Richard Saffery

Summary

Affiliation: Royal Children's Hospital
Country: Australia

Publications

  1. pmc Time for a standardized system of reporting sites of genomic methylation
    Richard Saffery
    Cancer and Disease Epigenetics, Murdoch Childrens Research Institute, Royal Children s Hospital, Flemington Road, Parkville, Australia
    Genome Biol 16:85. 2015
  2. pmc Stability of gene expression and epigenetic profiles highlights the utility of patient-derived paediatric acute lymphoblastic leukaemia xenografts for investigating molecular mechanisms of drug resistance
    Nicholas C Wong
    Children s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW, PO Box 81, Sydney, NSW 2052, Australia
    BMC Genomics 15:416. 2014
  3. pmc Optimized DNA extraction from neonatal dried blood spots: application in methylome profiling
    Akram Ghantous
    Epigenetics Group, International Agency for Research on Cancer IARC, 150 rue Albert Thomas, 69008 Lyon, France
    BMC Biotechnol 14:60. 2014
  4. pmc Evidence for transcript-specific epigenetic regulation of glucocorticoid-stimulated skeletal muscle 11β-hydroxysteroid dehydrogenase-1 activity in type 2 diabetes
    Warrick J Inder
    Department of Endocrinology and Diabetes, St Vincent s Hospital, 41 Victoria Parade, Fitzroy, VIC 3065, Australia
    Clin Epigenetics 4:24. 2012
  5. doi request reprint A convergent model for placental dysfunction encompassing combined sub-optimal one-carbon donor and vitamin D bioavailability
    Richard Saffery
    Department of Paediatrics, Developmental Epigenetics, Murdoch Childrens Research Institute, University of Melbourne, Parkville, Victoria 3052, Australia
    Med Hypotheses 73:1023-8. 2009
  6. pmc Wide-ranging DNA methylation differences of primary trophoblast cell populations and derived cell lines: implications and opportunities for understanding trophoblast function
    Boris Novakovic
    Cancer, Disease and Developmental Epigenetics Group, Murdoch Children s Research Institute, Royal Children s Hospital Melbourne, Parkville, Australia
    Mol Hum Reprod 17:344-53. 2011
  7. pmc Neonatal DNA methylation profile in human twins is specified by a complex interplay between intrauterine environmental and genetic factors, subject to tissue-specific influence
    Lavinia Gordon
    Bioinformatics Unit, Murdoch Childrens Research Institute, Parkville, Victoria 3052, Australia
    Genome Res 22:1395-406. 2012
  8. pmc DNA methylation-mediated down-regulation of DNA methyltransferase-1 (DNMT1) is coincident with, but not essential for, global hypomethylation in human placenta
    Boris Novakovic
    Developmental Epigenetics, Murdoch Children s Research Institute, Royal Children s Hospital, Parkville, Victoria 3052, Australia
    J Biol Chem 285:9583-93. 2010
  9. pmc Evidence for widespread changes in promoter methylation profile in human placenta in response to increasing gestational age and environmental/stochastic factors
    Boris Novakovic
    Cancer, Disease and Developmental Epigenetics, Murdoch Childrens Research Institute, Royal Children s Hospital and Department of Paediatrics, University of Melbourne, Parkville, Victoria 3052, Australia
    BMC Genomics 12:529. 2011
  10. pmc DNA methylation at IL32 in juvenile idiopathic arthritis
    Braydon Meyer
    Genes, Environment and Complex Disease, Murdoch Childrens Research Institute, Parkville, Victoria, Australia
    Sci Rep 5:11063. 2015

Detail Information

Publications53

  1. pmc Time for a standardized system of reporting sites of genomic methylation
    Richard Saffery
    Cancer and Disease Epigenetics, Murdoch Childrens Research Institute, Royal Children s Hospital, Flemington Road, Parkville, Australia
    Genome Biol 16:85. 2015
    ..The authors argue that the lack of a widely used, systematic way to report sites of DNA methylation is a often a barrier to reproducibility and therefore holds back research. ..
  2. pmc Stability of gene expression and epigenetic profiles highlights the utility of patient-derived paediatric acute lymphoblastic leukaemia xenografts for investigating molecular mechanisms of drug resistance
    Nicholas C Wong
    Children s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW, PO Box 81, Sydney, NSW 2052, Australia
    BMC Genomics 15:416. 2014
    ....
  3. pmc Optimized DNA extraction from neonatal dried blood spots: application in methylome profiling
    Akram Ghantous
    Epigenetics Group, International Agency for Research on Cancer IARC, 150 rue Albert Thomas, 69008 Lyon, France
    BMC Biotechnol 14:60. 2014
    ..Thus it is important to develop methodologies that maximize both the yield and quality of DNA from DBS for downstream analyses...
  4. pmc Evidence for transcript-specific epigenetic regulation of glucocorticoid-stimulated skeletal muscle 11β-hydroxysteroid dehydrogenase-1 activity in type 2 diabetes
    Warrick J Inder
    Department of Endocrinology and Diabetes, St Vincent s Hospital, 41 Victoria Parade, Fitzroy, VIC 3065, Australia
    Clin Epigenetics 4:24. 2012
    ..Analysis of HSD11B1 promoter methylation (P1 and P2) was performed using Sequenom MassARRAY EpiTYPER analysis...
  5. doi request reprint A convergent model for placental dysfunction encompassing combined sub-optimal one-carbon donor and vitamin D bioavailability
    Richard Saffery
    Department of Paediatrics, Developmental Epigenetics, Murdoch Childrens Research Institute, University of Melbourne, Parkville, Victoria 3052, Australia
    Med Hypotheses 73:1023-8. 2009
    ....
  6. pmc Wide-ranging DNA methylation differences of primary trophoblast cell populations and derived cell lines: implications and opportunities for understanding trophoblast function
    Boris Novakovic
    Cancer, Disease and Developmental Epigenetics Group, Murdoch Children s Research Institute, Royal Children s Hospital Melbourne, Parkville, Australia
    Mol Hum Reprod 17:344-53. 2011
    ..This study also confirms the need for caution in the interpretation of data generated from manipulation of such pathways in vitro...
  7. pmc Neonatal DNA methylation profile in human twins is specified by a complex interplay between intrauterine environmental and genetic factors, subject to tissue-specific influence
    Lavinia Gordon
    Bioinformatics Unit, Murdoch Childrens Research Institute, Parkville, Victoria 3052, Australia
    Genome Res 22:1395-406. 2012
    ..This is the first study to analyze DNA methylation on a genome scale in twins at birth, further highlighting the importance of the intrauterine environment on shaping the neonatal epigenome...
  8. pmc DNA methylation-mediated down-regulation of DNA methyltransferase-1 (DNMT1) is coincident with, but not essential for, global hypomethylation in human placenta
    Boris Novakovic
    Developmental Epigenetics, Murdoch Children s Research Institute, Royal Children s Hospital, Parkville, Victoria 3052, Australia
    J Biol Chem 285:9583-93. 2010
    ..This strongly implicates epigenetic regulation of the DNMT gene family in the establishment of the unique epigenetic profile of extraembryonic tissue in humans...
  9. pmc Evidence for widespread changes in promoter methylation profile in human placenta in response to increasing gestational age and environmental/stochastic factors
    Boris Novakovic
    Cancer, Disease and Developmental Epigenetics, Murdoch Childrens Research Institute, Royal Children s Hospital and Department of Paediatrics, University of Melbourne, Parkville, Victoria 3052, Australia
    BMC Genomics 12:529. 2011
    ..However, the factors contributing to this variation in gene expression remain poorly understood...
  10. pmc DNA methylation at IL32 in juvenile idiopathic arthritis
    Braydon Meyer
    Genes, Environment and Complex Disease, Murdoch Childrens Research Institute, Parkville, Victoria, Australia
    Sci Rep 5:11063. 2015
    ..73, p = 0.0009), but this was not a JIA-associated CpG. Overall, our data further confirms that reduced IL32 methylation is associated with JIA, and that SNPs play an interactive role...
  11. doi request reprint The Peri/postnatal Epigenetic Twins Study (PETS)
    Yuk Jing Loke
    Department of Paediatrics, Royal Children s Hospital, Melbourne, Australia
    Twin Res Hum Genet 16:13-20. 2013
    ....
  12. doi request reprint Maternal vitamin D predominates over genetic factors in determining neonatal circulating vitamin D concentrations
    Boris Novakovic
    Cancer and Disease Epigenetics Group, Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Australia
    Am J Clin Nutr 96:188-95. 2012
    ..There are multiple potential regulators of neonatal vitamin D status of environmental, genetic, and epigenetic origins. The relation between these factors and circulating neonatal vitamin D has yet to be fully characterized...
  13. pmc Independent confirmation of juvenile idiopathic arthritis genetic risk loci previously identified by immunochip array analysis
    Rachel C Chiaroni-Clarke
    Genes, Environment and Complex Disease, Murdoch Childrens Research Institute, 50 Flemington Rd, Parkville, Victoria 3052 Australia Department of Paediatrics, The University of Melbourne, Parkville, VIC 3010 Australia
    Pediatr Rheumatol Online J 12:53. 2014
    ..However, independent replication of findings has yet to be performed. We therefore attempted to replicate these newly identified loci in the Australian CLARITY JIA case-control sample...
  14. pmc Hypermethylation and down-regulation of DLEU2 in paediatric acute myeloid leukaemia independent of embedded tumour suppressor miR-15a/16-1
    Leah Morenos
    Cancer and Disease Epigenetics, Murdoch Childrens Research Institute, Melbourne, Victoria, Australia
    Mol Cancer 13:123. 2014
    ..However, only limited DNA methylation studies have elucidated any associations in paediatric AML...
  15. doi request reprint Exploring the utility of human DNA methylation arrays for profiling mouse genomic DNA
    Nicholas C Wong
    Cancer and Disease Epigenetics Group, Murdoch Childrens Research Institute, Department of Paediatrics, The University of Melbourne, Royal Children s Hospital, Parkville, Victoria 3052, Australia
    Genomics 102:38-46. 2013
    ..In the absence of a mouse counterpart, the Infinium Human Methylation BeadChip arrays have utility for methylation profiling in non-human species...
  16. doi request reprint In vitro exposure of human blood mononuclear cells to active vitamin D does not induce substantial change to DNA methylation on a genome-scale
    Raul A Chavez Valencia
    Genes, Environment and Complex Disease, Murdoch Childrens Research Institute, 50 Flemington Road, Parkville, Victoria 3052, Australia Department of Paediatrics, The University of Melbourne, Victoria 3010, Australia Electronic address
    J Steroid Biochem Mol Biol 141:144-9. 2014
    ..Our data suggests that, over the exposure period measured, changes to DNA methylation may not be a predominant mechanism through which vitamin D impacts gene expression in human immune cells. ..
  17. pmc Prospects for epigenetic epidemiology
    Debra L Foley
    Orygen Youth Health Research Centre and Department of Psychiatry, University of Melbourne, Australia
    Am J Epidemiol 169:389-400. 2009
    ..Methodological considerations for epidemiologic studies that seek to include epigenetic analysis are also discussed...
  18. ncbi request reprint DNA methylation mediated up-regulation of TERRA non-coding RNA is coincident with elongated telomeres in the human placenta
    Boris Novakovic
    Murdoch Childrens Research Institute Cancer and Disease Epigenetics, Royal Children s Hospital Flemington Road, Parkville, Melbourne, Victoria 3052, Australia
    Mol Hum Reprod 22:791-799. 2016
    ..What factors regulate elongated telomere length in the human placenta?..
  19. doi request reprint Cord blood monocyte-derived inflammatory cytokines suppress IL-2 and induce nonclassic "T(H)2-type" immunity associated with development of food allergy
    Yuxia Zhang
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia The University of Melbourne, Parkville, Victoria 3010, Australia Guangzhou Institute of Pediatrics, Guangzhou Women and Children s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510623, China
    Sci Transl Med 8:321ra8. 2016
    ..These findings provide a mechanistic explanation for susceptibility to food allergy in infants and suggest anti-inflammatory approaches to its prevention...
  20. pmc Variable promoter methylation contributes to differential expression of key genes in human placenta-derived venous and arterial endothelial cells
    Jihoon E Joo
    Cancer and Disease Epigenetics, Murdoch Childrens Research Institute, Royal Children s Hospital, Flemington Road, Parkville, Melbourne, Australia
    BMC Genomics 14:475. 2013
    ..The aim of this study was to investigate the potential for DNA methylation to act as a driver of the specific gene expression profiles of arterial and venous endothelial cells...
  21. doi request reprint Glucose as a fetal nutrient: dynamic regulation of several glucose transporter genes by DNA methylation in the human placenta across gestation
    Boris Novakovic
    Cancer and Disease Epigenetics, Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Victoria 3052, Australia
    J Nutr Biochem 24:282-8. 2013
    ..These findings warrant a reexamination of the role of additional GLUT family members in the placenta in pregnancy and disease...
  22. pmc Evaluation of microRNA expression in patient bone marrow aspirate slides
    Leah Morenos
    Cancer and Disease Epigenetics, Murdoch Children s Research Institute, Melbourne, Victoria, Australia
    PLoS ONE 7:e42951. 2012
    ....
  23. pmc Normal DNA methylation dynamics in DICER1-deficient mouse embryonic stem cells
    Jonathan Ip
    Theme of Genetic Disorders, Murdoch Childrens Research Institute, The Royal Children s Hospital, Parkville, Victoria, Australia
    PLoS Genet 8:e1002919. 2012
    ....
  24. doi request reprint A distinct DNA methylation signature defines pediatric pre-B cell acute lymphoblastic leukemia
    Nicholas C Wong
    Murdoch Childrens Research Institute, Department of Paediatrics, The University of Melbourne, Royal Children s Hospital, Melbourne, Victoria, Australia
    Epigenetics 7:535-41. 2012
    ..By revealing new DNA methylation markers associated with disease, this study has identified putative targets for development of novel epigenetic-based therapies...
  25. doi request reprint DNA methylation analysis of multiple tissues from newborn twins reveals both genetic and intrauterine components to variation in the human neonatal epigenome
    Miina Ollikainen
    Developmental Epigenetics, Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Victoria 3052, Australia
    Hum Mol Genet 19:4176-88. 2010
    ..This has implications for the effects of maternal environment on the development of the newborn epigenome and supports an epigenetic mechanism for the previously described phenomenon of 'fetal programming' of disease risk...
  26. doi request reprint Effects of early-life environment and epigenetics on cardiovascular disease risk in children: highlighting the role of twin studies
    Cong Sun
    Environmental and Genetic Epidemiology Research Group, Public Health Genes and Environment Theme, Murdoch Childrens Research Institute, Royal Children s Hospital, Melbourne, Australia
    Pediatr Res 73:523-30. 2013
    ....
  27. pmc Genome-scale case-control analysis of CD4+ T-cell DNA methylation in juvenile idiopathic arthritis reveals potential targets involved in disease
    Justine A Ellis
    Genes, Environment and Complex Disease, Murdoch Childrens Research Institute, 50 Flemington Rd, Parkville, Vic, Australia
    Clin Epigenetics 4:20. 2012
    ..Genome-scale methylation analysis was carried out using the Illumina Infinium HumanMethylation27 BeadChip. Methylation data at >25,000 CpGs was compared in a case-control study design...
  28. pmc Centromere RNA is a key component for the assembly of nucleoproteins at the nucleolus and centromere
    Lee H Wong
    Chromosome and Chromatin Research Laboratory, Murdoch Children s Research Institute and Department of Paediatrics, University of Melbourne, Royal Children s Hospital, Parkville, Victoria, Australia
    Genome Res 17:1146-60. 2007
    ....
  29. doi request reprint Epigenetic modifications in trinucleotide repeat diseases
    Marguerite V Evans-Galea
    Bruce Lefroy Centre for Genetic Health Research, Murdoch Childrens Research Institute, Parkville, Victoria, 3052, Australia Department of Paediatrics, The University of Melbourne, Parkville, Victoria, 3010, Australia Electronic address
    Trends Mol Med 19:655-63. 2013
    ..This review presents the current evidence of epigenetic changes in several TNR diseases. ..
  30. doi request reprint DNA methylation and miRNA expression profiling in childhood B-cell acute lymphoblastic leukemia
    Zac Chatterton
    Developmental Epigenetics, Early Development and Disease Theme, Murdoch Children s Research Institute, Melbourne, Australia
    Epigenomics 2:697-708. 2010
    ..A number of DNA methylation and miRNA profiling studies have investigated the role of both in childhood ALL. Here, we review these profiling efforts, summarize their major findings and speculate as to what the future may hold...
  31. doi request reprint FXN methylation predicts expression and clinical outcome in Friedreich ataxia
    Marguerite V Evans-Galea
    Bruce Lefroy Centre for Genetic Health Research, Murdoch Childrens Research Institute, Parkville, Victoria, Australia
    Ann Neurol 71:487-97. 2012
    ..This leads to epigenetic modifications and reduced frataxin. We investigated the relationships between genetic, epigenetic, and clinical parameters in a large case-control study of FA...
  32. doi request reprint DNA methylation profiling highlights the unique nature of the human placental epigenome
    Boris Novakovic
    Developmental Epigenetics, Murdoch Childrens Research Institute, Royal Children s Hospital and Department of Paediatrics, University of Melbourne, Parkville, Victoria, 3052, Australia
    Epigenomics 2:627-38. 2010
    ....
  33. ncbi request reprint Centromere proteins Cenpa, Cenpb, and Bub3 interact with poly(ADP-ribose) polymerase-1 protein and are poly(ADP-ribosyl)ated
    Alka Saxena
    Murdoch Childrens Research Institute, Royal Children s Hospital, Flemington Rd, Parkville 3052, Australia
    J Biol Chem 277:26921-6. 2002
    ....
  34. doi request reprint Epigenetic modifications: mechanisms of disease and biomarkers of food allergy
    David J Martino
    Murdoch Childrens Research Institute, The University of Melbourne Department of Paediatrics, Royal Children s Hospital, Melbourne, Australia The University of Melbourne, Department of Paediatrics, Australia Telethon Institute for Child Health Research, Australia University of Western Australia, Department of Paediatrics, Australia IN FLAME International Inflammation Network, Australia
    Curr Opin Immunol 42:9-15. 2016
    ..Here we discuss these potential applications and their implications for food allergy practise...
  35. doi request reprint Epigenetic regulation of neurodevelopmental genes in response to in utero exposure to phthalate plastic chemicals: How can we delineate causal effects?
    Anne Louise Ponsonby
    Murdoch Childrens Research Institute, Royal Children s Hospital, University of Melbourne, Parkville, Victoria, Australia Electronic address
    Neurotoxicology 55:92-101. 2016
    ..Characterizing the relationship between the modern environment and the human molecular pathways underpinning its impact on early development is paramount to understanding the public health significance of modern day chemical exposures. ..
  36. pmc Paediatric leukaemia DNA methylation profiling using MBD enrichment and SOLiD sequencing on archival bone marrow smears
    Nicholas Cl Wong
    Cancer and Disease Epigenetics Research Group, Murdoch Childrens Research Institute, Royal Children s Hospital, Flemington Road, Parkville, 3052 Victoria Australia Department of Paediatrics, The University of Melbourne, Children s Hospital, Flemington Road, Parkville, 3052 Victoria Australia Translational Genomics and Epigenomics Research Group, Ludwig Cancer Research, Olivia Newton John Cancer and Wellness Centre, Austin Hospital, Burgundy Street, Heidelberg, 3084 Victoria Australia Pacific Edge Limted, 84 St David Street, Dunedin 9016, New Zealand
    Gigascience 4:11. 2015
    ..The causal molecular mechanisms remain unclear. Here, we performed sequencing-based genomic DNA methylation profiling of eight paediatric ALL patients using archived bone marrow smear microscope slides...
  37. doi request reprint Genome-wide association study of peanut allergy reproduces association with amino acid polymorphisms in HLA-DRB1
    David J Martino
    Murdoch Childrens Research Institute, The University of Melbourne Department of Paediatrics, The Royal Children s Hospital, Melbourne, Australia
    Clin Exp Allergy . 2016
    ..Genetic variants for IgE-mediated peanut allergy are yet to be fully characterized and to date only one genome-wide association study (GWAS) has been published...
  38. doi request reprint Heterozygosity for the common perforin mutation, p.A91V, impairs the cytotoxicity of primary natural killer cells from healthy individuals
    Imran G House
    1 Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia 2 Sir Peter MacCallum Department of Oncology, Parkville, Victoria, Australia 3 Department of Pathology, University of Melbourne, Parkville, Victoria, Australia
    Immunol Cell Biol 93:575-80. 2015
    ..A91V. Also, the fact that monoallelic mutations of PRF1 decrease NK-cell cytotoxicity should be considered in individuals presenting with the manifestations of immune deficiency states that impinge on NK-cell cytotoxicity. ..
  39. doi request reprint Epigenetic regulation of human placental function and pregnancy outcome: considerations for causal inference
    Vania Januar
    Cancer and Disease Epigenetics, Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Australia
    Am J Obstet Gynecol 213:S182-96. 2015
    ..The importance of animal or in vitro models in establishing a functional role of epigenetic variation identified in human beings, which is key to establishing causation, should not be underestimated...
  40. pmc Human active X-specific DNA methylation events showing stability across time and tissues
    Jihoon Eric Joo
    Cancer and Disease Epigenetics, Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Victoria, Australia
    Eur J Hum Genet 22:1376-81. 2014
    ..Further work is needed to investigate these phenomena. ..
  41. doi request reprint Archived Guthrie blood spots as a novel source for quantitative DNA methylation analysis
    Nicholas Wong
    Developmental Epigenetics, Murdoch Childrens Research Institute, Royal Children s Hospital, Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia
    Biotechniques 45:423-4, 426, 428 passim. 2008
    ..This provides a new source of material for epigenetic analysis of birth samples and provides an invaluable reference point to track temporal change in epigenetic profiles possibly linked with health and disease...
  42. pmc Investigating the potential role of genetic and epigenetic variation of DNA methyltransferase genes in hyperplastic polyposis syndrome
    Musa Drini
    Colorectal Medicine and Genetics, Royal Melbourne Hospital, Department of Medicine, University of Melbourne, Parkville, Victoria, Australia
    PLoS ONE 6:e16831. 2011
    ..In this study, we investigated the potential for interaction of genetic and epigenetic variation in DNMT genes, in the aetiology of HPS...
  43. doi request reprint A case-sibling assessment of the association between skin pigmentation and other vitamin D-related factors and type 1 diabetes mellitus
    Anne Louise Ponsonby
    Murdoch Children s Research Institute, Royal Children s Hospital, Department of Paediatrics, University of Melbourne, Melbourne, Vic, Australia
    Photochem Photobiol 85:1267-70. 2009
    ..The previously demonstrated association between light skin pigmentation and T1DM risk was evident even in this comparison across sibling pairs. Further work on past UVR exposure and related factors such as skin pigmentation is required...
  44. doi request reprint Cohort Profile: The Barwon Infant Study
    Peter Vuillermin
    Barwon Health, Geelong, Vic, Australia, Murdoch Childrens Research Institute, Parkville, Vic, Australia, Deakin University, Geelong, Vic, Australia, University of Melbourne, Parkville, Vic, Australia
    Int J Epidemiol 44:1148-60. 2015
    ..Data access enquiries can be made at [www.barwoninfantstudy.org.au] or via [peter.vuillermin@deakin.edu.au]. ..
  45. doi request reprint Epigenetics as the mediator of fetal programming of adult onset disease: what is the evidence?
    Richard Saffery
    Cancer and Disease Epigenetics, Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Victoria, Australia Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia
    Acta Obstet Gynecol Scand 93:1090-8. 2014
    ....
  46. pmc Inherent promoter bidirectionality facilitates maintenance of sequence integrity and transcription of parasitic DNA in mammalian genomes
    Paul Kalitsis
    Chromosome and Chromatin Research, Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Melbourne 3052, Victoria, Australia
    BMC Genomics 10:498. 2009
    ....
  47. pmc Placenta-specific methylation of the vitamin D 24-hydroxylase gene: implications for feedback autoregulation of active vitamin D levels at the fetomaternal interface
    Boris Novakovic
    Developmental Epigenetics, Murdoch Childrens Research Institute, Royal Children s Hospital, and Department of Paediatrics, University of Melbourne, Parkville, Victoria 3052, Australia
    J Biol Chem 284:14838-48. 2009
    ..This study strongly suggests that epigenetic decoupling of vitamin D feedback catabolism plays an important role in maximizing active vitamin D bioavailability at the fetomaternal interface...
  48. pmc Active transcription and essential role of RNA polymerase II at the centromere during mitosis
    F Lyn Chan
    Chromosome and Chromatin Research, Department of Paediatrics, Murdoch Childrens Research Institute, Royal Children s Hospital, University of Melbourne, Parkville, Victoria 3052, Australia
    Proc Natl Acad Sci U S A 109:1979-84. 2012
    ..These findings demonstrate an essential role of RNAPII in the transcription of α-satellite DNA, binding of centromere protein C, and the proper functioning of the mitotic kinetochore...
  49. doi request reprint Characterisation of histone variant distribution in human embryonic stem cells by transfection of in vitro transcribed mRNA
    Margaret L Shaw
    Developmental Epigenetics, Department of Paediatrics, Murdoch Childrens Research Institute, Royal Children s Hospital, University of Melbourne, Parkville, Melbourne, Victoria, Australia
    Mol Reprod Dev 76:1128-42. 2009
    ..We also provide the first evidence for MACROH2A accumulation on the Y-chromosome in XY hESCs...
  50. ncbi request reprint Effects of scaffold/matrix alteration on centromeric function and gene expression
    Huseyin Sumer
    Murdoch Childrens Research Institute, Department of Pediatrics, Royal Children s Hospital, Flemington Road, Melbourne 3052, Australia
    J Biol Chem 279:37631-9. 2004
    ....
  51. pmc Imprinted CDKN1C is a tumor suppressor in rhabdoid tumor and activated by restoration of SMARCB1 and histone deacetylase inhibitors
    Elizabeth M Algar
    Children s Cancer Centre research laboratory, Murdoch Children s Research Institute, Royal Children s Hospital, Parkville, Australia
    PLoS ONE 4:e4482. 2009
    ....
  52. ncbi request reprint Analysis of mitotic and expression properties of human neocentromere-based transchromosomes in mice
    Lee H Wong
    Murdoch Childrens Research Institute and Department of Pediatrics, University of Melbourne, Royal Children s Hospital, Flemington Road, Parkville 3052, Victoria, Australia
    J Biol Chem 280:3954-62. 2005
    ..They also highlight the need to further understand and overcome the factors that are responsible for the definable rates of instability of these transchromosomes in a mouse model...