Divergent effects of NO synthase inhibition on systemic and myocardial O2 delivery and consumption during dobutamine infusion in sheep
    Daniel J Penny
    Department of Cardiology, Royal Children s Hospital, Parkville, 3052, Victoria, Australia
    Pflugers Arch 443:601-8. 2002
    ..These results suggest that NO modulated the baseline balance between systemic, but not myocardial, DO2 and. However, NO did not additionally alter dobutamine-related changes in either systemic or myocardial DO2 and balance...
  21. ncbi request reprint A semi-automatic feature detection algorithm for hemodynamic signals using curvature-based feature extraction
    Jonathan P Mynard
    Heart Research Group, Murdoch Children s Research Institute, Melbourne, Australia
    Conf Proc IEEE Eng Med Biol Soc 2007:1691-4. 2007
    ..A particular feature is selected manually in the first beat and then detected automatically in subsequent beats...
  22. doi request reprint Impact of levosimendan on brain injury patterns in a lamb model of infant cardiopulmonary bypass
    Poongundran Namachivayam
    1 Pediatric Intensive Care Unit, The Royal Children s Hospital, Melbourne, Australia 2 Murdoch Children s Research Institute, Melbourne, Australia
    Pediatr Res 76:64-71. 2014
    ..The effects of levosimendan (Levo) on injury patterns in the immature brain following cardiopulmonary bypass (CPB) are unknown...
  23. doi request reprint Influence of anatomical dominance and hypertension on coronary conduit arterial and microcirculatory flow patterns: a multiscale modeling study
    Jonathan P Mynard
    Heart Research, Clinical Sciences, Murdoch Childrens Research Institute, Parkville, Victoria, Australia and Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia
    Am J Physiol Heart Circ Physiol 311:H11-23. 2016
    ..These findings highlight the importance of interactions between coronary arterial dominance and hypertension in modulating coronary hemodynamics. ..
  24. doi request reprint Novel wave power analysis linking pressure-flow waves, wave potential, and the forward and backward components of hydraulic power
    Jonathan P Mynard
    Heart Research, Clinical Sciences, Murdoch Childrens Research Institute, Parkville, Victoria, Australia and Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia
    Am J Physiol Heart Circ Physiol 310:H1026-38. 2016
    ..The proposed "wave power analysis," encompassing wave power, wave potential, and wave separation of hydraulic power provides a potent time-domain approach for analyzing hemodynamics. ..
  25. doi request reprint Elevated Blood Pressure with Reduced Left Ventricular and Aortic Dimensions in Adolescents Born Extremely Preterm
    Remi R Kowalski
    Heart Research, Murdoch Children s Research Institute, Parkville, Victoria, Australia Department of Cardiology, Royal Children s Hospital, Parkville, Victoria, Australia Department of Pediatrics, University of Melbourne, Parkville, Victoria, Australia Electronic address
    J Pediatr 172:75-80.e2. 2016
    ..To evaluate the long-term cardiovascular effects of extremely preterm birth in a cohort of adolescents followed prospectively, who were largely free from intrauterine growth restriction...
  26. ncbi request reprint Beyond the aorta: partial transmission of reflected waves from aortic coarctation into supra-aortic branches modulates cerebral hemodynamics and left ventricular load
    Jonathan P Mynard
    Heart Research, Clinical Sciences, Murdoch Childrens Research Institute, 50 Flemington Road, Parkville, Vic, 3052, Australia
    Biomech Model Mechanobiol . 2016
    ..These findings suggest that wave transmission into supra-aortic branches has an important impact on both cerebral hemodynamics and LV load in aortic coarctation...
  27. doi request reprint Safety of Intracoronary Human Cord Blood Stem Cells in a Lamb Model of Infant Cardiopulmonary Bypass
    Christian P Brizard
    Heart Research, Murdoch Childrens Research Institute, Melbourne, Victoria, Australia Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia Department of Cardiac Surgery, The Royal Children s Hospital, Melbourne, Victoria, Australia
    Ann Thorac Surg 100:1021-9. 2015
    ..We evaluated the acute safety, functional effects, and fate of human CBMNCs in a novel model of coronary vasculature delivery in a lamb model of infant CPB...
  28. doi request reprint One-dimensional haemodynamic modeling and wave dynamics in the entire adult circulation
    Jonathan P Mynard
    Heart Research, Clinical Sciences, Murdoch Childrens Research Institute, 50 Flemington Rd, Parkville, Vic, 3052, Australia
    Ann Biomed Eng 43:1443-60. 2015
    ..The model will be an important resource for studying the mechanics underlying pressure/flow waveforms throughout the circulation, along with global interactions between the heart and vessels under normal and pathological conditions. ..
  29. doi request reprint Wave potential and the one-dimensional windkessel as a wave-based paradigm of diastolic arterial hemodynamics
    Jonathan P Mynard
    Heart Research, Clinical Sciences, Murdoch Childrens Research Institute, Parkville, Victoria, Australia and Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia
    Am J Physiol Heart Circ Physiol 307:H307-18. 2014
    ..The combination of wave and wave potential concepts leads to a comprehensive one-dimensional (i.e., wave-based) explanation of arterial hemodynamics, including the diastolic pressure decay...
  30. pmc Tissue-specific splicing of an Ndufs6 gene-trap insertion generates a mitochondrial complex I deficiency-specific cardiomyopathy
    Bi xia Ke
    Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, VIC 3052, Australia
    Proc Natl Acad Sci U S A 109:6165-70. 2012
    ..This model of CI deficiency will facilitate studies of pathogenesis, modifier genes, and testing of therapeutic approaches...
  31. ncbi request reprint Predictors of surgery after percutaneous mitral valvuloplasty
    Adam D Zimmet
    Cardiothoracic Surgery Unit, Monash Medical Center, Clayton, Victoria, Australia
    Ann Thorac Surg 82:828-33. 2006
    ..In general, the procedure is well-tolerated with a high success rate. However, relatively little is known about the predictors of surgical intervention after PMV...
  32. ncbi request reprint Lack of the antioxidant glutathione peroxidase-1 does not increase atherosclerosis in C57BL/J6 mice fed a high-fat diet
    Judy B de Haan
    Oxidative Stress Group, Baker Heart Research Institute, Melbourne, Australia
    J Lipid Res 47:1157-67. 2006
    ..In summary, a specific deficiency in Gpx1 was not accompanied by an increase in markers of oxidative damage or increased atherosclerosis in a murine model of HFD-induced atherogenesis...