Fraser M Rogerson

Summary

Affiliation: Royal Children's Hospital
Country: Australia

Publications

  1. doi request reprint Evidence of a novel aggrecan-degrading activity in cartilage: Studies of mice deficient in both ADAMTS-4 and ADAMTS-5
    Fraser M Rogerson
    University of Melbourne Department of Paediatrics, and Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Victoria, Australia
    Arthritis Rheum 58:1664-73. 2008
  2. doi request reprint Cytokine-induced increases in ADAMTS-4 messenger RNA expression do not lead to increased aggrecanase activity in ADAMTS-5-deficient mice
    Fraser M Rogerson
    University of Melbourne, Murdoch Childrens Research Institute, and Royal Children s Hospital, Melbourne, Victoria, Australia
    Arthritis Rheum 62:3365-73. 2010
  3. ncbi request reprint ADAMTS-1-knockout mice do not exhibit abnormalities in aggrecan turnover in vitro or in vivo
    Chris B Little
    Arthritis Research Group, University of Melbourne, Royal Children s Hospital, Parkville, Victoria, Australia
    Arthritis Rheum 52:1461-72. 2005
  4. ncbi request reprint ADAMTS-5 deficiency does not block aggrecanolysis at preferred cleavage sites in the chondroitin sulfate-rich region of aggrecan
    Charlotte J East
    Department of Paediatrics and Murdoch Childrens Research Institute, University of Melbourne, Royal Children s Hospital, Parkville 3052, Australia
    J Biol Chem 282:8632-40. 2007
  5. ncbi request reprint ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro
    Heather Stanton
    University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, 3052 Victoria, Australia
    Nature 434:648-52. 2005
  6. ncbi request reprint Distinguishing aggrecan loss from aggrecan proteolysis in ADAMTS-4 and ADAMTS-5 single and double deficient mice
    Mirna Z Ilic
    School of Human Biosciences and Musculoskeletal Research Centre, La Trobe University, Melbourne, Vic, Australia
    J Biol Chem 282:37420-8. 2007
  7. doi request reprint Investigating ADAMTS-mediated aggrecanolysis in mouse cartilage
    Heather Stanton
    University of Melbourne Department of Paediatrics, Parkville, Victoria, Australia
    Nat Protoc 6:388-404. 2011
  8. pmc A Disintegrin and Metalloproteinase with Thrombospondin Motifs-5 (ADAMTS-5) Forms Catalytically Active Oligomers
    Hansen J Kosasih
    From the Department of Paediatrics, University of Melbourne, Parkville 3052, Australia, The Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville 3052, Australia
    J Biol Chem 291:3197-208. 2016
  9. doi request reprint Identification and characterization of a ligand-selective mineralocorticoid receptor coactivator
    Fraser M Rogerson
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    FASEB J 28:4200-10. 2014
  10. pmc Structural and functional characterization of the interdomain interaction in the mineralocorticoid receptor
    Jyotsna B Pippal
    Prince Henry s Institute of Medical Research, P O Box 5152, Clayton 3168, Victoria, Australia
    Mol Endocrinol 23:1360-70. 2009

Collaborators

Detail Information

Publications11

  1. doi request reprint Evidence of a novel aggrecan-degrading activity in cartilage: Studies of mice deficient in both ADAMTS-4 and ADAMTS-5
    Fraser M Rogerson
    University of Melbourne Department of Paediatrics, and Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, Victoria, Australia
    Arthritis Rheum 58:1664-73. 2008
    ..To characterize aggrecan catabolism and the overall phenotype in mice deficient in both ADAMTS-4 and ADAMTS-5 (TS-4/TS-5 Delta-cat) activity...
  2. doi request reprint Cytokine-induced increases in ADAMTS-4 messenger RNA expression do not lead to increased aggrecanase activity in ADAMTS-5-deficient mice
    Fraser M Rogerson
    University of Melbourne, Murdoch Childrens Research Institute, and Royal Children s Hospital, Melbourne, Victoria, Australia
    Arthritis Rheum 62:3365-73. 2010
    ..To compare the regulation of aggrecanase messenger RNA (mRNA) and enzyme activity by proinflammatory cytokines in primary mouse chondrocytes...
  3. ncbi request reprint ADAMTS-1-knockout mice do not exhibit abnormalities in aggrecan turnover in vitro or in vivo
    Chris B Little
    Arthritis Research Group, University of Melbourne, Royal Children s Hospital, Parkville, Victoria, Australia
    Arthritis Rheum 52:1461-72. 2005
    ..To determine the role of the proteinase ADAMTS-1 in normal and accelerated catabolism of aggrecan in articular and growth plate cartilage of mice...
  4. ncbi request reprint ADAMTS-5 deficiency does not block aggrecanolysis at preferred cleavage sites in the chondroitin sulfate-rich region of aggrecan
    Charlotte J East
    Department of Paediatrics and Murdoch Childrens Research Institute, University of Melbourne, Royal Children s Hospital, Parkville 3052, Australia
    J Biol Chem 282:8632-40. 2007
    ..The data show that there are differential aggrecanase activities with preferences for separate regions of the core protein...
  5. ncbi request reprint ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro
    Heather Stanton
    University of Melbourne Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, 3052 Victoria, Australia
    Nature 434:648-52. 2005
    ....
  6. ncbi request reprint Distinguishing aggrecan loss from aggrecan proteolysis in ADAMTS-4 and ADAMTS-5 single and double deficient mice
    Mirna Z Ilic
    School of Human Biosciences and Musculoskeletal Research Centre, La Trobe University, Melbourne, Vic, Australia
    J Biol Chem 282:37420-8. 2007
    ....
  7. doi request reprint Investigating ADAMTS-mediated aggrecanolysis in mouse cartilage
    Heather Stanton
    University of Melbourne Department of Paediatrics, Parkville, Victoria, Australia
    Nat Protoc 6:388-404. 2011
    ..The protocol is robust, reliable and takes 7-11 d to complete...
  8. pmc A Disintegrin and Metalloproteinase with Thrombospondin Motifs-5 (ADAMTS-5) Forms Catalytically Active Oligomers
    Hansen J Kosasih
    From the Department of Paediatrics, University of Melbourne, Parkville 3052, Australia, The Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville 3052, Australia
    J Biol Chem 291:3197-208. 2016
    ..The data identify the surface provided by the catalytic and disintegrin-like domains of ADAMTS-5 as a legitimate target for the design of aggrecanase inhibitors. ..
  9. doi request reprint Identification and characterization of a ligand-selective mineralocorticoid receptor coactivator
    Fraser M Rogerson
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    FASEB J 28:4200-10. 2014
    ..Tesmin thus represents a novel MR coregulator that exhibits a differential interaction, providing further evidence of the adoption of ligand-dependent conformations by the MR-LBD...
  10. pmc Structural and functional characterization of the interdomain interaction in the mineralocorticoid receptor
    Jyotsna B Pippal
    Prince Henry s Institute of Medical Research, P O Box 5152, Clayton 3168, Victoria, Australia
    Mol Endocrinol 23:1360-70. 2009
    ....
  11. ncbi request reprint Differences in the determinants of eplerenone, spironolactone and aldosterone binding to the mineralocorticoid receptor
    Fraser M Rogerson
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    Clin Exp Pharmacol Physiol 31:704-9. 2004
    ....